Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
phosphorus-oxygen lyases - metabolism (408) 408
index medicus (309) 309
phosphorus-oxygen lyases - genetics (283) 283
biochemistry & molecular biology (230) 230
humans (171) 171
bacterial proteins - metabolism (166) 166
microbiology (165) 165
cyclic gmp - analogs & derivatives (155) 155
escherichia coli proteins - metabolism (153) 153
phosphorus-oxygen lyases (150) 150
cyclic gmp - metabolism (144) 144
animals (139) 139
bacterial proteins - genetics (130) 130
phosphorus-oxygen lyases - chemistry (130) 130
molecular sequence data (124) 124
escherichia-coli (123) 123
amino acid sequence (114) 114
escherichia coli proteins - genetics (111) 111
biopterin - analogs & derivatives (96) 96
enzymes (94) 94
physiological aspects (93) 93
kinetics (91) 91
research (91) 91
bacteria (86) 86
biofilm formation (86) 86
mutation (85) 85
gene expression regulation, bacterial (76) 76
c-di-gmp (75) 75
models, molecular (74) 74
proteins (72) 72
escherichia coli proteins (71) 71
biosynthesis (68) 68
signal transduction (68) 68
analysis (66) 66
phosphoric diester hydrolases - metabolism (65) 65
genetic aspects (64) 64
biofilms (63) 63
female (63) 63
gene expression (62) 62
biofilms - growth & development (61) 61
identification (61) 61
pseudomonas-aeruginosa (60) 60
bacterial proteins - chemistry (58) 58
diguanylate cyclase (56) 56
alcohol oxidoreductases - metabolism (55) 55
research article (54) 54
tetrahydrobiopterin (54) 54
base sequence (53) 53
escherichia coli - enzymology (52) 52
escherichia coli - genetics (52) 52
genetics & heredity (52) 52
protein (52) 52
binding sites (50) 50
male (50) 50
lyases - metabolism (49) 49
protein binding (49) 49
allosteric control (48) 48
protein structure, tertiary (48) 48
expression (47) 47
recombinant proteins - metabolism (47) 47
response regulator (47) 47
crystallography, x-ray (45) 45
mice (45) 45
protein conformation (45) 45
biophysics (44) 44
catalysis (44) 44
cloning, molecular (44) 44
biopterin - biosynthesis (43) 43
sequence alignment (43) 43
sequence homology, amino acid (42) 42
acetobacter-xylinum (40) 40
escherichia coli proteins - chemistry (40) 40
article (39) 39
genes (39) 39
motility (39) 39
virulence (39) 39
biotechnology & applied microbiology (38) 38
escherichia coli - metabolism (38) 38
gtp cyclohydrolase - metabolism (38) 38
escherichia coli (37) 37
substrate specificity (37) 37
cell biology (36) 36
shikimic acid - metabolism (36) 36
biopterin - deficiency (35) 35
biopterin - metabolism (35) 35
cyclic-di-gmp (35) 35
multidisciplinary sciences (35) 35
phenotype (35) 35
purification (35) 35
vibrio-cholerae (35) 35
mechanism (34) 34
phosphoric diester hydrolases - genetics (34) 34
phosphorus-oxygen lyases - deficiency (34) 34
shikimate pathway (34) 34
cyclic di-gmp (33) 33
gene (33) 33
6-pyruvoyl tetrahydropterin synthase (32) 32
enzyme (31) 31
phosphodiesterase (31) 31
phosphorus-oxygen lyases - antagonists & inhibitors (30) 30
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (636) 636
Chinese (9) 9
Japanese (3) 3
French (2) 2
German (2) 2
Polish (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text The shikimate pathway and aromatic amino acid biosynthesis in plants
by Maeda, Hiroshi and Dudareva, Natalia
Annual Review of Plant Biology, ISSN 1543-5008, 06/2012, Volume 63, Issue 1, pp. 73 - 105
L-tryptophan, L-phenylalanine, and L-tyrosine are aromatic amino acids (AAAs) that are used for the synthesis of proteins and that in plants also serve as... 
metabolite transport | metabolic engineering | subcellular localization | plant metabolism | metabolic regulation | Phenylalanine - biosynthesis | Tyrosine - biosynthesis | Amino Acids, Aromatic - biosynthesis | Humans | Alkyl and Aryl Transferases - metabolism | 3-Deoxy-7-Phosphoheptulonate Synthase - genetics | Shikimic Acid - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Tryptophan - biosynthesis | Biological Transport | Plants - genetics | Alkyl and Aryl Transferases - genetics | Transcription, Genetic | Hydro-Lyases - metabolism | Anthranilate Synthase - metabolism | Phosphorus-Oxygen Lyases - metabolism | Physiological aspects | Amino acids | Biosynthesis | Research | Phytochemistry | Plant metabolites
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Cyclic di-AMP: Another second messenger enters the fray
by Corrigan, Rebecca M and Gründling, Angelika
Nature Reviews Microbiology, ISSN 1740-1526, 08/2013, Volume 11, Issue 8, pp. 513 - 524
Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms of life. In recent years, the discovery of new signalling... 
DNA SENSOR | ESSENTIAL GENES | BACILLUS-SUBTILIS | PSEUDOMONAS-AERUGINOSA | CHECKPOINT PROTEIN | MICROBIOLOGY | STAPHYLOCOCCUS-AUREUS | BETA INTERFERON | GMP-AMP | LACTOCOCCUS-LACTIS | PILZ DOMAIN | Protein Structure, Tertiary | Bacteria - metabolism | Phosphorus-Oxygen Lyases - genetics | Signal Transduction | Cell Wall - genetics | Eukaryotic Cells - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Dinucleoside Phosphates - metabolism | Bacteria - genetics | Protein Transport | Host-Pathogen Interactions | Carrier Proteins - genetics | Carrier Proteins - metabolism | Proteolysis | Cell Wall - metabolism | Dinucleoside Phosphates - genetics | Phosphorus-Oxygen Lyases - classification | Transcription, Genetic | Gene Expression Regulation, Bacterial | Phosphorus-Oxygen Lyases - metabolism | Eukaryotic Cells - microbiology | Intracellular Signaling Peptides and Proteins - genetics | Cellular signal transduction | Microbial enzymes | Research | Properties | Bacterial proteins
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Cyclic Di-AMP homeostasis in bacillus subtilis: Both lack and high level accumulation of the nucleotide are detrimental for cell growth
by Mehne, Felix M. P and Gunka, Katrin and Eilers, Hinnerk and Herzberg, Christina and Kaever, Volkhard and Stülke, Jörg
Journal of Biological Chemistry, ISSN 0021-9258, 01/2013, Volume 288, Issue 3, pp. 2004 - 2017
The genome of the Gram-positive soil bacterium Bacillus subtilis encodes three potential diadenylate cyclases that may synthesize the signaling nucleotide... 
BACTERIA | RNA | GLMS RIBOZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RIBOSOMAL-PROTEIN | CHECKPOINT PROTEIN | GMP | OPERON | IDENTIFICATION | STRESS | Recombinant Proteins - metabolism | Genome, Bacterial | Phosphorus-Oxygen Lyases - genetics | Signal Transduction | Isoenzymes - genetics | Cell Wall - genetics | Homeostasis | Models, Molecular | Recombinant Proteins - chemistry | Magnesium - metabolism | Isoenzymes - chemistry | Recombinant Proteins - genetics | Spores, Bacterial - metabolism | Dinucleoside Phosphates - metabolism | Bacillus subtilis - genetics | Spores, Bacterial - genetics | Escherichia coli - genetics | Isoenzymes - metabolism | Cell Wall - metabolism | Phosphorus-Oxygen Lyases - chemistry | Phosphorus-Oxygen Lyases - metabolism | Bacillus subtilis - metabolism | Diadenylate Cyclase | Cell Wall Metabolism | Microbiology | Prokaryotic Signal Transduction | Bacterial Signal Transduction | Bacillus | c-di-AMP | Cyclic Nucleotides | Protein-Protein Interactions | DAC Domain
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
by Joshua J. Woodward and Anthony T. Iavarone and Daniel A. Portnoy
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5986, pp. 1703 - 1705
Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells. Induction of this host response is often... 
Molecules | Pathogens | Microorganisms | Interferons | B lymphocytes | REPORTS | Ligands | Innate immunity | Bacteria | Infections | Cytosol | PATHOGENESIS | CYTOSOLIC SURVEILLANCE PATHWAY | ESSENTIAL GENES | FLAGELLIN | PEPTIDOGLYCAN | RECOGNITION | BACILLUS-SUBTILIS | MULTIDISCIPLINARY SCIENCES | CHECKPOINT PROTEIN | MULTIDRUG TRANSPORTERS | INFECTION | Genes, Bacterial | Phosphorus-Oxygen Lyases - genetics | Operon | Cytosol - immunology | Listeria monocytogenes - immunology | Dinucleoside Phosphates - metabolism | Immunity, Innate | Animals | Interferon-beta - metabolism | Mass Spectrometry | Listeria monocytogenes - genetics | Listeria monocytogenes - metabolism | Bacterial Proteins - metabolism | Female | Membrane Transport Proteins - metabolism | Cytosol - microbiology | Mice | Phosphorus-Oxygen Lyases - metabolism | Macrophages - immunology | Macrophages - microbiology | Physiological aspects | Listeria monocytogenes | Interferon | Genetic aspects | Research | Bacterial genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability
by Lai, Yanhao and Weizmann, Yossi and Liu, Yuan
Nucleic Acids Research, ISSN 0305-1048, 09/2018, Volume 46, Issue 17, pp. 8940 - 8952
Abstract Trinucleotide repeat (TNR) instability is associated with over 42 neurodegenerative diseases and cancer, for which the molecular mechanisms remain to... 
SITE | BASE EXCISION-REPAIR | MECHANISM | SPECIFICITY | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPANSION | 8-KDA DOMAIN | RESIDUES | BINDING | Trinucleotide Repeats | Genomic Instability | Humans | Genetic Complementation Test | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | DNA - biosynthesis | DNA Polymerase beta - metabolism | DNA Polymerase beta - genetics | Flap Endonucleases - genetics | Fibroblasts - chemistry | Fibroblasts - metabolism | Phosphorus-Oxygen Lyases - genetics | Cell-Free System - chemistry | Gene Expression Regulation | DNA Replication | Flap Endonucleases - metabolism | Oligonucleotides - chemical synthesis | Trinucleotide Repeat Expansion | DNA - genetics | Oligonucleotides - metabolism | Animals | Cell-Free System - metabolism | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | DNA Repair | Mice | Phosphorus-Oxygen Lyases - metabolism | Genome Integrity, Repair and
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Identification of a conserved 5′-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair
by De Ory, Ana and Nagler, Katja and Carrasco, Begoña and Raguse, Marina and Zafra, Olga and Moeller, Ralf and De Vega, Miguel
Nucleic Acids Research, ISSN 0305-1048, 01/2016, Volume 44, Issue 4, pp. 1833 - 1844
Bacillus subtilis is one of the bacterial members provided with a nonhomologous end joining (NHEJ) system constituted by the DNA-binding Ku homodimer that... 
IN-VITRO | SUBSTRATE-SPECIFICITY | IV APURINIC/APYRIMIDINIC-ENDONUCLEASE | POLY(ADP-RIBOSE) POLYMERASE 1 | ABASIC SITES | END-JOINING FUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | PHOSPHATE LYASE | DOUBLE-STRAND BREAK | BACILLUS-SUBTILIS SPORES | Phosphorus-Oxygen Lyases - genetics | DNA End-Joining Repair - genetics | DNA Ligases - genetics | Pseudomonas aeruginosa - enzymology | Bacillus subtilis - enzymology | DNA Repair - genetics | Phosphorus-Oxygen Lyases - metabolism | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | Nucleic Acid Enzymes
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Principles of c-di-GMP signalling in bacteria
by Hengge, Regine
Nature Reviews Microbiology, ISSN 1740-1526, 04/2009, Volume 7, Issue 4, pp. 263 - 273
On the stage of bacterial signal transduction and regulation, bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has long played the part of... 
DIRECT OXYGEN SENSOR | CYCLIC DIMERIC GMP | DIGUANYLATE CYCLASE | HD-GYP DOMAIN | ENTERICA SEROVAR TYPHIMURIUM | PSEUDOMONAS-AERUGINOSA | REGULATES BIOFILM FORMATION | AMP RECEPTOR PROTEIN | ESCHERICHIA-COLI | MICROBIOLOGY | VIBRIO-CHOLERAE | Bacteria - metabolism | Escherichia coli Proteins | Phosphoric Diester Hydrolases - metabolism | Cyclic GMP - analogs & derivatives | Cyclic GMP - metabolism | Signal Transduction | Phosphorus-Oxygen Lyases - metabolism | Physiological aspects | Bacteria | Cellular signal transduction | Research | Purine nucleotides
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa
by Dorit Cohen and Undine Mechold and Hadas Nevenzal and Yafit Yarmiyhu and Trevor E. Randall and Denice C. Bay and Jacquelyn D. Rich and Matthew R. Parsek and Volkhard Kaever and Joe J. Harrison and Ehud Banin
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2015, Volume 112, Issue 36, pp. 11359 - 11364
The second messenger cyclic diguanylate (c-di-GMP) controls diverse cellular processes among bacteria. Diguanylate cyclases synthesize c-di-GMP, whereas it is... 
Biofilm | Pseudomonas aeruginosa | Oligoribonuclease | EAL domain | Cyclic diguanylate | cyclic diguanylate | PROTEIN | C-DI-GMP | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MULTIPLE | oligoribonuclease | BACILLUS-SUBTILIS | biofilm | GENE-EXPRESSION | PHOSPHODIESTERASE | VECTORS | ACETOBACTER-XYLINUM | BIOFILM FORMATION | Exoribonucleases - genetics | Phosphoric Diester Hydrolases - metabolism | Phosphorus-Oxygen Lyases - genetics | Signal Transduction | Bacterial Proteins - genetics | Homeostasis | Escherichia coli Proteins - metabolism | Phosphoric Diester Hydrolases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cyclic GMP - analogs & derivatives | Cyclic GMP - metabolism | Pseudomonas aeruginosa - genetics | Pseudomonas aeruginosa - metabolism | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Deoxyguanine Nucleotides - metabolism | Mutation | Gene Expression Regulation, Bacterial | Phosphorus-Oxygen Lyases - metabolism | Exoribonucleases - metabolism | Host-bacteria relationships | Cellular signal transduction | Observations | Health aspects | Cyclic guanylic acid | Exoribonucleases | Bacteriology | Bacterial Proteins | Life Sciences | Phosphoric Diester Hydrolases | Microbiology and Parasitology | Escherichia coli Proteins | Phosphorus-Oxygen Lyases | Cyclic GMP | Deoxyguanine Nucleotides | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control
by Tuckerman, Jason R and Gonzalez, Gonzalo and Sousa, Eduardo H. S and Wan, Xuehua and Saito, Jennifer A and Alam, Maqsudul and Gilles-Gonzalez, Marie-Alda
Biochemistry, ISSN 0006-2960, 10/2009, Volume 48, Issue 41, pp. 9764 - 9774
A commonly observed coupling of sensory domains to GGDEF-class diguanylate cyclases and EAL-class phosphodiesterases has long suggested that c-di-GMP... 
HEME-BASED SENSOR | SIGNAL-TRANSDUCTION | CELLULOSE SYNTHESIS | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES BIOFILM FORMATION | ESCHERICHIA-COLI | CYCLIC DIGUANYLATE | PAS-DOMAIN | ACETOBACTER-XYLINUM | RAY CRYSTAL-STRUCTURE | Humans | Bacteria - drug effects | Bacterial Proteins - chemistry | Homeostasis | Oxygen - metabolism | Cyclic GMP - isolation & purification | Cyclic GMP - analogs & derivatives | Bordetella pertussis - metabolism | Cyclic GMP - chemistry | Escherichia coli - metabolism | Phosphorus-Oxygen Lyases - chemistry | Escherichia coli - enzymology | Phosphoric Diester Hydrolases - metabolism | Phosphorus-Oxygen Lyases - genetics | Bacterial Infections - drug therapy | Models, Molecular | Phosphorus-Oxygen Lyases - isolation & purification | Escherichia coli Proteins - metabolism | Phosphoric Diester Hydrolases - genetics | Escherichia coli Proteins - isolation & purification | Operon - genetics | Phosphoric Diester Hydrolases - chemistry | Bacterial Infections - physiopathology | Gene Expression Regulation, Enzymologic | Phosphoric Diester Hydrolases - isolation & purification | Cyclic GMP - metabolism | Escherichia coli - genetics | Protein Binding | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Escherichia coli Proteins - chemistry | Phosphorus-Oxygen Lyases - metabolism | Bordetella pertussis - enzymology | Hydrogen-Ion Concentration | Research | Chemical properties | Structure | Phosphodiesterases | Escherichia coli | Organic compounds
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
by Dey, Bappaditya and Dey, Ruchi Jain and Cheung, Laurene S and Pokkali, Supriya and Guo, Haidan and Lee, Jong-Hee and Bishai, William R
Nature Medicine, ISSN 1078-8956, 04/2015, Volume 21, Issue 4, pp. 401 - 408
Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger, by the host cytoplasmic surveillance pathway (CSP) is known to elicit... 
MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | I INTERFERON RESPONSE | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | GMP | C-DI-AMP | CELL BIOLOGY | HOST-CELL | DNA | INFECTION | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Virulence | Interferon-gamma - metabolism | Dinucleoside Phosphates - metabolism | Autophagy | Genetic Complementation Test | Macrophages - metabolism | Animals | Interferon-beta - metabolism | Mycobacterium tuberculosis | Tuberculosis - prevention & control | Bacterial Proteins - metabolism | Cytosol - metabolism | Female | Mice | Mice, Inbred BALB C | Nucleotidyltransferases - metabolism | Phosphorus-Oxygen Lyases - metabolism | Tuberculosis - metabolism | Medicine, Experimental | Medical research | Care and treatment | Tuberculosis | Research | Immunotherapy | Signal transduction | Gene expression | Molecular biology | Immune system
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Human DNA polymerase θ possesses 5′-dRP lyase activity and functions in single-nucleotide base excision repair in vitro
by Prasad, Rajendra and Longley, Matthew J and Sharief, Farida S and Hou, Esther W and Copeland, William C and Wilson, Samuel H
Nucleic Acids Research, ISSN 0305-1048, 4/2009, Volume 37, Issue 6, pp. 1868 - 1877
DNA polymerase θ (Pol θ) is a low-fidelity DNA polymerase that belongs to the family A polymerases and has been proposed to play a role in somatic... 
POLQ | SITE | DEOXYRIBOSE PHOSPHATE LYASE | SOMATIC HYPERMUTATION | DEOXYNUCLEOTIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IG GENES | SENSITIVITY PROTEIN MUS308 | INSERTION FIDELITY | IDENTIFICATION | BETA | Protein Structure, Tertiary | Catalytic Domain | Peptides - chemistry | DNA Repair | Humans | Phosphorus-Oxygen Lyases - chemistry | DNA-Directed DNA Polymerase - chemistry | DNA-Directed DNA Polymerase - metabolism | Kinetics | Phosphorus-Oxygen Lyases - metabolism | Nucleic Acid Enzymes
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa
by Yasuhiko Irie and Bradley R. Borlee and Jennifer R. O'Connor and Preston J. Hill and Caroline S. Harwood and Daniel J. Wozniak and Matthew R. Parsek
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. 20632 - 20636
Bacteria have a tendency to attach to surfaces and grow as structured communities called biofilms. Chronic biofilm infections are a problem because they tend... 
Proteins | Cytometry | Polysaccharides | Receptors | Liquids | Biofilms | Fluorescence | Pseudomonas aeruginosa | Extracellular matrix | Infections | SYSTEM | PROTEIN | VARIANTS | C-DI-GMP | MULTIDISCIPLINARY SCIENCES | PSL | RECEPTOR | EXTRACELLULAR-MATRIX | MODULATION | POLYSACCHARIDE | MOTILITY | Genes, Bacterial | Phosphorus-Oxygen Lyases - genetics | Signal Transduction | Bacterial Proteins - genetics | Biofilms - growth & development | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - physiology | Feedback, Physiological | Polysaccharides, Bacterial - physiology | DNA, Bacterial - genetics | Cyclic GMP - analogs & derivatives | Cyclic GMP - metabolism | Pseudomonas aeruginosa - genetics | Base Sequence | Extracellular Matrix - physiology | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Phosphorus-Oxygen Lyases - metabolism | Second Messenger Systems | Physiological aspects | Cellular signal transduction | Research | Microbial mats | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues
by Daskalova, Sasha M and Bhattacharya, Chandrabali and Dedkova, Larisa M and Hecht, Sidney M
Biochemistry, ISSN 0006-2960, 01/2017, Volume 56, Issue 3, pp. 500 - 513
DNA polymerase beta (Pol beta) is a key enzyme in mammalian base excision repair (BER), contributing stepwise S'-deoxyribose phosphate (dRP) lyase and... 
BASE-EXCISION-REPAIR | MECHANISM | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NONNATURAL SIDE-CHAINS | CRYSTAL-STRUCTURES | SITE-SPECIFIC INCORPORATION | MAMMALIAN-CELLS | ABASIC SITE | CHEMICAL AMINOACYLATION | MISACYLATED TRANSFER-RNAS | Codon - metabolism | Protein Biosynthesis | Humans | DNA Polymerase beta - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Protein Domains | Transcription, Genetic | Lysine - metabolism | Phosphorus-Oxygen Lyases - chemistry | Codon - genetics | DNA Polymerase beta - metabolism | DNA Polymerase beta - genetics | RNA, Transfer, Lys - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Lysine - analogs & derivatives | Catalytic Domain | RNA, Transfer, Lys - chemistry | Phosphorus-Oxygen Lyases - genetics | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | DNA - metabolism | RNA, Transfer, Lys - genetics | DNA - genetics | DNA - chemistry | Escherichia coli - genetics | DNA Repair | Schiff Bases - chemistry | Schiff Bases - metabolism | Phosphorus-Oxygen Lyases - metabolism | Polymerase chain reaction | Schiff bases | Usage | Chemical properties | Nucleophiles
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights