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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14250 - 14257
The histidine-phosphorylatable phosphocarrier protein (HPr) is an essential component of the sugar-transporting phosphotransferase system (PTS) in many... 
COMPLEX | DOMAIN | PATHOGEN | glucosamine 6-phosphate deaminase | GLYCOGEN-PHOSPHORYLASE | adenylate kinase (ADK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycolysis | phosphofructokinase | isomerase | adenylate kinase | Histidine phosphocarrier protein | GLUCOSAMINE-6-PHOSPHATE DEAMINASE | SUBSTRATE-BINDING | PYRUVATE-KINASE | REPRESSION | pyruvate kinase | protein-protein interaction | PHOSPHOENOLPYRUVATE | ALLOSTERIC ACTIVATION | Phosphorylation | Allosteric Regulation | Bacterial Proteins - chemistry | Pyruvate Kinase - chemistry | Isoenzymes - chemistry | Histidine - metabolism | Adenylate Kinase - chemistry | Recombinant Fusion Proteins - metabolism | Isoenzymes - metabolism | Adenylate Kinase - metabolism | Escherichia coli - metabolism | Escherichia coli Proteins - agonists | Protein Interaction Domains and Motifs | Binding Sites | Aldose-Ketose Isomerases - metabolism | Phosphoenolpyruvate Sugar Phosphotransferase System - chemistry | Phosphoenolpyruvate Sugar Phosphotransferase System - genetics | Recombinant Proteins - metabolism | Aldose-Ketose Isomerases - chemistry | Phosphofructokinase-2 - chemistry | Escherichia coli - enzymology | Pyruvate Kinase - metabolism | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Phosphofructokinase-2 - metabolism | Energy Metabolism | Phosphofructokinase-2 - genetics | Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism | Proteomics | Escherichia coli Proteins - genetics | Glycolysis | Bacterial Proteins - metabolism | Protein Conformation | Protein Processing, Post-Translational | Aldose-Ketose Isomerases - genetics | Enzyme Activation | Escherichia coli Proteins - chemistry | Adenylate Kinase - genetics | Pyruvate Kinase - genetics | Metabolism
Journal Article
Science, ISSN 0036-8075, 3/2004, Volume 303, Issue 5665, pp. 1800 - 1805
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 6, pp. 403 - 416
AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and whole-body energy metabolism. We have identified a thienopyridone family... 
SIGNALING | SKELETAL-MUSCLE | PROTEIN-KINASE CASCADE | FATTY-ACID OXIDATION | MALONYL-COA | GLYCOGEN-PHOSPHORYLASE | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | ACETYL-COA CARBOXYLASE | CELLULAR-ENERGY | ISOLATED RAT HEPATOCYTES | GLOBULAR DOMAIN | CELL BIOLOGY | Enzyme Activators - pharmacology | Glucose-6-Phosphatase - genetics | Thiophenes - therapeutic use | Metformin - therapeutic use | Molecular Weight | Fatty Acid Synthases - metabolism | Enzyme Activators - therapeutic use | Humans | Phosphoenolpyruvate Carboxykinase (GTP) - drug effects | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Multienzyme Complexes - metabolism | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | RNA, Messenger - metabolism | Metabolic Syndrome - drug therapy | Pyrones - pharmacology | AMP-Activated Protein Kinases | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Dose-Response Relationship, Drug | Pyrones - chemistry | Enzyme Activators - chemistry | Fatty Acid Synthases - genetics | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Fatty Acid Synthases - drug effects | RNA, Messenger - drug effects | Cell Line | Metformin - chemistry | Metformin - pharmacology | RNA, Messenger - genetics | Rats | Thiophenes - pharmacology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Glucose-6-Phosphatase - metabolism | Glucose-6-Phosphatase - drug effects | Animals | Protein-Serine-Threonine Kinases - drug effects | Pyrones - therapeutic use | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - drug therapy | In Vitro Techniques | Thiophenes - chemistry | Enzyme Activation - physiology | Multienzyme Complexes - drug effects | Type 2 diabetes | Synthesis | Analysis | Insulin resistance | Lipids | Triglycerides | Glucose | Gene expression | Protein kinases | Fatty acids | Dextrose
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article