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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 07/2017, Volume 95, Issue 7, pp. 1427 - 1437
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 11/1996, Volume 16, Issue 11, pp. 6486 - 6493
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
MOTIFS | ACTIVATION | DOMAIN | CONSERVED FEATURES | DETERMINANTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | IDENTIFICATION | FAMILY | CELL BIOLOGY | NIMA-Related Kinase 1 | Protein Kinases - metabolism | Cyclin-Dependent Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - chemistry | Protein Kinases - chemistry | Substrate Specificity | Crystallography, X-Ray | Cyclin-Dependent Kinase 2 | Muscle Proteins - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Oligopeptides - chemistry | Protein-Serine-Threonine Kinases - metabolism | Databases, Factual | Cyclic AMP-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinases | Amino Acid Sequence | Phosphopeptides - chemistry | Caenorhabditis elegans Proteins | CDC2-CDC28 Kinases | Casein Kinase II | Casein Kinases | Cyclin-Dependent Kinases - chemistry | Models, Molecular | Calmodulin-Binding Proteins - chemistry | Calmodulin-Binding Proteins - metabolism | Oligopeptides - metabolism | Cyclin-Dependent Kinase 5 | Calcium-Calmodulin-Dependent Protein Kinases - chemistry | Phosphorylase Kinase - metabolism | Protein Conformation | Muscle Proteins - chemistry | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Cell Cycle Proteins | Mitogen-Activated Protein Kinase 3 | NIMA-Related Kinases | Phosphopeptides - isolation & purification
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e49284
This study provides a comprehensive computational procedure for the discovery of novel urea-based antineoplastic kinase inhibitors while focusing on... 
FAMILY KINASE | SYK KINASE | SPLEEN TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITY | T-CELL-RECEPTOR | GENE-EXPRESSION | INTERACTION MAP | ANTICANCER DRUG DISCOVERY | PHARMACOLOGICAL EVALUATION | POTENT INHIBITORS | Protein-Tyrosine Kinases - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Support Vector Machine | Urea - chemistry | Protein Kinase Inhibitors - chemistry | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Antineoplastic Agents - classification | Syk Kinase | Cyclin-Dependent Kinase 2 - metabolism | Protein Kinase Inhibitors - chemical synthesis | Protein Kinase Inhibitors - classification | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Antineoplastic Agents - chemistry | Drug Discovery | Algorithms | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Electrons | Protein-Tyrosine Kinases - antagonists & inhibitors | Urea | Protein kinases | Analysis | Profiling | Similarity | Cytotoxicity | Selectivity | ZAP-70 protein | Electron distribution | Kinases | Anticancer properties | Filters | Cell cycle | Trees | Spleen | Feasibility studies | Pharmacology | Tumor cell lines | Src protein | Chemistry | Protein arrays | Inhibitors | Computation | Protein kinase | Searching | Pharmacy | Cell lines | Computer applications | Antitumor activity | Syk protein | Bayesian analysis | Cancer | Structural analysis | Pharmaceuticals
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2004, Volume 303, Issue 5665, pp. 1800 - 1805
Journal Article