X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (141603) 141603
Publication (16892) 16892
Book Review (8207) 8207
Newspaper Article (1646) 1646
Book Chapter (448) 448
Conference Proceeding (210) 210
Dissertation (75) 75
Book / eBook (29) 29
Reference (19) 19
Magazine Article (18) 18
Data Set (15) 15
Trade Publication Article (15) 15
Government Document (12) 12
Newsletter (11) 11
Paper (7) 7
Web Resource (4) 4
Streaming Video (3) 3
Report (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (128799) 128799
phosphorylation (101626) 101626
animals (81801) 81801
humans (68813) 68813
mice (35232) 35232
rats (29606) 29606
biochemistry & molecular biology (29448) 29448
male (29254) 29254
phosphorylation - drug effects (28095) 28095
cell biology (26785) 26785
signal transduction (23880) 23880
proteins (23734) 23734
apoptosis (21772) 21772
activation (21162) 21162
kinases (19982) 19982
cells, cultured (19734) 19734
signal transduction - drug effects (19043) 19043
expression (18354) 18354
female (18315) 18315
oncology (17393) 17393
cell line, tumor (17390) 17390
cell line (15064) 15064
cancer (14101) 14101
research (12657) 12657
neurosciences (12398) 12398
cells (12357) 12357
apoptosis - drug effects (12233) 12233
gene expression (12013) 12013
pharmacology & pharmacy (11594) 11594
enzyme inhibitors - pharmacology (11552) 11552
dose-response relationship, drug (11181) 11181
inhibition (10731) 10731
article (10586) 10586
blotting, western (10326) 10326
multidisciplinary sciences (10110) 10110
research article (10023) 10023
rodents (9797) 9797
analysis (9753) 9753
physiological aspects (9722) 9722
rats, sprague-dawley (9333) 9333
physiology (9273) 9273
cell proliferation - drug effects (8990) 8990
proto-oncogene proteins c-akt - metabolism (8930) 8930
medicine (8670) 8670
time factors (8502) 8502
oxidative stress (8183) 8183
enzyme activation - drug effects (7945) 7945
gene-expression (7541) 7541
biology (7445) 7445
cell cycle (7430) 7430
mutation (7398) 7398
tyrosine phosphorylation (7221) 7221
science (7204) 7204
inflammation (7036) 7036
protein (7036) 7036
in-vitro (6897) 6897
transfection (6866) 6866
mice, inbred c57bl (6858) 6858
health aspects (6759) 6759
kinetics (6693) 6693
enzyme activation (6534) 6534
cell survival - drug effects (6500) 6500
calcium - metabolism (6425) 6425
biophysics (6370) 6370
protein-serine-threonine kinases - metabolism (6369) 6369
cell proliferation (6325) 6325
in vitro techniques (6300) 6300
protein kinases (6299) 6299
protein binding (6275) 6275
in-vivo (6262) 6262
immunology (6213) 6213
biochemistry (6203) 6203
signal transduction - physiology (6174) 6174
genetic aspects (6165) 6165
metabolism (6085) 6085
growth (6073) 6073
endocrinology & metabolism (6050) 6050
abridged index medicus (6017) 6017
tumor cells, cultured (6009) 6009
kinase (6007) 6007
pathway (5998) 5998
antineoplastic agents - pharmacology (5971) 5971
protein kinase inhibitors - pharmacology (5908) 5908
molecular sequence data (5796) 5796
mitogen-activated protein kinases - metabolism (5774) 5774
disease models, animal (5538) 5538
rats, wistar (5418) 5418
amino acid sequence (5409) 5409
proliferation (5371) 5371
phosphatidylinositol 3-kinases - metabolism (5367) 5367
receptor (5352) 5352
protein-kinase (5300) 5300
mitochondria (5266) 5266
medicine, research & experimental (5212) 5212
enzymes (5193) 5193
tumors (5130) 5130
rna, messenger - metabolism (5078) 5078
protein kinase c - metabolism (4988) 4988
extracellular signal-regulated map kinases - metabolism (4915) 4915
brain (4773) 4773
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (21) 21
UofT at Mississauga - Stacks (4) 4
Online Resources - Online (3) 3
Collection Dvlpm't (Acquisitions) - Vendor file (2) 2
UTL at Downsview - May be requested (2) 2
Chemistry (A D Allen) - Stacks (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Engineering & Comp. Sci. - Reference (1) 1
St. Michael's College (John M. Kelly) - Circulation Desk (1) 1
UofT at Mississauga - Missing (1) 1
UofT at Mississauga - Reference (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (141774) 141774
Russian (709) 709
Chinese (466) 466
French (151) 151
Japanese (132) 132
German (89) 89
Ukrainian (61) 61
Spanish (35) 35
Polish (30) 30
Italian (20) 20
Slovak (16) 16
Bulgarian (7) 7
Czech (4) 4
Dutch (4) 4
Hungarian (4) 4
Portuguese (4) 4
Serbian (2) 2
Korean (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Index Medicus | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102798 - e102798
The Library of Integrated Network-Based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in... 
BREAST-CANCER CELLS | APOPTOSIS | BOOLEAN NETWORKS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | P38 MAPK | CONSEQUENCES | PROLIFERATION | GENERATION | P53 | Cell Cycle - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Gene Regulatory Networks - drug effects | Breast Neoplasms - metabolism | Phosphorylation - genetics | MCF-7 Cells | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Phosphorylation - drug effects | Proteomics - methods | Genomics - methods | Hydroxamic Acids - pharmacology | Gene Regulatory Networks - genetics | Tumor Suppressor Protein p53 - metabolism | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Digoxigenin - pharmacology | Programming, Linear | Breast Neoplasms - genetics | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Histone Deacetylase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Cycle - drug effects | Proteome - metabolism | Staurosporine - pharmacology | Cellular signal transduction | Drug discovery | Tumor proteins | Gene expression | Histone deacetylase | Phosphorylation | Staurosporine | Genomics | p53 Protein | Digoxigenin | Biology | Kinases | Cancer therapies | Proteins | Signal transduction | Cell activation | Pathways | Cellular communication | Cell cycle | Trichostatin A | Bioinformatics | Linear programming | Breast cancer | Topology | Medicine | Signaling | Cyclin-dependent kinase inhibitor p21 | Proteomics | Computer applications | Ordinary differential equations | Transduction | Prostate cancer | Prostate | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 413 - 417
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy(1-3). BET bromodomain... 
SELECTIVE-INHIBITION | SUPER-ENHANCERS | RNA-SEQ | SUBTYPES | INFLAMMATION | STRATEGY | MULTIDISCIPLINARY SCIENCES | CELL IDENTITY | C-MYC | PP2A | LEUKEMIA | Chromatin - metabolism | Transcription, Genetic - drug effects | Humans | Transcription Factors - deficiency | Triple Negative Breast Neoplasms - drug therapy | Genome, Human - drug effects | Nuclear Proteins - deficiency | Protein Binding - drug effects | Triple Negative Breast Neoplasms - pathology | Female | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Nuclear Proteins - genetics | Triazoles - therapeutic use | Cell Proliferation - genetics | Mediator Complex Subunit 1 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Phosphoserine - metabolism | Genome, Human - genetics | Azepines - therapeutic use | Azepines - pharmacology | Binding, Competitive - drug effects | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Triple Negative Breast Neoplasms - genetics | Epigenesis, Genetic - genetics | Triple Negative Breast Neoplasms - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Proteomics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Chromatin - genetics | Casein Kinase II - metabolism | Drug Resistance, Neoplasm - drug effects | Protein Structure, Tertiary - drug effects | Antimitotic agents | Enzyme inhibitors | Patient outcomes | Breast cancer | Dosage and administration | Drug therapy | Antineoplastic agents | Studies | Inhibitor drugs | Drug resistance | Gene expression | Drug dosages | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Index Medicus | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small... 
CELL LUNG-CANCER | EGFR KINASE | GROWTH-FACTOR RECEPTOR | TARGETED THERAPIES | GEFITINIB | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MUTATIONS | AZD9291 | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Drug Resistance, Multiple - drug effects | Protein Conformation - drug effects | Lung Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Allosteric Regulation - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Drug Resistance, Multiple - genetics | Lung Neoplasms - enzymology | Allosteric Site - drug effects | Mutant Proteins - genetics | Cetuximab - pharmacology | Mutant Proteins - metabolism | Receptor, Epidermal Growth Factor - chemistry | Drug Synergism | Drug Resistance, Neoplasm - genetics | Animals | Mutant Proteins - chemistry | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Studies | Phosphorylation | Nuclear magnetic resonance--NMR | Epidermal growth factor | Mutation | Kinases | Enzyme kinetics | Tumors | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 01/2006, Volume 107, Issue 2, pp. 752 - 759
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2014, Volume 23, Issue 17, pp. 4491 - 4509
A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD)... 
WILD-TYPE | INCLUSION FORMATION | OXIDATIVE STRESS | HUMAN PLASMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | RAT-BRAIN NEURONS | MONOCLONAL-ANTIBODY | SOLUTION NMR-SPECTROSCOPY | PULSED ESR MEASUREMENTS | TRANSGENIC MICE | PHOSPHOLIPID-BINDING | Neurons - pathology | Humans | alpha-Synuclein - ultrastructure | Saccharomyces cerevisiae - drug effects | Protein Transport - drug effects | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Sodium Dodecyl Sulfate - pharmacology | Cell Membrane - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Phosphorylation - drug effects | Buffers | Inclusion Bodies - metabolism | Neurons - drug effects | Protein Aggregation, Pathological - genetics | Cell Membrane - drug effects | Neuroblastoma - pathology | Protein Aggregates - drug effects | Cell Line | Parkinson Disease - pathology | Protein Structure, Secondary | Subcellular Fractions - drug effects | Cells, Cultured | Inclusion Bodies - drug effects | Mitochondria - metabolism | alpha-Synuclein - secretion | Mitochondria - drug effects | Parkinson Disease - genetics | Mutation - genetics | Subcellular Fractions - metabolism | alpha-Synuclein - chemistry | Brain - drug effects | Unilamellar Liposomes - metabolism | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Cell Differentiation - drug effects | Brain - pathology | Cell Nucleus - drug effects | Index Medicus
Journal Article