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1. Full Text Inositol pyrophosphates: Between signalling and metabolism
by Wilson, Miranda S. C and Livermore, Thomas M and Saiardi, Adolfo
Biochemical Journal, ISSN 0264-6021, 06/2013, Volume 452, Issue 3, pp. 369 - 379
The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by... 
kinase (IP6K) | Bisdiphosphoinositol tetrakisphosphate (IP | Inositol hexakisphosphate (IP | PP-IP | 5-diphosphoinositol pentakisphosphate (IP | Inositol phosphate | Metabolism | kinase (PPIP5K) | Polymer inorganic polyphosphate (polyP) | INORGANIC POLYPHOSPHATE | HYPEROSMOTIC STRESS | OVARIAN-CARCINOMA CELLS | FATTY-ACID SYNTHESIS | 1,4,5-TRISPHOSPHATE 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEXAKISPHOSPHATE KINASE-2 | SACCHAROMYCES-CEREVISIAE | bisdiphosphoinositol tetrakisphosphate (IP8) | inositol phosphate | polymer inorganic polyphosphate (polyP) | 5-diphosphoinositol pentakisphosphate (IP7) | metabolism | inositol hexakisphosphate (IP6) kinase (IP6K) | PP-IP5 kinase (PPIP5K) | DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE | TELOMERE LENGTH | SCHIZOSACCHAROMYCES-POMBE | Diphosphates - metabolism | Humans | Inositol Phosphates - physiology | Signal Transduction - genetics | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Diphosphates - chemistry | Inositol Phosphates - chemistry | Animals | Phosphotransferases (Phosphate Group Acceptor) - physiology | Signal Transduction - physiology | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Energy Metabolism - genetics | Energy Metabolism - physiology | Inositol Phosphates - metabolism
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2. Full Text A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 Protein selectively cleaves the β-Phosphate from 5-Diphosphoinositol Pentakisphosphate (5PP-IP5)
by Steidle, Elizabeth A and Chong, Lucy S and Wu, Mingxuan and Crooke, Elliott and Fiedler, Dorothea and Resnick, Adam C and Rolfes, Ronda J
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 6772 - 6783
Inositol pyrophosphates are high energy signaling molecules involved in cellular processes, such as energetic metabolism, telomere maintenance, stress... 
Gene Expression Regulation, Fungal | Recombinant Proteins - metabolism | Signal Transduction | Saccharomyces cerevisiae - genetics | Phosphotransferases (Phosphate Group Acceptor) - genetics | Substrate Specificity | Protein Tyrosine Phosphatases - metabolism | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Genetic Complementation Test | Protein Tyrosine Phosphatases - genetics | Escherichia coli - genetics | Gene Deletion | Cloning, Molecular | Escherichia coli - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Kinetics | Inositol Phosphates - metabolism
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3. Full Text Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
by Wang, Huanchen and Falck, J.R and Hall, Traci M. Tanaka and Shears, Stephen B
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 1, pp. 111 - 116
Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that regulate diverse cellular activities. Inositol pyrophosphates have... 
DIPHOSPHOINOSITOL PENTAKISPHOSPHATE | HEXAKISPHOSPHATE | SPECIFICITY | CRYSTAL-STRUCTURE | ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | POLYPHOSPHATES | IDENTIFICATION | BINDING | FAMILY | Biocatalysis | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Phosphates - chemistry | Models, Molecular | Substrate Specificity | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Phosphates - metabolism | Protein Structure, Quaternary | Protein Binding | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Structural Homology, Protein | Mutation
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4. Full Text A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
by Sashidhar Mulugu and Wenli Bai and Peter C. Fridy and Robert J. Bastidas and James C. Otto and D. Eric Dollins and Timothy A. Haystead and Anthony A. Ribeiro and John D. York
Science, ISSN 0036-8075, 4/2007, Volume 316, Issue 5821, pp. 106 - 109
Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously... 
Inositols | Yeasts | Enzymes | Cell growth | Cell walls | B lymphocytes | Reports | Diphosphates | Nuclear magnetic resonance | High temperature | Cells | DICTYOSTELIUM | ACTIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | TETRAKISPHOSPHATE | PHOSPHATES | ARP2/3 COMPLEX | MESSENGER-RNA EXPORT | POLYPHOSPHATES | SACCHAROMYCES-CEREVISIAE | PYROPHOSPHATES | Recombinant Fusion Proteins - isolation & purification | Schizosaccharomyces pombe Proteins - chemistry | Phosphorylation | Schizosaccharomyces - growth & development | Temperature | Cytoskeletal Proteins - genetics | Saccharomyces cerevisiae - genetics | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Molecular Sequence Data | Substrate Specificity | Cytoskeletal Proteins - isolation & purification | Chromatography, High Pressure Liquid | Recombinant Fusion Proteins - metabolism | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Schizosaccharomyces - genetics | Phytic Acid - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Actin-Related Protein 3 - metabolism | Conserved Sequence | Cytoskeletal Proteins - metabolism | Saccharomyces cerevisiae Proteins - isolation & purification | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Phosphotransferases (Phosphate Group Acceptor) - isolation & purification | Inositol Phosphates - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Catalytic Domain | Schizosaccharomyces pombe Proteins - genetics | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Schizosaccharomyces pombe Proteins - isolation & purification | Sequence Alignment | Animals | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Schizosaccharomyces - enzymology | Schizosaccharomyces - cytology | Saccharomyces cerevisiae Proteins - chemistry | Inositol phosphates | Research | Proteins | Cellular | Alterations | Regulators | Kinases | Metabolism
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5. Full Text Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants
by Desai, Mintu and Rangarajan, Padma and Donahue, Janet L and Williams, Sarah P and Land, Eric S and Mandal, Mihir K and Phillippy, Brian Q and Perera, Imara Y and Raboy, Victor and Gillaspy, Glenda E
The Plant Journal, ISSN 0960-7412, 11/2014, Volume 80, Issue 4, pp. 642 - 653
Inositol pyrophosphates are unique cellular signaling molecules with recently discovered roles in energy sensing and metabolism. Studies in eukaryotes have... 
Arabidopsis thaliana | InsP | At5g15070 | inositol pyrophosphate | inositol kinase | At3g01310 | InsP 6 | DIPHOSPHOINOSITOL PENTAKISPHOSPHATE | ARABIDOPSIS-THALIANA | PHYTATE | PHOSPHOINOSITIDE | POLYPHOSPHATES | IDENTIFICATION | FAMILY | PLANT SCIENCES | PERCEPTION | GENETICS | PHYTIC-ACID | Zea mays - genetics | Arabidopsis Proteins - genetics | Seeds - metabolism | Phosphotransferases (Phosphate Group Acceptor) - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Chromatography, High Pressure Liquid | Phylogeny | Genetic Complementation Test | Transcription Factors, General - genetics | Arabidopsis - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Proteins - genetics | Yeasts - genetics | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Plant Proteins - metabolism | Mutation | Zea mays - metabolism | Inositol Phosphates - metabolism | Transcription Factors, General - metabolism | Proteins | Phosphates | Inositol | Analysis | Physiological aspects | Plants | Phosphotransferases | Plant biology | Biosynthesis | Seeds | Metabolism | Kinases | Index Medicus
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6. Full Text "Candidatus accumulibacter" population structure in enhanced biological phosphorus removal sludges as revealed by polyphosphate kinase genes
by He, Shaomei and Gall, Daniel L and McMahon, Katherine D
Applied and Environmental Microbiology, ISSN 0099-2240, 09/2007, Volume 73, Issue 18, pp. 5865 - 5874
We investigated the fine-scale population structure of the "Candidatus Accumulibacter" lineage in enhanced biological phosphorus removal (EBPR) systems using... 
REAL-TIME PCR | ORGANISMS | BACTERIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACTIVATED-SLUDGE | QUANTIFICATION | PLANTS | MICROBIOLOGY | MICROBIAL COMMUNITY | PHOSPHATE REMOVAL | Genes, Bacterial | Proteobacteria - metabolism | Phosphotransferases (Phosphate Group Acceptor) - genetics | Molecular Sequence Data | Proteobacteria - classification | Phylogeny | Proteobacteria - genetics | Phosphorus - metabolism | RNA, Bacterial - genetics | RNA, Ribosomal, 16S - genetics | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Environmental Restoration and Remediation | Proteobacteria - enzymology | Sewage - microbiology | Environmental aspects | Phosphorus compounds | Genetic markers | Structure | Analysis
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7. Full Text Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta
by Andrew J. Simkin and Grégory Guirimand and Nicolas Papon and Vincent Courdavault and Insaf Thabet and Olivia Ginis and Sadok Bouzid and Nathalie Giglioli-Guivarc'h and Marc Clastre
Planta, ISSN 0032-0935, 11/2011, Volume 234, Issue 5, pp. 903 - 914
In plants, the mevalonic acid (MVA) pathway provides precursors for the formation of triterpenes, sesquiterpenes, phytosterols and primary metabolites... 
Proteins | Enzymes | Yeasts | Haploidy | Peroxisomes | Complementary DNA | Plasmids | Terpenoids | Alleles | Cytosol | Life Sciences | Arabidopsis | Mevalonic acid pathway | Forestry | Peroxisome | Ecology | Agriculture | Isoprenoid | Plant Sciences | Catharanthus | PHOSPHOMEVALONATE KINASE | SUBCELLULAR-LOCALIZATION | PLANT SCIENCES | HMG-COA SYNTHASE | ISOPRENOID BIOSYNTHESIS | PROTEOME ANALYSIS | THALIANA | GENES | REDUCTASE | TARGETING SIGNALS | ARABIDOPSIS LEAF PEROXISOMES | Transformation, Genetic | Amino Acid Sequence | Catharanthus - enzymology | Saccharomyces cerevisiae - genetics | Phosphotransferases (Phosphate Group Acceptor) - genetics | DNA, Complementary - genetics | Molecular Sequence Data | Phosphotransferases (Alcohol Group Acceptor) - genetics | RNA, Plant - genetics | Mevalonic Acid - metabolism | Genetic Complementation Test | Peroxisomes - metabolism | Arabidopsis - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Arabidopsis - genetics | Mevalonic Acid - analogs & derivatives | Saccharomyces cerevisiae - metabolism | Cloning, Molecular | Gene Expression Regulation, Plant | Cytosol - metabolism | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Catharanthus - genetics | DNA, Complementary - metabolism | Luminescent Proteins - metabolism | Arabidopsis thaliana | Saponins | Sesquiterpenes | Phytosterols | Fluorescence | Plant metabolites
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8. Full Text The regulation of runt‐related transcription factor 2 by fibroblast growth factor‐2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade
by Niger, Corinne and Luciotti, Maria A and Buo, Atum M and Hebert, Carla and Ma, Vy and Stains, Joseph P
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2013, Volume 28, Issue 6, pp. 1468 - 1477
Connexin43 (Cx43) plays a critical role in osteoblast function and bone mass accrual, yet the identity of the second messengers communicated by Cx43 gap... 
PHOSPHOLIPASE C GAMMA | INOSITOL POLYPHOSPHATE MULTIKINASE | INOSITOL HEXAKISPHOSPHATE KINASE | INOSITOL PYROPHOSPHATE | BONE | FIBROBLAST GROWTH FACTOR 2 | GAP JUNCTION | GAP-JUNCTION CHANNELS | PROTEIN | PHOSPHORYLATION | CELL-SURVIVAL | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | ALTERS EXPRESSION | DIFFERENTIATION | COMMUNICATION | PYROPHOSPHATES | Cell Line | Phospholipase C gamma - metabolism | Connexin 43 - metabolism | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Gene Expression Regulation - physiology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Kinase C-delta - metabolism | Animals | Fibroblast Growth Factor 2 - genetics | Phospholipase C gamma - genetics | Fibroblast Growth Factor 2 - metabolism | Signal Transduction - physiology | Mice | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Osteoblasts - cytology | Inositol Phosphates - metabolism | Osteoblasts - metabolism | Inositol Phosphates - genetics | Protein Kinase C-delta - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Connexin 43 - genetics
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9. Full Text IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
by Wang, Huanchen and Derose, Eugene F and London, Robert E and Shears, Stephen B
Nature Communications, ISSN 2041-1723, 06/2014, Volume 5, Issue 1, pp. 4178 - 4178
Inositol trisphosphate kinases (IP3Ks) and inositol hexakisphosphate kinases (IP6Ks) each regulate specialized signalling activities by phosphorylating either... 
HEXAKISPHOSPHATE KINASE | 1,4,5-TRISPHOSPHATE 3-KINASE | METABOLISM | CRYSTAL-STRUCTURE | 1,3,4,5,6-PENTAKISPHOSPHATE 2-KINASE | MULTIDISCIPLINARY SCIENCES | MULTIKINASE | GENE DELETION | CELL-SURVIVAL | DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE | PYROPHOSPHATES | Multigene Family | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Crystallography, X-Ray | Protozoan Proteins - genetics | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Inositol Phosphates - chemistry | Entamoeba histolytica - chemistry | Protozoan Proteins - metabolism | Entamoeba histolytica - genetics | Adenosine Triphosphate - metabolism | Entamoeba histolytica - enzymology | Sensitivity and Specificity | Protozoan Proteins - chemistry | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Catalysis | Adenosine Triphosphate - chemistry | Inositol Phosphates - metabolism | Binding Sites | Evolution, Molecular | Index Medicus
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10. Full Text Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates
by Padmanabhan, Usha and Dollins, D. Eric and Fridy, Peter C and York, John D and Downes, C. Peter
Journal of Biological Chemistry, ISSN 0021-9258, 04/2009, Volume 284, Issue 16, pp. 10571 - 10582
Inositol hexakisphosphate kinases (IP6Ks) phosphorylate inositol hexakisphosphate (InsP(6)) to yield 5-diphosphoinositol pentakisphosphate (5-[PP]-InsP(5) or... 
PHOSPHATE MULTIKINASE | HYPEROSMOTIC STRESS | PROTEIN | PENTAKISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1,4,5-TRISPHOSPHATE 3-KINASE ACTIVITY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE | FAMILY | Diphosphates - metabolism | Vacuoles - ultrastructure | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Molecular Sequence Data | Enzyme Inhibitors - chemistry | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Inositol Phosphates - metabolism | Amino Acid Sequence | Cell Line | Phosphotransferases (Phosphate Group Acceptor) - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Purines - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Saccharomyces cerevisiae Proteins - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Saccharomyces cerevisiae - cytology | Diphosphates - chemistry | Inositol Phosphates - chemistry | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Insulin - metabolism | Sequence Alignment | Animals | Purines - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Thapsigargin - metabolism | Saccharomyces cerevisiae - enzymology | Vacuoles - metabolism | Enzyme Catalysis and Regulation
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11. Full Text Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2
by Rao, Feng and Cha, Jiyoung and Xu, Jing and Xu, Risheng and Vandiver, M. Scott and Tyagi, Richa and Tokhunts, Robert and Koldobskiy, Michael A and Fu, Chenglai and Barrow, Roxanne and Barrow, James C and Wu, Mingxuan and Fiedler, Dorothea and Snyder, Solomon H
Molecular Cell, ISSN 1097-2765, 04/2014, Volume 54, Issue 1, pp. 119 - 132
The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM.... 
CASEIN KINASE-2 | DNA-PKCS | APOPTOSIS | COMPLEX | DAMAGE-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | GENE DELETION | HEXAKISPHOSPHATE KINASE-2 | P53 | ATR | CELL BIOLOGY | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Proto-Oncogene Proteins c-ets - genetics | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Serine | Casein Kinase II - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Telomere-Binding Proteins - genetics | Transfection | Neoplasms - genetics | RNA Interference | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | HEK293 Cells | Proto-Oncogene Proteins c-ets - metabolism | B-Lymphocytes - pathology | Inositol Phosphates - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Binding Sites | B-Lymphocytes - enzymology | Signal Transduction | HCT116 Cells | Enzyme Stability | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Neoplasms - pathology | Casein Kinase II - metabolism | Apoptosis | Medical colleges | Inositol | Neurosciences | Cell death | DNA | Automated teller machines | Biochemistry | Tumor proteins | Phosphotransferases | B cells
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12. Full Text Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival
by Pfleger, J and He, M and Abdellatif, M
Cell Death and Disease, ISSN 2041-4889, 07/2015, Volume 6, Issue 7, pp. e1835 - e1835
The survival of a cell depends on its ability to meet its energy requirements. We hypothesized that the mitochondrial reserve respiratory capacity (RRC) of a... 
EXCITOTOXICITY | APOPTOSIS | OXIDATIVE STRESS | DEFECTS | ACTIVATED PROTEIN-KINASE | DEATH | VENTRICULAR MYOCYTES | EXPRESSION | DEHYDROGENASE | DEFICIENCY | CELL BIOLOGY | RNA, Small Interfering - genetics | Sirtuin 3 - metabolism | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Sirtuin 3 - antagonists & inhibitors | Pyruvate Dehydrogenase Complex - genetics | Cell Respiration - genetics | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Animals, Newborn | Pyruvate Dehydrogenase Complex - metabolism | Sirtuin 3 - genetics | Electron Transport Complex II - genetics | Signal Transduction | Cell Survival | Gene Expression Regulation | Muscle Cells - metabolism | Oxidative Phosphorylation | Rats | Mitochondria - metabolism | Rats, Sprague-Dawley | Muscle Cells - cytology | Animals | Electron Transport Complex II - metabolism | Primary Cell Culture | Cell Hypoxia - genetics | RNA, Small Interfering - metabolism | Original
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13. Full Text Inositol hexakisphosphate kinase 1 (IP6K1) regulates inositol synthesis in mammalian cells
by Yu, Wenxi and Ye, Cunqi and Greenberg, Miriam L
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 20, pp. 10437 - 10444
myo-Inositol, the precursor of all inositol compounds, has pivotal roles in cell metabolism and signaling pathways. Although physiological studies indicate a... 
MYOINOSITOL 1-PHOSPHATE | DNA METHYLATION | METABOLISM | HISTONE H3 | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-PHOSPHATE SYNTHASE | PHOSPHATIDIC-ACID | TRANSCRIPTION FACTOR | 1,4,5-TRISPHOSPHATE | PYROPHOSPHATES | Recombinant Proteins - metabolism | Cell Line | Intramolecular Lyases - metabolism | Saccharomyces cerevisiae - genetics | Phosphotransferases (Phosphate Group Acceptor) - genetics | Recombinant Proteins - genetics | Gene Knockout Techniques | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Saccharomyces cerevisiae - metabolism | DNA Methylation | Animals | Cell Nucleus - metabolism | Intramolecular Lyases - genetics | Models, Biological | Transcription, Genetic | Inositol - biosynthesis | Mice | Phosphatidic Acids - metabolism | Phosphotransferases (Phosphate Group Acceptor) - metabolism | ISYNA1 | genetics | Lipids | inositol | inositol pyrophosphate | metabolism | phosphatidic acid | Opi1 | lipid | inositol phosphate
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14. Full Text Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis
by Zhu, Qingzhang and Ghoshal, Sarbani and Rodrigues, Ana and Gao, Su and Asterian, Alice and Kamenecka, Theodore M and Barrow, James C and Chakraborty, Anutosh
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4273 - 4288
Enhancing energy expenditure (EE) is an attractive strategy to combat obesity and diabetes. Global deletion of Ip6k1 protects mice from diet-induced obesity... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | ENERGY-EXPENDITURE | PYROPHOSPHATES MEDIATE | MITOCHONDRIAL BIOGENESIS | INOSITOL HEXAKISPHOSPHATE KINASE | AERODIGESTIVE TRACT CARCINOMA | POLYPHOSPHATE MULTIKINASE | BROWN ADIPOSE-TISSUE | INSULIN SENSITIVITY | SMALL-MOLECULE ACTIVATORS | Adipose Tissue, White - pathology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | AMP-Activated Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Obesity - chemically induced | Uncoupling Protein 1 - metabolism | Phosphotransferases (Phosphate Group Acceptor) - genetics | Adipose Tissue, White - metabolism | Signal Transduction - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Adipocytes, White - pathology | Animals | Thermogenesis | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Mice | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Energy Metabolism - genetics | AMP-Activated Protein Kinases - genetics | Adipocytes, White - metabolism | Adipose tissues | Obesity | Gene mutations | Physiological aspects | Genetic aspects | Research | Risk factors | Phosphates | Insulin resistance | Kinases | Rodents
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