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NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 1 - 10
Tpt1 is an essential agent of fungal tRNA splicing that removes the 2'-PO4 at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique... 
2'-PHOSPHOTRANSFERASE | CRYSTAL-STRUCTURE | TOXIN | MULTIDISCIPLINARY SCIENCES | 2'-PHOSPHATE | LIGATED TRANSFER-RNA | SACCHAROMYCES-CEREVISIAE | LIGASE | Phosphates | Fungicides | tRNA | Splicing | Transesterification | Ribonucleic acid--RNA | ADP | Substrates | NAD | Fungi | Ribose | Ribosylation | Crystal structure | ADP-ribosylation
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3354 - 13
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2018, Volume 34, Issue 1, pp. 136 - 147.e6
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 09/2019, Volume 37, Issue 9, pp. 1038 - 1038
We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Physiological aspects | Phosphotransferases | Inhibitors | Fibrosis | Feasibility studies | Machine learning | Pharmacokinetics | Kinases | Biological activity | Design optimization
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 05/2019, Volume 15, Issue 5, pp. 510 - 510
Protein phosphorylation regulates key processes in all organisms. In Gram-positive bacteria, protein arginine phosphorylation plays a central role in protein... 
REFINEMENT | EVOLUTION | PHOSPHOARGININE | TYROSINE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLPC OPERON | CRYSTALLOGRAPHY | INDUCED-FIT | STRESS | PHOSPHATASES | Tyrosine | Biodegradation | Phosphorylation | Transcription factors | Threonine | Serine | Gram-positive bacteria | Kinases | Substrates | Domains | Proteins | Arginine | Protein kinase | Quality control | Phosphotransferase | Catalysis | Protein structure
Journal Article
Journal of Computer-Aided Molecular Design, ISSN 0920-654X, 04/2019, Volume 33, Issue 4, pp. 405 - 417
Journal Article
Journal Article
3 Biotech, ISSN 2190-572X, 3/2019, Volume 9, Issue 3, pp. 1 - 7
Acetate is a potential low-cost carbon source and can be used for microbial production of valuable chemicals in Escherichia coli. In this study, separate and... 
Stem Cells | Biotechnology | Chemistry | Escherichia coli | Cancer Research | Metabolic engineering | Agriculture | Acetate | Phosphoenolpyruvate:carbohydrate phosphotransferase system | Bioinformatics | Biomaterials | ACID | ENZYME | METABOLISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES
Journal Article
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 2/2019, Volume 103, Issue 3, pp. 1243 - 1254
Journal Article