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European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 1041 - 1056
Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of... 
X-ray crystallography | Inhibitor | Antibacterial | NAD kinase | Adenosine analogue | CHEMISTRY, MEDICINAL | RECOGNITION | ANALOGS | DISCOVERY | ENZYME | BIOSYNTHESIS | TARGETS | MYCOBACTERIUM-TUBERCULOSIS H37RV | ATP | Amino Acid Sequence | Staphylococcus aureus - enzymology | Enzyme Inhibitors - metabolism | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Humans | Enzyme Inhibitors - pharmacology | Ribose - chemistry | Structure-Activity Relationship | Adenosine - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Listeria monocytogenes - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Adenosine - metabolism | Protein Binding | Protein Conformation | Adenosine - chemistry | Molecular Docking Simulation | Phosphates | Niacinamide | Purines | Drug resistance in microorganisms | Listeria | Physiological aspects | Anti-infective agents | Phosphotransferases | Enzymes | Crystals | Structure | Antibacterial agents | Adenosine/metabolism | Adenosine/chemistry | Phosphotransferases (Alcohol Group Acceptor)/metabolism | Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors | Phosphotransferases (Alcohol Group Acceptor)/chemistry | Enzyme Inhibitors/metabolism | Enzyme Inhibitors/pharmacology | Chemical Sciences | Listeria monocytogenes/enzymology | Life Sciences | Organic chemistry | Staphylococcus aureus/enzymology | Adenosine/pharmacology | Enzyme Inhibitors/chemistry | Ribose/chemistry
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 9, pp. 3767 - 3793
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 06/2008, Volume 7, Issue 6, pp. 2234 - 2245
We considered, on a global scale, the relationship between the predicted fraction of protein disorder and the RNA and protein expression in Escherichia coli.... 
Protein abundance | Disordered proteins | PONDR | CAI | Gene expression | Microarrays | disordered proteins | MOLECULAR RECOGNITION FEATURES | BIOCHEMICAL RESEARCH METHODS | CODON ADAPTATION INDEX | ELONGATION-FACTOR NUSA | ACETYL-COA CARBOXYLASE | microarrays | NATIVELY UNFOLDED PROTEINS | SUGAR PHOSPHOTRANSFERASE SYSTEM | GRAM-NEGATIVE BACTERIA | protein abundance | DEHYDROGENASE MULTIENZYME COMPLEX | N-TERMINAL DOMAIN | CARBOXYL CARRIER PROTEIN | gene expression | Peptidoglycan - metabolism | Peptide Elongation Factors - metabolism | Molecular Chaperones - metabolism | Transcription Factors - chemistry | Oligonucleotide Array Sequence Analysis | Escherichia coli - drug effects | Bacterial Proteins - chemistry | Dihydrolipoyllysine-Residue Acetyltransferase - metabolism | Gene Expression Profiling | Transcriptional Elongation Factors | Glycine Decarboxylase Complex H-Protein - genetics | Dihydrolipoyllysine-Residue Acetyltransferase - genetics | Phosphoenolpyruvate Sugar Phosphotransferase System - genetics | Fatty Acid Synthase, Type II | Bacterial Proton-Translocating ATPases - chemistry | Bacterial Proton-Translocating ATPases - metabolism | Molecular Chaperones - genetics | DNA-Directed RNA Polymerases - genetics | Peptidoglycan - genetics | DNA-Binding Proteins - chemistry | Acyl Carrier Protein - chemistry | Peptide Elongation Factors - chemistry | Bacterial Outer Membrane Proteins - metabolism | Escherichia coli - genetics | Chaperonin 10 - genetics | Prokaryotic Initiation Factor-1 - metabolism | Chaperonin 10 - chemistry | Protein Conformation | Dihydrolipoyllysine-Residue Acetyltransferase - chemistry | DNA-Directed RNA Polymerases - metabolism | Escherichia coli Proteins - chemistry | Gene Expression Regulation, Bacterial | Acetyl-CoA Carboxylase - metabolism | Acetyl-CoA Carboxylase - chemistry | Apoproteins - chemistry | Ribosomal Proteins - chemistry | Lipoproteins - genetics | Peptidoglycan - chemistry | Glycine Decarboxylase Complex H-Protein - chemistry | Molecular Chaperones - chemistry | Acyltransferases - metabolism | Acyltransferases - genetics | Acetyl-CoA Carboxylase - genetics | Ribosomal Proteins - metabolism | DNA-Binding Proteins - metabolism | Chaperonin 10 - metabolism | Escherichia coli - metabolism | Lipoproteins - metabolism | Prokaryotic Initiation Factor-1 - chemistry | Carrier Proteins - chemistry | DNA-Directed RNA Polymerases - chemistry | Glycine Decarboxylase Complex H-Protein - metabolism | Peptide Elongation Factors - genetics | Apoproteins - metabolism | Bacterial Outer Membrane Proteins - genetics | Phosphoenolpyruvate Sugar Phosphotransferase System - chemistry | Ribosomal Proteins - genetics | Acyl Carrier Protein - metabolism | Bacterial Proton-Translocating ATPases - genetics | Bacterial Proteins - genetics | Bacterial Outer Membrane Proteins - chemistry | Escherichia coli Proteins - metabolism | Lipoproteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Prokaryotic Initiation Factor-1 - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Acyl Carrier Protein - genetics | Culture Media - pharmacology | Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism | Apoproteins - genetics | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Acyltransferases - chemistry
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7389, pp. 336 - 340
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are... 
CHRONIC MYELOGENOUS LEUKEMIA | CHRONIC PHASE | COMPLEX | C-ABL | ACTIVE-SITE | SRC | MULTIDISCIPLINARY SCIENCES | ELECTRIC-FIELDS | IMATINIB | MUTATION | CLINICAL RESISTANCE | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Binding sites
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | INHIBITORY-ACTIVITY | EFFICIENT SYNTHESIS | NATIONAL-CANCER-INSTITUTE | DOMINO SYNTHESIS | SUBSTITUTED QUINAZOLINES | BIOLOGICAL EVALUATION | OXIDATIVE SYNTHESIS | HETEROGENEOUS CATALYST | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2003, Volume 197, Issue 2, pp. 263 - 268
Journal Article