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Development (Cambridge), ISSN 0950-1991, 11/2013, Volume 140, Issue 22, pp. 4510 - 4521
Muller glia function as retinal stem cells in adult zebrafish. In response to loss of retinal neurons, Muller glia partially dedifferentiate, re-express... 
Müller glia | N-cadherin | Retinal regeneration | Alcama | Muller glia | STEM-CELLS | DEDIFFERENTIATION | PROLIFERATION | DEVELOPMENTAL BIOLOGY | GOLDFISH RETINA | ADULT ZEBRAFISH | VERTEBRATE RETINA | ROD PHOTORECEPTORS | SIGNALING PATHWAY | NEUROGENESIS | LINEAGE | Cadherins - metabolism | Multipotent Stem Cells - metabolism | Photoreceptor Cells, Vertebrate - drug effects | Ependymoglial Cells - metabolism | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Retinal Ganglion Cells - metabolism | Retinal Neurons - cytology | Retinal Ganglion Cells - cytology | Neurogenesis - drug effects | Retinal Neurons - drug effects | Asymmetric Cell Division - drug effects | Ouabain - pharmacology | Biomarkers - metabolism | Cell Dedifferentiation - drug effects | Zebrafish Proteins - metabolism | Neural Stem Cells - drug effects | Photoreceptor Cells, Vertebrate - cytology | Cell Adhesion - drug effects | Ependymoglial Cells - drug effects | Regeneration - drug effects | Animals | Retinal Neurons - metabolism | Models, Biological | Multipotent Stem Cells - cytology | Zebrafish - metabolism | Ependymoglial Cells - cytology | Heterozygote | Neuroepithelial Cells - metabolism | Photoreceptor Cells, Vertebrate - metabolism | Cell Cycle - drug effects | Neural Stem Cells - metabolism | Retinal Ganglion Cells - drug effects | Index Medicus | Stem Cells and Regeneration
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2013, Volume 33, Issue 9, pp. 3834 - 3843
Journal Article
STEM CELLS, ISSN 1066-5099, 04/2012, Volume 30, Issue 4, pp. 673 - 686
Journal Article
Science, ISSN 0036-8075, 07/2016, Volume 353, Issue 6294, pp. aaf3646 - aaf3646
Regenerative therapies are limited by unfavorable environments in aging and diseased tissues. A promising strategy to improve success is to balance... 
SURVIVAL | MICROGLIAL ACTIVATION | NEUROTROPHIC FACTOR | MACROPHAGES | DNA | MULTIDISCIPLINARY SCIENCES | MOUSE | DIFFERENTIATION | DROSOPHILA | BLOOD-CELLS | DEGENERATION | Retina - drug effects | Egg Proteins - metabolism | Neuroprotective Agents - immunology | Drosophila melanogaster - immunology | Hemocytes - immunology | Photoreceptor Cells, Vertebrate - drug effects | Gene Expression Profiling | Drosophila Proteins - immunology | Drosophila Proteins - metabolism | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Photoreceptor Cells, Invertebrate - drug effects | Models, Animal | Wound Healing - drug effects | Signal Transduction | Immunomodulation | Mice, Inbred C57BL | Nerve Growth Factors - immunology | Recombinant Proteins - pharmacology | Immunity, Innate | Wound Healing - immunology | Retina - physiology | Platelet-Derived Growth Factor - metabolism | Animals | Recombinant Proteins - immunology | Nerve Growth Factors - genetics | Retinal Degeneration - therapy | Mice | Drosophila Proteins - genetics | Photoreceptor Cells, Invertebrate - metabolism | Photoreceptor Cells, Vertebrate - metabolism | Retina - injuries | Evolution, Molecular | Cellular biology | Tissue engineering | Immune system | Index Medicus | Immune systems | Regenerative | Therapy | Modulation | Retina | Strategy | Damage | Repair
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 369 - 383
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 34, pp. 8771 - 8781
Abstract We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the... 
Advanced Basic Science | Dentistry | Retinal degeneration | Nanoceria | Longevity | Antioxidant | Gene expression | Tubby mouse | OXIDATIVE STRESS | MATERIALS SCIENCE, BIOMATERIALS | REDOX STATE | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | MACULAR DEGENERATION | ENDOPLASMIC-RETICULUM STRESS | OPSIN MISLOCALIZATION | CELL-DEATH | CERIUM OXIDE NANOPARTICLES | RETINITIS-PIGMENTOSA | Retina - drug effects | Retina - metabolism | Intravitreal Injections | Opsins - genetics | Photoreceptor Cells, Vertebrate - drug effects | Retinal Rod Photoreceptor Cells - metabolism | Retinal Degeneration - prevention & control | Cerium - therapeutic use | Retinal Cone Photoreceptor Cells - pathology | Retinal Rod Photoreceptor Cells - drug effects | Cerium - administration & dosage | Retinal Degeneration - genetics | Mice, Inbred C57BL | Retina - physiopathology | Retinal Degeneration - physiopathology | Opsins - analysis | Gene Expression Regulation - drug effects | Animals | Retinal Cone Photoreceptor Cells - drug effects | Mice | Oxidative Stress - drug effects | Photoreceptor Cells, Vertebrate - metabolism | Retinal Degeneration - pathology | Photoreceptor Cells, Vertebrate - pathology | Retina - pathology | Retinal Cone Photoreceptor Cells - metabolism | Retinal Rod Photoreceptor Cells - pathology | Antioxidants | Eye diseases | Biological products | Analysis | Genes | Index Medicus | longevity | antioxidant | retinal degeneration | tubby mouse | gene expression | nanoceria
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Experimental Eye Research, ISSN 0014-4835, 2007, Volume 85, Issue 2, pp. 234 - 241
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182407 - e0182407
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular occlusion. The goal of this study was to evaluate the potential... 
OPTIC-NERVE | AUTOIMMUNE GLAUCOMA MODEL | PROLIFERATIVE DIABETIC-RETINOPATHY | PRESSURE-INDUCED ISCHEMIA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | RAT RETINA | GANGLION-CELLS | MACULAR DEGENERATION | GLIAL-CELLS | ENDOTHELIAL GROWTH-FACTOR | Amacrine Cells - drug effects | Microglia - metabolism | Cell Count | Humans | Photoreceptor Cells, Vertebrate - drug effects | Amacrine Cells - metabolism | Retina | Ranibizumab - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Protective Agents - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Retinal Ganglion Cells - metabolism | Rhodopsin - metabolism | Aqueous Humor - metabolism | Synapses - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Microfilament Proteins - metabolism | Ischemia - pathology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Synapses - drug effects | Microglia - drug effects | Reperfusion Injury - pathology | Cholinergic Neurons - metabolism | RNA, Messenger - genetics | Rats | Cholinergic Neurons - drug effects | Ranibizumab - pharmacology | Animals | Ischemia - drug therapy | Mice | Photoreceptor Cells, Vertebrate - metabolism | Retinal Ganglion Cells - drug effects | Retinal diseases | Care and treatment | Occlusion | Immunohistochemistry | Intervention | Diabetic retinopathy | Neurosciences | Retinopathy | Disorders | Neurobiology | Activation | Eye | Macular degeneration | Proteins | Cell growth | Ischemia | Rodents | Eye (anatomy) | Vascular endothelial growth factor | Retinal cells | Glial fibrillary acidic protein | Diabetes mellitus | Brn-3 protein | Microglia | Vascular endothelial growth factor receptors | Studies | Polymerase chain reaction | Retinal ganglion cells | Pathology | Hospitals | Cell number | Morphology | Eye disorders | Amacrine cells | Photoreceptors | Diabetes | Glia | Apoptosis | Index Medicus
Journal Article