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Cell Stem Cell, ISSN 1934-5909, 06/2016, Volume 18, Issue 6, pp. 769 - 781
Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood blindness. Photoreceptors are especially sensitive to an intronic... 
RETINAL DEGENERATION | JOUBERT-SYNDROME | CELLS | LEBER CONGENITAL AMAUROSIS | TRANSITION ZONE | MUTATION | GENES | LINKED RETINITIS-PIGMENTOSA | CEP290 | CENTROSOMAL PROTEIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Leber Congenital Amaurosis - pathology | Optic Disk - cytology | Retinal Pigment Epithelium - metabolism | Humans | Blindness - pathology | Male | Organogenesis - drug effects | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Retinal Pigment Epithelium - pathology | Retinal Pigment Epithelium - ultrastructure | RNA Splicing - genetics | Antigens, Neoplasm - metabolism | Cilia - drug effects | Inheritance Patterns - genetics | Blindness - therapy | Induced Pluripotent Stem Cells - cytology | Neoplasm Proteins - genetics | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Retinal Pigment Epithelium - drug effects | rab GTP-Binding Proteins - metabolism | Antigens, Neoplasm - genetics | RNA Splicing - drug effects | Photoreceptor Cells, Vertebrate - ultrastructure | Induced Pluripotent Stem Cells - drug effects | RNA, Messenger - genetics | Exons - genetics | Fibroblasts - pathology | Cilia - metabolism | Eye Proteins - metabolism | Cell Differentiation - drug effects | Fibroblasts - drug effects | Morpholinos - pharmacology | Opsins - metabolism | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2009, Volume 106, Issue 44, pp. 18751 - 18756
Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris... 
Protein isoforms | Cardiovascular system | Pathology | Vascular endothelial growth factors | Blood vessels | Photoreceptors | Retina | Mice | Lesions | Endothelial cells | Geographic atrophy | Bruch's membrane | Retinal pigmented epithelium | Age-related macular degeneration | CELLS | geographic atrophy | MULTIDISCIPLINARY SCIENCES | MACULAR DEGENERATION | BRUCHS MEMBRANE | retinal pigmented epithelium | TIGHT JUNCTIONS | IN-VITRO | VISUAL FUNCTION | age-related macular degeneration | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | RETINAL-PIGMENT EPITHELIUM | AGE | Electroretinography | Retinal Pigment Epithelium - metabolism | Phosphorylation | Photoreceptor Cells, Vertebrate - ultrastructure | Choroid - metabolism | Macular Degeneration - physiopathology | Mice, Inbred C57BL | Choroid - blood supply | Solubility | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Blood-Aqueous Barrier - pathology | Aging - pathology | Atrophy | Retinal Pigment Epithelium - pathology | Vision, Ocular - physiology | Choroid - ultrastructure | Animals | Retinal Pigment Epithelium - ultrastructure | Choroid - pathology | Photoreceptor Cells, Vertebrate - pathology | Apoptosis | Macular Degeneration - pathology | Physiological aspects | Chemical properties | Vascular endothelial growth factor | Retinal pigment epithelium | Pigments | Molecules | Membranes | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 369 - 383
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2013, Volume 110, Issue 6, pp. E517 - E525
Journal Article
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 34, pp. 8771 - 8781
Abstract We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the... 
Advanced Basic Science | Dentistry | Retinal degeneration | Nanoceria | Longevity | Antioxidant | Gene expression | Tubby mouse | OXIDATIVE STRESS | MATERIALS SCIENCE, BIOMATERIALS | REDOX STATE | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | MACULAR DEGENERATION | ENDOPLASMIC-RETICULUM STRESS | OPSIN MISLOCALIZATION | CELL-DEATH | CERIUM OXIDE NANOPARTICLES | RETINITIS-PIGMENTOSA | Retina - drug effects | Retina - metabolism | Intravitreal Injections | Opsins - genetics | Photoreceptor Cells, Vertebrate - drug effects | Retinal Rod Photoreceptor Cells - metabolism | Retinal Degeneration - prevention & control | Cerium - therapeutic use | Retinal Cone Photoreceptor Cells - pathology | Retinal Rod Photoreceptor Cells - drug effects | Cerium - administration & dosage | Retinal Degeneration - genetics | Mice, Inbred C57BL | Retina - physiopathology | Retinal Degeneration - physiopathology | Opsins - analysis | Gene Expression Regulation - drug effects | Animals | Retinal Cone Photoreceptor Cells - drug effects | Mice | Oxidative Stress - drug effects | Photoreceptor Cells, Vertebrate - metabolism | Retinal Degeneration - pathology | Photoreceptor Cells, Vertebrate - pathology | Retina - pathology | Retinal Cone Photoreceptor Cells - metabolism | Retinal Rod Photoreceptor Cells - pathology | Antioxidants | Eye diseases | Biological products | Analysis | Genes | Index Medicus | longevity | antioxidant | retinal degeneration | tubby mouse | gene expression | nanoceria
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2891 - 2903
Journal Article