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1. Full Text Mechanisms in photodynamic therapy: part one—photosensitizers, photochemistry and cellular localization
by Castano, Ana P and Demidova, Tatiana N and Hamblin, Michael R
Photodiagnosis and Photodynamic Therapy, ISSN 1572-1000, 2004, Volume 1, Issue 4, pp. 279 - 293
The use of non-toxic dyes or photosensitizers (PS) in combination with harmless visible light that is known as photodynamic therapy (PDT) has been known for... 
Photodynamic therapy | Photophysics | Tissue optics | Subcellular localization | Photosensitizers | Photochemistry | ONCOLOGY | Lipids | Mitochondrial DNA | Synthesis | Photosensitizing compounds | Active oxygen | Heme | Photodynamic therapy Photosensitizers
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2. Full Text Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(2) N-Alkylpyridylporphyrins
by Ezzeddine, Rima and Al-Banaw, Anwar and Tovmasyan, Artak and Craik, James D and Batinic-Haberle, Ines and Benov, Ludmil T
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 51, pp. 36579 - 36588
Background: Delivering molecules to selected cellular compartments is important for analytical and practical purposes. Results: Varying the length and... 
CATIONIC PORPHYRINS | Cell Proliferation | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZERS | MITOCHONDRIA | Fluorescence | Subcellular Distribution | PORPHYRIN DERIVATIVES | MECHANISMS | DEATH PATHWAYS | OF-THE-ART | DERMATOLOGY | Porphyrin | Cellular Uptake | Phototoxicity | SINGLET OXYGEN | Membrane Bilayer | Photodynamic Therapy | Photosensitizer | Zn Porphyrin | Lysosomes - drug effects | Cell Survival - drug effects | Humans | Radiation-Sensitizing Agents - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Static Electricity | Zinc - chemistry | Isomerism | Metalloporphyrins - pharmacology | Lysosomes - metabolism | Biological Transport | MCF-7 Cells | Light | Metalloporphyrins - chemistry | Cell Membrane - metabolism | Cell Proliferation - drug effects | Radiation-Sensitizing Agents - chemistry | Zinc - pharmacology | Cell Membrane - drug effects | Cell Biology
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3. Full Text Singlet oxygen luminescence kinetics in a heterogeneous environment - identification of the photosensitizer localization in small unilamellar vesicles
by Hackbarth, S and Röder, B
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, ISSN 1474-905X, 02/2015, Volume 14, Issue 2, pp. 329 - 334
In vivo measurement of singlet oxygen luminescence kinetics is affected by the heterogeneity of biological samples. Even though singlet oxygen luminescence... 
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4. Full Text Establishing the subcellular localization of photodynamically-induced ROS using 3,3′-diaminobenzidine: A methodological proposal, with a proof-of-concept demonstration
by Stockert, Juan C and Blázquez-Castro, Alfonso
Methods, ISSN 1046-2023, 10/2016, Volume 109, pp. 175 - 179
The critical involvement of reactive oxygen species (ROS) in both physiological and pathological processes in cell biology makes their detection and assessment... 
Colorimetric reaction | 3,3′-Diaminobenzidine | Photoactive dyes | ROS | Localized ROS generation | Photosensitizers | IN-SITU DETECTION | SINGLET OXYGEN PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGHT | BIOCHEMICAL RESEARCH METHODS | Calorimetric reaction | ELECTRON-MICROSCOPY | CELL-PROLIFERATION | SUPEROXIDE ANION | REACTIVE OXYGEN | FLUORESCENT-PROBES | PHOTOCONVERSION | 3,3 '-Diaminobenzidine | PHOTOOXIDATION | 3,3'-Diaminobenzidine - chemistry | Cytoplasm - chemistry | Reactive Oxygen Species - isolation & purification | Cytoplasm - radiation effects | Reactive Oxygen Species - chemistry | Light | Oxidation-Reduction - radiation effects | Molecular Biology - methods | Analysis | Cells
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5. Full Text Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy
by Tachikawa, Shoji and Sato, Shinichi and Hazama, Hisanao and Kaneda, Yasufumi and Awazu, Kunio and Nakamura, Hiroyuki
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2015, Volume 23, Issue 24, pp. 7578 - 7584
The protoporphyron (PPIX)-lipid (PL-C17) liposomes were successfully prepared from the corresponding micelles by post-inserted method. Both the PL-C17 micelles... 
Photodynamic therapy (PDT) | Reactive oxygen species (ROS) | Liposome | Micelle | Protoporphyrin IX (PPIX) | Drug delivery system (DDS) | Lipid | CHEMISTRY, MEDICINAL | HEMATOPORPHYRIN | PHOTOSENSITIZER | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | CHEMISTRY, ORGANIC | DEATH | PLASMA-MEMBRANE | CANCER | TUMORS | METABOLISM | ENVELOPE | Cell Line | Protoporphyrins - administration & dosage | Photosensitizing Agents - chemistry | Reactive Oxygen Species - metabolism | Humans | Protoporphyrins - pharmacology | Phosphatidylcholines - chemistry | Phosphatidylcholines - metabolism | Protoporphyrins - pharmacokinetics | Photochemotherapy | Neoplasms - drug therapy | Photosensitizing Agents - administration & dosage | Liposomes - chemistry | Photosensitizing Agents - pharmacology | Micelles | Photosensitizing Agents - pharmacokinetics | Liposomes - metabolism | HeLa Cells | Protoporphyrins - chemistry | Cancer
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6. Full Text Comparative Studies of the Cellular Uptake, Subcellular Localization, and Cytotoxic and Phototoxic Antitumor Properties of Ruthenium(II)–Porphyrin Conjugates with Different Linkers
by Zhang, Jing-Xiang and Zhou, Jun-Wei and Chan, Chi-Fai and Lau, Terrence Chi-Kong and Kwong, Daniel W. J and Tam, Hoi-Lam and Mak, Nai-Ki and Wong, Ka-Leung and Wong, Wai-Kwok
Bioconjugate Chemistry, ISSN 1043-1802, 08/2012, Volume 23, Issue 8, pp. 1623 - 1638
Six water-soluble free-base porphyrin-Ru(II) conjugates, 1–3, and Zn(II) porphyrin-Ru(II) conjugates, 4–6, with different linkers between the hydrophobic... 
PHOTODYNAMIC THERAPY | BUILDING-BLOCKS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZERS | BIOCHEMICAL RESEARCH METHODS | INTRACELLULAR PH | CHEMISTRY, ORGANIC | RUTHENIUM | PORPHYRIN | CANCER | CHEMISTRY, MULTIDISCIPLINARY | ENERGY-TRANSFER | PHTHALOCYANINES | LIVING CELLS | Photosensitizing Agents - chemistry | Metalloporphyrins - metabolism | Humans | Molecular Imaging | Photosensitizing Agents - metabolism | Antineoplastic Agents - chemistry | Metalloporphyrins - pharmacology | Ruthenium - chemistry | Antineoplastic Agents - metabolism | Photosensitizing Agents - pharmacology | Absorption | Biological Transport | Intracellular Space - metabolism | Metalloporphyrins - chemistry | Water - chemistry | Hydrophobic and Hydrophilic Interactions | Antineoplastic Agents - pharmacology | HeLa Cells | Hydrogen-Ion Concentration
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7. Full Text Singlet oxygen luminescence kinetics in a heterogeneous environment-identification of the photosensitizer localization in small unilamellar vesicles
by Hackbarth, S and Röder, B
Photochemical and Photobiological Sciences, ISSN 1474-905X, 02/2015, Volume 14, Issue 2, pp. 329 - 334
In vivo measurement of singlet oxygen luminescence kinetics is affected by the heterogeneity of biological samples. Even though singlet oxygen luminescence... 
TRANSITION | CELLS | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIQUID | DIFFUSION-COEFFICIENTS | CHEMISTRY, PHYSICAL | WATER
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8. Magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyanine in phosphate buffer: Supramolecular organization, cytotoxicity and accumulation/localization in tumor cells of HeLa
by Lapshina, M.A and Norko, S.I and Baulin, V.E and Terentiev, A.A and Tsivadze, A. Yu and Goldshleger, N.F
Macroheterocycles, ISSN 1998-9539, 2018, Volume 11, Issue 4, pp. 396 - 403
For the first time, magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyanine (Mgcr Pc-8) was explored as a potential PDT agent. Presence of crown-containing... 
Phthalocyanine | Hela cells | Sodium deoxycholate | Spectral properties | Crown ether conjugates | Cytotoxicity | Localization | Accumulation | Fluorescence microscopy | Solubility in water | Supramolecular organization | localization | supramolecular organization | crown ether conjugates | PHOTODYNAMIC THERAPY | accumulation | PHOTOSENSITIZERS | fluorescence microscopy | CANCER | CHEMISTRY, MULTIDISCIPLINARY | solubility in water | sodium dcoxycholate | HeLa cells | spectral properties | PHTHALOCYANINES | cytotoxicity
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9. Full Text Endoplasmic reticulum and Golgi apparatus are the preferential sites of Foscan localisation in cultured tumour cells
by Teiten, M.-H and Bezdetnaya, L and Morlière, P and Santus, R and Guillemin, F
British Journal of Cancer, ISSN 0007-0920, 01/2003, Volume 88, Issue 1, pp. 146 - 152
Intracellular photosensitiser localisation significantly influences the mechanism of response to photodynamic therapy (PDT), since the primary sites of damage... 
Intracellular localisation | Confocal microscopy | Foscan | Microspectrofluorometry | CARCINOMA-CELLS | M-THPC | PHOTODYNAMIC THERAPY | Foscan((R)) | microspectrofluorometry | PHOTOSENSITIZERS | SUBCELLULAR-LOCALIZATION | CELLULAR UPTAKE | BREAST-CANCER CELLS | IN-VITRO | ONCOLOGY | confocal microscopy | SINGLET OXYGEN | intracellular localisation | CHLORIN | Microscopy, Confocal | Humans | Endoplasmic Reticulum - metabolism | Spectrometry, Fluorescence | Golgi Apparatus - metabolism | Mesoporphyrins - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Tumor Cells, Cultured | Subcellular Fractions | Photochemistry | Experimental Therapeutics
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10. Full Text Oligo- and polypeptide conjugates of cationic porphyrins: binding, cellular uptake, and cellular localization
by Orosz, Ádám and Bősze, Szilvai and Mező, Gábor and Szabó, Ildikó and Herényi, Levente and Csík, Gabriella
Amino Acids, ISSN 0939-4451, 07/2017, Volume 49, Issue 7, pp. 1263 - 1276
Recently, we have characterized the DNA and nucleoprotein (NP) binding of bis(4-N-methylpyridyl)-15,20-di(4-carboxyphenyl)porphyrin (BMPCP) and... 
Lipid association constant | Cellular uptake | Intracellular localization | Cationic porphyrin | Peptide conjugate | DNA binding | CELLS | DESIGN | PHOTODYNAMIC THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZERS | CARRIER | DNA | CHARGE | Oligopeptides - chemical synthesis | Cell Nucleus - metabolism | Humans | Oligopeptides - pharmacokinetics | Porphyrins - chemistry | HL-60 Cells | DNA - metabolism | Porphyrins - pharmacokinetics | Porphyrins - pharmacology | Oligopeptides - pharmacology | Oligopeptides - chemistry | Peptides | Lysine | Analysis | Radiation | Porphyrins | Binding | Flow cytometry | Conjugates | Polypeptides | DNA probes | L-lysine | Chain branching | Fluorescence | Confocal microscopy | Spectroscopic analysis | Fluorescent indicators | Chains (polymeric) | Confocal | Derivatives | Cytometry | Mitochondria | Poly-L-lysine | Cations | Absorption spectra | Localization | Deoxyribonucleic acid--DNA
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11. Full Text Water‐Soluble Zinc Porphyrin Capable of Light‐Induced Photocleavage of DNA: Cell Localization Studies in Drosophila Melanogaster and Light Activated Treatment of Lung Cancer Cells
by Yoho, Joshua and Wogensthal, Kevin and Bennett, Thomas L and Palmer, Jessica and Comfort, Kristen K and Kango‐Singh, Madhuri and Swavey, Shawn and Stuart, Christopher H and Gmeiner, William H
European Journal of Inorganic Chemistry, ISSN 1434-1948, 01/2017, Volume 2017, Issue 1, pp. 153 - 159
A new water‐soluble zinc(II) porphyrin has been synthesized and characterized by high resolution mass spectroscopy, elemental analysis, and electronic... 
Zinc porphyrin | Cytotoxicity | Photodynamic therapy | DNA | Cancer | PHOTOSENSITIZERS | MECHANISMS | CHEMISTRY, INORGANIC & NUCLEAR | INACTIVATION | MIXED-LIGAND COMPLEXES | IN-VITRO | SINGLET OXYGEN | BINDING | DERIVATIVES | Care and treatment | Drosophila | Lung cancer | Oncology, Experimental | Respiratory agents | Research | Analysis | Genetic research | Genetic aspects | Mass spectrometry | Porphyrins | Lungs | Toxicity | Deoxyribonucleic acid | Irradiation | Position (location)
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12. Full Text The primary subcellular localization of Zinc phthalocyanine and its cellular impact on viability, proliferation and structure of breast cancer cells (MCF-7)
by Tynga, I.M and Houreld, N.N and Abrahamse, H
Journal of Photochemistry & Photobiology, B: Biology, ISSN 1011-1344, 03/2013, Volume 120, pp. 171 - 176
► ZnPcS is an effective photodynamic agent . ► ZnPcS localizes in mitochondria, lysosomes and Golgi apparatus. ► ZnPcS in its inactive form, showed no apparent... 
Zinc phthalocyanine | Breast cancer | Photodynamic therapy | APOPTOSIS | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZERS | MECHANISMS | DERIVATIVES | Cell Survival - drug effects | Cell Death - radiation effects | Intracellular Space - drug effects | Photosensitizing Agents - chemistry | Humans | Laser Therapy | Photosensitizing Agents - metabolism | Cell Survival - radiation effects | Sulfonic Acids - chemistry | Indoles - metabolism | Photosensitizing Agents - pharmacology | Biological Transport | MCF-7 Cells | Organometallic Compounds - metabolism | Breast Neoplasms - pathology | Intracellular Space - metabolism | Indoles - pharmacology | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Cell Death - drug effects | Indoles - chemistry | Intracellular Space - radiation effects | Organometallic Compounds - pharmacology | Cell Proliferation - radiation effects | Mitochondrial DNA | Phthalocyanins | Cancer cells
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13. Full Text Correlation between subcellular localization and photodynamic efficacy
by Kessel, David
Journal of Porphyrins and Phthalocyanines, ISSN 1088-4246, 08/2004, Volume 8, Issue 8, pp. 1009 - 1014
A variety of agents have now been identified that can selectively sensitize neoplastic cells and other tissues to light. This review classifies a group of... 
Drug delivery | Photodynamic | Localization | Photosensitizer | localization | CATIONIC PORPHYRINS | CELLS | MITOCHONDRIAL | drug delivery | CHEMISTRY, MULTIDISCIPLINARY | photodynamic | photosensitizer | PHOTODAMAGE | CYTOCHROME-C | APOPTOTIC RESPONSE | BCL-2 | THERAPY | PHOTOSENSITIZATION | ENDOPLASMIC-RETICULUM
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14. Full Text One small molecule as a theranostic agent: Naphthalimide dye for subcellular fluorescence localization and photodynamic therapy: In vivo
by Zhang, Lei and Lei, Kecheng and Zhang, Jingwen and Song, Wenlin and Zheng, Yuanhong and Tan, Shaoying and Gao, Yuwei and Xu, Yufang and Liu, Jianwen and Qian, Xuhong
MedChemComm, ISSN 2040-2503, 2016, Volume 7, Issue 6, pp. 1171 - 1175
A novel single and small molecular theranostic agent (1a) based on a naphthalimide dye has been developed and characterized. The agent (1a) displays excellent... 
BODIPY | CHEMISTRY, MEDICINAL | AGGREGATION-INDUCED EMISSION | ANTICANCER AGENTS | PHOTOSENSITIZER | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETEROCYCLIC FUSED NAPHTHALIMIDES | HIGHLY-EFFICIENT | AMINOALKYL SIDE-CHAINS | CANCER-THERAPY | LIVING CELLS
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15. Full Text Hypocrellin B in hepatocellular carcinoma cells: Subcellular localization and sonodynamic damage
by Wang, Xinna and Luo, Jianmei and Leung, Albert Wingnang and Li, Yajun and Zhang, Hongwei and Xu, Chuanshan
International Journal of Radiation Biology, ISSN 0955-3002, 05/2015, Volume 91, Issue 5, pp. 399 - 406
Abstract Purpose: To study subcellular localization of hypocrellin B in hepatocellular carcinoma cells, and hypocrellin B-mediated sonodynamic action-induced... 
hypocrellin B | subcellular localization | Sonodynamic therapy | mitochondrial damage | apoptosis | hepatocellular carcinoma cells | clonogenic survival | Clonogenic survival | Hypocrellin B | Mitochondrial damage | Subcellular localization | Hepatocellular carcinoma cells | Apoptosis | PHOTODYNAMIC THERAPY | CURCUMIN | PHOTOSENSITIZERS | SENSITIZERS | RADIATION | NUCLEAR SCIENCE & TECHNOLOGY | BIOLOGY | INTENSITY FOCUSED ULTRASOUND | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Perylene - analogs & derivatives | Cell Survival | Humans | Intracellular Space - metabolism | Carcinoma, Hepatocellular - pathology | Membrane Potential, Mitochondrial | Liver Neoplasms - pathology | Perylene - metabolism | Ultrasonic Therapy - adverse effects | Hep G2 Cells | Protein Transport | Quinones - metabolism
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16. Full Text The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells
by Sobczyński, Jan and Kristensen, Solveig and Berg, Kristian
Photochemical and Photobiological Sciences, ISSN 1474-905X, 2014, Volume 13, Issue 1, pp. 8 - 22
Many photosensitizers (PSs) for use in photodynamic therapy (PDT) are characterized by poor solubility and a tendency to aggregate in aqueous environments.... 
BLOCK-COPOLYMERS | PHOTODYNAMIC THERAPY | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOXORUBICIN | TRAFFICKING | CHEMISTRY, PHYSICAL | MICELLES | PORPHYRIN | CELLULAR UPTAKE | DELIVERY | NANOPARTICLES | BIOPHYSICS | Benzimidazoles | Amines | Humans | Male | Endosomes - metabolism | Photochemical Processes | Dose-Response Relationship, Drug | Photosensitizing Agents - pharmacology | Cell Nucleus - metabolism | Lysosomes - metabolism | Poloxamer - pharmacology | Biological Transport | Light | Endosomes - drug effects | Female | Lysosomes - drug effects | Photosensitizing Agents - chemical synthesis | Cell Survival - drug effects | Porphyrins - chemical synthesis | Spectrometry, Fluorescence | Porphyrins - pharmacology | Drug Carriers - pharmacology | Microscopy, Confocal | Cell Line, Tumor | Cell Nucleus - drug effects | Fluorescent Dyes
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17. Full Text One small molecule as a theranostic agent: naphthalimide dye for subcellular fluorescence localization and photodynamic therapy in vivo
by Zhang, Lei and Lei, Kecheng and Zhang, Jingwen and Song, Wenlin and Zheng, Yuanhong and Tan, Shaoying and Gao, Yuwei and Xu, Yufang and Liu, Jianwen and Qian, Xuhong
MedChemComm, ISSN 2040-2503, 2016, Volume 7, Issue 6, pp. 1171 - 1175
A novel single and small molecular theranostic agent (1a) based on a naphthalimide dye has been developed and characterized. The agent (1a) displays excellent... 
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