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Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6082, pp. 717 - 721
Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that... 
Cartilage | Molecules | REPORTS | Chondrocytes | Collagens | Stem cells | Lead | Arthritis | Chondrogenesis | Osteoarthritis | Vehicles | PATHOGENESIS | GENE | ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | FILAMIN | OSTEOARTHRITIS | BONE | TRANSCRIPTION FACTOR | EXPRESSION | CHONDROGENESIS | CHONDROCYTE DIFFERENTIATION | Anilides - therapeutic use | Chondrocytes - cytology | Phthalic Acids - chemistry | Humans | Anilides - chemistry | Structure-Activity Relationship | Osteoarthritis - drug therapy | Osteoarthritis - physiopathology | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cell Nucleus - metabolism | Chondrocytes - physiology | Cattle | Microfilament Proteins - metabolism | Osteoarthritis - pathology | Phthalic Acids - pharmacology | Contractile Proteins - metabolism | Chondrocytes - metabolism | Mesenchymal Stromal Cells - physiology | Core Binding Factor beta Subunit - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | Phthalic Acids - therapeutic use | Core Binding Factor Alpha 2 Subunit - metabolism | Cartilage, Articular - cytology | Filamins | Phthalic Acids - administration & dosage | Regeneration | Animals | High-Throughput Screening Assays | Anilides - administration & dosage | Small Molecule Libraries | Anilides - pharmacology | Mice | Care and treatment | Physiological aspects | Transplantation | Methods | Molecular biology | Biomedical materials | Effectiveness | Breakdown | Biocompatibility | Articular | Adults
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 2/2009, Volume 117, Issue 2, pp. 185 - 189
Journal Article
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 105 - 112
Phosphodiesterase (PDE) 4 inhibition is a well-known anti-inflammatory mechanism, but the development of PDE4 inhibitors has been hampered by side effects such... 
SCRATCHING BEHAVIOR | INTERLEUKIN-4 | DISEASE | PHARMACOLOGY & PHARMACY | ITCH-ASSOCIATED RESPONSES | AGENTS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | EMESIS | T-CELLS | NC/NGA MICE | HYPERSENSITIVITY | Skin - metabolism | Antipruritics - therapeutic use | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Male | Metabolic Clearance Rate | Antipruritics - pharmacokinetics | Monocytes - immunology | Antipruritics - pharmacology | Tissue Distribution | Quinazolines - administration & dosage | Phthalic Acids - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Lymphocytes - metabolism | Phthalic Acids - therapeutic use | Phosphodiesterase 4 Inhibitors - pharmacokinetics | Phosphodiesterase 4 Inhibitors - therapeutic use | Rats | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Monocytes - drug effects | Phthalic Acids - administration & dosage | Dermatitis, Atopic - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Mice | Quinazolines - pharmacology | Quinazolines - pharmacokinetics | Monocytes - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lymphocytes - immunology | Phosphodiesterase 4 Inhibitors - administration & dosage | Dermatitis, Atopic - immunology | Female | Skin - immunology | Cytokines - metabolism | Cytokines - secretion | Antipruritics - administration & dosage | Mice, Inbred Strains | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Quinazolines - therapeutic use | Lymphocytes - drug effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Phthalic Acids - pharmacokinetics | Dermatitis, Atopic - blood | Cytokines - antagonists & inhibitors | Administration, Topical | Dermatitis, Atopic - metabolism | Skin - drug effects
Journal Article