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PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 404 - 421
Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with severe motor impairments caused by the loss of dopaminergic innervation... 
LOCALIZATION | TRANSMISSION | ACTIVATION | MEDIATED MODULATION | GLUTAMATE-RECEPTOR-4 | MGLUR4 | NEURONS | PHARMACOLOGY & PHARMACY | RAT-BRAIN | DYSFUNCTION | AGONISTS | Catalepsy - drug therapy | Receptors, G-Protein-Coupled - metabolism | Pyrimidines - blood | Humans | Male | Thallium - metabolism | Picolinic Acids - metabolism | Pyrimidines - metabolism | Brain - metabolism | Motor Neuron Disease - drug therapy | Corpus Striatum - pathology | Disease Models, Animal | Triazoles - therapeutic use | Glutamic Acid - pharmacology | Adenosine A2 Receptor Antagonists - therapeutic use | Brain - physiopathology | Rats | Psychomotor Performance - drug effects | Motor Neuron Disease - chemically induced | Rats, Sprague-Dawley | Motor Neuron Disease - pathology | Brain - drug effects | Drug Synergism | Triazoles - metabolism | Calcium Signaling - drug effects | Picolinic Acids - pharmacokinetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Brain - pathology | Corpus Striatum - drug effects | Tyrosine 3-Monooxygenase - metabolism | Triazoles - blood | Rats, Wistar | Substantia Nigra - pathology | Picolinic Acids - blood | Parkinson Disease - drug therapy | Receptors, Metabotropic Glutamate - metabolism | Receptors, G-Protein-Coupled - agonists | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Adenosine A2 Receptor Antagonists - metabolism | Motor Neuron Disease - metabolism | Oxidopamine - pharmacology | Transfection | Receptors, Metabotropic Glutamate - genetics | Reaction Time - drug effects | HEK293 Cells | Catalepsy - chemically induced | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Drug Therapy, Combination | Motor Neuron Disease - physiopathology | Haloperidol - pharmacology | Picolinic Acids - pharmacology | 3,4-Dihydroxyphenylacetic Acid - metabolism | Corpus Striatum - physiopathology | Levodopa - therapeutic use | Substantia Nigra - drug effects | Animals | Picolinic Acids - therapeutic use | Pyrimidines - therapeutic use | Adenosine A2 Receptor Antagonists - blood | Protein Binding | Receptors, Metabotropic Glutamate - agonists | Levodopa - metabolism | Monoamine Oxidase - metabolism
Journal Article
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 08/2003, Volume 81, Issue 4, pp. 247 - 265
The immune system continuously modulates the balance between responsiveness to pathogens and tolerance to non‐harmful antigens. The mechanisms that mediate... 
indoleamine 2 | NAD | poly ADP‐ribose polymerase | tryptophan dioxygenase | 3‐dioxygenase | niacin | quinolinic acid | macrophage | kynurenine | dendritic cell | tolerance | Dendritic cell | Indoleamine 2, 3-dioxygenase | Kynurenine | Tolerance | Poly ADP-ribose polymerase | Quinolinic acid | Niacin | Tryptophan dioxygenase | Macrophage | poly ADP-ribose polymerase | NITRIC-OXIDE SYNTHASE | IMMUNOLOGY | 3-dioxygenase | NICOTINAMIDE ADENINE-DINUCLEOTIDE | CELL BIOLOGY | EXCESSIVE L-TRYPTOPHAN | T-CELL PROLIFERATION | INTERFERON-GAMMA | 3-HYDROXYANTHRANILIC ACID | KYNURENINE PATHWAY METABOLISM | PULMONARY INDOLEAMINE 2,3-DIOXYGENASE | PICOLINIC-ACID | QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE | Immune System - physiology | Quinolinic Acid - immunology | Humans | Dendritic Cells - physiology | Immune Tolerance | Dioxygenases | Tryptophan - metabolism | Tryptophan Oxygenase - metabolism | Oxygenases - biosynthesis | Poly(ADP-ribose) Polymerases - metabolism | Tryptophan - biosynthesis | Animals | Oxygenases - metabolism | Quinolinic Acid - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase | Kynurenine - metabolism | NAD - metabolism | Human | Poly(ADP-ribose) Polymerases, metabolism | NAD, metabolism | Tryptophan Oxygenase, metabolism | Kynurenine, metabolism | Oxygenases, metabolism | Immune System, physiology | Tryptophan, metabolism | Dendritic Cells, physiology | Oxygenases, biosynthesis | Quinolinic Acid, immunology | Tryptophan, biosynthesis | Quinolinic Acid, metabolism | indoleamine-2,3-dioxygenase
Journal Article