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Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24770 - 24780
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment... 
LIPOFUSCIN FLUOROPHORE | RAT | DYSTROPHY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPONENT | RPE CELLS | N-RETINYLIDENE ETHANOLAMINE | BINDING | PHOTORECEPTORS | Retinoids - metabolism | Epithelial Cells - metabolism | Lipofuscin - pharmacology | Antioxidants - metabolism | Humans | Lysosomes - genetics | Rats, Long-Evans | Adenosine Triphosphate - genetics | Phagocytosis - genetics | Membrane Potential, Mitochondrial - drug effects | Mitosis - genetics | Oxidative Phosphorylation - drug effects | DNA, Mitochondrial - genetics | Lysosomes - metabolism | Aging - genetics | Cell Death - genetics | Mitochondria - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Pyruvic Acid - metabolism | Lysosomes - pathology | Cell Death - drug effects | Cell Line | Phagocytosis - drug effects | DNA, Mitochondrial - metabolism | Rats | Epithelial Cells - pathology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - pathology | Aging - pathology | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Point Mutation | Pyridinium Compounds - pharmacology | Animals | Mitosis - drug effects | Macular Degeneration - genetics | Glucose - metabolism | Pigment Epithelium of Eye - pathology | Pyridinium Compounds - metabolism | Lipofuscin - metabolism | Retinoids - pharmacology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus | Molecular Basis of Cell and Developmental Biology
Journal Article
Journal Article
American Journal of Ophthalmology, ISSN 0002-9394, 2007, Volume 143, Issue 4, pp. 607 - 615.e2
Journal Article
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2006, Volume 27, Issue 7, pp. 983 - 993
Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-related diseases including age-related macular degeneration (AMD), a... 
Mitochondria | Peroxisomes | Age-related macular degeneration | Lipofuscin | Electron microscopy | Morphometry | Retinal pigment epithelium | ACTIVATED RECEPTORS ALPHA | BETA-OXIDATION | OXIDATIVE STRESS | mitochondria | DNA DAMAGE | morphometry | FATTY-ACIDS | NEUROSCIENCES | PERMEABILITY TRANSITION | GERIATRICS & GERONTOLOGY | SKELETAL-MUSCLE | GENE-EXPRESSION | lipofuscin | peroxisomes | electron microscopy | PPAR-GAMMA | retinal pigment epithelium | age-related macular degeneration | Humans | Middle Aged | Pigment Epithelium of Eye - physiopathology | Child, Preschool | Male | Cytoplasmic Granules - metabolism | Aged, 80 and over | Adult | Female | Energy Metabolism - physiology | Child | Peroxisomes - pathology | Microscopy, Electron, Transmission | Cytoplasmic Granules - pathology | Macular Degeneration - physiopathology | Mitochondria - metabolism | Mitochondria - pathology | Disease Progression | Peroxisomes - metabolism | Aging - pathology | Mitochondrial Membranes - metabolism | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Mitochondrial Membranes - pathology | Adolescent | Pigment Epithelium of Eye - pathology | Aged | Lipofuscin - metabolism | Aging - metabolism | Macular Degeneration - pathology | Macular degeneration | Animal pigments | Neurosciences | Physiological aspects | Mitochondrial DNA | Ophthalmology | Universities and colleges | Epithelium | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2004, Volume 101, Issue 22, pp. 8491 - 8496
Docosahexaenoic acid (DHA) is a lipid peroxidation target in oxidative injury to retinal pigment epithelium (RPE) and retina. Photoreceptor and synaptic... 
Oxidative stress | Biological Sciences | Transcriptional regulatory elements | Neurons | DNA | DNA fragmentation | Photoreceptors | Lipids | Retina | Fatty acids | Apoptosis | Neuroprotection | Bcl-2 proteins | Age-related macular degeneration | Neurodegeneration | Docosanoids | INDUCED APOPTOSIS | RHESUS-MONKEYS | MULTIDISCIPLINARY SCIENCES | neurodegeneration | LIGHT-DAMAGE | BINDING PROTEIN | docosanoids | PHOTORECEPTOR CELLS | TERM INFANTS | OUTER SEGMENT MEMBRANES | BRAIN ISCHEMIA | neuroprotection | FREE FATTY-ACIDS | GENE-EXPRESSION | age-related macular degeneration | Cell Line | Interleukin-1 - metabolism | Pigment Epithelium of Eye - drug effects | Epithelial Cells - metabolism | Oxidative Stress | Docosahexaenoic Acids - chemistry | Cyclooxygenase 2 | Epithelial Cells - drug effects | Humans | Membrane Proteins | Pigment Epithelium of Eye - metabolism | Docosahexaenoic Acids - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Isoenzymes - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | DNA Fragmentation | Caspase 3 | Molecular Structure | Apoptosis - physiology | Pigment Epithelium of Eye - cytology | Lipid Peroxidation | Docosahexaenoic Acids - metabolism | Macular degeneration | Research | Neurology | Pigments | Oxidation | Eyes & eyesight | Cells | Stress | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2014, Volume 25, Issue 8, pp. 1338 - 1354
Journal Article