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Journal Article
The American Journal of Pathology, ISSN 0002-9440, 2005, Volume 167, Issue 5, pp. 1451 - 1459
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24770 - 24780
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment... 
LIPOFUSCIN FLUOROPHORE | RAT | DYSTROPHY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPONENT | RPE CELLS | N-RETINYLIDENE ETHANOLAMINE | BINDING | PHOTORECEPTORS | Retinoids - metabolism | Epithelial Cells - metabolism | Lipofuscin - pharmacology | Antioxidants - metabolism | Humans | Lysosomes - genetics | Rats, Long-Evans | Adenosine Triphosphate - genetics | Phagocytosis - genetics | Membrane Potential, Mitochondrial - drug effects | Mitosis - genetics | Oxidative Phosphorylation - drug effects | DNA, Mitochondrial - genetics | Lysosomes - metabolism | Aging - genetics | Cell Death - genetics | Mitochondria - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Pyruvic Acid - metabolism | Lysosomes - pathology | Cell Death - drug effects | Cell Line | Phagocytosis - drug effects | DNA, Mitochondrial - metabolism | Rats | Epithelial Cells - pathology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - pathology | Aging - pathology | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Point Mutation | Pyridinium Compounds - pharmacology | Animals | Mitosis - drug effects | Macular Degeneration - genetics | Glucose - metabolism | Pigment Epithelium of Eye - pathology | Pyridinium Compounds - metabolism | Lipofuscin - metabolism | Retinoids - pharmacology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus | Molecular Basis of Cell and Developmental Biology
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2006, Volume 27, Issue 7, pp. 983 - 993
Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-related diseases including age-related macular degeneration (AMD), a... 
Mitochondria | Peroxisomes | Age-related macular degeneration | Lipofuscin | Electron microscopy | Morphometry | Retinal pigment epithelium | ACTIVATED RECEPTORS ALPHA | BETA-OXIDATION | OXIDATIVE STRESS | mitochondria | DNA DAMAGE | morphometry | FATTY-ACIDS | NEUROSCIENCES | PERMEABILITY TRANSITION | GERIATRICS & GERONTOLOGY | SKELETAL-MUSCLE | GENE-EXPRESSION | lipofuscin | peroxisomes | electron microscopy | PPAR-GAMMA | retinal pigment epithelium | age-related macular degeneration | Humans | Middle Aged | Pigment Epithelium of Eye - physiopathology | Child, Preschool | Male | Cytoplasmic Granules - metabolism | Aged, 80 and over | Adult | Female | Energy Metabolism - physiology | Child | Peroxisomes - pathology | Microscopy, Electron, Transmission | Cytoplasmic Granules - pathology | Macular Degeneration - physiopathology | Mitochondria - metabolism | Mitochondria - pathology | Disease Progression | Peroxisomes - metabolism | Aging - pathology | Mitochondrial Membranes - metabolism | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Mitochondrial Membranes - pathology | Adolescent | Pigment Epithelium of Eye - pathology | Aged | Lipofuscin - metabolism | Aging - metabolism | Macular Degeneration - pathology | Macular degeneration | Animal pigments | Neurosciences | Physiological aspects | Mitochondrial DNA | Ophthalmology | Universities and colleges | Epithelium | Index Medicus
Journal Article
Ophthalmology, ISSN 0161-6420, 02/2007, Volume 114, Issue 2, pp. 253 - 262
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. E4069 - E4078
The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification. Herein, we report a previously undescribed... 
Oxidized low density lipoprotein | Toxin metabolism | Retinal disease | Retinal pigment epithelium | DRUSEN | retinal disease | MULTIDISCIPLINARY SCIENCES | MOUSE | LOW-DENSITY-LIPOPROTEIN | toxin metabolism | oxidized low density lipoprotein | DIOXIN RECEPTOR | MODEL | PATHOGENESIS | GENE | LIVER | MICE | retinal pigment epithelium | PIGMENT | Receptors, Aryl Hydrocarbon - deficiency | Bruch Membrane - pathology | Humans | Middle Aged | Extracellular Matrix - metabolism | Male | Bruch Membrane - ultrastructure | Young Adult | Aging - genetics | RNA Interference | Pigment Epithelium of Eye - ultrastructure | Adult | Female | Lipoproteins, LDL - metabolism | Child | Disease Models, Animal | Tight Junctions - metabolism | Cell Line | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Microscopy, Electron | Aging - pathology | Mice, Knockout | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Animals | Macular Degeneration - genetics | Adolescent | Pigment Epithelium of Eye - pathology | Mice | Bruch Membrane - metabolism | Lipofuscin - metabolism | Lipoproteins, LDL - blood | Tight Junctions - pathology | Aging - metabolism | Macular Degeneration - pathology | Macular degeneration | Pathogenesis | Rodents | Hydrocarbons | T cell receptors | Metabolism | Low density lipoprotein | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2013, Volume 54, Issue 3, pp. 2013 - 2018
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2008, Volume 359, Issue 14, pp. 1456 - 1463
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2005, Volume 102, Issue 20, pp. 7227 - 7232
Journal Article