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1. Full Text Macular degeneration: recent advances and therapeutic opportunities
by Nathans, Jeremy and Rattner, Amir
Nature Reviews Neuroscience, ISSN 1471-003X, 11/2006, Volume 7, Issue 11, pp. 860 - 872
The central retina mediates high acuity vision, and its progressive dysfunction due to macular degeneration is the leading cause of visual disability among... 
COMPLEMENT FACTOR-H | AGE-RELATED MACULOPATHY | SCANNING LASER OPHTHALMOSCOPE | HEMOLYTIC-UREMIC SYNDROME | OPTICAL COHERENCE TOMOGRAPHY | GLOMERULONEPHRITIS TYPE-II | SORSBYS-FUNDUS-DYSTROPHY | NEUROSCIENCES | RETINAL-PIGMENT EPITHELIUM | ENDOTHELIAL GROWTH-FACTOR | BEAVER DAM EYE | Genetic Predisposition to Disease - genetics | Retina - metabolism | Macular Degeneration - physiopathology | Retinaldehyde - antagonists & inhibitors | Humans | Laser Therapy | Pigment Epithelium of Eye - physiopathology | Retina - physiopathology | Retinaldehyde - metabolism | Nerve Tissue Proteins - genetics | Aging - pathology | Nerve Tissue Proteins - metabolism | Pigment Epithelium of Eye - metabolism | Animals | Retinal Artery - physiopathology | Macular Degeneration - genetics | Macular Degeneration - therapy | Retinal Artery - pathology | Pigment Epithelium of Eye - pathology | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Retina - pathology | Aging - metabolism
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2. Full Text A comparison of some organizational characteristics of the mouse central retina and the human macula
by Volland, Stefanie and Esteve-Rudd, Julian and Hoo, Juyea and Yee, Claudine and Williams, David S
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0125631
Mouse models have greatly assisted our understanding of retinal degenerations. However, the mouse retina does not have a macula, leading to the question of... 
LIPOFUSCIN ACCUMULATION | AGE-RELATED MACULOPATHY | PHOTORECEPTOR OUTER SEGMENTS | MULTIDISCIPLINARY SCIENCES | FOVEAL CONES | MICE | BRUCHS MEMBRANE | MODEL | BLOOD-FLOW | PIGMENT-EPITHELIUM | DEGENERATION | Macula Lutea - ultrastructure | Macular Degeneration - physiopathology | Humans | Pigment Epithelium of Eye - physiopathology | Retina - physiopathology | Macula Lutea - physiopathology | Bruch Membrane - physiopathology | Retinal Degeneration - physiopathology | Microscopy, Electron | Aging - pathology | Animals | Retina - ultrastructure | Mice | Disease Models, Animal | Macular degeneration | Usage | Animal models in research | Physiological aspects | Development and progression | Retina | Models | Research | Neurosciences | Animal models | Pathogenesis | Neurobiology | Electron microscopy | Monkeys & apes | Density | Cell density | Medicine | Phagocytes | Brain research | Microscopy | Retinal degeneration | Photoreceptors | Molecular biology | Age
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3. Full Text Transplantation of the RPE in AMD
by Binder, Susanne and Stanzel, Boris V and Krebs, Ilse and Glittenberg, Carl
Progress in Retinal and Eye Research, ISSN 1350-9462, 2007, Volume 26, Issue 5, pp. 516 - 554
The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper between photoreceptors (PRs) and the choriocapillaries. The RPE and... 
ROD OUTER SEGMENTS | AGE-RELATED MACULOPATHY | ANTERIOR LENS CAPSULE | OPHTHALMOLOGY | FACTOR-H POLYMORPHISM | MACULAR TRANSLOCATION SURGERY | HUMAN BRUCHS MEMBRANE | RETINAL-PIGMENT EPITHELIUM | ENDOTHELIAL GROWTH-FACTOR | GLYCATION END-PRODUCTS | SUBFOVEAL CHOROIDAL NEOVASCULARIZATION | Stem Cell Transplantation | Animals | Macular Degeneration - surgery | Macular Degeneration - physiopathology | Humans | Pigment Epithelium of Eye - physiopathology | Aging | Prostheses and Implants | Transplantation, Autologous | Pigment Epithelium of Eye - transplantation | Tissue Transplantation - methods | Macular degeneration | Stem cells | Physiological aspects | Eye diseases | Development and progression | Chromophores | Fibroblast growth factors | Transplantation
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4. Full Text Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration
by Feher, Janos and Kovacs, Illes and Artico, Marco and Cavallotti, Carlo and Papale, Antonio and Balacco Gabrieli, Corrado
Neurobiology of Aging, ISSN 0197-4580, 2006, Volume 27, Issue 7, pp. 983 - 993
Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-related diseases including age-related macular degeneration (AMD), a... 
Mitochondria | Peroxisomes | Age-related macular degeneration | Lipofuscin | Electron microscopy | Morphometry | Retinal pigment epithelium | ACTIVATED RECEPTORS ALPHA | BETA-OXIDATION | OXIDATIVE STRESS | mitochondria | DNA DAMAGE | morphometry | FATTY-ACIDS | NEUROSCIENCES | PERMEABILITY TRANSITION | GERIATRICS & GERONTOLOGY | SKELETAL-MUSCLE | GENE-EXPRESSION | lipofuscin | peroxisomes | electron microscopy | PPAR-GAMMA | retinal pigment epithelium | age-related macular degeneration | Humans | Middle Aged | Pigment Epithelium of Eye - physiopathology | Child, Preschool | Male | Cytoplasmic Granules - metabolism | Aged, 80 and over | Adult | Female | Energy Metabolism - physiology | Child | Peroxisomes - pathology | Microscopy, Electron, Transmission | Cytoplasmic Granules - pathology | Macular Degeneration - physiopathology | Mitochondria - metabolism | Mitochondria - pathology | Disease Progression | Peroxisomes - metabolism | Aging - pathology | Mitochondrial Membranes - metabolism | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Mitochondrial Membranes - pathology | Adolescent | Pigment Epithelium of Eye - pathology | Aged | Lipofuscin - metabolism | Aging - metabolism | Macular Degeneration - pathology | Macular degeneration | Animal pigments | Neurosciences | Physiological aspects | Mitochondrial DNA | Ophthalmology | Universities and colleges | Epithelium
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5. Full Text Time Course Changes of the Mechanical Properties of the Iris Pigment Epithelium in a Rat Chronic Ocular Hypertension Model
by Li, Tan and Li, Lin and Liu, Zhicheng
BioMed Research International, ISSN 2314-6133, 2018, Volume 2018, pp. 4862309 - 10
Background. The flow field of aqueous humor correlates to the stiffness of iris pigment epithelium (IPE) which acts as a wall of posterior chamber. We focus on... 
MEDICINE, RESEARCH & EXPERIMENTAL | 5-FLUOROURACIL | BIOMECHANICAL PROPERTIES | GLAUCOMA MODEL | STIFFNESS | INTRACRANIAL ANEURYSMS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PUPILLARY BLOCK | STRESS | HUMAN TRABECULAR MESHWORK | AGE | HEMODYNAMICS | Ocular Hypertension - physiopathology | Pigment Epithelium of Eye - physiopathology | Rats | Biomechanical Phenomena - physiology | Male | Pigment Epithelium of Eye - diagnostic imaging | Rats, Sprague-Dawley | Elasticity - physiology | Iris - cytology | Animals | Iris - physiopathology | Time Factors | Disease Models, Animal | Hypertension | Glaucoma | Atomic force microscopy | Atomic force microscopes | Mechanical properties | Histology | Research | Epithelium | Cell density | Eye | Biomechanics | Iris | Hypotheses | Stiffness | Age | Intraocular pressure
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6. Full Text RPE lipofuscin and its role in retinal pathobiology
by Sparrow, Janet R and Boulton, Mike
Experimental Eye Research, ISSN 0014-4835, 2005, Volume 80, Issue 5, pp. 595 - 606
Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that... 
lipofuscin | retinal pigment epithelial cell | A2E | photooxidation | age-related macular degeneration | light damage | Retinal pigment epithelial cell | Light damage | Lipofuscin | Age-related macular degeneration | Photooxidation | LIGHT-INDUCED DAMAGE | PHOTORECEPTOR OUTER SEGMENTS | FUNDUS FLAVIMACULATUS | LYSOSOMAL DEGRADATIVE FUNCTIONS | BLUE-LIGHT | SINGLET-OXYGEN GENERATION | PIGMENT EPITHELIAL-CELLS | STARGARDT MACULAR DYSTROPHY | CONE-ROD DYSTROPHY | AGE-RELATED-CHANGES | OPHTHALMOLOGY | Retinoids - metabolism | Oxidation-Reduction | Humans | Pigment Epithelium of Eye - physiopathology | Retinal Diseases - metabolism | Vitamin A - metabolism | Pigment Epithelium of Eye - metabolism | Aging - physiology | Light | Photoreceptor Cells - metabolism | Pyridinium Compounds - metabolism | Retinal Diseases - physiopathology | Lipofuscin - metabolism | Melanosomes - metabolism | Microscopy, Fluorescence
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