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Tetrahedron Letters, ISSN 0040-4039, 06/2015, Volume 56, Issue 23, pp. 3662 - 3666
[Display omitted] In this Letter, an unambiguous synthetic strategy is reported for the preparation of enantiomerically pure cis-5-halo-piperazic acid... 
Monamycins | Kutznerides | Bromomonamycins | Ph3P/NCS chlorination | Piperazimycin A | The A1,3-rotamer effect | 5-Halo-piperazic acids | N-Acyl-piperazic acids | The A | rotamer effect | P/NCS chlorination
Journal Article
Synthetic Communications, ISSN 0039-7911, 09/2014, Volume 44, Issue 17, pp. 2510 - 2519
Synthesis of cyclic α -hydrazino acids of five- to nine-membered rings has been described. Di-tert-butyl or dibenzyl malonate was used as starting materials... 
malonates | Cyclic | aza proline | hydrazino acids | (S)/(R) | (S)/(R)-1,2-diazepane-3-carboxylic acid | (S)/(R)-piperazic acid | Cyclic α -hydrazino acids | (S)/(R)- δ -aza proline | ASYMMETRIC-SYNTHESIS | Cyclic alpha-hydrazino acids | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | (S)/(R)-delta-aza proline | PIPERAZIMYCIN | AMINO-ACIDS | PROGRESS | INHIBITOR | DERIVATIVES
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2016, Volume 26, Issue 18, pp. 4423 - 4426
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2410 - 2414
[Display omitted] The discovery of a novel series of peptide deformylase inhibitors incorporating a piperazic acid amino acid found in nature is described.... 
Piperazic acid | Peptide deformylase | Reverse hydroxamate | Antibacterial | Sch-382583 | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Peptides | Analysis | Crystals | Amino acids | Skin | Structure | Health aspects | Antibacterial agents
Journal Article
Tetrahedron, ISSN 0040-4020, 09/2012, Volume 68, Issue 39, pp. 8347 - 8357
Synthesis of five-, six-, seven-, eight-, and nine-membered cyclic α-hydrazino acids from a common starting material ‘diethylmalonate’ with 26, 16, 34, 13.5,... 
Piperazic acid | Delta aza-proline | Unnatural amino acids | Diethylmalonate | α-Hydrazino acids | ASYMMETRIC-SYNTHESIS | AZAPROLINE | CHEMISTRY, ORGANIC | PIPERAZIMYCIN | IMPACT | PEPTIDES | AMINO-ACIDS | alpha-Hydrazino acids | PROGRESS | INHIBITOR | DERIVATIVES
Journal Article
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 09/2013, Volume 17, Issue 9, pp. 1209 - 1213
A novel and efficient manufacturing technology is disclosed in the present work for the preparation of (S)-1-benzyloxycarbonylhexahydropyridazine-3-carboxylic... 
HYDRAZINATION | DEPSIPEPTIDE | ANTIBIOTICS | PEPTIDES | STREPTOMYCES | PRODUCTS | AMINO-ACIDS | PIPERAZIC ACID | CHEMISTRY, ORGANIC | CHEMISTRY, APPLIED | INHIBITOR | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2015, Volume 56, Issue 23, pp. 3075 - 3081
[Display omitted] Nitrogen-containing heterocycles are central to the chemical reactions that occur in all organisms. The metabolic transformation of amino... 
Biosynthesis | Enzymatic transformations | Amino acid morphing | Nitrogen heterocycles | ASPERGILLUS-FUMIGATUS | STAUROSPORINE | PIPERAZIC ACID | COMPLEXITY GENERATION | CHEMISTRY, ORGANIC | POSTTRANSLATIONAL MODIFICATIONS | ANTIBIOTIC BIOSYNTHESIS | BETA-LACTAM | ASSEMBLY-LINE | CHROMOPYRROLIC ACID | REBECCAMYCIN | Enzymes | Amino acids | Plant metabolites
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 02/2020, Volume 85, Issue 3, pp. 1680 - 1686
A six-step synthesis of orthogonally protected (S)-epsilon-oxapipecolic acid is described, starting from a commercially available glutamate diester. The... 
PIPECOLIC ACID | RAPAMYCIN AY-22,989 | ATOMIC-STRUCTURE | PEPTIDES | PIPERAZIC ACID | CHEMISTRY | CHEMISTRY, ORGANIC | PROLINE ANALOGS | CONFORMATIONAL-ANALYSIS | N-AMINATION | EFFICIENT
Journal Article
Organic Letters, ISSN 1523-7060, 05/2018, Volume 20, Issue 9, pp. 2707 - 2710
The first chemical synthesis of L-156,373 (1), a potent oxytocin receptor antagonist isolated from Streptomyces silvensis, is reported. Assembly of the unusual... 
AMINO-ACIDS | DIELS-ALDER REACTION | CHEMISTRY, ORGANIC | ACETYL-L-PROLINE | ELECTROPHILIC AMINATION | STREPTOMYCES-SILVENSIS | HYDRAZINO ACIDS | PEPTIDE-SYNTHESIS | AMYCOLATOPSIS SP | CYCLIC HEXAPEPTIDE | PIPERAZIC ACID-DERIVATIVES
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 01/2009, Volume 57, Issue 1, pp. 49 - 54
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2009, Volume 57, Issue 1, pp. 49 - 54
The short-step synthesis of the unsubstituted, 5-hydroxy- and 5-chloropiperidazine-3-carboxylic acids using an aza Diels-Alder reaction between the 1,3-diene... 
aza Diels-Alder reaction | piperidazine-3-carboxylic acid | azodicarboxylate | piperazic acid
Journal Article
Synthesis, ISSN 0039-7881, 6/2007, Volume 2007, Issue 11, pp. 1677 - 1682
ABSTRACT A short and flexible route for the synthesis of 1,2-diisopropyl-3-methyl-(3S,4R,5R)-4,5-dihydroxyhexahydro-1,2,3-pyrid­azinetricarboxylate, from... 
paper | Piperazic acid | Dihydroxylation | Intramolecular cyclisation | α-hydrazination | L-proline | DEPSIPEPTIDE | ANTIBIOTICS | BBM-928-A | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | ALDEHYDES | intramolecular cyclisation | PHYSICOCHEMICAL PROPERTIES | STREPTOMYCES SP | ALPHA-AMINATION | AMINO-ACIDS | dihydroxylation | ACTINOMADURA-LUZONENSIS | alpha-hydrazination | piperazic acid
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 06/2015, Volume 56, Issue 23, pp. 3662 - 3666
In this Letter, an unambiguous synthetic strategy is reported for the preparation of enantiomerically pure cis-5-halo-piperazic acid derivatives in single... 
CONVENIENT SYNTHESIS | Ph3P/NCS chlorination | (3S,5S)-5-HYDROXYPIPERAZIC ACID | CHEMISTRY, ORGANIC | Piperazimycin A | The A(1,3)-rotamer effect | PEPTIDES | Monamycins | Kutznerides | Bromomonamycins | AMINO-ACIDS | PROGRESS | 5-Halo-piperazic acids | CHLORINATION | N-Acyl-piperazic acids
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 2004, Volume 15, Issue 21, pp. 3477 - 3481
[Display omitted] The highly efficient synthesis of ( R)- and ( S)-piperazic acids, components of naturally occurring antibiotic cyclodepsipeptides, was... 
ENANTIOSELECTIVE SYNTHESIS | POLYOXYPEPTINS | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | 3-COMPONENT MANNICH REACTION | ALDOL REACTIONS | ALDEHYDES | (2S,3R)-3-HYDROXY-3-METHYLPROLINE | CHEMISTRY, INORGANIC & NUCLEAR | KINETIC RESOLUTION | AMINO-ACIDS | STREPTOMYCES SP A92-308110 | (3S)-PIPERAZIC ACIDS
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 2010, Volume 21, Issue 18, pp. 2302 - 2306
Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been... 
(3S)-2,3,4,5-TETRAHYDROPYRIDAZINE-3-CARBOXYLIC ACID | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | ALDOL REACTIONS | PIPERAZIC ACID-DERIVATIVES | CHEMISTRY, INORGANIC & NUCLEAR | ALPHA-AMINATION | BIOLOGICAL-ACTIVITY | UNUSUAL AMINO-ACID | ANTRIMYCIN-DV | PROLINE | CYCLIC HEXAPEPTIDE | LUZOPEPTIN-A
Journal Article
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