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Blood, ISSN 1528-0020, 2008, Volume 111, Issue 8, pp. 4022 - 4028
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e56980
1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIMYCOBACTERIAL | ASSAY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | ANTIFUNGAL ACTIVITIES | PYRROLE DERIVATIVE BM212 | IDENTIFICATION | STREPTOMYCIN | Bacterial Proteins - antagonists & inhibitors | Cell Line | Microsomes - metabolism | Humans | Bacterial Proteins - genetics | Piperazines - toxicity | Piperazines - chemistry | Antibiotics, Antitubercular - pharmacology | Antibiotics, Antitubercular - toxicity | Mycobacterium tuberculosis - drug effects | Piperazines - pharmacology | Microbial Sensitivity Tests | Pyrroles - pharmacology | Animals | Antibiotics, Antitubercular - chemistry | Pyrroles - toxicity | Tuberculosis - drug therapy | Pyrroles - chemistry | Bacterial Proteins - metabolism | Female | Mice | Mycobacterium tuberculosis - metabolism | Tuberculosis - metabolism | Mycobacterium tuberculosis - genetics | Tuberculosis | Drug discovery | Chemical properties | Gene mutations | Health aspects | Drugs | Animal models | Oxygen | Research & development--R&D | Pyrroles | Thiomorpholine | Infections | Mutants | Gene sequencing | Morpholine | Discovery tools | Mutation | Sulfur | Lipophilicity | Piperazines | Microsomes | Bacterial Proteins | Life Sciences | Mycobacterium tuberculosis | Antibiotics, Antitubercular | Pharmaceutical sciences | Research & development | R&D
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2015, Volume 373, Issue 18, pp. 1697 - 1708
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2007, Volume 35, Issue 7, pp. 1096 - 1104
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2015, Volume 33, Issue 3, pp. 244 - 250
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 334, Issue 6061, pp. 1372 - 1377
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against... 
Schizonts | Malaria | RESEARCH ARTICLES | Liver | Antimalarials | Infections | Parasites | Inhibitory concentration 50 | Scaffolds | Blood | Chemicals | RESISTANCE | TARGETS | INFECTIONS | MUTATIONS | MULTIDISCIPLINARY SCIENCES | METHEMOGLOBINEMIA | Plasmodium berghei - physiology | Humans | Imidazoles - chemistry | Plasmodium - physiology | Piperazines - chemistry | Plasmodium falciparum - drug effects | Plasmodium - growth & development | Imidazoles - therapeutic use | Plasmodium falciparum - physiology | Antimalarials - pharmacokinetics | Antimalarials - therapeutic use | Imidazoles - pharmacology | Piperazines - therapeutic use | Random Allocation | Piperazines - pharmacology | Plasmodium berghei - cytology | Small Molecule Libraries | Malaria - parasitology | Cell Line, Tumor | Plasmodium berghei - growth & development | Mice | Mice, Inbred BALB C | Liver - parasitology | Erythrocytes - parasitology | Plasmodium berghei - drug effects | Plasmodium - cytology | Plasmodium falciparum - cytology | Plasmodium - drug effects | Imidazoles - pharmacokinetics | Plasmodium yoelii - growth & development | Protozoan Proteins - genetics | Sporozoites - growth & development | Protozoan Proteins - metabolism | Plasmodium yoelii - drug effects | Protozoan Proteins - chemistry | Molecular Structure | Piperazines - pharmacokinetics | Drug Evaluation, Preclinical | Sporozoites - drug effects | Drug Resistance | Plasmodium yoelii - physiology | Plasmodium yoelii - cytology | Drug Discovery | Antimalarials - pharmacology | Malaria - prevention & control | Animals | Antimalarials - chemistry | Polymorphism, Single Nucleotide | Malaria - drug therapy | Plasmodium falciparum - growth & development | Pharmaceutical research | Plasmodium | Care and treatment | Analysis | Research | Drug therapy
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2015, Volume 373, Issue 3, pp. 209 - 219
In women with hormone-receptor–positive metastatic breast cancer that had progressed after endocrine therapy, palbociclib plus fulvestrant was associated with... 
TARGET | MEDICINE, GENERAL & INTERNAL | THERAPY | FULVESTRANT | CLINICAL-TRIALS | CYCLIN D | RESISTANCE | MUTATIONS | COMBINATION | ESTROGEN-RECEPTOR | 4/6 INHIBITOR PALBOCICLIB | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Estradiol - analogs & derivatives | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptors, Estrogen - analysis | Protein Kinase Inhibitors - adverse effects | Receptors, Progesterone - analysis | Pyridines - adverse effects | Aged, 80 and over | Estradiol - adverse effects | Adult | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyridines - therapeutic use | Double-Blind Method | Estradiol - therapeutic use | Biomarkers - analysis | Piperazines - therapeutic use | Breast Neoplasms - drug therapy | Piperazines - adverse effects | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Aged | Receptor, ErbB-2 - analysis | Women | Hormone receptors | Care and treatment | Usage | Breast cancer | Diagnosis | Health aspects | Thrombocytopenia | Leukopenia | Endocrine therapy | Fatigue | Metastasis | Cancer therapies | Cyclin-dependent kinase 4 | Fulvestrant | Metastases | Epidermal growth factor | Womens health | S phase | Cell cycle | Neutropenia | G1 phase
Journal Article