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Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 04/2019, Volume 62, Issue 4, pp. 166 - 177
In spite of previous efforts, there is lack of a radiotracer for imaging the 5HT 1A receptor density in human brain, which is involved in several neurological... 
1A | 5HT | docking | 1‐(2‐methoxyphenyl)piperazine (MPP) | 2‐ethynylpyridine | WAY100635 | click chemistry | homology model | Binding | Neuroimaging | Brain | Radiolabelling | Serotonin | Pharmacology | Radioactive tracers | Single photon emission computed tomography | Neurological diseases | Organic chemistry | Receptors | Piperazine | Precursors | Radiochemistry | Docking | Receptor density | Ligands | Chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 4, pp. 1572 - 1582
A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized to explore two main parameters related to the... 
NOREPINEPHRINE REUPTAKE | GLUTAMATE RECEPTORS | CHEMISTRY, MEDICINAL | ATYPICAL ANTIPSYCHOTIC ACTIVITY | DOPAMINE RELEASE | PYRIDOBENZODIAZEPINE DERIVATIVES | N-DESMETHYLCLOZAPINE | PROTEIN-COUPLED RECEPTORS | DISCRIMINATIVE STIMULUS | MAJOR METABOLITE | PREFRONTAL CORTEX | Brain - anatomy & histology | Cricetulus | Pyridines - chemistry | Receptors, Dopamine D4 - agonists | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Piperazines - chemistry | Structure-Activity Relationship | Receptors, Dopamine D2 - metabolism | Antipsychotic Agents - chemical synthesis | Brain - metabolism | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Oxazepines - chemical synthesis | Serotonin 5-HT1 Receptor Agonists - chemistry | Radioligand Assay | Serotonin 5-HT1 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Cricetinae | Receptors, Dopamine D2 - agonists | Pyridines - chemical synthesis | Models, Molecular | Rats | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Organ Specificity | Piperazines - pharmacology | Rats, Sprague-Dawley | Oxazepines - pharmacology | Brain - drug effects | Animals | Antipsychotic Agents - chemistry | Piperazines - chemical synthesis | Receptors, Dopamine D4 - metabolism | Pyridines - pharmacology | Antipsychotic Agents - pharmacology | In Vitro Techniques | Receptor, Serotonin, 5-HT2A - metabolism | Oxazepines - chemistry | Index Medicus
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 2019, Volume 62, Issue 4, p. 166
In spite of previous efforts, there is lack of a radiotracer for imaging the 5HT receptor density in human brain, which is involved in several neurological... 
2-ethynylpyridine | 5HT | docking | WAY100635 | click chemistry | 1-(2-methoxyphenyl)piperazine (MPP) | homology model
Journal Article
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, ISSN 0362-4803, 04/2019, Volume 62, Issue 4, pp. 166 - 177
In spite of previous efforts, there is lack of a radiotracer for imaging the 5HT(1A) receptor density in human brain, which is involved in several neurological... 
2-ethynylpyridine | CHEMISTRY, ANALYTICAL | CHEMISTRY, MEDICINAL | WAY100635 | COMPLEXES | BIOCHEMICAL RESEARCH METHODS | click chemistry | BIOMOLECULES | 5HT(1A) homology model | docking | TECHNETIUM | 5-HT1A RECEPTOR | IN-VIVO | 1-(2-methoxyphenyl)piperazine (MPP) | METAL | LIGAND | MOLECULAR-DYNAMICS SIMULATIONS | BRAIN
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2005, Volume 127, Issue 32, pp. 11505 - 11515
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | DEPENDENT KINASE INHIBITOR | BREAST-CANCER | POTENT INHIBITOR | STRUCTURAL BASIS | CDK4/6 INHIBITOR | PHARMACOLOGY & PHARMACY | ERECTILE DYSFUNCTION | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Index Medicus | Full Paper | Full Papers
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2010, Volume 132, Issue 41, pp. 14376 - 14378
A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report... 
CHAETOCIN | DEHYDROGLIOTOXIN | VERTICILLIN | EPIDITHIODIOXOPIPERAZINES | PENICILLIUM | CONCISE TOTAL-SYNTHESIS | ANALOGS | GLIOTOXIN | EPITETRATHIODIOXOPIPERAZINE | SPORIDESMINS | CHEMISTRY, MULTIDISCIPLINARY | Stereoisomerism | Piperazines - chemical synthesis | Piperazines - chemistry | Index Medicus
Journal Article
Journal Article
Organic Communications, ISSN 1307-6175, 04/2012, Volume 5, Issue 2, pp. 50 - 57
A green and efficient method for the preparation of α-hydroxyphosphonates (3a-n) in minutes of time with high yields is accomplished by grinding the mixture of... 
α-Hydroxyphosphonates | Green process | Diethylphosphite | Piperazine | Grinding | diethylphosphite | α -Hydroxyphosphonates | green process | piperazine | grinding
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2016, Volume 138, Issue 3, p. 1057
Journal Article