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Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
.... Whilst the interest in this underrepresented functional group in drug discovery is clearly on the rise, there remains an incomplete understanding of the medicinal‐chemistry... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | BUILDING-BLOCKS | DEPENDENT KINASE INHIBITOR | NH-SULFOXIMINES | POTENT INHIBITOR | LIGANDS | STRUCTURAL BASIS | CDK4/6 INHIBITOR | ABL PROTEIN | PHARMACOLOGY & PHARMACY | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 10/2016, Volume 49, Issue 10, pp. 2295 - 2306
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 124 - 134
The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology.... 
Hot Melt Extrusion | Crystalline Solid Dispersion | Disintegrating Tablets | Bitter API | Chemical Imaging | Screw Configuration | Taste Masking | Crystalline solid dispersion | Taste masking | Hot melt extrusion | Disintegrating tablets | Chemical imaging | Screw configuration | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY | Phosphodiesterase 5 Inhibitors - chemistry | Piperazines - administration & dosage | Drug Carriers - adverse effects | Tablets | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Drug Carriers - administration & dosage | Acetates - chemistry | Piperazines - chemistry | Povidone - analogs & derivatives | Purines - administration & dosage | Saliva - chemistry | Equipment Design | Gastric Juice - chemistry | Drug Carriers - chemistry | Sildenafil Citrate | Cellulose - chemistry | Excipients - chemistry | Surface Properties | Purines - adverse effects | Cellulose - analogs & derivatives | Sulfonamides - chemistry | Phosphodiesterase 5 Inhibitors - administration & dosage | Solubility | Hot Temperature | Piperazines - adverse effects | Drug Compounding - instrumentation | Povidone - chemistry | Purines - chemistry | Models, Biological | Sulfonamides - adverse effects | Polymers - chemistry | Vasodilator Agents - chemistry | Taste | Vasodilator Agents - adverse effects | Vasodilator Agents - administration & dosage | Sulfonamides - administration & dosage
Journal Article
Journal Article
Oncogene, ISSN 1476-5594, 2009, Volume 27, Issue S1, pp. S149 - S157
Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One... 
Bcl-2 | Drug resistance and ABT-737 | BH3 mimetic | Apoptosis | Cancer | PROAPOPTOTIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | BCL-2 FAMILY PROTEINS | apoptosis | OUTER MITOCHONDRIAL-MEMBRANE | ANTIAPOPTOTIC BCL-2 | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | CYTOCHROME-C | SURVIVAL-PROMOTING PROTEINS | ONCOLOGY | X-L | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer | drug resistance and ABT-737 | Neoplasms - metabolism | Sulfones - therapeutic use | Multigene Family | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Piperazines - chemistry | Structure-Activity Relationship | Nitrophenols - chemistry | Drug Delivery Systems | Benzamides - therapeutic use | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Thionucleotides - chemistry | Sulfones - chemistry | Drug Design | Proto-Oncogene Proteins c-bcl-2 - chemistry | Antineoplastic Agents - pharmacology | Biphenyl Compounds - chemistry | Antineoplastic Agents - classification | Pyrroles - therapeutic use | Dimerization | Benzamides - chemistry | Binding, Competitive | Protein Structure, Tertiary | Sulfonamides - chemistry | Thionucleotides - therapeutic use | Clinical Trials as Topic | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Piperazines - pharmacology | Neoplasms - drug therapy | Animals | Sulfonamides - therapeutic use | Pyrroles - chemistry | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | Mitochondria - physiology | Drug Screening Assays, Antitumor | Proteins | Signal transduction | Oncology | Molecular biology
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
ACTIVATION | MEK INHIBITION | DETERMINANTS | RAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | DEFICIENCY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0146292
An open-tubular capillary electrochromatography column was prepared by chemically immobilized beta-cyclodextrin modified gold nanoparticles onto new surface... 
ELECTROMIGRATION TECHNIQUES | ALKYLTHIOL GOLD NANOPARTICLES | SEPARATION | LIQUID-CHROMATOGRAPHY | TRENDS | MULTIDISCIPLINARY SCIENCES | Carbazoles - chemistry | Stereoisomerism | Piperazines - chemistry | Tropanes - isolation & purification | Chemistry Techniques, Analytical - methods | Azabicyclo Compounds - isolation & purification | Azabicyclo Compounds - chemistry | Cyclobutanes - isolation & purification | Venlafaxine Hydrochloride - isolation & purification | Cyclodextrins - chemistry | Terbutaline - chemistry | Venlafaxine Hydrochloride - chemistry | Carbazoles - isolation & purification | Microscopy, Electron, Transmission | Tropanes - chemistry | Metal Nanoparticles - chemistry | Brompheniramine - isolation & purification | Terbutaline - isolation & purification | Capillary Electrochromatography | Piperazines - isolation & purification | Propanolamines - isolation & purification | beta-Cyclodextrins - chemistry | Brompheniramine - chemistry | Carvedilol | Propanolamines - chemistry | Cyclobutanes - chemistry | Drugs | Infrared spectroscopy | Separation | Sibutramine | Enantiomers | pH effects | Nanoparticles | Terbutaline | Spectrum analysis | Venlafaxine | Trends | Stationary phase | Gold | Scanning electron microscopy | Spectroscopy | Capillary electrophoresis | Electron microscopy | Chromatography | Zopiclone | Cyclodextrin | Transmission electron microscopy | Acids | Electrochromatography | Synergistic effect | Sulfate
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are... 
CHRONIC MYELOGENOUS LEUKEMIA | CHRONIC PHASE | COMPLEX | C-ABL | ACTIVE-SITE | SRC | MULTIDISCIPLINARY SCIENCES | ELECTRIC-FIELDS | IMATINIB | MUTATION | CLINICAL RESISTANCE | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Spectroscopic analysis | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites
Journal Article