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American Journal of Managed Care, ISSN 1088-0224, 2014, Volume 20, Issue 3, pp. e90 - e97
Objectives: A "chiral switch" occurs in the pharmaceutical market when a drug made up of 2 enantiomer forms is replaced with a purified single-enantiomer... 
MEDICATION | NAMES | MULTICENTER | EROSIVE ESOPHAGITIS | OMEPRAZOLE | RANDOMIZED CONTROLLED-TRIAL | 8-WEEK COMPARATIVE TRIAL | MEDICINE, GENERAL & INTERNAL | COST | HEALTH CARE SCIENCES & SERVICES | DOUBLE-BLIND | HEALTH POLICY & SERVICES | HEALTH | Proton Pump Inhibitors - economics | Formoterol Fumarate | Hypnotics and Sedatives - chemistry | Medicaid - economics | Stereoisomerism | United States | Humans | Dexmethylphenidate Hydrochloride - chemistry | Drugs, Generic - economics | Piperazines - economics | Esomeprazole - chemistry | Drug Approval | Piperazines - chemistry | Esomeprazole - economics | Eszopiclone | Azabicyclo Compounds - chemistry | Benzhydryl Compounds - chemistry | Antidotes - economics | Bronchodilator Agents - chemistry | Levoleucovorin - chemistry | Histamine H1 Antagonists, Non-Sedating - economics | Dexmethylphenidate Hydrochloride - economics | Dexlansoprazole - chemistry | Retrospective Studies | Central Nervous System Stimulants - economics | United States Food and Drug Administration | Wakefulness-Promoting Agents - chemistry | Levoleucovorin - economics | Antidotes - chemistry | Bronchodilator Agents - economics | Azabicyclo Compounds - economics | Benzhydryl Compounds - economics | Cetirizine - chemistry | Cetirizine - economics | Ethanolamines - economics | Ethanolamines - chemistry | Patents as Topic | Hypnotics and Sedatives - economics | Wakefulness-Promoting Agents - economics | Drug Prescriptions - statistics & numerical data | Proton Pump Inhibitors - chemistry | Central Nervous System Stimulants - chemistry | Dexlansoprazole - economics | Histamine H1 Antagonists, Non-Sedating - chemistry
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 01/2013, Volume 11, Issue 1, pp. 81 - 91
Background:  The CYP2C19 genotype is a predictor of adverse cardiovascular events in acute coronary syndrome (ACS) patients undergoing percutaneous coronary... 
clopidogrel | cost‐effectiveness | prasugrel | antiplatelet therapy | genetic testing | acute coronary syndromes | Antiplatelet therapy | Prasugrel | Clopidogrel | Genetic testing | Acute coronary syndromes | Cost-effectiveness | cost-effectiveness | LAST YEAR | CYP2C19 GENOTYPE | TREATED PATIENTS | BYPASS GRAFT-SURGERY | ATRIAL-FIBRILLATION | ACUTE MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | ST-SEGMENT ELEVATION | HEMATOLOGY | OF-CARE | CLINICAL-OUTCOMES | Prasugrel Hydrochloride | Predictive Value of Tests | Thiophenes - therapeutic use | Percutaneous Coronary Intervention - mortality | Acute Coronary Syndrome - economics | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Thiophenes - metabolism | Medicare - economics | Models, Economic | Pharmacogenetics - economics | Time Factors | Ticlopidine - economics | Myocardial Infarction - etiology | Insurance, Health, Reimbursement - economics | Quality-Adjusted Life Years | Genetic Predisposition to Disease | Risk Assessment | Gene Frequency | Risk Factors | Piperazines - therapeutic use | Ticlopidine - analogs & derivatives | Phenotype | Acute Coronary Syndrome - therapy | Thrombosis - genetics | Percutaneous Coronary Intervention - economics | Percutaneous Coronary Intervention - adverse effects | Thrombosis - economics | Drug Costs | Platelet Aggregation Inhibitors - economics | Markov Chains | Ticlopidine - therapeutic use | United States | Acute Coronary Syndrome - mortality | Piperazines - economics | Piperazines - metabolism | Computer Simulation | Hemorrhage - etiology | Ticlopidine - metabolism | Thiophenes - economics | Platelet Aggregation Inhibitors - metabolism | Thrombosis - prevention & control | Platelet Aggregation Inhibitors - therapeutic use | Decision Support Techniques | Kaplan-Meier Estimate | Treatment Outcome | Cerebrovascular Disorders - etiology | Aryl Hydrocarbon Hydroxylases - metabolism | Disease-Free Survival | Health Care Costs | Cytochrome P-450 CYP2C19 | Cost-Benefit Analysis | Acute Coronary Syndrome - diagnosis | Acute Coronary Syndrome - genetics | Genetic Testing - economics | Transluminal angioplasty | Care and treatment | Medicare | Analysis | Cardiac patients | Cytochrome P-450 | Markov processes | Cost benefit analysis | Coronary heart disease | Genetic screening | Angina pectoris | Genotype & phenotype
Journal Article
European Journal of Cancer, ISSN 0959-8049, 11/2017, Volume 85, pp. 146 - 154
The addition of to improves progression-free survival in the first-line treatment of hormone receptor positive advanced breast cancer (ABC). This study... 
Advanced breast cancer | Cost-effectiveness | Letrozole | Cost-utility | Palbociclib | SURVIVAL | 1ST-LINE TREATMENT | CANADA | CARE | SOCIETY | OF-LIFE | WOMEN | THERAPY | ONCOLOGY | AROMATASE INHIBITORS | Drug Costs | Nitriles - economics | Breast Neoplasms - economics | Humans | Piperazines - economics | Antineoplastic Agents - therapeutic use | Models, Economic | Protein Kinase Inhibitors - adverse effects | Breast Neoplasms - chemistry | Pyridines - adverse effects | Stochastic Processes | Time Factors | Antineoplastic Agents - adverse effects | Computer Simulation | Antineoplastic Combined Chemotherapy Protocols - economics | Triazoles - economics | Female | Aromatase Inhibitors - therapeutic use | Pyridines - therapeutic use | Triazoles - therapeutic use | Protein Kinase Inhibitors - economics | Biomarkers, Tumor - analysis | Decision Support Techniques | Treatment Outcome | Piperazines - therapeutic use | Breast Neoplasms - drug therapy | Piperazines - adverse effects | Antineoplastic Agents - economics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aromatase Inhibitors - economics | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Cost-Benefit Analysis | Pyridines - economics | Quality of Life | Decision Trees | Ontario | Nitriles - therapeutic use | Analysis | Breast cancer | Hormones | Index Medicus
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2015, Volume 139, Issue 1, pp. 59 - 62
Abstract Purpose To determine the cost-effectiveness of olaparib, a PARP inhibitor, as maintenance therapy for platinum-sensitive (PS) recurrent ovarian... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | BRCA | PARP inhibitiors | Olaparib | Cost-effectiveness | Ovarian cancer | GYNECOLOGIC-ONCOLOGY-GROUP | STAGE-III | CHEMOTHERAPY | PACLITAXEL | OBSTETRICS & GYNECOLOGY | TRIAL | WOMEN | CISPLATIN | ONCOLOGY | Neoplasm Recurrence, Local - economics | United States | Humans | Neoplasm Recurrence, Local - drug therapy | Piperazines - economics | Phthalazines - economics | Antineoplastic Agents - therapeutic use | Models, Economic | Ovarian Neoplasms - genetics | Maintenance Chemotherapy - methods | Antineoplastic Combined Chemotherapy Protocols - economics | Genes, BRCA2 | Germ-Line Mutation | Female | Genes, BRCA1 | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Paclitaxel - economics | Decision Support Techniques | Carboplatin - administration & dosage | Piperazines - therapeutic use | Carboplatin - economics | Antineoplastic Agents - economics | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Disease-Free Survival | Poly(ADP-ribose) Polymerase Inhibitors - economics | Phthalazines - therapeutic use | Ovarian Neoplasms - economics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cost-Benefit Analysis | Maintenance Chemotherapy - economics | Neoplasm Recurrence, Local - genetics | Relapse | Cost benefit analysis | Analysis | Diseases
Journal Article
Circulation, ISSN 0009-7322, 01/2010, Volume 121, Issue 1, pp. 71 - 79
Background-In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by... 
Infarction | Coronary disease | Thrombus | Cost- benefit analysis | Revascularization | revascularization | CARDIAC & CARDIOVASCULAR SYSTEMS | CONFIDENCE-INTERVALS | CARDIOVASCULAR EVENTS | infarction | thrombus | coronary disease | IMPACT | cost-benefit analysis | PERIPHERAL VASCULAR DISEASE | ST-SEGMENT ELEVATION | HEMATOLOGY | CLINICAL-OUTCOMES | Platelet Aggregation Inhibitors - economics | Prasugrel Hydrochloride | Thiophenes - therapeutic use | United States - epidemiology | Myocardial Infarction - mortality | Follow-Up Studies | Ticlopidine - therapeutic use | Acute Coronary Syndrome - economics | Humans | Acute Coronary Syndrome - mortality | Hemorrhage - mortality | Piperazines - economics | Angioplasty, Balloon, Coronary | Drug Costs - statistics & numerical data | Life Expectancy | Ticlopidine - economics | Myocardial Infarction - economics | Thiophenes - economics | Stroke - mortality | Platelet Aggregation Inhibitors - therapeutic use | Databases, Factual | Multicenter Studies as Topic - statistics & numerical data | Randomized Controlled Trials as Topic - statistics & numerical data | Thrombolytic Therapy - economics | Combined Modality Therapy | Piperazines - therapeutic use | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Outcome and Process Assessment (Health Care) - economics | Myocardial Infarction - drug therapy | Cost-Benefit Analysis | Hospitalization - economics | Usage | Patient outcomes | Clopidogrel | Drug therapy | Comparative analysis | Health aspects | Heart attack
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Clinical Therapeutics, ISSN 0149-2918, 2012, Volume 34, Issue 8, pp. 1774 - 1787
Abstract Background Chronic graft-versus-host disease (cGvHD) is the leading cause of late nonrelapse mortality (transplant-related mortality) after... 
Internal Medicine | Medical Education | cost-effectiveness | extracorporeal photopheresis | chronic graft | host disease | Host disease | Extracorporeal photopheresis | Cost-effectiveness | Chronic graft | EXTRACORPOREAL PHOTOCHEMOTHERAPY | T-CELL LYMPHOMA | MONOCLONAL-ANTIBODY | TRANSPLANTATION | ECONOMIC-EVALUATION | RITUXIMAB | SALVAGE THERAPY | PHARMACOLOGY & PHARMACY | PHOTOPHERESIS | REFRACTORY CHRONIC GVHD | IMATINIB MESYLATE | Drug Costs | Graft vs Host Disease - therapy | Humans | Immunosuppressive Agents - therapeutic use | Needs Assessment - economics | Photopheresis - economics | Piperazines - economics | Health Services Needs and Demand - economics | Models, Economic | Time Factors | Computer Simulation | Immunosuppressive Agents - economics | Graft vs Host Disease - diagnosis | Graft vs Host Disease - economics | Quality-Adjusted Life Years | Photopheresis - adverse effects | Antibodies, Monoclonal, Murine-Derived - economics | National Health Programs - economics | Rituximab | Treatment Outcome | Piperazines - therapeutic use | Pyrimidines - economics | Imatinib Mesylate | Piperazines - adverse effects | Spain | Health Care Costs | Pyrimidines - therapeutic use | Cost-Benefit Analysis | Pyrimidines - adverse effects | Immunosuppressive Agents - adverse effects | Benzamides | Antibodies, Monoclonal, Murine-Derived - adverse effects | Chronic Disease | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Health Care Rationing - economics | Transplantation | Hematopoietic stem cells | Stem cells | Studies | Transplants & implants | Mortality | Economia de la salut | Espanya | Medical economics
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American Journal of Cardiology, The, ISSN 0002-9149, 2013, Volume 112, Issue 3, pp. 355 - 362
Assays monitoring P2Y12 platelet reactivity can accurately predict which patients will have a poor response to clopidogrel. We sought to determine the... 
Cardiovascular | INFARCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | CLOPIDOGREL | TICAGRELOR | ASPIRIN AND/OR RESISTANCE | CARDIOVASCULAR-DISEASE | PATIENTS SHOWING RESISTANCE | TAILORING TREATMENT | INTERVENTION | PRIMARY PREVENTION | TIROFIBAN | Platelet Aggregation Inhibitors - economics | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Markov Chains | Ticlopidine - therapeutic use | Acute Coronary Syndrome - economics | Humans | Receptors, Purinergic P2Y12 - drug effects | Acute Coronary Syndrome - mortality | Drugs, Generic - economics | Piperazines - economics | Male | Drugs, Generic - therapeutic use | Dose-Response Relationship, Drug | Drug Costs - statistics & numerical data | Receptors, Purinergic P2Y12 - blood | Adenosine - therapeutic use | Ticlopidine - economics | Female | Myocardial Revascularization - economics | Thiophenes - economics | Platelet Aggregation Inhibitors - therapeutic use | Quality-Adjusted Life Years | Survival Rate | Piperazines - therapeutic use | Drug Therapy, Combination - economics | Ticlopidine - analogs & derivatives | Platelet Function Tests - economics | Acute Coronary Syndrome - drug therapy | Adenosine - analogs & derivatives | Cost-Benefit Analysis | Adenosine - economics | Aged | Decision Trees | Cohort Studies | Markov processes | Monte Carlo method | Coronary heart disease | Analysis | Cardiac patients | Medical care, Cost of | Aspirin | Heart attacks | Drug therapy | Acute coronary syndromes
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Breast Cancer Research and Treatment, ISSN 0167-6806, 7/2016, Volume 158, Issue 1, pp. 51 - 57
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