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Journal Article
Toxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due... 
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
Journal Article
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 02/2018, Volume 48, pp. 151 - 160
Journal Article
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 08/2017, Volume 177, Issue 2, pp. 595 - 595
Journal Article
Journal Article
Clinical Toxicology, ISSN 1556-3650, 03/2018, Volume 56, Issue 3, pp. 226 - 228
Journal Article
Chemical Engineering Journal, ISSN 1385-8947, 10/2017, Volume 326, pp. 911 - 920
Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2008, Volume 106, Issue 1, pp. 153 - 161
Journal Article
Environmental Toxicology, ISSN 1520-4081, 01/2012, Volume 27, Issue 1, pp. 18 - 25
The presence of pharmaceutical substances in the municipal effluents is currently considered the principal source of bio‐active molecule emissions into aquatic... 
genotoxicity | diffusion assay | RAPD‐PCR | pharmacological products | zebrafish | comet assay | RAPD-PCR | Zebrafish | Comet assay | Diffusion assay | Genotoxicity | Pharmacological products | GEMFIBROZIL | PHARMACEUTICALS | ZEBRAFISH DANIO-RERIO | HEAVY-METALS | WATER RESOURCES | THERAPEUTIC DRUGS | ARBITRARY PRIMERS |