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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 2, pp. 601 - 635
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7477, pp. 493 - 499
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-alpha... 
CRUCIAL ROLE | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | ADIPONECTIN LEVELS | EXPRESSION | Liver - pathology | Obesity - drug therapy | Longevity - drug effects | Adipose Tissue, White - metabolism | Receptors, Adiponectin - metabolism | Diabetes Mellitus, Type 2 - metabolism | Muscle Fibers, Skeletal - drug effects | Obesity - genetics | Glucose Intolerance - drug therapy | Liver - drug effects | Piperidines - pharmacology | Inflammation - drug therapy | Adenylate Kinase - metabolism | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Receptors, Adiponectin - agonists | Adiponectin - metabolism | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Adipose Tissue, White - pathology | Adiponectin - pharmacology | Dyslipidemias - drug therapy | Piperidines - administration & dosage | Administration, Oral | Obesity - complications | Piperidines - metabolism | Liver - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Obesity - physiopathology | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Triglycerides - metabolism | Small Molecule Libraries - chemistry | Receptors, Adiponectin - deficiency | Animals | Signal Transduction - drug effects | Piperidines - therapeutic use | Muscle Fibers, Skeletal - cytology | Mice | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue, White - drug effects | Receptors, Adiponectin - genetics | Muscles - cytology | Obesity | Insulin resistance | Muscular system | Kinases | Rodents
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 2006, Volume 34, Issue 5, pp. 248 - 273
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 10, pp. 1167 - 1174
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2017, Volume 376, Issue 18, pp. 1723 - 1736
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2017, Volume 377, Issue 9, pp. 829 - 838
Alectinib, a potent ALK tyrosine kinase inhibitor, was more effective and somewhat less toxic than crizotinib when used as primary therapy in patients with ALK... 
RESISTANT | MEDICINE, GENERAL & INTERNAL | MODELS | ANTITUMOR-ACTIVITY | INHIBITOR ALECTINIB | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Central Nervous System Neoplasms - secondary | Young Adult | Pyridines - adverse effects | Anaplastic Lymphoma Kinase | Antineoplastic Agents - adverse effects | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Receptor Protein-Tyrosine Kinases - analysis | Pyrazoles - adverse effects | Pyridines - therapeutic use | Crizotinib | Carbazoles - adverse effects | Kaplan-Meier Estimate | Carcinoma, Non-Small-Cell Lung - mortality | Disease-Free Survival | Animals | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Intention to Treat Analysis | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Central Nervous System Neoplasms - drug therapy | Drugs | Care and treatment | Analysis | Comparative analysis | Lung cancer, Non-small cell | Health aspects | Systemic diseases | Toxicity | Lung cancer | Central nervous system | Non-small cell lung carcinoma | Oncology | Nervous system | Metastasis | Radiation therapy | Patients | Lymphoma | Cancer therapies | Survival | Mutation | Protein-tyrosine kinase | Drug dosages | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9089 - 9099
A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed... 
MAMMALIAN THIOREDOXIN | CHEMISTRY, MEDICINAL | ACETYLCHOLINESTERASE | PEROXYNITRITE | DIPHENYL DISELENIDE | AMYLOID-BETA-PEPTIDES | ORGANOSELENIUM COMPOUNDS | HUMAN HEALTH | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | BIOLOGICAL ASSESSMENT | Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 22, pp. 7170 - 7185
Journal Article
Blood, ISSN 0006-4971, 03/2009, Volume 113, Issue 12, pp. 2637 - 2645
We previously reported interim results of a phase 1 trial in patients with chronic lymphocytic leukemia (CLL) whereby flavopiridol was administered... 
SURVIVAL | APOPTOSIS | TRANSCRIPTIONAL REPRESSION | DOWN-REGULATION | 72-HOUR CONTINUOUS-INFUSION | BREAST-CARCINOMA CELLS | DEPENDENT KINASE INHIBITOR | PROTEINS | HEMATOLOGY | CANCER | P53 | Inactivation, Metabolic | Recurrence | Uridine Diphosphate Glucuronic Acid - metabolism | Injections, Intravenous | Area Under Curve | Humans | Middle Aged | Salvage Therapy | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Flavonoids - adverse effects | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Flavonoids - therapeutic use | Piperidines - blood | Tumor Lysis Syndrome - etiology | Antineoplastic Agents - adverse effects | Aged, 80 and over | Flavonoids - administration & dosage | Adult | Female | Piperidines - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Piperidines - administration & dosage | Treatment Outcome | Vidarabine - analogs & derivatives | Flavonoids - pharmacokinetics | Protein Kinase Inhibitors - blood | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Vidarabine - pharmacology | Flavonoids - blood | Models, Biological | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Piperidines - adverse effects | Antineoplastic Agents - blood | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Infusions, Intravenous | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Cell Cycle - drug effects | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Drugs, ISSN 0012-6667, 06/2017, Volume 77, Issue 9, pp. 1029 - 1034
Oral niraparib, a highly-selective, potent poly(ADP-ribose) polymerase (PARP)-1 and PARP-2 inhibitor, is approved in the USA for the maintenance treatment of... 
THERAPY | HUMAN LUNG | MK-4827 | POLYMERASE INHIBITOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CANCER | RADIATION | United States | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Drug Approval | Indazoles - administration & dosage | Peritoneal Neoplasms - drug therapy | Piperidines - pharmacology | Adult | Female | Maintenance Chemotherapy | Ovarian Neoplasms - drug therapy | United States Food and Drug Administration | Fallopian Tube Neoplasms - drug therapy | Piperidines - administration & dosage | Double-Blind Method | Poly(ADP-ribose) Polymerase Inhibitors - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Randomized Controlled Trials as Topic | Indazoles - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Piperidines - therapeutic use | Piperidines - adverse effects | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indazoles - adverse effects | Indazoles - therapeutic use | Drug therapy | Ovarian cancer | Ovarian carcinoma | Homology | Metastasis | Neuroblastoma | Fallopian tube | ADP | Cancer therapies | DNA repair | Ribose | Platinum | Cell cycle | Drug dosages | Deoxyribonucleic acid--DNA | Recombinant | Enzymes | Poly(ADP-ribose) polymerase | Breast cancer | Maintenance | Radiation therapy | Patients | Studies | Polymerase | Chemotherapy | Mutation | Solid tumors | Prostate cancer | Prostate | Tumors | Cancer | Apoptosis | Peritoneum | Index Medicus
Journal Article