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ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
.... Whilst the interest in this underrepresented functional group in drug discovery is clearly on the rise, there remains an incomplete understanding of the medicinal‐chemistry... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | BUILDING-BLOCKS | DEPENDENT KINASE INHIBITOR | NH-SULFOXIMINES | POTENT INHIBITOR | LIGANDS | STRUCTURAL BASIS | CDK4/6 INHIBITOR | ABL PROTEIN | PHARMACOLOGY & PHARMACY | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 486, Issue 7404, pp. 518 - 522
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 485, Issue 7398, pp. 327 - 332
Journal Article
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2017, Volume 24, Issue 16, pp. 1 - 16
The old-fashioned anticancer approaches, aiming at arresting cancer cell proliferation interfering with non-specific targets (e.g. DNA), have been replaced, in... 
Tumor microenvironment | Fda-Approved drugs | Multitargeted drugs | Anticancer agents | Polypharmacology | Tyrosine kinase receptors | Oncogene addiction | CHRONIC MYELOGENOUS LEUKEMIA | CHEMISTRY, MEDICINAL | GROWTH-FACTOR-RECEPTOR | TARGETED-THERAPY | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGORAFENIB BAY 73-4506 | BCR-ABL INHIBITOR | anticancer agents | FDA-approved drugs | CELL LUNG-CANCER | tyrosine kinase receptors | oncogene addiction | polypharmacology | PHILADELPHIA-CHROMOSOME | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | tumor microenvironment | GASTROINTESTINAL STROMAL TUMORS | Neoplasms - metabolism | Niacinamide - analogs & derivatives | Anilides - therapeutic use | Pyrazoles - therapeutic use | Pyridines - chemistry | Humans | Anilides - chemistry | Imidazoles - chemistry | Imatinib Mesylate - therapeutic use | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Niacinamide - chemistry | Phenylurea Compounds - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Imidazoles - therapeutic use | Pyrroles - therapeutic use | Quinazolines - chemistry | Pyridazines - therapeutic use | Pyridines - therapeutic use | Piperidines - chemistry | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate - chemistry | Neoplasms - drug therapy | Pyridazines - chemistry | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Pyrroles - chemistry | Indoles - therapeutic use | Neoplasms - pathology | Indoles - chemistry | Tyrosine | Cell proliferation | Drugs | Medical research | Phenotypes | Clinical trials | Kinases | Proteins | Inhibitors | Modulation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0149008
Journal Article