X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (15707) 15707
Publication (7) 7
Book Chapter (6) 6
Magazine Article (5) 5
Conference Proceeding (2) 2
Government Document (2) 2
Book / eBook (1) 1
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (10935) 10935
piperidines - pharmacology (10108) 10108
male (7537) 7537
humans (6683) 6683
rats (5786) 5786
pharmacology & pharmacy (3544) 3544
female (3367) 3367
mice (3261) 3261
neurosciences (2487) 2487
dose-response relationship, drug (2314) 2314
piperidines - therapeutic use (2173) 2173
piperidines - metabolism (2078) 2078
rats, sprague-dawley (1896) 1896
piperidines - chemistry (1732) 1732
in vitro techniques (1698) 1698
pyrazoles - pharmacology (1672) 1672
piperidines - administration & dosage (1550) 1550
biochemistry & molecular biology (1546) 1546
rats, wistar (1403) 1403
brain - metabolism (1277) 1277
adult (1229) 1229
middle aged (1205) 1205
piperidines - pharmacokinetics (1199) 1199
structure-activity relationship (1183) 1183
chemistry, medicinal (1151) 1151
time factors (1051) 1051
kinetics (1015) 1015
expression (966) 966
brain (956) 956
disease models, animal (955) 955
cells, cultured (909) 909
piperidines - chemical synthesis (899) 899
aged (898) 898
analysis (831) 831
enzyme inhibitors - pharmacology (829) 829
mice, inbred c57bl (822) 822
receptor, cannabinoid, cb1 - antagonists & inhibitors (804) 804
activation (776) 776
endocrinology & metabolism (776) 776
ligands (775) 775
inhibition (768) 768
guinea pigs (762) 762
piperidines (739) 739
receptor (728) 728
piperidines - adverse effects (719) 719
rat (715) 715
brain - drug effects (708) 708
cell line, tumor (698) 698
oncology (671) 671
receptor, cannabinoid, cb1 - metabolism (662) 662
research (645) 645
receptors (635) 635
drug interactions (632) 632
rats, inbred strains (608) 608
pyridines - pharmacology (592) 592
binding sites (591) 591
endocannabinoids (590) 590
cell biology (588) 588
binding (587) 587
neurons - drug effects (585) 585
cell line (584) 584
in-vitro (583) 583
apoptosis (581) 581
psychiatry (571) 571
neurons (568) 568
molecular structure (563) 563
metabolism (554) 554
administration, oral (548) 548
calcium - metabolism (545) 545
signal transduction - drug effects (539) 539
rimonabant (535) 535
physiology (531) 531
pharmacokinetics (529) 529
rodents (518) 518
indoles - pharmacology (513) 513
cancer (508) 508
cells (505) 505
antagonist (503) 503
pharmacology (502) 502
chemistry, organic (495) 495
physiological aspects (495) 495
apoptosis - drug effects (490) 490
binding, competitive (483) 483
protein binding (482) 482
radioligand assay (465) 465
oligopeptides - pharmacology (462) 462
models, molecular (461) 461
alzheimer's disease (458) 458
rat-brain (455) 455
behavior, animal - drug effects (452) 452
dogs (451) 451
neurons - metabolism (449) 449
treatment outcome (449) 449
research article (445) 445
antineoplastic agents - pharmacology (443) 443
in-vivo (442) 442
proteins (442) 442
phosphorylation (441) 441
analysis of variance (437) 437
excitatory amino acid antagonists - pharmacology (437) 437
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (15437) 15437
Japanese (244) 244
German (101) 101
French (61) 61
Russian (58) 58
Chinese (48) 48
Italian (15) 15
Spanish (11) 11
Hungarian (8) 8
Czech (6) 6
Polish (6) 6
Dutch (4) 4
Bulgarian (3) 3
Slovak (3) 3
Finnish (2) 2
Norwegian (2) 2
Portuguese (2) 2
Ukrainian (2) 2
Welsh (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 9, pp. 1744 - 1756
.... Active uptake clearance (CLactive, (u)), bidirectional passive diffusion (P-diff), intracellular binding, and metabolism were estimated for bosentan, pitavastatin... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Drug metabolism and disposition, ISSN 0090-9556, 01/2016, Volume 44, Issue 1, pp. 28 - 39
Journal Article
Journal of Virology, ISSN 0022-538X, 12/2004, Volume 78, Issue 24, pp. 13522 - 13533
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
RNA-POLYMERASE-II | CYCLIN-DEPENDENT KINASES | ACTIVATION | VIROLOGY | TAT-ASSOCIATED KINASE | IN-VIVO | CARBOXYL-TERMINAL DOMAIN | HIGH-AFFINITY | HIV-1 TAT | PROTEINS SPECIFICALLY ASSOCIATE | ELONGATION-FACTOR | tat Gene Products, Human Immunodeficiency Virus | Gene Products, tat - genetics | HIV-1 - metabolism | Phosphorylation | Chromosomal Proteins, Non-Histone - metabolism | Humans | Transcriptional Activation | Cells, Cultured | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | HIV-1 - genetics | Spodoptera | Transcriptional Elongation Factors - metabolism | Gene Products, tat - metabolism | DNA Methylation | Animals | Piperidines - pharmacology | Trans-Activators - metabolism | Transcription, Genetic | Cyclin-Dependent Kinase 9 - metabolism | Flavonoids - pharmacology | HeLa Cells | Histones - metabolism | Trans-Activators/metabolism | Flavonoids/pharmacology | Histones/metabolism | Cyclin-Dependent Kinase 9/metabolism | Life Sciences | Chromosomal Proteins, Non-Histone/metabolism | HIV-1/genetics | Gene Products, tat/metabolism | Transcriptional Elongation Factors/metabolism | HIV-1/metabolism | Virology | Microbiology and Parasitology | Human health and pathology | Infectious diseases | Positive Transcriptional Elongation Factor B/metabolism | Cyclin-Dependent Kinase 9/antagonists & inhibitors | RNA Polymerase II/metabolism | Piperidines/pharmacology | Gene Products, tat/genetics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 7, pp. 2699 - 2704
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 2008, Volume 10, Issue 2, pp. R43 - R43
Introduction Cannabis-based medicines have a number of therapeutic indications, including anti- inflammatory and analgesic effects. The endocannabinoid... 
C-REACTIVE PROTEIN | CB2 | ACTIVATION | INHIBITION | ANGIOGENESIS | ACID AMIDE HYDROLASE | INFLAMMATION | ANANDAMIDE | RHEUMATOLOGY | MECHANICALLY EVOKED-RESPONSES | DORSAL-HORN | Mitogen-Activated Protein Kinase 3 - analysis | Cytokines - analysis | Humans | Middle Aged | Synovial Fluid - metabolism | RNA, Messenger - analysis | Male | Synovial Fluid - chemistry | Arthritis, Rheumatoid - metabolism | Arachidonic Acids - analysis | Arachidonic Acids - metabolism | Piperidines - pharmacology | Glycerides - analysis | Mass Spectrometry | Chromatography, Liquid | Female | Phosphorylation - drug effects | Amidohydrolases - analysis | Endocannabinoids | Fibroblasts - metabolism | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Knee Joint - metabolism | Cytokines - metabolism | Cells, Cultured | Osteoarthritis - metabolism | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mitogen-Activated Protein Kinase 1 - analysis | Polyunsaturated Alkamides - analysis | Synovial Membrane - metabolism | Blotting, Western | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Aged | Mitogen-Activated Protein Kinase 1 - metabolism | Synovial fluid | Cannabinoids | Dosage and administration | Research | Drug therapy | Osteoarthritis | Health aspects
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 503, Issue 7477, pp. 493 - 499
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-alpha... 
CRUCIAL ROLE | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | ADIPONECTIN LEVELS | EXPRESSION | Liver - pathology | Obesity - drug therapy | Longevity - drug effects | Adipose Tissue, White - metabolism | Receptors, Adiponectin - metabolism | Diabetes Mellitus, Type 2 - metabolism | Muscle Fibers, Skeletal - drug effects | Obesity - genetics | Glucose Intolerance - drug therapy | Liver - drug effects | Piperidines - pharmacology | Inflammation - drug therapy | Adenylate Kinase - metabolism | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Receptors, Adiponectin - agonists | Adiponectin - metabolism | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Adipose Tissue, White - pathology | Adiponectin - pharmacology | Dyslipidemias - drug therapy | Piperidines - administration & dosage | Administration, Oral | Obesity - complications | Piperidines - metabolism | Liver - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Obesity - physiopathology | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Triglycerides - metabolism | Small Molecule Libraries - chemistry | Receptors, Adiponectin - deficiency | Animals | Signal Transduction - drug effects | Piperidines - therapeutic use | Muscle Fibers, Skeletal - cytology | Mice | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue, White - drug effects | Receptors, Adiponectin - genetics | Muscles - cytology | Obesity | Insulin resistance | Muscular system | Kinases | Rodents
Journal Article
Journal Article
Journal of investigative dermatology, ISSN 0022-202X, 02/2011, Volume 131, Issue 2, pp. 468 - 479
Farnesyl transferase inhibitors (FTIs) inhibit the farnesylation of proteins, including RAS and RHEB (Ras homolog enriched in brain). RAS signals to the... 
Skin Neoplasms/metabolism | Humans | Apoptosis/drug effects | Phenylurea Compounds | Proto-Oncogene Proteins c-akt/metabolism | Signal Transduction/drug effects | Melanoma/metabolism | Transcription Factor CHOP/metabolism | Basic Helix-Loop-Helix Transcription Factors/metabolism | TOR Serine-Threonine Kinases/antagonists & inhibitors | Antineoplastic Agents/pharmacology | Farnesyltranstransferase/antagonists & inhibitors | Benzenesulfonates/pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Sorafenib | Mitogen-Activated Protein Kinase Kinases/metabolism | Cell Line, Tumor | Endoplasmic Reticulum/drug effects | Piperidines/pharmacology | Proto-Oncogene Proteins c-bcl-2/metabolism | Neoplasm Proteins/metabolism | Niacinamide/analogs & derivatives | Pyridines/pharmacology | PATHWAYS | TRIAL | CISPLATIN | GROWTH | DOWN-REGULATION | DEATH | PROLIFERATION | B-RAF | MUTATIONS | EXPRESSION | DERMATOLOGY | Niacinamide - analogs & derivatives | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Neoplasm Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Piperidines - pharmacology | Endoplasmic Reticulum - drug effects | Antineoplastic Agents - pharmacology | Farnesyltranstransferase - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Endoplasmic Reticulum - physiology | Melanoma - pathology | Skin Neoplasms - metabolism | Signal Transduction - drug effects | Pyridines - pharmacology | Transcription Factor CHOP - metabolism
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2016, Volume 92, Issue 2, pp. 479 - 492
Long-term changes of neurotransmitter release are critical for proper brain function. However, the molecular mechanisms underlying these changes are poorly... 
endocannabinoid | protein translation | CB1 receptor | presynaptic | GABA | interneuron | inhibition | superresolution microscopy | synaptic plasticity | LTD | CANNABINOID RECEPTORS | RAT HIPPOCAMPAL-NEURONS | DEPRESSION | POTENTIATION | INHIBITORY SYNAPSES | GABAERGIC SYNAPSES | AXONAL MESSENGER-RNA | TRANSLATION INITIATION | LOCAL TRANSLATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | Optical Imaging | Pyramidal Cells - metabolism | Protein Biosynthesis | Neural Inhibition | TOR Serine-Threonine Kinases - metabolism | gamma-Aminobutyric Acid - metabolism | Ribosomes - metabolism | Neuronal Plasticity - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Neurons - metabolism | Imaging, Three-Dimensional | Pyrazoles - pharmacology | Signal Transduction | Mice, Inbred C57BL | Axons - metabolism | Morpholines - pharmacology | Rats | Cell Body - metabolism | Hippocampus - cytology | Rats, Sprague-Dawley | Long-Term Synaptic Depression | Molecular Dynamics Simulation | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Patch-Clamp Techniques | Animals | Interneurons - metabolism | Image Processing, Computer-Assisted | Microscopy | Benzoxazines - pharmacology | Presynaptic Terminals - metabolism | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Medical colleges | Protein biosynthesis | Neurophysiology | Genetic translation | Resveratrol | Proteins | Short term | Scholarships & fellowships | Localization | Protein synthesis
Journal Article
Free Radical Research, ISSN 1071-5762, 04/2011, Volume 45, Issue 4, pp. 417 - 430
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 03/2012, Volume 55, Issue 3, pp. 790 - 799
.... Nevertheless, recent data indicate that inactivation of peripheral CB1R could also be directly involved in the control of lipid metabolism independently of central CB1R... 
RISK-FACTORS | COENZYME-A REDUCTASE | CONJUGATED LINOLEIC-ACID | FOOD-INTAKE | OVERWEIGHT PATIENTS | WEIGHT-LOSS | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTIONAL REGULATION | GLUCOKINASE GENE | INDUCED OBESE MICE | CB1 RECEPTORS | Protein Kinases - metabolism | Carbohydrate Metabolism - drug effects | Male | RNA, Messenger - metabolism | Piperidines - pharmacology | Mice, Mutant Strains | Dyslipidemias - prevention & control | Dyslipidemias - etiology | Disease Models, Animal | Pyrazoles - pharmacology | Fatty Liver - metabolism | Obesity - complications | Tissue Culture Techniques | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Obesity - physiopathology | Cholesterol - metabolism | Obesity - metabolism | Gene Expression Regulation - drug effects | Animals | Receptor, Cannabinoid, CB1 - genetics | Oxygen Consumption - drug effects | Lipid Metabolism - drug effects | Receptor, Cannabinoid, CB1 - drug effects | Dyslipidemias - metabolism | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Lipid Metabolism - physiology | Fatty Liver - etiology | Obesity | Dyslipidemias | Pyrazoles | Liver | Carbohydrate Metabolism | Gene Expression Regulation | Oxygen Consumption | Lipid Metabolism | Cholesterol | Fatty Liver | Life Sciences | Protein Kinases | Piperidines | Receptor, Cannabinoid, CB1 | Food and Nutrition | RNA, Messenger
Journal Article