Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (3077) 3077
life sciences & biomedicine (2903) 2903
animals (2423) 2423
humans (2143) 2143
piperidines - pharmacology (1984) 1984
male (1912) 1912
biological and medical sciences (1454) 1454
medical sciences (1321) 1321
female (1238) 1238
pharmacology & pharmacy (1090) 1090
rats (1051) 1051
piperidines - therapeutic use (1023) 1023
pharmacology. drug treatments (915) 915
mice (873) 873
piperidines - administration & dosage (688) 688
dose-response relationship, drug (679) 679
piperidines - toxicity (596) 596
piperidines - adverse effects (565) 565
middle aged (559) 559
oncology (532) 532
adult (524) 524
neurosciences & neurology (514) 514
neurosciences (482) 482
aged (479) 479
piperidines - chemistry (377) 377
rats, sprague-dawley (347) 347
toxicology (340) 340
piperidines - pharmacokinetics (329) 329
analysis (313) 313
chemistry (300) 300
disease models, animal (292) 292
rats, wistar (287) 287
biochemistry & molecular biology (285) 285
treatment outcome (285) 285
neuropharmacology (259) 259
research (255) 255
time factors (255) 255
cancer (254) 254
drug toxicity and drugs side effects treatment (252) 252
abridged index medicus (248) 248
structure-activity relationship (241) 241
physical sciences (232) 232
cell line, tumor (227) 227
drug therapy (225) 225
neurology (219) 219
piperidines (209) 209
piperidine (208) 208
fundamental and applied biological sciences. psychology (204) 204
administration, oral (199) 199
pyrazoles - pharmacology (197) 197
antineoplastic agents - therapeutic use (194) 194
toxicity (194) 194
antineoplastic agents (193) 193
cells, cultured (188) 188
chemotherapy (188) 188
antineoplastic agents - pharmacology (187) 187
apoptosis (187) 187
pharmacology/toxicology (186) 186
psychiatry (185) 185
donepezil (184) 184
drug interactions (183) 183
alzheimer's disease (182) 182
piperidines - chemical synthesis (182) 182
tumors (178) 178
apoptosis - drug effects (177) 177
double-blind method (177) 177
medicine & public health (177) 177
piperidines - metabolism (177) 177
psychology. psychoanalysis. psychiatry (175) 175
cell biology (171) 171
mice, inbred c57bl (166) 166
chemistry, medicinal (163) 163
cell survival - drug effects (161) 161
aged, 80 and over (159) 159
in vitro techniques (158) 158
health aspects (157) 157
alzheimer disease - drug therapy (156) 156
care and treatment (154) 154
rodents (154) 154
indans - therapeutic use (153) 153
research article (153) 153
neurons - drug effects (152) 152
clinical trials (150) 150
pharmacology (150) 150
molecular structure (149) 149
enzyme inhibitors - pharmacology (146) 146
dogs (143) 143
guinea pigs (143) 143
protein kinase inhibitors - therapeutic use (141) 141
proteins (138) 138
alkaloids - pharmacology (137) 137
indans - pharmacology (137) 137
clinical neurology (135) 135
clinical trials as topic (135) 135
behavior, animal - drug effects (132) 132
piperine (132) 132
psychopharmacology (130) 130
cell proliferation - drug effects (128) 128
drug synergism (127) 127
cholinesterase inhibitors - therapeutic use (124) 124
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (4108) 4108
German (38) 38
Japanese (34) 34
Russian (26) 26
French (17) 17
Italian (10) 10
Chinese (7) 7
Portuguese (5) 5
Slovak (5) 5
Bulgarian (2) 2
Danish (2) 2
Dutch (2) 2
Polish (2) 2
Spanish (2) 2
Czech (1) 1
Hungarian (1) 1
Romanian (1) 1
Swedish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity
by Elnaggar, Yosra S.R and Etman, Samar M and Abdelmonsif, Doaa A and Abdallah, Ossama Y
Journal of pharmaceutical sciences, ISSN 0022-3549, 10/2015, Volume 104, Issue 10, pp. 3544 - 3556
drug targeting | nanotechnology | chitosan | polymeric drug delivery systems | Alzheimer's disease | nasal drug delivery | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Apoptosis - drug effects | Caspase 3 - metabolism | Polyunsaturated Alkamides - therapeutic use | Male | Polyunsaturated Alkamides - toxicity | Benzodioxoles - administration & dosage | Brain Diseases - chemically induced | Drug Delivery Systems | Nanoparticles | Benzodioxoles - toxicity | Benzodioxoles - therapeutic use | Piperidines - toxicity | Alkaloids - toxicity | Piperidines - administration & dosage | Alzheimer Disease - drug therapy | Rats | Antioxidants - pharmacology | Cognition - drug effects | Administration, Intranasal | Particle Size | Polyunsaturated Alkamides - administration & dosage | Animals | Brain Diseases - pathology | Cholinesterase Inhibitors - pharmacology | Piperidines - therapeutic use | Alkaloids - administration & dosage | Alkaloids - therapeutic use | Chitosan | Drugs | Brain | Drug delivery systems | Drug therapy | Vehicles | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Attenuating Aβ1–42 -induced toxicity by a novel acetylcholinesterase inhibitor
by Mishra, N and Sasmal, D and Singh, K.K
Neuroscience, ISSN 0306-4522, 2013, Volume 250, pp. 309 - 319
Neurology | acetylcholinesterase inhibitor | Multi-target-directed ligand | amnesia | Scopolamine | Alzheimer’s disease | β-amyloid | Acetylcholinesterase inhibitor | Amnesia | Alzheimer's disease | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Immunohistochemistry | Memory - drug effects | Glutathione - metabolism | Peptide Fragments - toxicity | Male | Dose-Response Relationship, Drug | Scopolamine Hydrobromide - pharmacology | Piperidines - pharmacology | Muscarinic Antagonists - pharmacology | Exploratory Behavior - drug effects | Tissue Fixation | Pyrazoles - pharmacology | Monoamine Oxidase Inhibitors - pharmacology | Memory Disorders - psychology | Microscopy, Electron, Scanning | Oxidation-Reduction | Amyloid beta-Peptides - toxicity | Psychomotor Performance - drug effects | Maze Learning - drug effects | Anthracenes - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Mice | Acetylcholinesterase - metabolism | Indans - pharmacology | Memory Disorders - chemically induced | Monoamine Oxidase - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Rational Design and Multibiological Profiling of Novel Donepezil–Trolox Hybrids against Alzheimer’s Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties
by Cai, Pei and Fang, Si-Qiang and Yang, Xue-Lian and Wu, Jia-Jia and Liu, Qiao-Hong and Hong, Hao and Wang, Xiao-Bing and Kong, Ling-Yi
ACS chemical neuroscience, ISSN 1948-7193, 11/2017, Volume 8, Issue 11, pp. 2496 - 2511
acetylcholinesterase inhibitors | antioxidant | Alzheimer's disease | neuroprotection | β-amyloid aggregation | cognitive improvement | Biochemistry & Molecular Biology | Neurosciences | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Chemistry, Medicinal | Science & Technology | Central Nervous System Agents - therapeutic use | Cholinesterase Inhibitors - toxicity | Humans | Amyloid beta-Peptides - drug effects | Male | Structure-Activity Relationship | Indans - therapeutic use | PC12 Cells | Chromans - pharmacology | Piperidines - pharmacology | Drug Design | Copper | Drug Evaluation, Preclinical | Chelating Agents - therapeutic use | Monoamine Oxidase Inhibitors - therapeutic use | Cell Line | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - toxicity | Microglia - drug effects | Oxidants - toxicity | Alzheimer Disease - drug therapy | Rats | Neurotoxins - toxicity | Antioxidants - pharmacology | Chelating Agents - pharmacology | Protein Aggregation, Pathological - drug therapy | Mice, Inbred ICR | Antioxidants - toxicity | Monoamine Oxidase Inhibitors - toxicity | Antioxidants - therapeutic use | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Chromans - therapeutic use | Piperidines - therapeutic use | Central Nervous System Agents - pharmacology | Peptide Fragments - drug effects | Indans - toxicity | Molecular Docking Simulation | Chromans - toxicity | Cholinesterase Inhibitors - therapeutic use | Central Nervous System Agents - toxicity | Blood-Brain Barrier | Indans - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities
by Moore, Kathleen N and Mirza, Mansoor Raza and Matulonis, Ursula A
Gynecologic oncology, ISSN 0090-8258, 04/2018, Volume 149, Issue 1, pp. 214 - 220
Thrombocytopenia | Niraparib | PARP | Toxicity | Oncology | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Piperidines - administration & dosage | Humans | Piperidines - adverse effects | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Female | Clinical Trials as Topic | Poly(ADP-ribose) Polymerase Inhibitors - adverse effects | Indazoles - administration & dosage | Indazoles - adverse effects | Ovarian Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Hypertension | Chemotherapy | Anemia | Analysis | Leukemia | Immunotherapy | Drug approval | Sugars | Monosaccharides | Ovarian cancer | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Pesticide cocktails can interact synergistically on aquatic crustaceans
by Nørgaard, Katrine Banke and Cedergreen, Nina
Environmental science and pollution research international, ISSN 0944-1344, 5/2010, Volume 17, Issue 4, pp. 957 - 967
Environment, general | Pyrethroid insecticide | EBI fungicide | Dapnia magna | Environment | Synergy | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | Industrial Pollution Prevention | Mixture toxicity | Atmospheric Protection/Air Quality Control/Air Pollution | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Piperidines - toxicity | Pyrethrins - toxicity | Insecticides - chemistry | Piperidines - chemistry | Triazoles - chemistry | Imidazoles - chemistry | Fungicides, Industrial - toxicity | Water Pollutants, Chemical - chemistry | Fungicides, Industrial - chemistry | Morpholines - chemistry | Pyrethrins - chemistry | Dose-Response Relationship, Drug | Drug Synergism | Daphnia - drug effects | Animals | Triazoles - toxicity | Water Pollutants, Chemical - toxicity | Morpholines - toxicity | Imidazoles - toxicity | Toxicity Tests | Fungicides | Triazoles | Analysis | Phytosterols | Insecticides | Plant lipids | Universities and colleges | Pesticides | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen
by Luo, Zonghua and Sheng, Jianfei and Sun, Yang and Lu, Chuanjun and Yan, Jun and Liu, Anqiu and Luo, Hai-bin and Huang, Ling and Li, Xingshu
Journal of medicinal chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9089 - 9099
Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Gelidiella acerosa protects against Aβ 25-35-induced toxicity and memory impairment in Swiss Albino mice: an in vivo report
by Nisha, Syad Arif and Devi, Kasi Pandima
Pharmaceutical biology, ISSN 1388-0209, 01/2017, Volume 55, Issue 1, pp. 1423 - 1435
toxicity | AChE | BuChE | β-secretase | apoptosis | Alzheimer's disease | oxidative stress | monoamine oxidase | caspase-3 | Oxidative stress | Monoamine oxidase | Alzheimer’s disease | Toxicity | Caspase-3 | Apoptosis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Plant Sciences | Medical Laboratory Technology | Science & Technology | Memory - drug effects | Peptide Fragments | Apoptosis - drug effects | Caspase 3 - metabolism | Brain - enzymology | Memory Disorders - metabolism | Male | Protein Carbonylation - drug effects | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Alzheimer Disease - prevention & control | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides | Lipid Peroxidation - drug effects | Escape Reaction - drug effects | Behavior, Animal - drug effects | Alzheimer Disease - chemically induced | Alzheimer Disease - psychology | Disease Models, Animal | Memory Disorders - psychology | Brain - physiopathology | Nootropic Agents - isolation & purification | bcl-2-Associated X Protein - metabolism | Neuroprotective Agents - toxicity | Maze Learning - drug effects | GPI-Linked Proteins - metabolism | Brain - drug effects | Nootropic Agents - toxicity | Amyloid Precursor Protein Secretases - metabolism | Memory Disorders - prevention & control | Animals | Neuroprotective Agents - isolation & purification | Alzheimer Disease - metabolism | Brain - pathology | Mice | Oxidative Stress - drug effects | Seaweed - chemistry | Acetylcholinesterase - metabolism | Nootropic Agents - pharmacology | Indans - pharmacology | Memory Disorders - chemically induced | Monoamine Oxidase - metabolism | Neuroprotection | Bax protein | Peptides | Neurodegenerative diseases | Albinism | Hydrocarbons | Seaweeds | Amine oxidase (flavin-containing) | Western blotting | Plant extracts | Proteins | Antioxidants | Benzene | β-Amyloid | Oxidation | Secretase | Index Medicus | alzheimer’s disease | ache | buche
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Assessment of bromide-based ionic liquid toxicity toward aquatic organisms and QSAR analysis
by Wang, Chao and Wei, Zhongbo and Wang, Liansheng and Sun, Ping and Wang, Zunyao
Ecotoxicology and environmental safety, ISSN 0147-6513, 05/2015, Volume 115, pp. 112 - 118
V. fischeri | QSAR | Bromide-based ionic liquids | D. magna | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Piperidines - toxicity | Cations - toxicity | Piperidines - chemistry | Cations - chemistry | Imidazoles - chemistry | Ionic Liquids - chemistry | Hydrocarbons, Brominated - toxicity | Pyrrolidines - chemistry | Daphnia - drug effects | Animals | Pyrrolidines - toxicity | Aliivibrio fischeri - drug effects | Ionic Liquids - toxicity | Hydrocarbons, Brominated - chemistry | Imidazoles - toxicity | Pyridinium Compounds - chemistry | Pyridinium Compounds - toxicity | Quantitative Structure-Activity Relationship | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text New therapeutic approaches and novel alternatives for organophosphate toxicity
by Katz, Francine S and Pecic, Stevan and Schneider, Laura and Zhu, Zhengxiang and Hastings-Robinson, Ashley and Luzac, Michal and Macdonald, Joanne and Landry, Donald W and Stojanovic, Milan N
Toxicology letters, ISSN 0378-4274, 07/2018, Volume 291, pp. 1 - 10
Acetylcholinesterase (AChE) | Butyrylcholinesterase (BuChE) | Non-oxime reactivators | Organophosphate compounds (OPCs) | Structure activity relationship (SAR) study | Life Sciences & Biomedicine | Toxicology | Science & Technology | Indans - chemistry | Piperidines - chemistry | Cholinesterase Inhibitors - toxicity | Humans | Cholinesterase Reactivators - therapeutic use | Oximes - therapeutic use | Organophosphate Poisoning - drug therapy | Imidazoles - pharmacology | Structure-Activity Relationship | Piperazines - pharmacology | Hydrolysis | High-Throughput Screening Assays | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Donepezil | Pyridines - pharmacology | Kinetics | Acetylcholinesterase - metabolism | Indans - pharmacology | Enzymes | Nerve gas | Poisoning | War use | Health aspects | Gases, Asphyxiating and poisonous | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin
by Wang, Jin and Wang, Zhi-Min and Li, Xue-Mei and Li, Fan and Wu, Jia-Jia and Kong, Ling-Yi and Wang, Xiao-Bing
Bioorganic & medicinal chemistry, ISSN 0968-0896, 09/2016, Volume 24, Issue 18, pp. 4324 - 4338
Melatonin | Biometal chelators | Alzheimer’s disease | Donepezil | Antioxidant activity | Cholinesterase | Alzheimer's disease | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights