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Journal of the American Society for Mass Spectrometry, ISSN 1044-0305, 2013, Volume 24, Issue 8, pp. 1228 - 1241
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 7, pp. 2586 - 2591
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2012, Volume 57, pp. 344 - 361
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7519, pp. 517 - 522
The ribosome is a molecular machine responsible for protein synthesis and a major target for small-molecule inhibitors. Compared to the wealth of structural... 
CRYPTOPLEURINE RESISTANCE | AMARYLLIDACEAE ALKALOIDS | SACCHAROMYCES-CEREVISIAE MUTANTS | NUCLEOTIDE RESOLUTION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PEPTIDE-BOND FORMATION | TRANSLATION INITIATION | TRANSFER-RNA | PROTEIN-SYNTHESIS | AMINOGLYCOSIDE ANTIBIOTICS | Eukaryotic Cells - chemistry | Protein Synthesis Inhibitors - chemistry | Molecular Weight | Species Specificity | Ribosomes - metabolism | Substrate Specificity | Crystallography, X-Ray | Molecular Targeted Therapy | RNA, Messenger - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Base Sequence | Macrolides - pharmacology | RNA, Transfer - genetics | Protein Synthesis Inhibitors - pharmacology | Binding Sites - drug effects | Eukaryotic Cells - enzymology | Peptidyl Transferases - metabolism | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | Peptidyl Transferases - chemistry | RNA, Messenger - genetics | Ribosomes - chemistry | Models, Molecular | Drug Resistance - drug effects | Peptide Chain Elongation, Translational - drug effects | Piperidones - pharmacology | Cycloheximide - pharmacology | Saccharomyces cerevisiae - chemistry | Eukaryotic Cells - drug effects | Ribosomes - drug effects | Ribosome Subunits, Large, Eukaryotic - drug effects | Kinetics | Eukaryotes | Analysis | Ribosomes | Ribonucleoproteins | Research | Health aspects | Transfer RNA | Proteins | Yeast | Peptides | Antibiotics | Protein synthesis | Bacteria | Drug resistance | Binding sites | Index Medicus
Journal Article
Biochemistry, ISSN 0006-2960, 12/2014, Volume 53, Issue 49, pp. 7854 - 7865
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and... 
STREPTOMYCES-PLATENSIS | GENE-CLUSTER | CYTOCHROME-P450 ENZYMES | CELL-MIGRATION INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | TUMOR-METASTASIS | ANTIFUNGAL ANTIBIOTICS | TRANSFORMED NIH/3T3 CELLS | PHOSPHOPANTETHEINYL TRANSFERASE | POTENT INHIBITORS | Multigene Family | Macrolides - isolation & purification | Antibiotics, Antineoplastic - pharmacology | Stereoisomerism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Polyketides - chemistry | Antibiotics, Antineoplastic - isolation & purification | Structure-Activity Relationship | Polyketides - metabolism | Polyketide Synthases - metabolism | Antibiotics, Antineoplastic - chemistry | Macrolides - chemistry | Base Sequence | Drug Design | Protein Engineering | Macrolides - pharmacology | Molecular Structure | Piperidones - isolation & purification | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Cell Survival - drug effects | Polyketide Synthases - antagonists & inhibitors | Streptomyces - genetics | Bacterial Proteins - genetics | Gene Silencing | Antibiotics, Antineoplastic - biosynthesis | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Macrolides - metabolism | Piperidones - pharmacology | Neoplasms - drug therapy | Piperidones - chemistry | Polyketide Synthases - chemistry | Bioreactors | Models, Biological | Mutant Proteins - chemistry | Polyketides - isolation & purification | Cell Line, Tumor | Bacterial Proteins - metabolism | Streptomyces - enzymology | Piperidones - metabolism | Polyketide Synthases - genetics | Polyketides - pharmacology | Streptomyces | Physiological aspects | Biosynthesis | Analysis | Index Medicus
Journal Article