X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
piperidones - pharmacology (516) 516
animals (414) 414
humans (351) 351
index medicus (313) 313
mice (210) 210
piperidones - chemistry (203) 203
male (196) 196
pharmacology & pharmacy (180) 180
chemistry, medicinal (149) 149
rats (148) 148
piperidones - chemical synthesis (143) 143
cell line, tumor (123) 123
female (122) 122
structure-activity relationship (113) 113
antineoplastic agents - pharmacology (111) 111
apoptosis (109) 109
dose-response relationship, drug (90) 90
biochemistry & molecular biology (83) 83
molecular structure (81) 81
apoptosis - drug effects (77) 77
piperidones (76) 76
cancer (71) 71
spiro compounds - pharmacology (71) 71
cell proliferation - drug effects (60) 60
piperidones - therapeutic use (60) 60
oncology (59) 59
antineoplastic agents - chemistry (57) 57
chemistry, organic (55) 55
cell survival - drug effects (53) 53
article (52) 52
inhibition (51) 51
benzylidene compounds - pharmacology (50) 50
cells (48) 48
antineoplastic agents - chemical synthesis (47) 47
expression (47) 47
analysis (46) 46
piperidines - pharmacology (46) 46
piperidones - administration & dosage (46) 46
piperidones - metabolism (43) 43
stereoisomerism (43) 43
chemistry, multidisciplinary (42) 42
pyridines - pharmacology (42) 42
cell line (41) 41
cytotoxicity (41) 41
piperazines - pharmacology (41) 41
time factors (41) 41
research (40) 40
drug screening assays, antitumor (39) 39
magnetic resonance spectroscopy (38) 38
activation (37) 37
in vitro techniques (37) 37
mice, nude (36) 36
piperidones - isolation & purification (36) 36
rats, sprague-dawley (36) 36
xenograft model antitumor assays (36) 36
drug design (35) 35
curcumin (34) 34
derivatives (34) 34
serotonin antagonists - pharmacology (34) 34
immunology (33) 33
analogs (32) 32
cell biology (32) 32
signal transduction - drug effects (32) 32
anti-bacterial agents - pharmacology (31) 31
cell movement - drug effects (31) 31
disease models, animal (31) 31
models, molecular (31) 31
neurosciences (31) 31
piperidones - pharmacokinetics (31) 31
biotechnology & applied microbiology (30) 30
mice, inbred balb c (30) 30
adult (29) 29
inhibitors (28) 28
pyrroles - pharmacology (28) 28
rats, wistar (28) 28
proteins (27) 27
research article (27) 27
serotonin (27) 27
curcumin - analogs & derivatives (26) 26
phosphorylation (26) 26
piperidone (26) 26
reactive oxygen species - metabolism (26) 26
tumor cells, cultured (26) 26
chemistry (25) 25
curcumin - pharmacology (25) 25
inhibitory concentration 50 (25) 25
macrolides - pharmacology (25) 25
molecular conformation (25) 25
cancer-cells (24) 24
cells, cultured (24) 24
discovery (24) 24
in-vivo (24) 24
mice, inbred c57bl (24) 24
serotonin receptor agonists - pharmacology (24) 24
administration, oral (23) 23
chemotherapy (23) 23
guinea pigs (23) 23
metastasis (23) 23
cell cycle - drug effects (22) 22
ef24 (22) 22
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (702) 702
German (28) 28
Japanese (13) 13
Chinese (7) 7
French (5) 5
Italian (4) 4
Bulgarian (3) 3
Polish (3) 3
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


European Neuropsychopharmacology, ISSN 0924-977X, 11/2018, Volume 28, Issue 11, pp. 1247 - 1259
Endocannabinoids and their receptors not only contribute to the control of natural processes of appetite regulation and energy balance but also have an... 
Appetite regulation | Gamma-aminobutyric acid | Cannabinoids | CB1 | Serotonin | Paraventricular hypothalamic nucleus | POMC NEURONS | ENDOGENOUS CANNABINOIDS | HYPERPHAGIA | PSYCHIATRY | ENDOCANNABINOID SYSTEM | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROPEPTIDE-Y | BODY-WEIGHT | OBESITY | CANNABINOID RECEPTOR | INHIBITION | PHARMACOLOGY & PHARMACY | AUTORADIOGRAPHY | Piperazines - administration & dosage | Cyproheptadine - administration & dosage | Serotonin - administration & dosage | Serotonin Antagonists - administration & dosage | Receptors, Serotonin, 5-HT1 - physiology | gamma-Aminobutyric Acid - metabolism | Amphetamines - pharmacology | Spiro Compounds - administration & dosage | Male | Amphetamines - administration & dosage | Serotonin - pharmacology | Receptor, Cannabinoid, CB1 - physiology | Eating - physiology | Serotonin Receptor Agonists - pharmacology | Cyproheptadine - pharmacology | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Tritium - metabolism | Piperidines - pharmacology | Pyrroles - administration & dosage | Pyrazoles - pharmacology | Piperidines - administration & dosage | Pyridines - administration & dosage | Microinjections | Rats | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Piperidones - pharmacology | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Arachidonic Acids - pharmacology | Piperidones - administration & dosage | Pyrazoles - administration & dosage | Pyrroles - pharmacology | 8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage | Animals | Serotonin - metabolism | Paraventricular Hypothalamic Nucleus - metabolism | Pyridines - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Serotonin Receptor Agonists - administration & dosage | Spiro Compounds - pharmacology | GABA | Control systems | RNA | Neurophysiology
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2005, Volume 510, Issue 1-2, pp. 49 - 57
Vilazodone has been reported to be an inhibitor of 5-hydoxytryptamine (5-HT) reuptake and a partial agonist at 5-HT receptors. Using [ S]GTPγS binding in rat... 
Paroxetine | receptor | Microdialysis | Serotonin (5-hydroxytryptamine, 5-HT) | Frontal cortex | 5-HT | N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(pyridinyl) cyclohexanecarboxamide) (WAY-100635 | IN-VIVO MICRODIALYSIS | DIALYSATE LEVELS | serotonin (5-hydroxytryptamine, 5-HT) | N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(pyridinyl)cyclohexanecarboxamide) (WAY-100635 | FRONTAL-CORTEX | SEROTONIN REUPTAKE | EXTRACELLULAR 5-HT | 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) | frontal cortex | FREELY-MOVING RATS | paroxetine | POSITRON-EMISSION-TOMOGRAPHY | microdialysis | FLUOXETINE-INDUCED INCREASES | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | DORSAL RAPHE NUCLEUS | 5-HT1A receptor | Serotonin 5-HT1 Receptor Agonists | Frontal Lobe - metabolism | Extracellular Space - drug effects | Benzofurans - pharmacology | Male | Tritium | Serotonin - pharmacology | Serotonin Receptor Agonists - pharmacology | Benzylamines - metabolism | Dose-Response Relationship, Drug | Time Factors | Vilazodone Hydrochloride | Indoles - pharmacology | Cell Membrane - metabolism | Cell Membrane - drug effects | Dopamine - metabolism | Rats | Sulfur Radioisotopes | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Frontal Lobe - chemistry | Piperidones - pharmacology | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Binding, Competitive - drug effects | Hippocampus - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Norepinephrine - metabolism | Frontal Lobe - drug effects | Serotonin - metabolism | Extracellular Space - chemistry | Pyridines - pharmacology | Paroxetine - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Spiro Compounds - pharmacology
Journal Article
Journal Article
Phytotherapy Research, ISSN 0951-418X, 12/2018, Volume 32, Issue 12, pp. 2520 - 2530
The present study evaluated the possible antiallodynic effect induced by [6]‐gingerol in rats with L5–L6 spinal nerve ligation (SNL). Moreover, we determined... 
gingerol | allodynia | neuropathic pain | nitric oxide | potassium channels | serotoninergic receptors | CHEMISTRY, MEDICINAL | MORPHINE | TACTILE ALLODYNIA | RECEPTOR | MODEL | GABAPENTIN | PAIN | SPINAL NERVE LIGATION | GINGER | PHARMACOLOGY & PHARMACY | PUNGENT CONSTITUENTS | EXPRESSION | Analgesics - pharmacology | Rats, Wistar | Neuralgia - metabolism | Male | Neuralgia - pathology | Hyperalgesia - pathology | Fatty Alcohols - pharmacology | Biphenyl Compounds - pharmacology | Adenosine Triphosphate - metabolism | Catechols - pharmacology | Female | Serotonergic Neurons - physiology | Hyperalgesia - metabolism | Serotonergic Neurons - drug effects | Rats | Piperidones - pharmacology | Piperazines - pharmacology | Neuralgia - drug therapy | Receptors, Serotonin - metabolism | Animals | Cyclic GMP - metabolism | Hyperalgesia - drug therapy | Guanosine Monophosphate - metabolism | Pyridines - pharmacology | Nitric Oxide - metabolism | Spiro Compounds - pharmacology | Muscle proteins | Immunoglobulin A | Cyclic guanylic acid | Nitric oxide | Adenosine triphosphate | Pain perception | AMP | Opioid receptors | Serotonin | Guanosine | Activation | Tactile stimuli | Potassium channels | Guanylate cyclase | Receptors | Inhibitors | Naloxone | Arginine | Gingerol | Filaments | Cyclic GMP | Glibenclamide | ATP | Methiothepin | Tactile
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 13, pp. 5242 - 5255
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2651 - 2673
Journal Article
CNS Drugs, ISSN 1172-7047, 3/2014, Volume 28, Issue 3, pp. 273 - 278
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2011, Volume 17, Issue 12, pp. 1636 - 1640
Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BORTEZOMIB | 26S PROTEASOME | CELL-DEATH | P53 | CELL BIOLOGY | UBIQUITINATION | ROLES | DEGRADATION | EXPRESSION | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Ubiquitin - metabolism | Breast Neoplasms | Protease Inhibitors - pharmacology | Multiple Myeloma - drug therapy | Ubiquitination | Proteasome Endopeptidase Complex - drug effects | Microarray Analysis | Ubiquitin Thiolesterase - metabolism | Female | Antineoplastic Agents - pharmacology | Ubiquitin Thiolesterase - antagonists & inhibitors | Disease Models, Animal | Bortezomib | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Carboxypeptidases - antagonists & inhibitors | Mice, SCID | Piperidones - pharmacology | Ubiquitin Thiolesterase - genetics | bcl-2-Associated X Protein - antagonists & inhibitors | Gene Expression Regulation, Enzymologic | Animals | Cell Line, Tumor | Carboxypeptidases - metabolism | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Apoptosis | Boronic Acids - pharmacology | Physiological aspects | Care and treatment | Research | Ubiquitin-proteasome system | Cancer | Proteins | Inhibitor drugs | Molecular biology | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Journal Article