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1. Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug
by Bourgault, S and Chatenet, D and Wurtz, O and Doan, N.D and Leprince, J and Vaudry, H and Fournier, A and Vaudry, D
Current pharmaceutical design, ISSN 1381-6128, 04/2011, Volume 17, Issue 10, pp. 1002 - 1024
G protein-coupled receptor | Neuroprotection | Stroke | Bioactive conformation | Traumatic brain injury | PACAP | Peptide drug design | VIP | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neuroprotective Agents - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Brain Injuries - drug therapy | Humans | Astrocytes - pathology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Drug Discovery - methods | Nerve Growth Factors - metabolism | Brain Ischemia - immunology | Brain Injuries - immunology | Neuroprotective Agents - adverse effects | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Cytokines - immunology | Astrocytes - drug effects | Cell Survival - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - adverse effects | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - therapeutic use | Brain Ischemia - drug therapy | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Ischemia - pathology | Brain Injuries - pathology | Astrocytes - metabolism | Drugs | Cytokines | Astrocytes | Macromolecules | Inflammation | Drug development | Neuroprotective agents | Blood | Microglia | Pituitary adenylate cyclase-activating polypeptide | Chemical modification | Neurotransmitters | Side effects | Molecular modelling | Ischemia | Pharmacokinetics | Apoptosis
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2. Full Text Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR Review 1
by Harmar, Anthony J and Fahrenkrug, Jan and Gozes, Illana and Laburthe, Marc and May, Victor and Pisegna, Joseph R and Vaudry, David and Vaudry, Hubert and Waschek, James A and Said, Sami I
British journal of pharmacology, ISSN 0007-1188, 05/2012, Volume 166, Issue 1, pp. 4 - 17
agonists and antagonists | VPAC1 receptor | PACAP | signal transduction | VPAC2 receptor | accessory proteins | class B GPCR | VIP | splice variant | PAC1 receptor | PAC | receptor | VPAC | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Central Nervous System - physiology | Receptors, Vasoactive Intestinal Peptide - metabolism | Vasoactive Intestinal Peptide - metabolism | Immunity - physiology | Animals | Humans | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Central Nervous System - physiopathology | Inflammation - physiopathology | Pituitary gland | Growth hormones | Pharmacology | Polypeptides | Index Medicus | Reviews | Themed Section
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3. Full Text Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity
by Han, Pengcheng and Tang, Zhiwei and Yin, Junxiang and Maalouf, Marwan and Beach, Thomas G and Reiman, Eric M and Shi, Jiong
Neurobiology of aging, ISSN 0197-4580, 2014, Volume 35, Issue 9, pp. 2064 - 2071
Neurology | Internal Medicine | Mitochondrial respiration | PACAP | Alzheimer's disease | SIRT3 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Alzheimer Disease - etiology | Neurons - pathology | Neuroprotective Agents | Sirtuin 3 - metabolism | Humans | Molecular Targeted Therapy | Brain - metabolism | Mitochondria - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Amyloid beta-Peptides - metabolism | Neurons - metabolism | Brain - cytology | Gene Expression | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Amyloid beta-Peptides - toxicity | Cells, Cultured | Alzheimer Disease - drug therapy | Mice, Transgenic | Signal Transduction - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Animals | Nerve Growth Factors | Pituitary Adenylate Cyclase-Activating Polypeptide - therapeutic use | Signal Transduction - physiology | Alzheimer Disease - genetics | Mitochondria - physiology | Sirtuin 3 - physiology | Index Medicus
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4. Full Text Pituitary Adenylate Cyclase–Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male Sprague-Dawley Rats
by Donahue, Rachel J and Venkataraman, Archana and Carroll, F. Ivy and Meloni, Edward G and Carlezon, William A
Biological psychiatry (1969), ISSN 0006-3223, 2015, Volume 80, Issue 12, pp. 955 - 964
Psychiatry | Model | Anhedonia | Rat | Social interaction | Pituitary adenylate cyclase–activating peptide (PACAP) | Attention | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Rats | Male | Rats, Sprague-Dawley | Motivation - drug effects | Animals | Anhedonia - drug effects | Social Behavior | Neurotransmitter Agents - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Attention - drug effects | Behavior, Animal - drug effects | Neurotransmitter Agents - administration & dosage | Pituitary Adenylate Cyclase-Activating Polypeptide - administration & dosage | Disease Models, Animal | Social aspects | Anxiety | Index Medicus | social interaction | attention | model | pituitary adenylate cyclase-activating peptide OR PACAP | rat | anhedonia
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5. Full Text Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
by David Vaudry and Anthony Falluel-Morel and Steve Bourgault and Magali Basille and Delphine Burel and Olivier Wurtz and Alain Fournier and Billy K. C. Chow and Hitoshi Hashimoto and Ludovic Galas and Hubert Vaudry
Pharmacological reviews, ISSN 0031-6997, 09/2009, Volume 61, Issue 3, pp. 283 - 357
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Animals | Humans | Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Index Medicus | Life Sciences | Neurons and Cognition
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