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1. Full Text Diagnostic Accuracy of Placental Growth Factor in Women With Suspected Preeclampsia: A Prospective Multicenter Study
by Chappell, Lucy C and Duckworth, Suzy and Seed, Paul T and Griffin, Melanie and Myers, Jenny and Mackillop, Lucy and Simpson, Nigel and Waugh, Jason and Anumba, Dilly and Kenny, Louise C and Redman, Christopher W.G and Shennan, Andrew H
Circulation, ISSN 0009-7322, 11/2013, Volume 128, Issue 19, pp. 2121 - 2131
BACKGROUND—Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of... 
diagnosis | angiogenesis inducers | hypertension | pregnancy | REVIEWS | TESTS | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK | ANGIOGENIC FACTORS | PREDICTION | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | OUTCOMES | Pre-Eclampsia - epidemiology | Predictive Value of Tests | Reproducibility of Results | Prospective Studies | Follow-Up Studies | Humans | Risk Factors | Biomarkers - blood | Chemistry, Clinical - standards | Pregnancy | Pregnancy Proteins - blood | Pre-Eclampsia - blood | Sensitivity and Specificity | Placenta Growth Factor | Adult | Female | Pre-Eclampsia - diagnosis | Physiological aspects | Research | Diagnosis | Growth factors | Preeclampsia | Index Medicus | Abridged Index Medicus
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2. Full Text A Novel Human-Specific Soluble Vascular Endothelial Growth Factor Receptor 1: Cell Type-Specific Splicing and Implications to Vascular Endothelial Growth Factor Homeostasis and Preeclampsia
by Sela, Shay and Itin, Ahuva and Natanson-Yaron, Shira and Greenfield, Caryn and Goldman-Wohl, Debra and Yagel, Simcha and Keshet, Eli
Circulation Research, ISSN 0009-7330, 06/2008, Volume 102, Issue 12, pp. 1566 - 1574
A human-specific splicing variant of vascular endothelial growth factor (VEGF) receptor 1 (Flt1) was discovered, producing a soluble receptor (designated... 
Vascular smooth muscle cell | Splicing | Soluble VEGF receptor | Preeclampsia | VEGF | CARDIAC & CARDIOVASCULAR SYSTEMS | PLACENTA | soluble VEGF receptor | preeclampsia | REACTIVE OXYGEN | GENE-EXPRESSION | MALARIA | PERIPHERAL VASCULAR DISEASE | splicing | vascular smooth muscle cell | HYPERTENSION | HEMATOLOGY | Muscle, Smooth, Vascular - metabolism | Humans | Recombinant Fusion Proteins - physiology | Vascular Endothelial Growth Factor Receptor-1 - physiology | Homeostasis | Molecular Sequence Data | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Protein Isoforms - blood | RNA Splicing - physiology | Protein Processing, Post-Translational - drug effects | Protein Isoforms - chemistry | Female | Phosphorylation - drug effects | Myocytes, Smooth Muscle - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Amino Acid Sequence | Trophoblasts - metabolism | Endothelial Cells - metabolism | Cornea - chemistry | Muscle, Smooth, Vascular - cytology | Organ Specificity | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Protein Isoforms - physiology | Placenta - metabolism | Pregnancy | Neovascularization, Physiologic - physiology | Placenta - blood supply | Animals | Pre-Eclampsia - blood | Signal Transduction - physiology | Cells, Cultured - metabolism | Vascular Endothelial Growth Factor Receptor-1 - blood | Sus scrofa | Protein Isoforms - genetics | Index Medicus
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3. Full Text Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension
by Spradley, Frank T and Tan, Adelene Y and Joo, Woo S and Daniels, Garrett and Kussie, Paul and Karumanchi, S Ananth and Granger, Joey P
Hypertension, ISSN 0194-911X, 04/2016, Volume 67, Issue 4, pp. 740 - 747
Preeclampsia is a pregnancy-specific disorder of new-onset hypertension. Unfortunately, the most effective treatment is early delivery of the fetus and... 
blood pressure | preeclampsia | rat | RUPP | pregnancy | CHRONIC REDUCTIONS | SEVERE PREECLAMPSIA | RENAL-FUNCTION | RISK | CIRCULATING ANGIOGENIC FACTORS | WOMEN | ENDOTHELIUM | CARDIOVASCULAR-DISEASE | PREGNANT RATS | PERIPHERAL VASCULAR DISEASE | UTERINE PERFUSION-PRESSURE | Pregnancy, Animal | Humans | Oxidative Stress - physiology | Reference Values | Pregnancy Proteins - metabolism | Hypertension, Pregnancy-Induced - drug therapy | Pregnancy Proteins - pharmacology | Ischemia - complications | Female | Placental Circulation - drug effects | Enzyme-Linked Immunosorbent Assay | Risk Assessment | Rats | Placental Insufficiency | Pre-Eclampsia - etiology | Rats, Sprague-Dawley | Placenta - metabolism | Pregnancy | Placenta - blood supply | Animals | Pre-Eclampsia - drug therapy | Analysis of Variance | Ischemia - drug therapy | Placenta Growth Factor | Hypertension, Pregnancy-Induced - etiology | Placental Circulation - physiology | Index Medicus
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4. Full Text Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma
by Snuderl, Matija and Batista, Ana and Kirkpatrick, Nathaniel D and Ruiz de Almodovar, Carmen and Riedemann, Lars and Walsh, Elisa C and Anolik, Rachel and Huang, Yuhui and Martin, John D and Kamoun, Walid and Knevels, Ellen and Schmidt, Thomas and Farrar, Christian T and Vakoc, Benjamin J and Mohan, Nishant and Chung, Euiheon and Roberge, Sylvie and Peterson, Teresa and Bais, Carlos and Zhelyazkova, Boryana H and Yip, Stephen and Hasselblatt, Martin and Rossig, Claudia and Niemeyer, Elisabeth and Ferrara, Napoleone and Klagsbrun, Michael and Duda, Dan G and Fukumura, Dai and Xu, Lei and Carmeliet, Peter and Jain, Rakesh K
Cell, ISSN 0092-8674, 02/2013, Volume 152, Issue 5, pp. 1065 - 1076
Medulloblastoma is the most common pediatric malignant brain tumor. Although current therapies improve survival, these regimens are highly toxic and are... 
DOSE-ESCALATION | METASTASIS | ANGIOGENESIS | TB-403 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | TUMOR-GROWTH | PHASE-I | CANCER | CELL-LINE | PLGF | CELL BIOLOGY | Neoplasm Transplantation | Paracrine Communication | Signal Transduction | Neuropilin-1 - metabolism | Cerebellum - metabolism | Humans | Cells, Cultured | Transplantation, Heterologous | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Medulloblastoma - metabolism | Pregnancy Proteins - metabolism | Mice, Knockout | Animals | Medulloblastoma - pathology | Placenta Growth Factor | Mice | Cerebellar Neoplasms - pathology | Cerebellar Neoplasms - metabolism | Medical colleges | Endothelial growth factors | Nuclear radiation | Medulloblastoma | Brain tumors | Index Medicus
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5. Full Text Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
by Relf, Michele and Lejeune, Susan and Scott, Prudence A. E and Fox, Stephen and Smith, Kenneth and Leek, Russell and Moghaddam, Amir and Whitehouse, Ruth and Bicknell, Roy and Harris, Adrian L
Cancer Research, ISSN 0008-5472, 1997, Volume 57, Issue 5, pp. 963 - 969
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis irt vivo are not well defined, Multiple angiogenic... 
ANTIBODIES | SURAMIN | INHIBITION | PERMEABILITY FACTOR | ONCOLOGY | PROLIFERATION | IDENTIFICATION | FACTOR RECEPTOR | CARCINOMA | BINDING | THYMIDINE PHOSPHORYLASE | Carrier Proteins - physiology | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Humans | Lymphokines - physiology | Middle Aged | RNA, Messenger - genetics | Neovascularization, Pathologic | Thymidine Phosphorylase - physiology | Transforming Growth Factor beta - physiology | Breast Neoplasms - blood supply | Cytokines - physiology | Breast Neoplasms - metabolism | Disease-Free Survival | Gene Expression Regulation, Developmental | Placenta Growth Factor | Pregnancy Proteins - physiology | Fibroblast Growth Factor 1 - physiology | Fibroblast Growth Factor 2 - physiology | Endothelial Growth Factors - physiology | Index Medicus
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6. Full Text Reduced expression of the epidermal growth factor signaling system in preeclampsia
by Armant, D.R and Fritz, R and Kilburn, B.A and Kim, Y.M and Nien, J.K and Maihle, N.J and Romero, R and Leach, R.E
Placenta, ISSN 0143-4004, 2014, Volume 36, Issue 3, pp. 270 - 278
Abstract Introduction The epidermal growth factor (EGF) signaling system regulates trophoblast differentiation, and its disruption could contribute to... 
Internal Medicine | Obstetrics and Gynecology | Epidermal growth factors | Preeclampsia | Placenta | CELLS | OXIDATIVE STRESS | CYTOTROPHOBLASTS | EGF | HUMAN-PLACENTA | TROPHOBLAST APOPTOSIS | DEVELOPMENTAL BIOLOGY | FACTOR RECEPTOR | OBSTETRICS & GYNECOLOGY | RETARDATION | REPRODUCTIVE BIOLOGY | EARLY-PREGNANCY | ENDOMETRIAL | Receptor, Epidermal Growth Factor - genetics | Humans | Trophoblasts - pathology | Young Adult | Receptor, Epidermal Growth Factor - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Transforming Growth Factor alpha - blood | Epidermal Growth Factor - chemistry | Heparin-binding EGF-like Growth Factor - blood | Peptide Fragments - blood | Adult | Female | Pre-Eclampsia - metabolism | Transforming Growth Factor alpha - metabolism | Peptide Fragments - metabolism | Trophoblasts - metabolism | Placentation | Down-Regulation | Epidermal Growth Factor - metabolism | Chorionic Villi - metabolism | Pre-Eclampsia - pathology | Epidermal Growth Factor - blood | Receptor, Epidermal Growth Factor - chemistry | Heparin-binding EGF-like Growth Factor - metabolism | Placenta - metabolism | Pregnancy | Chorionic Villi - pathology | Pre-Eclampsia - blood | Placenta - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Line, Transformed | Apoptosis | Cohort Studies | Protein Isoforms - genetics | Physiological aspects | Medical colleges | Epidermal growth factor | Cells | Index Medicus | placenta | epidermal growth factors | preeclampsia
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7. Full Text Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer
by Alpini, Gianfranco and Glaser, Shannon S and Zhang, Jing-Ping and Francis, Heather and Han, Yuyan and Gong, Jiao and Stokes, Allison and Francis, Taylor and Hughart, Nathan and Hubble, Levi and Zhuang, Shi-Mei and Meng, Fanyin
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 6, pp. 1339 - 1345
Background & Aims microRNAs (miRNAs) are a class of small noncoding RNAs that can regulate gene expression by translation repression or mRNA degradation. Our... 
Gastroenterology and Hepatology | Liver cancer | Angiogenesis | microRNA | Methylation | PIGF | Invasion | CELLS | APOPTOSIS | HYPERMETHYLATION | SIGNATURES | FACTOR RECEPTOR-1 | PROLIFERATION | LIVER-CANCER | EPIGENETICS | BAK1 EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | CARCINOMA | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Pregnancy Proteins - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Matrix Metalloproteinase 9 - genetics | Base Sequence | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - blood supply | Liver Neoplasms - pathology | Liver Neoplasms - genetics | Endothelial Cells - metabolism | Neoplasm Invasiveness | RNA, Messenger - genetics | Matrix Metalloproteinase 2 - genetics | Liver Neoplasms - blood supply | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Placenta Growth Factor | MicroRNAs - genetics | Carcinoma, Hepatocellular - metabolism | Cell Movement | MicroRNA | Messenger RNA | Biological control | Oncology, Experimental | Genes | Genetically modified organisms | Research | Pests | Gene expression | Cancer | Index Medicus | liver cancer | invasion | angiogenesis | methylation
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8. Full Text Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies
by Taylor, Robert N and Taylor, Rennae S and Grimwood, Jane and McMaster, Michael T and Fisher, Susan J and North, Robyn A
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 01/2003, Volume 188, Issue 1, pp. 177 - 182
Complicated pregnancies demonstrate abnormal decidual and placental villous vasculature. We examined maternal concentrations of vascular endothelial growth... 
small for gestational age | Preeclampsia | angiogenesis | Angiogenesis | Small for gestational age | FACTOR VEGF | RECEPTOR | preeclampsia | RESTRICTION | OBSTETRICS & GYNECOLOGY | OXYGEN | FORMS | FACTOR PIGF | INFANTS | HYPERTENSION | EXPRESSION | Vascular Endothelial Growth Factor A | Cross-Sectional Studies | Enzyme-Linked Immunosorbent Assay | Vascular Endothelial Growth Factors | Humans | Lymphokines - blood | Reference Values | Gestational Age | Intercellular Signaling Peptides and Proteins - blood | Pregnancy | Placenta - blood supply | Pregnancy Proteins - blood | Endothelial Growth Factors - blood | Pre-Eclampsia - blood | Placenta Growth Factor | Adult | Female | Infant, Small for Gestational Age | Longitudinal Studies | Infant, Newborn | Neovascularization, Physiologic | Physiological aspects | Placenta | Neovascularization | Growth factors | Index Medicus | Abridged Index Medicus
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9. Full Text Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model
by Keiichi Kumasawa and Masahito Ikawa and Hiroyasu Kidoya and Hidetoshi Hasuwa and Tomoko Saito-Fujita and Yuka Morioka and Nobuyuki Takakura and Tadashi Kimura and Masaru Okabe and R. Michael Roberts
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1451 - 1455
Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the... 
Hypertension | Pregnancy | Animal models | Reproduction | Placenta | Fetal growth retardation | Preeclampsia | Blastocyst | Blood pressure | Female animals | Hemolytic anemia, elevated liver enzymes, and low platelet count | Trophoblast | 3-hydroxy-3-methyl-glutaryl-CoA | LOVASTATIN | ANGIOGENESIS | LENTIVIRUS | MULTIDISCIPLINARY SCIENCES | SOLUBLE ENDOGLIN | hemolytic anemia, elevated liver enzymes, and low platelet count | PREGNANCY | GENE-TRANSFER | FETAL | trophoblast | SIMVASTATIN | HYPERTENSION | EXPOSURE | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Pre-Eclampsia - genetics | Humans | Pregnancy Proteins - genetics | Male | Pregnancy Proteins - metabolism | Pre-Eclampsia - prevention & control | HEK293 Cells | Female | Lentivirus - genetics | Pre-Eclampsia - metabolism | Disease Models, Animal | Vascular Endothelial Growth Factor Receptor-1 - genetics | Animals, Newborn | Pravastatin - pharmacology | Cell Line | Transduction, Genetic | Injections, Intraperitoneal | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Placenta - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Pravastatin - administration & dosage | Placenta Growth Factor | Mice | Development and progression | Models | Dosage and administration | Drug therapy | Pravastatin | Vascular endothelial growth factor | Health aspects | Enzymes | Animal reproduction | Cell growth | Rodents | Kinases | Gene expression | Index Medicus | Biological Sciences
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10. Full Text Free heme regulates placenta growth factor through NRF2-antioxidant response signaling
by Kapetanaki, Maria G and Gbotosho, Oluwabukola T and Sharma, Deva and Weidert, Frances and Ofori-Acquah, Solomon F and Kato, Gregory J
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2019, Volume 143, pp. 300 - 308
Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of... 
Oxidative stress | NRF2 | Sickle cell disease | Placenta growth factor | Pulmonary hypertension | Index Medicus
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11. Full Text Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction
by Benton, Samantha J and McCowan, Lesley M and Heazell, Alexander E.P and Grynspan, David and Hutcheon, Jennifer A and Senger, Christof and Burke, Orlaith and Chan, Yuen and Harding, Jane E and Yockell-Lelièvre, Julien and Hu, Yuxiang and Chappell, Lucy C and Griffin, Melanie J and Shennan, Andrew H and Magee, Laura A and Gruslin, Andrée and von Dadelszen, Peter
Placenta, ISSN 0143-4004, 2016, Volume 42, pp. 1 - 8
Abstract Introduction Discriminating between placentally-mediated fetal growth restriction and constitutionally-small fetuses is a challenge in obstetric... 
Internal Medicine | Obstetrics and Gynecology | Placental lesions | Diagnosis | Placental growth factor | Fetal growth restriction | Placental dysfunction | UMBILICAL ARTERY DOPPLER | CONTROLLED-TRIAL | BIRTH-WEIGHT | PREECLAMPSIA | SERUM | DEVELOPMENTAL BIOLOGY | DIAGNOSTIC-ACCURACY | OBSTETRICS & GYNECOLOGY | WOMEN | REPRODUCTIVE BIOLOGY | PREGNANCIES | REACTION PATTERNS | FOR-GESTATIONAL-AGE | Placental Insufficiency - pathology | Humans | Placenta Growth Factor - blood | Biomarkers - blood | Fetal Growth Retardation - pathology | Pregnancy | Young Adult | Delivery, Obstetric | Fetal Growth Retardation - etiology | Ultrasonography, Prenatal | Placenta - pathology | Placental Insufficiency - diagnosis | Adult | Female | Fetal Growth Retardation - diagnosis | Fetus | Research institutes | Growth | Stem cells | Women | Health aspects | Index Medicus
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12. Full Text Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing
by Martino, Mikaël M and Briquez, Priscilla S and Güç, Esra and Tortelli, Federico and Kilarski, Witold W and Metzger, Stephanie and Rice, Jeffrey J and Kuhn, Gisela A and Mul̈ler, Ralph and Swartz, Melody A and Hubbell, Jeffrey A
Science, ISSN 0036-8075, 01/2014, Volume 343, Issue 6173, pp. 885 - 888
Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular... 
FACTOR-BINDING | REPAIR | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | Pregnancy Proteins - chemistry | Proto-Oncogene Proteins c-sis - chemistry | Humans | Pregnancy Proteins - genetics | Extracellular Matrix - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Bone Morphogenetic Protein 2 - chemistry | Male | Pregnancy Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Wound Healing | Vascular Endothelial Growth Factor A - genetics | Heparitin Sulfate - metabolism | Vascular Endothelial Growth Factor A - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Protein 2 - metabolism | Protein Engineering | Extracellular Matrix Proteins - metabolism | Disease Models, Animal | Protein Structure, Tertiary | Bone Morphogenetic Protein 2 - genetics | Extracellular Matrix Proteins - chemistry | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Animals | Heparitin Sulfate - chemistry | Placenta Growth Factor | Mice | Physiological aspects | Extracellular matrix | Genetic aspects | Regeneration (Biology) | Growth factors | Health aspects | Cellular biology | Tissue | Matrix | Index Medicus
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13. Full Text Insulin-like growth factor axis in pregnancies affected by fetal growth disorders
by Nawathe, Aamod R and Christian, Mark and Kim, Sung Hye and Johnson, Mark and Savvidou, Makrina D and Terzidou, Vasso
Clinical Epigenetics, ISSN 1868-7075, 01/2016, Volume 8, Issue 1, pp. 11 - 11
Background: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal... 
DNA methylation | Placental expression | Small fetus | Large fetus | Insulin growth factor | HUMAN PLACENTA | FACTOR-II | GENE-EXPRESSION PATTERNS | BIRTH-WEIGHT | IMPRINTED GENES | HORMONE | MESSENGER-RNA | ONCOLOGY | INTRAUTERINE GROWTH | BINDING-PROTEIN 3 | IGF-II | Insulin-Like Growth Factor Binding Protein 3 - genetics | Insulin-Like Growth Factor Binding Proteins - physiology | Insulin-Like Growth Factor II - physiology | Humans | Fetal Growth Retardation - genetics | Insulin-Like Growth Factor I - genetics | Promoter Regions, Genetic - genetics | Case-Control Studies | DNA Methylation | Insulin-Like Growth Factor II - genetics | Fetal Growth Retardation - etiology | Adult | Female | Insulin-Like Growth Factor Binding Protein 4 - physiology | Insulin-Like Growth Factor Binding Protein 2 - physiology | Infant, Newborn | Insulin-Like Growth Factor Binding Protein 3 - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 1 - physiology | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor Binding Protein 2 - genetics | Placenta - metabolism | Pregnancy | Insulin-Like Growth Factor I - physiology | Infant, Small for Gestational Age | Insulin-Like Growth Factor Binding Protein 1 - genetics | Infants (Newborn) | Epigenetic inheritance | RNA | Growth | Genes | Gene expression | Purines | Pyrimidines | Fetus | Binding proteins | Methylation | Protein binding | Index Medicus
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