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1. Full Text Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: Results of a multicenter fluorodeoxyglucose- positron emission tomography/computed tomography feasibility study
by Tawakol, Ahmed and Fayad, Zahi A and Mogg, Robin and Alon, Achilles and Klimas, Michael T and Dansky, Hayes and Subramanian, Sharath S and Abdelbaky, Amr and Rudd, James H.F and Farkouh, Michael E and Nunes, Irene O and Beals, Chan R and Shankar, Sudha S
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2013, Volume 62, Issue 10, pp. 909 - 917
atherosclerosis | FDG | plaque | inflammation | atorvastatin | statins | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Atherosclerosis (general aspects, experimental research) | Blood and lymphatic vessels | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Plaque, Atherosclerotic - diagnostic imaging | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Feasibility Studies | Atherosclerosis - diagnostic imaging | Inflammation - drug therapy | Pyrroles - administration & dosage | Multimodal Imaging - methods | Aged, 80 and over | Heptanoic Acids - administration & dosage | Adult | Female | Inflammation - diagnostic imaging | Pyrroles - therapeutic use | Aorta, Thoracic - pathology | Atherosclerosis - drug therapy | Double-Blind Method | Treatment Outcome | Positron-Emission Tomography - methods | Atorvastatin Calcium | Carotid Arteries - diagnostic imaging | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Fluorodeoxyglucose F18 | Aged | Carotid Arteries - pathology | Plaque, Atherosclerotic - drug therapy | Aorta, Thoracic - diagnostic imaging | Index Medicus | Abridged Index Medicus
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2. Full Text Atherosclerotic Plaque Destabilization Mechanisms, Models, and Therapeutic Strategies
by Silvestre-Roig, Carlos and de Winther, Menno P and Weber, Christian and Daemen, Mat J and Lutgens, Esther and Soehnlein, Oliver
Circulation research, ISSN 0009-7330, 2014, Volume 114, Issue 1, pp. 214 - 226
atherosclerosis | macrophages | neutrophils | necrotic core | efferocytosis | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Macrophages - physiology | Plaque, Atherosclerotic - metabolism | Anti-Inflammatory Agents - pharmacology | Humans | Neutrophils - drug effects | Neutrophils - physiology | Apolipoproteins E - metabolism | Macrophages - metabolism | Animals | Apolipoproteins E - genetics | Cell Death | Anti-Inflammatory Agents - therapeutic use | Macrophages - drug effects | Plaque, Atherosclerotic - drug therapy | Neutrophils - metabolism | Disease Models, Animal | Index Medicus
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3. Full Text mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques
by Martinet, Wim and De Loof, Hans and De Meyer, Guido R.Y
Atherosclerosis, ISSN 0021-9150, 2014, Volume 233, Issue 2, pp. 601 - 607
Cardiovascular | mTOR | Rapamycin | Everolimus | Autophagy | Atherosclerosis | Drug-eluting stent | MTOR | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Metformin - therapeutic use | Apolipoproteins E - deficiency | Cholesterol - blood | Humans | Coronary Artery Disease - blood | TOR Serine-Threonine Kinases - antagonists & inhibitors | Tissue Scaffolds | Rupture, Spontaneous - prevention & control | Drug Interactions | Hyperglycemia - chemically induced | Swine | Coronary Artery Disease - pathology | Receptors, LDL - deficiency | Dyslipidemias - prevention & control | Plaque, Atherosclerotic - blood | Drug Evaluation, Preclinical | Drug Therapy, Combination | Plaque, Atherosclerotic - pathology | Sirolimus - adverse effects | Hyperglycemia - prevention & control | Rabbits | Drug-Eluting Stents | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | AMP-Activated Protein Kinases - antagonists & inhibitors | Metformin - pharmacology | Clinical Trials as Topic | Coronary Artery Disease - drug therapy | Sirolimus - pharmacology | Absorbable Implants | Mice, Knockout | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Dyslipidemias - chemically induced | Triglycerides - blood | Macrophages - drug effects | Mice | Plaque, Atherosclerotic - drug therapy | Hyperglycemia | Hypoglycemic agents | Statins | Index Medicus
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4. Full Text Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe (-/-) mice
by Di Marco, E and Gray, S. P and Chew, P and Koulis, C and Ziegler, A and Szynalewiez, C and Touyz, R. M and Schmidt, H. H. H. W and Cooper, M. E and Slattery, R and Jandeleit-Dahm, K. A
Diabetologia, ISSN 0012-186X, 03/2014, Volume 57, Issue 3, pp. 633 - 642
Inflammation | Diabetes | NOX | Atherosclerosis | Immune system | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Cardiology. Vascular system | Diabetes. Impaired glucose tolerance | Atherosclerosis (general aspects, experimental research) | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Blood and lymphatic vessels | Endocrine pancreas. Apud cells (diseases) | Immunohistochemistry | Inflammation - pathology | Diabetes Mellitus, Experimental - drug therapy | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Male | Diabetic Angiopathies - pathology | Inflammation - drug therapy | NADPH Oxidases - drug effects | Aorta, Thoracic - drug effects | NADPH Oxidases - biosynthesis | Plaque, Atherosclerotic - pathology | Aorta, Thoracic - pathology | Pyrazoles - pharmacology | Oxidation-Reduction | Inflammation - immunology | Diabetic Angiopathies - drug therapy | Plaque, Atherosclerotic - immunology | Diabetes Mellitus, Experimental - immunology | Animals | Diabetic Angiopathies - immunology | Diabetes Mellitus, Experimental - pathology | Mice | Pyridines - pharmacology | Plaque, Atherosclerotic - drug therapy | Index Medicus
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5. Full Text Angiogenesis in the atherosclerotic plaque
by Camaré, Caroline and Pucelle, Mélanie and Nègre-Salvayre, Anne and Salvayre, Robert
Redox biology, ISSN 2213-2317, 08/2017, Volume 12, pp. 18 - 34
Angiogenesis | Hypercholesterolemia | Neovascularization | VEGF | Atherosclerosis | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Animals | Oxidative Stress | Plaque, Atherosclerotic - metabolism | Neovascularization, Pathologic - drug therapy | Humans | Angiogenesis Inhibitors - pharmacology | Angiogenesis Inhibitors - therapeutic use | Clinical Trials as Topic | Neovascularization, Pathologic - metabolism | Plaque, Atherosclerotic - drug therapy | Plaque, Atherosclerotic - pathology | Disease Progression | Index Medicus | Life Sciences
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6. Full Text Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy
by Fujimoto, Shinichiro and Hartung, Dagmar and Ohshima, Satoru and Edwards, D. Scott and Zhou, Jun and Yalamanchili, Padmaja and Azure, Michael and Fujimoto, Ai and Isobe, Satoshi and Matsumoto, Yuji and Boersma, Henikus and Wong, Nathan and Yamazaki, Junichi and Narula, Navneet and Petrov, Artiom and Narula, Jagat
Journal of the American College of Cardiology, ISSN 0735-1097, 12/2008, Volume 52, Issue 23, pp. 1847 - 1857
atherosclerosis | INCREASES COLLAGEN CONTENT | INCREASED EXPRESSION | EXPERIMENTAL ATHEROMA | DEFICIENT MICE | molecular imaging | CORONARY-ARTERY | UMCG Approved | IN-VIVO | HMG coenzyme reductase inhibitor | CAROTID PLAQUES | matrix metalloproteinase | VULNERABLE PLAQUE | POTENTIAL ROLE | ACUTE PLAQUE DISRUPTION | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Atherosclerosis (general aspects, experimental research) | Blood and lymphatic vessels | Immunohistochemistry | Rabbits | Atherosclerosis - pathology | Tomography, Emission-Computed, Single-Photon - methods | Atherosclerosis - drug therapy | Models, Chemical | Male | Combined Modality Therapy | Atherosclerosis - diet therapy | Technetium - pharmacology | Macrophages - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinase 2 - chemistry | Aorta, Abdominal - pathology | Matrix Metalloproteinase 9 - chemistry | High cholesterol diet | Technetium isotopes | Radioactive tracers | Technetium | Matrix metalloproteinase | Macrophages | Dosage | Fluvastatin | Computed tomography | Imaging | Atherosclerosis | Tomography | Aorta | Metalloproteinase | Lesions | Plaques | Statins | Photon emission | Enzymes | Medical imaging | Feasibility studies | Single photon emission computed tomography | Cholesterol | Molecular chains | Gelatinase B | Abdomen | Gelatinase A | Diet | Arteriosclerosis | Collagen | Coronary vessels | Infiltration | Laboratory animals | Immunoassays | Veins & arteries | Index Medicus | Abridged Index Medicus
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7. Full Text Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography
by Komukai, Kenichi, MD and Kubo, Takashi, MD, PhD and Kitabata, Hironori, MD, PhD and Matsuo, Yoshiki, MD, PhD and Ozaki, Yuichi, MD and Takarada, Shigeho, MD, PhD and Okumoto, Yasushi, MD and Shiono, Yasutsugu, MD and Orii, Makoto, MD and Shimamura, Kunihiro, MD and Ueno, Satoshi, MD and Yamano, Takashi, MD and Tanimoto, Takashi, MD, PhD and Ino, Yasushi, MD, PhD and Yamaguchi, Tomoyuki, MD and Kumiko, Hirata, MD, PhD and Tanaka, Atsushi, MD, PhD and Imanishi, Toshio, MD, PhD and Akagi, Hideharu, MD, PhD and Akasaka, Takashi, MD, PhD
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 64, Issue 21, pp. 2207 - 2217
Cardiovascular | Internal Medicine | atherosclerosis | macrophage | vulnerable plaque | statin therapy | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiovascular agents | Antilipemic agents | Heart attacks | Angina pectoris | Drug therapy | Cholesterol | Statins
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8. Full Text Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies Functional and Imaging Studies
by Jamasbi, Janina and Megens, Remco T. A and Bianchini, Mariaelvy and Muench, Goetz and Ungerer, Martin and Faussner, Alexander and Sherman, Shachar and Walker, Adam and Goyal, Pankaj and Jung, Stephanie and Brandl, Richard and Weber, Christian and Lorenz, Reinhard and Farndale, Richard and Elia, Natalie and Siess, Wolfgang
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2015, Volume 65, Issue 22, pp. 2404 - 2415
atherothrombosis | plaque rupture | antithrombotic | glycoprotein VI | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Carotid Arteries - drug effects | Carotid Stenosis - etiology | Plaque, Atherosclerotic - complications | Plaque, Atherosclerotic - diagnosis | Humans | Carotid Stenosis - drug therapy | Rats | Carotid Stenosis - physiopathology | Immunoglobulin Fab Fragments - pharmacology | Animals | Carotid Arteries - physiopathology | Platelet Membrane Glycoproteins - pharmacology | Carotid Arteries - pathology | Platelet Activation - drug effects | Plaque, Atherosclerotic - drug therapy | Blood Flow Velocity - physiology | Immunologic Factors - pharmacology | Blood Flow Velocity - drug effects | Proline | Atherosclerotic plaque | Collagen | Immunoglobulin G | Adenosine triphosphatase | Von Willebrand factor | Index Medicus | Abridged Index Medicus | Fc, fragment crystallizable region of IgG | Ig, immunoglobulin | TxA2, thromboxane A2 | GPO, glycine-proline-hydroxyproline | GPVI, glycoprotein VI | vWF, von Willebrand factor | plaque rupture | KD, dissociation constant | ADP, adenosine diphosphate | Original Investigation
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