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Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
NEUROTRANSMITTER | HIGH-AFFINITY RECOGNITION | MECHANISM | DETERMINANTS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | HUMAN SEROTONIN TRANSPORTER | CHLORIDE | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2007, Volume 449, Issue 7163, pp. 726 - 730
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15810 - 15815
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways... 
Side effects | Receptors | Neurotransmitters | Databases | Drug interactions | Ligands | Norepinephrine | Drug design | Binding sites | Neuroendocrine tumors | GENETIC-VARIATION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | BACTERIAL HOMOLOG | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RELEASE | LEUT | BINDING-SITES | MOLECULAR DOCKING | CONFORMATIONS | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Drug Discovery - methods | Prescription Drugs - metabolism | Norepinephrine - pharmacokinetics | Prescription Drugs - chemistry | Prescription Drugs - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - genetics | HEK293 Cells | Biological Transport - drug effects | Molecular Structure | Protein Structure, Tertiary | Amino Acid Sequence | Computational Biology - methods | Bacterial Proteins - genetics | Models, Molecular | Binding Sites - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Sequence Homology, Amino Acid | Algorithms | Norepinephrine - metabolism | Norepinephrine - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Drugs | Prescribing | Research | Noradrenaline | Health aspects | Biological Sciences | membrane protein | structure-based ligand discovery | comparative modeling | protein function prediction | polypharmacology
Journal Article
Biochimie, ISSN 0300-9084, 12/2015, Volume 119, pp. 146 - 165
Creatine is physiologically provided equally by diet and by endogenous synthesis from arginine and glycine with successive involvements of arginine glycine... 
GAMT | CRTR | SLC6A8 | AGAT | AMP activated protein kinase | Creatine | Secondary creatine disorders | GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | UREA CYCLE DISORDERS | MAGNETIC-RESONANCE-SPECTROSCOPY | RAT-KIDNEY TRANSAMIDINASE | LINKED MENTAL-RETARDATION | ACUTE MYOCARDIAL-INFARCTION | TERM-FOLLOW-UP | ARGININE-GLYCINE AMIDINOTRANSFERASE | Amino Acid Transport Systems, Basic - genetics | Humans | Nerve Tissue Proteins - deficiency | Movement Disorders - diagnosis | Amidinotransferases - genetics | Intellectual Disability - metabolism | Biological Transport, Active | Gyrate Atrophy - enzymology | Amino Acid Metabolism, Inborn Errors - genetics | Intellectual Disability - enzymology | Brain Diseases, Metabolic, Inborn - genetics | Hyperammonemia - diagnosis | Hyperammonemia - genetics | Creatine - genetics | Urea Cycle Disorders, Inborn - metabolism | Creatine - biosynthesis | Gyrate Atrophy - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Guanidinoacetate N-Methyltransferase - metabolism | Amidinotransferases - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Language Development Disorders - enzymology | Urea Cycle Disorders, Inborn - diagnosis | Energy Metabolism | Urea Cycle Disorders, Inborn - enzymology | Movement Disorders - genetics | Mutation | Ornithine - deficiency | Amino Acid Transport Systems, Basic - metabolism | Amino Acid Metabolism, Inborn Errors - enzymology | S-Adenosylmethionine - metabolism | AMP-Activated Protein Kinases - metabolism | Hyperammonemia - metabolism | Developmental Disabilities - metabolism | Guanidinoacetate N-Methyltransferase - genetics | Ornithine - genetics | Developmental Disabilities - genetics | Language Development Disorders - metabolism | Brain Diseases, Metabolic, Inborn - enzymology | Brain Diseases, Metabolic, Inborn - diagnosis | Intellectual Disability - genetics | Amino Acid Metabolism, Inborn Errors - diagnosis | Amino Acid Metabolism, Inborn Errors - metabolism | Mental Retardation, X-Linked - genetics | Mental Retardation, X-Linked - enzymology | Developmental Disabilities - enzymology | Language Development Disorders - diagnosis | Mental Retardation, X-Linked - diagnosis | Movement Disorders - enzymology | Creatine - metabolism | Hyperammonemia - enzymology | Creatine - deficiency | Gyrate Atrophy - diagnosis | Developmental Disabilities - diagnosis | Speech Disorders - diagnosis | Plasma Membrane Neurotransmitter Transport Proteins - deficiency | Speech Disorders - metabolism | Amidinotransferases - deficiency | Brain Diseases, Metabolic, Inborn - metabolism | Language Development Disorders - genetics | Ornithine - metabolism | Gyrate Atrophy - metabolism | Prenatal Diagnosis | Speech Disorders - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amino Acid Transport Systems, Basic - deficiency | Movement Disorders - metabolism | Animals | Urea Cycle Disorders, Inborn - genetics | Guanidinoacetate N-Methyltransferase - deficiency | Intellectual Disability - diagnosis | Movement Disorders - congenital | Speech Disorders - enzymology | Methylation | Mental Retardation, X-Linked - metabolism | Antioxidants | Phosphates | Algorithms | Animal behavior | Physiological aspects | GABA | Glycine | Phosphotransferases | Medical research | Medicine, Experimental | Protein kinases | Life Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26725 - 26738
Neurotransmitter: sodium symporters (NSSs) mediate reuptake of neurotransmitters from the synaptic cleft and are targets for several therapeutics and... 
SODIUM SYMPORTERS | BETA ADRENERGIC-RECEPTOR | SEROTONIN TRANSPORTER | CONFORMATIONAL-CHANGES | BACTERIAL HOMOLOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALTERNATING ACCESS | BINDING-SITE | MONOAMINE TRANSPORTERS | MOLECULAR-DYNAMICS SIMULATION | DOPAMINE TRANSPORTER | Spectrometry, Fluorescence - methods | Sodium - chemistry | Bacterial Proteins - chemistry | Molecular Sequence Data | Sodium - metabolism | Biological Transport | Cloning, Molecular | Escherichia coli - metabolism | Rhodamines - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Protein Structure, Secondary | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Molecular Dynamics Simulation | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Liposomes - chemistry | Norepinephrine - metabolism | Escherichia coli - genetics | Norepinephrine - chemistry | Protein Binding | Bacterial Proteins - metabolism | Liposomes - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | neurotransmitter transport | dopamine transporter | Membrane Biology | fluorescence quenching | gating | monoamine transporter | membrane protein | fluorescence spectroscopy | mechanisms of membrane transport | conformational change | amino acid transport
Journal Article
Journal Article