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Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | NOREPINEPHRINE TRANSPORTERS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | CONFORMATION | HUMAN SEROTONIN TRANSPORTER | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2007, Volume 449, Issue 7163, pp. 726 - 730
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1456 - 1471
Journal Article
Nature, ISSN 0028-0836, 08/2007, Volume 448, Issue 7156, pp. 952 - 956
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8489 - 8494
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15810 - 15815
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways... 
Side effects | Receptors | Neurotransmitters | Databases | Drug interactions | Ligands | Norepinephrine | Drug design | Binding sites | Neuroendocrine tumors | GENETIC-VARIATION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | BACTERIAL HOMOLOG | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RELEASE | LEUT | BINDING-SITES | MOLECULAR DOCKING | CONFORMATIONS | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Drug Discovery - methods | Prescription Drugs - metabolism | Norepinephrine - pharmacokinetics | Prescription Drugs - chemistry | Prescription Drugs - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - genetics | HEK293 Cells | Biological Transport - drug effects | Molecular Structure | Protein Structure, Tertiary | Amino Acid Sequence | Computational Biology - methods | Bacterial Proteins - genetics | Models, Molecular | Binding Sites - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Sequence Homology, Amino Acid | Algorithms | Norepinephrine - metabolism | Norepinephrine - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Drugs | Prescribing | Research | Noradrenaline | Health aspects | Prescription drugs | Molecules | Alzheimers disease | Neurons | Index Medicus | Biological Sciences | membrane protein | structure-based ligand discovery | comparative modeling | protein function prediction | polypharmacology
Journal Article