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1. Full Text Alginate/CaCO3 hybrid nanoparticles for efficient codelivery of antitumor gene and drug
by Zhao, Dong and Liu, Chuan-Jun and Zhuo, Ren-Xi and Cheng, Si-Xue
Molecular Pharmaceutics, ISSN 1543-8384, 2012, Volume 9, Issue 10, pp. 2887 - 2893
In this study, a facile strategy for efficient codelivery of gene and drug was developed. Using a coprecipitation method, doxorubicin hydrochloride (DOX), an... 
alginate | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | gene transfer | DOXORUBICIN | MESOPOROUS SILICA NANOPARTICLES | MULTIDRUG-RESISTANT CANCER | ANTICANCER DRUG | drug delivery | P53 FUNCTION | CO-DELIVERY | calcium carbonate | nanoparticles | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | NANOSTRUCTURED CALCIUM-CARBONATE | SIRNA | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Drug Carriers - administration & dosage | Hexuronic Acids - administration & dosage | Doxorubicin - chemistry | Antineoplastic Agents - administration & dosage | Calcium Carbonate - chemistry | Drug Carriers - chemistry | Plasmids - genetics | Calcium Carbonate - administration & dosage | Glucuronic Acid - administration & dosage | DNA Adducts - administration & dosage | Glucuronic Acid - chemistry | Doxorubicin - administration & dosage | Gene Transfer Techniques | DNA Adducts - chemistry | DNA - administration & dosage | Hexuronic Acids - chemistry | Antineoplastic Agents - chemistry | Alginates - administration & dosage | DNA - chemistry | Alginates - chemistry | Plasmids - chemistry | Cell Line, Tumor | Nanoparticles - administration & dosage | HeLa Cells | Drug Delivery Systems - methods | Plasmids - administration & dosage | Index Medicus
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2. Full Text Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp-/- mice
by Tai, E.K.K and Wu, W.K.K and Wang, X.J and Wong, H.P.S and Yu, L and Li, Z.J and Lee, C.W and Wong, C.C.M and Yu, J and Sung, J.J.Y and Gallo, R.L and Cho, C.H
Gene Therapy, ISSN 0969-7128, 02/2013, Volume 20, Issue 2, pp. 187 - 193
Cathelicidin is a pleiotropic host defense peptide secreted by epithelial and immune cells. Whether endogenous cathelicidin is protective against ulcerative... 
Cathelicidin | Mucin | IL-1 | TNF | Antimicrobial peptide | Ulcerative colitis | Tumor Necrosis Factor-alpha - metabolism | Genetic Therapy | Gene Expression | Tumor Necrosis Factor-alpha - genetics | Colitis, Ulcerative - genetics | Administration, Rectal | Interleukin-1beta - genetics | Mice, Knockout | Animals | Interleukin-1beta - metabolism | Mucins - metabolism | Plasmids - genetics | Colitis, Ulcerative - therapy | Peroxidase - genetics | Mice | Antimicrobial Cationic Peptides - genetics | Genetic Vectors | Mucins - genetics | Plasmids - administration & dosage | Apoptosis | Intestinal Mucosa - pathology | Peroxidase - metabolism | Inflammatory bowel disease | Immunology | Peptides | Gene therapy | Cells | Index Medicus
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3. Full Text Protection of olive flounder ( Paralichthys olivaceus) against Edwardsiella tarda infection by oral administration of auxotrophic mutant E. tarda ( Δalr Δasd E. tarda)
by Choi, Seung Hyuk and Kim, Ki Hong and Kim, Min Sun
Aquaculture, ISSN 0044-8486, 2011, Volume 317, Issue 1, pp. 48 - 52
A study was undertaken to evaluate the efficacy of oral vaccination of olive flounder ( ) with two auxotrophic gene-mutated ( ) that habors antibiotic... 
Combined vaccine | Oral vaccine | Auxotrophic mutant | Δalr Δasd Edwardsiella tarda | EFFICACY | VACCINE | GHOSTS | SALMONELLA | ANTIGENS | LIVE | Delta alr Delta asd Edwardsiella tarda | IMMUNIZATION | FISHERIES | MARINE & FRESHWATER BIOLOGY | CONSTRUCTION | FISH | GENERATION | Studies | Immunization | Plasmids | Bacteria | Mutation | Flounder | Aquaculture
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4. Full Text INF-γ encoding plasmid administration triggers bone loss and disrupts bone marrow microenvironment
by Agas, Dimitrios and Silva, Guilherme Gusmão and Laus, Fulvio and Marchegiani, Andrea and Capitani, Melania and Vullo, Cecilia and Catone, Giuseppe and Lacava, Giovanna and Concetti, Antonio and Marchetti, Luigi and Sabbieti, Maria Giovanna
Journal of Endocrinology, ISSN 0022-0795, 2017, Volume 232, Issue 2, pp. 309 - 321
IFN-gamma is a pleotropic cytokine produced in the bone microenvironment. Although IFN-gamma is known to play a critical role on bone remodeling, its function... 
Bone marrow | Plasmid DNA | INF-γ bone loss | ACTIVATION | PHOSPHORYLATION | IFN-GAMMA | INF-gamma | bone loss | bone marrow | MESENCHYMAL STEM-CELLS | OSTEOPOROSIS | plasmid DNA | OSTEOPONTIN | INHIBITION | INTERFERON-GAMMA | OSTEOBLASTS | ENDOCRINOLOGY & METABOLISM | MICE | Ovariectomy | Bone Marrow Cells - pathology | Cells, Cultured | Bone Diseases, Metabolic - pathology | Bone Remodeling - drug effects | Bone Diseases, Metabolic - metabolism | Bone Density - drug effects | Animals | Bone Marrow - metabolism | Interferon-gamma - administration & dosage | Bone Marrow Cells - drug effects | Female | Mice | Bone Marrow Cells - metabolism | Bone Marrow - drug effects | CXCL12 protein | Mesenchyme | Cytokines | Bone remodelling | Stem cell transplantation | Homeostasis | Inflammation | Bone (trabecular) | Rodents | γ-Interferon | Stem cells | Bone mineral density | Interferon | Bone loss | Bone (cortical) | Osteopenia | Index Medicus
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5. Full Text Dextran–protamine–solid lipid nanoparticles as a non-viral vector for gene therapy: In vitro characterization and in vivo transfection after intravenous administration to mice
by Delgado, Diego and Gascón, Alicia Rodríguez and del Pozo-Rodríguez, Ana and Echevarría, Enrique and Ruiz de Garibay, Aritz Pérez and Rodríguez, Juan Manuel and Solinís, Maria Ángeles
International Journal of Pharmaceutics, ISSN 0378-5173, 04/2012, Volume 425, Issue 1-2, pp. 35 - 43
The aim of present work is to evaluate the transfection capacity of a new multicomponent system based on dextran (Dex), protamine (Prot), and solid lipid... 
Endocytosis | Non-viral vectors | Gene therapy | Solid lipid nanoparticles | Intracellular trafficking | In vivo transfection | LOCALIZATION | TRANSCRIPTION | PEPTIDE | DELIVERY | CELL TRANSFECTION | DNA | NASAL EPITHELIUM | PHARMACOLOGY & PHARMACY | EXPRESSION | LIPOSOMES | Hemolysis - drug effects | Injections, Intravenous | Genetic Vectors - administration & dosage | Nanoparticles - chemistry | Humans | Dextrans - chemistry | Green Fluorescent Proteins - genetics | Transfection | HEK293 Cells | Erythrocytes - pathology | Protamines - administration & dosage | Female | Diglycerides - administration & dosage | Cell Line | Protamines - chemistry | Genetic Vectors - chemistry | Endocytosis - drug effects | DNA - administration & dosage | Erythrocytes - drug effects | DNA - chemistry | Animals | Mice, Nude | Diglycerides - chemistry | Hemagglutination - drug effects | Plasmids - chemistry | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Dextrans - administration & dosage | Plasmids - administration & dosage | Genetic Therapy - methods | Nanoparticles | Genetic vectors | Genes | Genetic aspects | Universities and colleges | Virus diseases | Dextran | Drugstores | Index Medicus | Spleen | Clathrin | Particle size | Surface charge | Intravenous administration | Caveolae | Gene transfer | Liver | Lung | Erythrocytes | Lipids | protamine | nanoparticles | Plasmids | Green fluorescent protein | Agglutination | Expression vectors
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6. Full Text High‐Pressure Nebulization as Application Route for the Peritoneal Administration of siRNA Complexes
by Minnaert, An‐Katrien and Dakwar, George R and Benito, Juan M and García Fernández, José M and Ceelen, W and De Smedt, Stefaan C and Remaut, Katrien
Macromolecular Bioscience, ISSN 1616-5187, 10/2017, Volume 17, Issue 10, pp. 1700024 - n/a
Peritoneal carcinomatosis is a severe form of cancer in the abdomen, currently treated with cytoreductive surgery and intravenous chemotherapy. Recently,... 
siRNA delivery | cyclodextrins | lipoplexes | peritoneal carcinomatosis | nebulization | MATERIALS SCIENCE, BIOMATERIALS | POLYMER SCIENCE | GENE DELIVERY | PARTICLES | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAPERITONEAL AEROSOL CHEMOTHERAPY | CANCER | DRUG-DELIVERY-SYSTEMS | NANOPARTICLES | THERAPY | POLYCATIONIC AMPHIPHILIC CYCLODEXTRINS | CARCINOMATOSIS | RNA, Small Interfering - genetics | Luciferases - metabolism | Humans | Plasmids - metabolism | Luciferases - genetics | Ovarian Neoplasms - genetics | Lipids - chemistry | Transfection - methods | Ascites - metabolism | Ascites - therapy | Peritoneal Neoplasms - genetics | RNA, Small Interfering - therapeutic use | Peritoneal Neoplasms - metabolism | Ascites - genetics | Cyclodextrins - chemistry | Plasmids - chemistry | Aerosols | Cell Line, Tumor | Ovarian Neoplasms - therapy | Female | Ovarian Neoplasms - metabolism | Peritoneal Neoplasms - therapy | RNA, Small Interfering - metabolism | Cyclodextrins | Dextrins | Chemotherapy | Cyclodextrin | Transfection | Intravenous administration | Invasiveness | RNA-mediated interference | Surgery | Drug delivery | siRNA | Ascites | Peritoneum | Cancer | Index Medicus
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7. Full Text Comparison of lacZ reporter gene expression in gilthead sea bream (Sparus aurata) following oral or intramuscular administration of plasmid DNA in chitosan nanoparticles
by Sáez, M.I and Vizcaíno, A.J and Alarcón, F.J and Martínez, T.F
Aquaculture, ISSN 0044-8486, 05/2017, Volume 474, pp. 1 - 10
The development of non-parenteral delivery systems allowing efficient intestinal absorption in fish is a current research topic drawing much interest.... 
Chitosan-nanoparticles | Transient gene expression | Tissue migration | Sparus aurata | Plasmid DNA | Oral gene delivery | MOLECULAR-MASS | RAINBOW-TROUT | ONCORHYNCHUS-MYKISS WALBAUM | SALMO-SALAR L | DELIVERY-SYSTEM | FISHERIES | TRANSGENE EXPRESSION | FLOUNDER PARALICHTHYS-OLIVACEUS | MARINE & FRESHWATER BIOLOGY | IN-VIVO | FISH | ATLANTIC SALMON | Nanoparticles | Genetic research | Comparative analysis | Gene expression | Genes | DNA | Anopheles | Gastrointestinal system
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8. Full Text Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is relieved by co-administration of cytokine-encoding vectors
by Bongard, Nadine and Lapuente, Dennis and Windmann, Sonja and Dittmer, Ulf and Tenbusch, Matthias and Bayer, Wibke
Retrovirology, ISSN 1742-4690, 04/2017, Volume 14, Issue 1, pp. 28 - 28
Background: Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but... 
Retrovirus | Immunosuppression | Adjuvant | Friend retrovirus | Vaccine | Envelope | Friend virus | Immune modulation | COLONY-STIMULATING FACTOR | ADENOVIRUS-BASED IMMUNIZATION | MURINE LEUKEMIA-VIRUS | DEFICIENT MICE | VIRAL-INFECTIONS | PROTECTIVE IMMUNITY | VIROLOGY | HIV-1 ENVELOPE | DNA VACCINE | CO-IMMUNIZATION | THERAPEUTIC VACCINATION | Vaccines, DNA - immunology | Interleukin-15 - immunology | Vaccines, DNA - administration & dosage | Viral Load | Interleukin-2 - immunology | Viral Envelope Proteins - metabolism | Female | Cytokines - genetics | Cytokines - immunology | Gene Products, gag - immunology | Immunization | Viral Envelope Proteins - genetics | Gene Products, gag - genetics | Friend murine leukemia virus - genetics | Adjuvants, Immunologic | Immunomodulation | Interleukin-2 - genetics | Animals | Interleukin-15 - genetics | Retroviridae Infections - immunology | Friend murine leukemia virus - immunology | Plasmids | Viral Envelope Proteins - immunology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Genetic Vectors | Viral Vaccines - immunology | Index Medicus
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9. Full Text Biodegradable nanoparticles composed of dendrigraft poly-l-lysine for gene delivery
by Kodama, Yukinobu and Nakamura, Tadahiro and Kurosaki, Tomoaki and Egashira, Kanoko and Mine, Toyoharu and Nakagawa, Hiroo and Muro, Takahiro and Kitahara, Takashi and Higuchi, Norihide and Sasaki, Hitoshi
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 08/2014, Volume 87, Issue 3, pp. 472 - 479
We developed novel gene vectors composed of dendrigraft poly- -lysine (DGL). The transgene expression efficiency of the pDNA/DGL complexes (DGL complexes) was... 
Gene delivery | Biodegradable | Dendrigraft poly-l-lysine | γ-Polyglutamic acid | Nanoparticle | Ternary complex | CAPSULAR ANTIGEN | CELLS | Dendrigraft poly-L-lysine | TRANSFECTION | COMPLEXES | gamma-Polyglutamic acid | DENDRIMERS | D-GLUTAMIC ACID | IN-VITRO | DENDRITIC POLY(L-LYSINE) | DNA | BACILLUS-ANTHRACIS | PHARMACOLOGY & PHARMACY | Polymers - administration & dosage | Genetic Vectors - administration & dosage | Nanoparticles - chemistry | Polylysine - analogs & derivatives | Melanoma, Experimental - drug therapy | Polylysine - administration & dosage | Erythrocytes | Male | Polyglutamic Acid - administration & dosage | Polylysine - chemistry | Anions - chemistry | Polyglutamic Acid - analogs & derivatives | Transfection - methods | Plasmids - genetics | Anions - administration & dosage | Gene Transfer Techniques | Genetic Vectors - chemistry | Lysine - administration & dosage | Genetic Vectors - genetics | DNA - genetics | Particle Size | Polyglutamic Acid - chemistry | Animals | Melanoma, Experimental - genetics | Cell Line, Tumor | Polymers - chemistry | Mice | Nanoparticles - administration & dosage | Lysine - chemistry | Plasmids - administration & dosage | Genetic Therapy - methods | Lysine | Index Medicus
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10. Full Text Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery
by Spyros A. Kalams and Scott D. Parker and Marnie Elizaga and Barbara Metch and Srilatha Edupuganti and John Hural and Stephen De Rosa and Donald K. Carter and Kyle Rybczyk and Ian Frank and Jonathan Fuchs and Beryl Koblin and Denny H. Kim and Patrice Joseph and Michael C. Keefer and Lindsey R. Baden and John Eldridge and Jean Boyer and Adam Sherwat and Massimo Cardinali and Mary Allen and Michael Pensiero and Chris Butler and Amir S. Khan and Jian Yan and Niranjan Y. Sardesai and James G. Kublin and David B. Weiner and NIAID HIV Vaccine Trials Network and the NIAID HIV Vaccine Trials Network
The Journal of Infectious Diseases, ISSN 0022-1899, 9/2013, Volume 208, Issue 5, pp. 818 - 829
Background. DNA vaccines have been very poorly immunogenic in humans but have been an effective priming modality in prime-boost regimens. Methods to increase... 
T lymphocytes | HIV/AIDS | Body mass index | Immune response | HIV | Interleukins | Plasmids | Vaccination | Electroporation | DNA vaccines | HIV 1 | plasmid cytokine adjuvant | electroporation | vaccination | INFECTIOUS DISEASES | PHASE-1 SAFETY | MICROBIOLOGY | CYTOKINE | IMMUNOLOGY | IL-12 | IN-VIVO ELECTROPORATION | VIREMIA | T-CELL RESPONSES | IMMUNE-RESPONSES | CANDIDATE VACCINE | GROWTH-FACTOR | RHESUS MACAQUES | Adjuvants, Immunologic - administration & dosage | Interleukin-12 - genetics | Humans | Middle Aged | AIDS Vaccines - immunology | Male | DNA - adverse effects | AIDS Vaccines - adverse effects | CD4-Positive T-Lymphocytes - immunology | Young Adult | Vaccination - methods | Adjuvants, Immunologic - genetics | Adult | Female | Drug Administration Routes | DNA - immunology | DNA - administration & dosage | HIV-1 - genetics | HIV-1 - immunology | Interleukin-12 - administration & dosage | Adolescent | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Cytokines - biosynthesis | Usage | AIDS vaccines | Interleukin-12 | Dosage and administration | Research | Human immunogenetics | Index Medicus | Abridged Index Medicus | Major and Brief Reports
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11. Full Text Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD
by Heine, Shannon J and Diaz-McNair, Jovita and Martinez-Becerra, Francisco J and Choudhari, Shyamal P and Clements, John D and Picking, Wendy L and Pasetti, Marcela F
Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 28, pp. 2919 - 2929
Highlights • Mice were immunized orally with Shigella TTSS proteins IpaB/IpaD and E. coli dmLT. • Vaccine-specific immune responses and moderate protection... 
Allergy and Immunology | Shigella vaccines | Oral immunization | Type III secretion proteins | O-SPECIFIC POLYSACCHARIDE | MEDICINE, RESEARCH & EXPERIMENTAL | BELLS-PALSY | SAFETY | VACCINE | SERUM ANTIBODIES | IMMUNOLOGY | INVASION PLASMID | ADAPTIVE IMMUNITY | FLEXNERI 2A | PLASMID-CODED ANTIGENS | TH17 CELLS | Vaccination | Antigens, Bacterial - immunology | Immunity, Mucosal | Antibodies, Bacterial - analysis | Dysentery, Bacillary - prevention & control | Shigella flexneri - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Female | Bacterial Proteins - immunology | Escherichia coli Proteins - immunology | Cytokines - immunology | Dysentery, Bacillary - immunology | Administration, Oral | Bacterial Toxins - immunology | Shigella Vaccines - administration & dosage | Antigens, Bacterial - administration & dosage | Vaccines, Subunit - immunology | Administration, Intranasal | Bacterial Proteins - administration & dosage | Enterotoxins - administration & dosage | Animals | Shigella Vaccines - immunology | Vaccines, Subunit - administration & dosage | Bacterial Toxins - administration & dosage | Mice | Mice, Inbred BALB C | Index Medicus | type III secretion proteins | oral immunization
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12. Full Text Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
by Alton, E.W.F.W and Boyd, A.C and Cheng, S.H and Davies, J.C and Davies, L.A and Dayan, A and Gill, D.R and Griesenbach, U and Higgins, T and Hyde, S.C and Innes, J.A and McLachlan, G and Porteous, D and Pringle, I and Scheule, R.K and Sumner-Jones, S and UK CF Gene Therapy Consortium Stra
Gene Therapy, ISSN 0969-7128, 01/2014, Volume 21, Issue 1, pp. 89 - 95
For gene therapy to improve lung function in cystic fibrosis (CF) subjects, repeated administration of the gene transfer agent over the lifetime of patients is... 
toxicology | repeat administration | cationic lipid | gene transfer | cystic fibrosis | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOVIRUS | REGULATOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DOUBLE-BLIND | NASAL EPITHELIUM | PLACEBO-CONTROLLED TRIAL | CYSTIC-FIBROSIS | GENE-TRANSFER | EXPRESSION | Cystic Fibrosis - therapy | Genetic Therapy | Reproducibility of Results | Humans | Cystic Fibrosis - pathology | Administration, Inhalation | Male | Combined Modality Therapy | Lipids - administration & dosage | Dose-Response Relationship, Drug | Animals | Plasmids | Lung - drug effects | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Female | Mice | Mice, Inbred BALB C | Genetic Vectors | Lipids - toxicity | Disease Models, Animal | Medical research | Care and treatment | Immune response | Patient outcomes | Medicine, Experimental | Cystic fibrosis | Research | Gene therapy | Toxicology | Lungs | Rodents | Lipids | Deoxyribonucleic acid--DNA | Index Medicus
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13. Full Text Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
by Best, Simon R and Peng, Shiwen and Juang, Chi-Mou and Hung, Chien-Fu and Hannaman, Drew and Saunders, John R and Wu, T.-C and Pai, Sara I
Vaccine, ISSN 0264-410X, 2009, Volume 27, Issue 40, pp. 5450 - 5459
Abstract DNA vaccines are an attractive approach to eliciting antigen-specific immunity. Intracellular targeting of tumor antigens through its linkage to... 
Allergy and Immunology | DNA vaccine | Head and neck cancer | Electroporation | Human papillomavirus (HPV) | Calreticulin (CRT) | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-TRIAL | DENDRITIC CELLS | NEUTRALIZING ANTIBODY | ANTIGEN PRESENTATION | HUMAN-PAPILLOMAVIRUS | IMMUNOLOGY | TUMOR-ANTIGEN | CLASS-II PRESENTATION | IN-VIVO ELECTROPORATION | HEALTHY-ADULTS | ELECTRIC PULSES | VETERINARY SCIENCES | Mice, Inbred C57BL | Vaccines, DNA - immunology | Papillomavirus E7 Proteins | Injections, Intramuscular | Antibodies, Viral - blood | Vaccines, DNA - administration & dosage | Animals | Vaccination - methods | Papillomavirus Infections - prevention & control | Interferon-gamma - immunology | Cell Line, Tumor | Female | Papillomavirus Vaccines - immunology | Mice | Oncogene Proteins, Viral - immunology | CD8-Positive T-Lymphocytes - immunology | Papillomavirus Vaccines - administration & dosage | Injections, Intradermal | Immune response | Tumor antigens | DNA | Vaccination | Genetic research | Business presentations | Vaccines | Comparative analysis | T cells | Health aspects | Papillomavirus infections | Tumors | Medical research | Antigens | Human papillomavirus | Plasmids | Index Medicus | human papillomavirus (HPV) | electroporation | head and neck cancer | calreticulin (CRT)
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