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1. Full Text The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: Evidence from mice and humans
by Sashindranath, Maithili and Sales, Eunice and Daglas, Maria and Freeman, Roxann and Samson, Andre L and Cops, Elisa J and Beckham, Simone and Galle, Adam and McLean, Catriona and Morganti-Kossmann, Cristina and Rosenfeld, Jeffrey V and Madani, Rime and Vassalli, Jean-Dominique and Su, Enming J and Lawrence, Daniel A and Medcalf, Robert L
Brain (London, England : 1878), ISSN 0006-8950, 2012, Volume 135, Issue 11, pp. 3251 - 3264
traumatic brain injury | matrix metalloproteinase-3 | plasminogen activator inhibitor-1 | tissue plasminogen activator | neurovascular unit | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Injuries of the nervous system and the skull. Diseases due to physical agents | Neurology | Biological and medical sciences | Medical sciences | Traumas. Diseases due to physical agents | Capillary Permeability - physiology | Tissue Plasminogen Activator - metabolism | Brain Injuries - drug therapy | Humans | Middle Aged | Injections, Intraventricular | Capillary Permeability - drug effects | Male | Brain Injuries - metabolism | Brain Injuries - physiopathology | Plasminogen Activator Inhibitor 1 - physiology | Matrix Metalloproteinase Inhibitors - therapeutic use | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Tissue Plasminogen Activator - antagonists & inhibitors | Plasminogen Activator Inhibitor 1 - metabolism | Aged, 80 and over | Recovery of Function - physiology | Adult | Disease Models, Animal | Albumins - metabolism | Mice, Inbred C57BL | Plasminogen Activator Inhibitor 1 - administration & dosage | Tissue Plasminogen Activator - administration & dosage | Tissue Plasminogen Activator - physiology | Animals | Brain Injuries - cerebrospinal fluid | Aged | Mice | Matrix Metalloproteinases - metabolism | Index Medicus | Abridged Index Medicus | Stroke | Central nervous system | Membrane permeability | Albumin | Homeostasis | Cerebrospinal fluid | Matrix metalloproteinase | Permeability | Trauma | Plasmin | t-Plasminogen activator | lipoprotein receptors | neuroserpin | plasminogen | Proteolysis | Plasma membranes | Chromium | Serine proteinase | Brain injury | Original
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2. Full Text Plasminogen Activator Inhibitor Type‐1 as a Regulator of Fibrosis
by Rabieian, Reyhaneh and Boshtam, Maryam and Zareei, Mahshid and Kouhpayeh, Shirin and Masoudifar, Aria and Mirzaei, Hamed
Journal of cellular biochemistry, ISSN 0730-2312, 01/2018, Volume 119, Issue 1, pp. 17 - 27
UROKINASE PLASMINOGEN ACTIVATOR (uPA) | FIBRINOLYSIS | TRANSFORMING GROWTH FACTOR‐β (TGF‐β) | PLASMINOGEN ACTIVATOR INHIBITOR‐1 (PAI‐1) | TISSUE PLASMINOGEN ACTIVATOR (tPA) | TRANSFORMING GROWTH FACTOR-β (TGF-β) | PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Disease - etiology | Fibrosis - genetics | Receptor Cross-Talk | Plasminogen Activator Inhibitor 1 - metabolism | Fibrosis - etiology | Humans | Gene Expression Regulation | Plasminogen Activator Inhibitor 1 - genetics | Plasminogen Activator Inhibitor 1 - physiology | Gene expression | Development and progression | Fibrosis | Smad protein | Pathogenesis | Transforming growth factor-b | Activation | t-Plasminogen activator | Degradation | Urokinase | Pathways | Etiology | Proteolysis | Extracellular matrix | Growth factors | Deposition | Injuries | Hypertension | Wound healing | Cytokines | Medical treatment | Diabetes mellitus | Polyamide-imides | Inflammation | U-Plasminogen activator | Inhibitors | Plasminogen activator inhibitors | Index Medicus
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3. Full Text Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis
by Huang, Wen-Tan and Vayalil, Praveen K and Miyata, Toshio and Hagood, James and Liu, Rui-Ming
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 01/2012, Volume 46, Issue 1, pp. 87 - 95
Animal model | TGF-β1 | (Myo)fibroblast apoptosis | PAI-1 inhibitor | Lung fibrosis therapy | Respiratory System | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Caspase 7 - metabolism | para-Aminobenzoates | Tissue Plasminogen Activator - metabolism | Apoptosis - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Caspase 3 - metabolism | Body Weight - drug effects | Male | Myofibroblasts - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | 4-Aminobenzoic Acid - pharmacology | Pulmonary Fibrosis - metabolism | Transforming Growth Factor beta1 - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Pulmonary Fibrosis - pathology | Myofibroblasts - drug effects | Piperazines - pharmacology | Fibronectins - metabolism | Animals | Urokinase-Type Plasminogen Activator - metabolism | Mice | Pulmonary Fibrosis - drug therapy | Index Medicus | lung fibrosis therapy | animal model | (myo)fibroblast apoptosis
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4. Full Text High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor–related protein 1 requires lysines 80, 88, and 207
by Migliorini, Mary and Li, Shih-Hon and Zhou, Anqi and Emal, Cory D and Lawrence, Daniel A and Strickland, Dudley K
The Journal of biological chemistry, ISSN 0021-9258, 01/2020, Volume 295, Issue 1, pp. 212 - 222
site-directed mutagenesis | fibrinolysis | plasminogen activation | LRP1 | serpin | PAI-1 | lipoprotein receptor-related protein (LRP) | surface plasmon resonance (SPR) | ligand recognition | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Lysine - genetics | Plasminogen Activator Inhibitor 1 - chemistry | Plasminogen Activator Inhibitor 1 - metabolism | Humans | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Protein Binding | Plasminogen Activator Inhibitor 1 - genetics | Binding Sites | Amino Acid Substitution | Index Medicus | Cell Biology
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5. Full Text Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer
by Humphries, Brock A and Buschhaus, Johanna M and Chen, Yu-Chih and Haley, Henry R and Qyli, Tonela and Chiang, Benjamin and Shen, Nathan and Rajendran, Shrila and Cutter, Alyssa and Cheng, Yu-Heng and Chen, Yu-Ting and Cong, Jason and Spinosa, Phillip C and Yoon, Euisik and Luker, Kathryn E and Luker, Gary D
Molecular cancer research, ISSN 1541-7786, 05/2019, Volume 17, Issue 5, pp. 1142 - 1154
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - genetics | Neoplasm Transplantation | Up-Regulation | Actin Cytoskeleton - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Gene Expression Profiling - methods | Lung Neoplasms - pathology | MAP Kinase Signaling System | Whole Genome Sequencing | Animals | Triple Negative Breast Neoplasms - genetics | Lung Neoplasms - secondary | Plasminogen Activator Inhibitor 1 - metabolism | Triple Negative Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Glycolysis | Female | High-Throughput Nucleotide Sequencing | Mice | Plasminogen Activator Inhibitor 1 - genetics | Cell Movement | Index Medicus | triple negative breast cancer | glycolytic metabolism | PAI1 | enhanced migration | actin reorganization
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6. Full Text Role of plasminogen activator inhibitor – 1 (PAI-1) in regulating the pathogenesis of S. aureus arthritis via plasminogen pathway
by Sultana, Sahin and Dey, Rajen and Bishayi, Biswadev
Immunology letters, ISSN 0165-2478, 05/2019, Volume 209, pp. 53 - 66
S. aureus | Plasminogen activator inhibitor-1 | Plasmin | Septic arthritis | Synovial joint | Life Sciences & Biomedicine | Immunology | Science & Technology | Arthritis, Infectious - metabolism | Cytokines - metabolism | Signal Transduction | Humans | Male | Plasminogen - metabolism | Bacterial Load | Arthritis, Infectious - microbiology | Staphylococcal Infections - mortality | Animals | Plasminogen Activator Inhibitor 1 - metabolism | Biomarkers | Mice | Staphylococcal Infections - microbiology | Staphylococcus aureus | Disease Models, Animal | Staphylococcal Infections - metabolism | Index Medicus
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7. Full Text Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
by Thuy, Sabine and Ladurner, Ruth and Volynets, Valentina and Wagner, Silvia and Strahl, Stefan and Königsrainer, Alfred and Maier, Klaus-Peter and Bischoff, Stephan C and Bergheim, Ina
The Journal of nutrition, ISSN 0022-3166, 08/2008, Volume 138, Issue 8, pp. 1452 - 1455
Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Biological and medical sciences | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Endotoxins - blood | Humans | Middle Aged | Male | Fatty Liver - chemically induced | RNA, Messenger - metabolism | Case-Control Studies | Dose-Response Relationship, Drug | Adult | Female | Plasminogen Activator Inhibitor 1 - genetics | Dietary Carbohydrates - administration & dosage | Fatty Liver - metabolism | Fructose - adverse effects | Fatty Liver - blood | Liver - metabolism | RNA, Messenger - genetics | Toll-Like Receptor 4 - genetics | Plasminogen Activator Inhibitor 1 - blood | Gene Expression Regulation - drug effects | Pilot Projects | Toll-Like Receptor 4 - blood | Diet | Dietary Carbohydrates - adverse effects | Fructose - administration & dosage | Fatty liver | Endotoxins | Carbohydrates, Refined | Chemical properties | Health aspects | Risk factors | Blood plasma | Index Medicus
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8. Full Text Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase‐3 and interleukin 1‐β in patients with different periodontal diseases
by Toyman, U and Tüter, G and Kurtiş, B and Kıvrak, E and Bozkurt, Ş and Yücel, A. A and Serdar, M
Journal of periodontal research, ISSN 0022-3484, 02/2015, Volume 50, Issue 1, pp. 44 - 51
interleukin‐1beta | matrix metalloproteinase‐3 | tissue plasminogen activator | plasminogen activator inhibitor 2 | Plasminogen activator inhibitor 2 | Interleukin-1beta | Tissue plasminogen activator | Matrix metalloproteinase-3 | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Interleukin-1beta - analysis | Periodontal Attachment Loss - classification | Plasminogen Activator Inhibitor 2 - analysis | Humans | Middle Aged | Serine Proteinase Inhibitors - analysis | Aggressive Periodontitis - metabolism | Dental Plaque Index | Male | Gingival Crevicular Fluid - chemistry | Matrix Metalloproteinase 3 - analysis | Periodontal Pocket - classification | Periodontal Attachment Loss - metabolism | Young Adult | Periodontal Index | Adult | Female | Tissue Plasminogen Activator - analysis | Chronic Periodontitis - metabolism | Fibrinolytic Agents - analysis | Periodontal Pocket - metabolism | Index Medicus | Dentistry
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