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Science (American Association for the Advancement of Science), ISSN 1095-9203, 11/2011, Volume 334, Issue 6061, pp. 1372 - 1377
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against... 
Schizonts | Malaria | RESEARCH ARTICLES | Liver | Antimalarials | Infections | Parasites | Inhibitory concentration 50 | Scaffolds | Blood | Chemicals | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium berghei - physiology | Humans | Imidazoles - chemistry | Plasmodium - physiology | Piperazines - chemistry | Plasmodium falciparum - drug effects | Plasmodium - growth & development | Imidazoles - therapeutic use | Plasmodium falciparum - physiology | Antimalarials - pharmacokinetics | Antimalarials - therapeutic use | Imidazoles - pharmacology | Piperazines - therapeutic use | Random Allocation | Piperazines - pharmacology | Plasmodium berghei - cytology | Small Molecule Libraries | Malaria - parasitology | Cell Line, Tumor | Plasmodium berghei - growth & development | Mice | Mice, Inbred BALB C | Liver - parasitology | Erythrocytes - parasitology | Plasmodium berghei - drug effects | Plasmodium - cytology | Plasmodium falciparum - cytology | Plasmodium - drug effects | Imidazoles - pharmacokinetics | Plasmodium yoelii - growth & development | Protozoan Proteins - genetics | Sporozoites - growth & development | Protozoan Proteins - metabolism | Plasmodium yoelii - drug effects | Protozoan Proteins - chemistry | Molecular Structure | Piperazines - pharmacokinetics | Drug Evaluation, Preclinical | Sporozoites - drug effects | Drug Resistance | Plasmodium yoelii - physiology | Plasmodium yoelii - cytology | Drug Discovery | Antimalarials - pharmacology | Malaria - prevention & control | Animals | Antimalarials - chemistry | Polymorphism, Single Nucleotide | Malaria - drug therapy | Plasmodium falciparum - growth & development | Pharmaceutical research | Plasmodium | Care and treatment | Analysis | Research | Drug therapy | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 06/2015, Volume 522, Issue 7556, pp. 315 - 320
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 10/2010, Volume 107, Issue 43, pp. 18640 - 18645
The first step of Plasmodium development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into... 
Hepatocytes | Liver | Sporozoites | Epidermis | Skin | Mice | Parasites | Hair follicles | Merozoites | Parasite hosts | Plasmodium | Intravital imaging | Schizogony | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Anopheles - parasitology | Mice, Inbred C57BL | Plasmodium berghei - genetics | Hair Follicle - parasitology | Mice, Hairless | Skin - parasitology | Green Fluorescent Proteins - genetics | Plasmodium yoelii - growth & development | Plasmodium yoelii - genetics | Sporozoites - growth & development | Epidermis - parasitology | Plasmodium yoelii - pathogenicity | Animals | Malaria - parasitology | Plasmodium berghei - growth & development | Merozoites - growth & development | Host-Parasite Interactions | Malaria - transmission | Dermis - parasitology | Plasmodium berghei - pathogenicity | Plasmodium falciparum | Research | Malaria | Growth | Reproduction, Asexual | Mosquitoes | Pathogenesis | Rodents | Parasitic protozoa | Index Medicus | Skin/parasitology | Epidermis/parasitology | Merozoites/growth & development | Hair Follicle/parasitology | Sporozoites/growth & development | Plasmodium yoelii/growth & development | Life Sciences | Plasmodium yoelii/pathogenicity | Plasmodium berghei/genetics | Microbiology and Parasitology | Plasmodium yoelii/genetics | Malaria/transmission | Anopheles/parasitology | Dermis/parasitology | Green Fluorescent Proteins/genetics | Plasmodium berghei/growth & development | Malaria/parasitology | Plasmodium berghei/pathogenicity | schizogony | Biological Sciences | intravital imaging
Journal Article
Nature (London), ISSN 1476-4687, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
Journal Article
by Hall, N
Science (American Association for the Advancement of Science), ISSN 1095-9203, 01/2005, Volume 307, Issue 5706, pp. 82 - 86
Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data,... 
Transcriptomes | Malaria | Genes | Rodents | Sporozoites | Genomes | Parasites | Gametocytes | Proteomes | Ookinetes | Research Article | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Protozoan - genetics | Plasmodium chabaudi - growth & development | Genome, Protozoan | Oligonucleotide Array Sequence Analysis | Plasmodium berghei - genetics | Genes, Protozoan | Gene Expression Profiling | Plasmodium yoelii - growth & development | RNA, Messenger - metabolism | Plasmodium yoelii - metabolism | Life Cycle Stages | Plasmodium falciparum - genetics | Plasmodium - growth & development | Plasmodium falciparum - metabolism | Transcription, Genetic | 3' Untranslated Regions | Anopheles - parasitology | Plasmodium - genetics | Plasmodium - metabolism | RNA, Messenger - genetics | Computational Biology | Gene Silencing | Selection, Genetic | Proteome - analysis | Plasmodium chabaudi - metabolism | Plasmodium yoelii - genetics | RNA, Protozoan - metabolism | Plasmodium berghei - metabolism | Animals | Plasmodium chabaudi - genetics | Malaria - parasitology | Proteomics | Plasmodium berghei - growth & development | Plasmodium falciparum - growth & development | Protozoan Proteins - analysis | Evolution, Molecular | Plasmodium | Genetic aspects | Research | Parasitic protozoa | Comparative analysis | Genomics | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 03/2016, Volume 5, Issue 2016, pp. 1 - 29
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent... 
artemisinin | evolutionary biology | infectious disease | plasmodium falciparum | microbiology | genomics | drug resistance | malaria | kelch13 | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Malaria, Falciparum - parasitology | Africa - epidemiology | Artemisinins - pharmacology | Plasmodium falciparum - classification | Molecular Epidemiology | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Malaria, Falciparum - epidemiology | Plasmodium falciparum - drug effects | Asia, Southeastern - epidemiology | Drug Resistance | Antimalarials - pharmacology | Drug resistance in microorganisms | Genetic aspects | Malaria | Drug therapy | Gene expression | Health aspects | Medical research | Genomics | Artemisinin | Genomes | Parasites | Epidemiology | Medicine | Studies | Proteins | Health surveillance | Collaboration | Quality control | Genetics | Mutation | Public health | Index Medicus | Malaria, Falciparum/parasitology | Plasmodium falciparum/genetics | Plasmodium falciparum/classification | Antimalarials/pharmacology | Plasmodium falciparum/drug effects | Life Sciences | Africa/epidemiology | Asia, Southeastern/epidemiology | Plasmodium falciparum/isolation & purification | Artemisinins/pharmacology | Malaria, Falciparum/epidemiology
Journal Article