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Nature (London), ISSN 1476-4687, 2010, Volume 465, Issue 7296, pp. 311 - 315
Journal Article
eLife, ISSN 2050-084X, 2016, Volume 5, Issue 2016, pp. 1 - 29
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations... 
artemisinin | evolutionary biology | infectious disease | plasmodium falciparum | microbiology | genomics | drug resistance | malaria | kelch13 | SOFT SWEEPS | PARASITES | MOLECULAR POPULATION-GENETICS | EVOLUTION | SUBSTITUTION MATRICES | SIGNATURES | MECHANISM | PLASMODIUM-FALCIPARUM | ADAPTATION | BIOLOGY | MUTATIONS | Malaria, Falciparum - parasitology | Africa - epidemiology | Artemisinins - pharmacology | Plasmodium falciparum - classification | Molecular Epidemiology | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Malaria, Falciparum - epidemiology | Plasmodium falciparum - drug effects | Asia, Southeastern - epidemiology | Drug Resistance | Antimalarials - pharmacology | Drug resistance in microorganisms | Genetic aspects | Malaria | Drug therapy | Gene expression | Health aspects | Medical research | Genomics | Artemisinin | Genomes | Parasites | Epidemiology | Medicine | Studies | Proteins | Health surveillance | Collaboration | Quality control | Genetics | Mutation | Public health | Malaria, Falciparum/parasitology | Plasmodium falciparum/genetics | Plasmodium falciparum/classification | Antimalarials/pharmacology | Plasmodium falciparum/drug effects | Life Sciences | Africa/epidemiology | Asia, Southeastern/epidemiology | Plasmodium falciparum/isolation & purification | Artemisinins/pharmacology | Malaria, Falciparum/epidemiology
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 361, Issue 5, pp. 455 - 467
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 505, Issue 7481, pp. 50 - 55
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide... 
POINT MUTATIONS | IN-VITRO | ANTIMALARIAL-DRUGS | WESTERN CAMBODIA | VIVO | PARASITE CLEARANCE | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | KEAP1 | KELCH-REPEAT SUPERFAMILY | CHLOROQUINE RESISTANCE | Malaria, Falciparum - drug therapy | Parasitic Sensitivity Tests | Cambodia | Humans | Half-Life | Blood Cells - parasitology | Drug Resistance - drug effects | Protein Structure, Tertiary - genetics | Plasmodium falciparum - drug effects | Mutation - genetics | Protozoan Proteins - genetics | Antimalarials - pharmacology | Drug Resistance - genetics | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Animals | Time Factors | Genetic Markers - genetics | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Alleles | Polymorphism, Single Nucleotide - genetics | Protozoan Proteins - chemistry | Plasmodium falciparum - growth & development | Plasmodium falciparum | Drug resistance in microorganisms | Microbiological research | Physiological aspects | Research | Molecular biology | Health aspects | Medical research | Mutation | Parasites | Malaria | Genomics | Protein Structure, Tertiary | Blood Cells | Malaria, Falciparum | Antimalarials | Protozoan Proteins | Genetic Markers | Life Sciences | Human health and pathology | Infectious diseases | Artemisinins | Polymorphism, Single Nucleotide | Drug Resistance
Journal Article
by Ménard, Didier and Khim, Nimol and Beghain, Johann and Adegnika, Ayola A and Shafiul-Alam, Mohammad and Amodu, Olukemi and Rahim-Awab, Ghulam and Barnadas, Céline and Berry, Antoine and Boum, Yap and Bustos, Maria D and Cao, Jun and Chen, Jun-Hu and Collet, Louis and Cui, Liwang and Thakur, Garib-Das and Dieye, Alioune and Djallé, Djibrine and Dorkenoo, Monique A and Eboumbou-Moukoko, Carole E and Espino, Fe-Esperanza-Caridad J and Fandeur, Thierry and Ferreira-da-Cruz, Maria-Fatima and Fola, Abebe A and Fuehrer, Hans-Peter and Hassan, Abdillahi M and Herrera, Socrates and Hongvanthong, Bouasy and Houzé, Sandrine and Ibrahim, Maman L and Jahirul-Karim, Mohammad and Jiang, Lubin and Kano, Shigeyuki and Ali-Khan, Wasif and Khanthavong, Maniphone and Kremsner, Peter G and Lacerda, Marcus and Leang, Rithea and Leelawong, Mindy and Li, Mei and Lin, Khin and Mazarati, Jean-Baptiste and Ménard, Sandie and Morlais, Isabelle and Muhindo-Mavoko, Hypolite and Musset, Lise and Na-Bangchang, Kesara and Nambozi, Michael and Niaré, Karamoko and Noedl, Harald and Ouédraogo, Jean-Bosco and Pillai, Dylan R and Pradines, Bruno and Quang-Phuc, Bui and Ramharter, Michael and Randrianarivelojosia, Milijaona and Sattabongkot, Jetsumon and Sheikh-Omar, Abdiqani and Silué, Kigbafori D and Sirima, Sodiomon B and Sutherland, Colin and Syafruddin, Din and Tahar, Rachida and Tang, Lin-Hua and Touré, Offianan A and Tshibangu-wa-Tshibangu, Patrick and Vigan-Womas, Inès and Warsame, Marian and Wini, Lyndes and Zakeri, Sedigheh and Kim, Saorin and Eam, Rotha and Berne, Laura and Khean, Chanra and Chy, Sophy and Ken, Malen and Loch, Kaknika and Canier, Lydie and Duru, Valentine and Legrand, Eric and Barale, Jean-Christophe and Stokes, Barbara and Straimer, Judith and Witkowski, Benoit and Fidock, David A and Rogier, Christophe and Ringwald, Pascal and Ariey, Frederic and Mercereau-Puijalon, Odile and KARMA Consortium
The New England journal of medicine, ISSN 1533-4406, 2016, Volume 374, Issue 25, pp. 2453 - 2464
Journal Article
by Ashley, Elizabeth A and Dhorda, Mehul and Fairhurst, Rick M and Amaratunga, Chanaki and Lim, Parath and Suon, Seila and Sreng, Sokunthea and Anderson, Jennifer M and Mao, Sivanna and Sam, Baramey and Sopha, Chantha and Chuor, Char Meng and Nguon, Chea and Sovannaroth, Siv and Pukrittayakamee, Sasithon and Jittamala, Podjanee and Chotivanich, Kesinee and Chutasmit, Kitipumi and Suchatsoonthorn, Chaiyaporn and Runcharoen, Ratchadaporn and Hien, Tran Tinh and Thuy-Nhien, Nguyen Thanh and Thanh, Ngo Viet and Phu, Nguyen Hoan and Htut, Ye and Han, Kay-Thwe and Aye, Kyin Hla and Mokuolu, Olugbenga A and Olaosebikan, Rasaq R and Folaranmi, Olaleke O and Mayxay, Mayfong and Khanthavong, Maniphone and Hongvanthong, Bouasy and Newton, Paul N and Onyamboko, Marie A and Fanello, Caterina I and Tshefu, Antoinette K and Mishra, Neelima and Valecha, Neena and Phyo, Aung Pyae and Nosten, Francois and Yi, Poravuth and Tripura, Rupam and Borrmann, Steffen and Bashraheil, Mahfudh and Peshu, Judy and Faiz, M. Abul and Ghose, Aniruddha and Hossain, M. Amir and Samad, Rasheda and Rahman, M. Ridwanur and Hasan, M. Mahtabuddin and Islam, Akhterul and Miotto, Olivo and Amato, Roberto and MacInnis, Bronwyn and Stalker, Jim and Kwiatkowski, Dominic P and Bozdech, Zbynek and Jeeyapant, Atthanee and Cheah, Phaik Yeong and Sakulthaew, Tharisara and Chalk, Jeremy and Intharabut, Benjamas and Silamut, Kamolrat and Lee, Sue J and Vihokhern, Benchawan and Kunasol, Chanon and Imwong, Mallika and Tarning, Joel and Taylor, Walter J and Yeung, Shunmay and Woodrow, Charles J and Flegg, Jennifer A and Das, Debashish and Smith, Jeffery and Venkatesan, Meera and Plowe, Christopher V and Stepniewska, Kasia and Guerin, Philippe J and Dondorp, Arjen M and Day, Nicholas P and White, Nicholas J and Tracking Resistance to Artemisinin Collaboration (TRAC)
The New England journal of medicine, ISSN 1533-4406, 2014, Volume 371, Issue 5, pp. 411 - 423
Journal Article
The American journal of tropical medicine and hygiene, ISSN 1476-1645, 2014, Volume 91, Issue 4, pp. 833 - 843
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug... 
PLUS SULFADOXINE-PYRIMETHAMINE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PLASMODIUM-FALCIPARUM-PFMDR1 ALLELES | DIHYDROARTEMISININ-PIPERAQUINE | IN-VIVO | TANZANIAN CHILDREN | PFMDR1 COPY NUMBER | UNCOMPLICATED MALARIA | COMBINATION THERAPIES | DRUG-RESISTANCE | TYROSINE-86 ALLELE | TROPICAL MEDICINE | Humans | Fluorenes - therapeutic use | Child, Preschool | Infant | Plasmodium falciparum - drug effects | Protozoan Proteins - genetics | Chloroquine - pharmacology | Membrane Transport Proteins - genetics | Plasmodium falciparum - genetics | Multidrug Resistance-Associated Proteins - genetics | Amodiaquine - therapeutic use | Drug Therapy, Combination | Child | Malaria, Falciparum - drug therapy | Datasets as Topic | Risk Factors | Kaplan-Meier Estimate | Genotype | Antimalarials - therapeutic use | Antimalarials - pharmacology | Polymorphism, Genetic | Drug Resistance - genetics | Malaria, Falciparum - parasitology | Artemisinins - therapeutic use | Genetic Markers - genetics | Artemether | Ethanolamines - therapeutic use | Lumefantrine | Drug Combinations | Amino Acid Substitution | Malaria, Falciparum | Chloroquine | Fluorenes | Antimalarials | Protozoan Proteins | Life Sciences | Plasmodium falciparum | Drug Resistance | Pharmaceutical sciences | Parasitology | Pharmacology | Genetic Markers | Ethanolamines | Human health and pathology | Microbiology and Parasitology | Infectious diseases | Artemisinins | Membrane Transport Proteins | Amodiaquine | Multidrug Resistance-Associated Proteins
Journal Article
Nature genetics, ISSN 1546-1718, 2015, Volume 47, Issue 3, pp. 226 - 234
Journal Article