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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2011, Volume 89, Issue 1, pp. 65 - 74
Four randomized, placebo‐controlled, crossover studies were conducted among 282 healthy subjects to investigate whether an interaction exists between... 
VARIABILITY | LANSOPRAZOLE | RABEPRAZOLE | THERAPY | CARDIOVASCULAR EVENTS | STENT PLACEMENT | PHARMACOLOGY & PHARMACY | OUTCOMES | ANTIPLATELET ACTION | PROTON-PUMP INHIBITORS | DRUG-INTERACTION | Proton Pump Inhibitors - pharmacology | Ticlopidine - pharmacology | Humans | Middle Aged | Half-Life | Male | 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology | Enzyme Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - blood | Young Adult | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Omeprazole - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Enzyme Inhibitors - adverse effects | Proton Pump Inhibitors - adverse effects | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Double-Blind Method | Drug Administration Schedule | 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects | Omeprazole - administration & dosage | Enzyme Inhibitors - pharmacology | Omeprazole - adverse effects | Ticlopidine - analogs & derivatives | Cross-Over Studies | Prodrugs - adverse effects | Prodrugs - pharmacokinetics | Cytochrome P-450 CYP2C19 | Platelet Activation - drug effects | 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage | Prodrugs - pharmacology | Ticlopidine - blood | Omeprazole | Pantoprazole | Drug interactions | Analysis | Dosage and administration | Research | Patients | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 4, pp. 354 - 362
The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel... 
MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | HEALTHY-SUBJECTS | INCREASED RISK | PLATELET INHIBITION | ACUTE CORONARY SYNDROMES | PRASUGREL | ST-SEGMENT ELEVATION | INDIVIDUAL RESPONSIVENESS | ATHEROTHROMBOTIC EVENTS | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Area Under Curve | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Cardiovascular Diseases - genetics | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Genotype | Thrombosis - epidemiology | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Heterozygote | Thrombosis - genetics | Mutation | Usage | Genetic variation | Cytochrome P-450 | Physiological aspects | Causes of | Clopidogrel | Cardiovascular diseases | Health aspects | Risk factors | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
JAMA, ISSN 0098-7484, 08/2009, Volume 302, Issue 8, pp. 849 - 857
Journal Article
ACS Nano, ISSN 1936-0851, 06/2009, Volume 3, Issue 6, pp. 1357 - 1364
Thrombotic disorders have emerged as serious threat to society. As anticoagulant and thrombolytic therapies are usually associated with serious bleeding... 
Antiplatelet | Platelet aggregation | Silver nanoparticles | Phosphotyrosine | Platelet Aggregation Inhibitors - pharmacology | Metal Nanoparticles - chemistry | Silver - chemistry | Index Medicus
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 53, Issue 10, pp. 849 - 856
Objectives The aim of this prospective trial was to assess whether platelet reactivity to clopidogrel assessed with multiple electrode platelet aggregometry... 
Cardiovascular | Internal Medicine | clopidogrel | whole blood aggregometry | stent thrombosis | platelet aggregation | ADVERSE CARDIOVASCULAR EVENTS | PERCUTANEOUS CORONARY INTERVENTION | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | IMPLANTATION | PREDICTORS | RESISTANCE | BARE-METAL | ANTAGONISTS | AGGREGOMETRY | Prospective Studies | Platelet Function Tests - methods | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Kaplan-Meier Estimate | Male | Thrombosis - epidemiology | Coronary Artery Disease - mortality | Electric Impedance | Ticlopidine - analogs & derivatives | Drug-Eluting Stents - adverse effects | Electrodes | Coronary Artery Disease - therapy | Point-of-Care Systems | Thrombosis - etiology | Ticlopidine - adverse effects | Platelet Aggregation Inhibitors - pharmacology | Female | Platelet Function Tests - instrumentation | Aged | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Transluminal angioplasty | Coenzymes | Vasodilators | Adenosine diphosphate | Coronary heart disease | Thrombosis | Stent (Surgery) | Blood clot | Aggregation | Disease transmission | Blood platelets | Analysis | Adenosine triphosphatase | Drug therapy | Intervention | Anticoagulants | Aspirin | Heart attacks | Medical imaging | Cardiovascular disease | Studies | Confidence intervals | Coronary vessels | Acute coronary syndromes | Stents | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 4, pp. 363 - 375
In a cohort of 2208 patients who presented with acute myocardial infarction and were treated with clopidogrel, single-nucleotide polymorphisms in five genes... 
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | HEALTHY JAPANESE SUBJECTS | CONTROLLED TRIAL | MYOCARDIAL-INFARCTION | DUODENAL ENTEROCYTES | OF-FUNCTION POLYMORPHISM | SEQUENCE VARIATIONS | ST-SEGMENT ELEVATION | DRUG RESPONSE | P-GLYCOPROTEIN | Myocardial Infarction - genetics | Myocardial Infarction - epidemiology | Follow-Up Studies | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Myocardial Infarction - therapy | Cytochrome P-450 CYP3A - genetics | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2Y12 | Ticlopidine - adverse effects | Platelet Aggregation Inhibitors - pharmacology | Female | Integrin beta3 - genetics | Registries | Stroke - epidemiology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Mortality | Genotype | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Aged | Mutation | Complications and side effects | Usage | Analysis | Clopidogrel | Cardiovascular diseases | Genetic polymorphisms | Risk factors | Heart attacks | Biomedical research | Angina pectoris | Acute coronary syndromes | Kinases | Index Medicus | Abridged Index Medicus
Journal Article