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1. Full Text The GPIIb/IIIa (integrin {alpha}IIb{beta}3) odyssey: A technology-driven saga of a receptor with twists, turns, and even a bend
by Coller, Barry S and Shattil, Sanford J
Blood, ISSN 0006-4971, 10/2008, Volume 112, Issue 8, pp. 3011 - 3025
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Hematology - history | History, 21st Century | History, 20th Century | Humans | Platelet Aggregation | Thrombasthenia - diagnosis | Animals | Medical Laboratory Science | Hematology - methods | Thrombasthenia - genetics | Fibrinogen - metabolism | Platelet Aggregation Inhibitors - pharmacology | Platelet Glycoprotein GPIIb-IIIa Complex - genetics | Platelet Glycoprotein GPIIb-IIIa Complex - chemistry | Index Medicus | Abridged Index Medicus | ASH 50th Anniversary Review
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2. Full Text Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: A connection to hematogenous metastasis
by Lonsdorf, Anke S and Krämer, Björn F and Fahrleitner, Manuela and Schönberger, Tanja and Gnerlich, Stephan and Ring, Sabine and Gehring, Sarah and Schneider, Stefan W and Kruhlak, Michael J and Meuth, Sven G and Nieswandt, Bernhard and Gawaz, Meinrad and Enk, Alexander H and Langer, Harald F
The Journal of biological chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 3, pp. 2168 - 2178
Blood Platelets - pathology | Melanoma - metabolism | Cell Adhesion - genetics | Cricetinae | Cricetulus | Humans | Antibodies, Neutralizing - pharmacology | Melanoma - pathology | Bone Marrow Neoplasms - genetics | Cell Adhesion - drug effects | Bone Marrow Neoplasms - secondary | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Neoplasm Metastasis | Animals | Bone Marrow Neoplasms - pathology | Blood Platelets - metabolism | Bone Marrow Neoplasms - metabolism | Melanoma - genetics | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Female | Mice | Platelet Glycoprotein GPIIb-IIIa Complex - genetics | CHO Cells | Index Medicus | Molecular Bases of Disease | Integrin | Metastasis | Platelets | Adhesion | Melanoma
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3. Full Text Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb IIIa inhibitor
by Ding, Guangliang and Jiang, Quan and Zhang, Li and Zhang, Zheng Gang and Li, Lian and Knight, Robert A and Ewing, James R and Wang, Ying and Chopp, Michael
Journal of cerebral blood flow and metabolism, ISSN 0271-678X, 01/2005, Volume 25, Issue 1, pp. 87 - 97
Magnetic resonance imaging (MRI) | Platelet | Recombinant tissue plasminogen activator (r-tPA) | Embolic stroke | Glycoprotein GP IIb/IIIa receptor inhibitor | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cardiovascular system | Neurology | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Vascular diseases and vascular malformations of the nervous system | Medical sciences | Vasodilator agents. Cerebral vasodilators | Nervous system (semeiology, syndromes) | Blood Platelets - pathology | Brain - diagnostic imaging | Intracranial Embolism and Thrombosis - diet therapy | Microcirculation - metabolism | Rats, Wistar | Stroke - diagnostic imaging | Male | Intracranial Embolism and Thrombosis - metabolism | Infarction, Middle Cerebral Artery - metabolism | Microcirculation - drug effects | Stroke - pathology | Brain - blood supply | Dextrans | Infarction, Middle Cerebral Artery - drug therapy | Platelet Aggregation - drug effects | Drug Therapy, Combination | Infarction, Middle Cerebral Artery - diagnostic imaging | Middle Cerebral Artery - diagnostic imaging | Cerebrovascular Circulation - drug effects | Rats | Fluorescein-5-isothiocyanate - analogs & derivatives | Middle Cerebral Artery - pathology | Tissue Plasminogen Activator - administration & dosage | Stroke - drug therapy | Infarction, Middle Cerebral Artery - pathology | Recombinant Proteins - administration & dosage | Echo-Planar Imaging | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Intracranial Embolism and Thrombosis - diagnostic imaging | Plasminogen Activators - administration & dosage | Radiography | Immunoglobulin Fab Fragments - administration & dosage | Stroke - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Blood Platelets - metabolism | Brain - pathology | Fibrin - metabolism | Intracranial Embolism and Thrombosis - pathology | Microscopy, Fluorescence | Index Medicus
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4. Full Text FK419, a novel nonpeptide GPIIb IIIa antagonist, restores microvascular patency and improves outcome in the guinea-pig middle cerebral artery thrombotic occlusion model: comparison with tirofiban
by Moriguchi, Akira and Maeda, Masashi and Mihara, Kayoko and Aoki, Toshiaki and Matsuoka, Nobuya and Mutoh, Seitaro
Journal of cerebral blood flow and metabolism, ISSN 0271-678X, 01/2005, Volume 25, Issue 1, pp. 75 - 86
Microcirculation | Platelet | Stroke | Guinea-pig | Tirofiban | FK419 | GPIIb/IIIa | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Neurology | Pharmacology. Drug treatments | Biological and medical sciences | Neuroprotective agent | Vascular diseases and vascular malformations of the nervous system | Medical sciences | Neuropharmacology | Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges | Blood Platelets - pathology | Microcirculation - metabolism | Recovery of Function - drug effects | Reperfusion Injury - drug therapy | Brain Ischemia - metabolism | Male | Propionates - administration & dosage | Infarction, Middle Cerebral Artery - metabolism | Microcirculation - drug effects | Tyrosine - analogs & derivatives | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Platelet Aggregation Inhibitors - administration & dosage | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Infarction, Middle Cerebral Artery - drug therapy | Platelet Aggregation - drug effects | Neutrophils - metabolism | Reperfusion Injury - metabolism | Disease Models, Animal | Neutrophils - pathology | Intracranial Thrombosis - pathology | Piperidines - administration & dosage | Guinea Pigs | Reperfusion Injury - pathology | Cerebrovascular Circulation - drug effects | Infarction, Middle Cerebral Artery - pathology | Intracranial Thrombosis - metabolism | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Animals | Blood Platelets - metabolism | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Brain - pathology | Tyrosine - administration & dosage | Index Medicus
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5. Full Text GPIIb/IIIa inhibitors: From bench to bedside and back to bench again
by P. C. Armstrong and K. Peter
Thrombosis and haemostasis, ISSN 0340-6245, 05/2012, Volume 107, Issue 5, pp. 808 - 814
thrombosis | GP IIb/IIIa | platelet pharmacology | Antiplatelet agents | Invited Clinical Focus | Platelet pharmacology | Thrombosis | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Hematologic and hematopoietic diseases | Biological and medical sciences | Blood coagulation. Blood cells | Molecular and cellular biology | Medical sciences | Platelet diseases and coagulopathies | Risk Assessment | Administration, Oral | Humans | Structure-Activity Relationship | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Animals | Blood Platelets - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Treatment Failure | Drug Design | Platelet Aggregation Inhibitors - chemistry | Ligands | Molecular Structure | Platelet Aggregation - drug effects | Thrombosis - drug therapy | Thrombosis - blood | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects
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6. Full Text Recreation of the Terminal Events in Physiological Integrin Activation
by Feng Ye and Guiqing Hu and Dianne Taylor and Boris Ratnikov and Andrey A. Bobkov and Mark A. McLean and Stephen G. Sligar and Kenneth A. Taylor and Mark H. Ginsberg
The Journal of cell biology, ISSN 0021-9525, 1/2010, Volume 188, Issue 1, pp. 157 - 173
Teeth | Antibodies | Lipids | Ligands | Phospholipids | Liposomes | Platelets | Density | Integrins | Image classification | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Nanostructures - ultrastructure | Cricetinae | Cricetulus | Humans | Models, Molecular | Cryoelectron Microscopy | Animals | Protein Structure, Quaternary | Platelet Glycoprotein GPIIb-IIIa Complex - physiology | Protein Binding | Mutation | Platelet Glycoprotein GPIIb-IIIa Complex - ultrastructure | Platelet Glycoprotein GPIIb-IIIa Complex - genetics | Platelet Glycoprotein GPIIb-IIIa Complex - chemistry | CHO Cells | Physiological aspects | Analysis | Membrane proteins | Proteins | Membranes | Molecular biology | Cells | Cell adhesion & migration | Index Medicus
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