Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 02/2006, Volume 4, Issue 2, pp. 312 - 319
Background: Closure time (CT), measured by platelet function analyzer (PFA‐100®) device, is now available to the clinical laboratory as a possible alternative...
PFA-100(TM) SYSTEM | PERCUTANEOUS CORONARY INTERVENTION | IN-VITRO | PRIMARY HEMOSTASIS | TEMPLATE BLEEDING-TIME | VON-WILLEBRAND-DISEASE | HIGH-SHEAR STRESS | PERIPHERAL VASCULAR DISEASE | HEALTHY-VOLUNTEERS | DYSFUNCTION | HEMATOLOGY | ASPIRIN RESISTANCE | Liver Diseases - blood | Coronary Disease - blood | Hemorrhage - therapy | Cardiopulmonary Bypass - adverse effects | Humans | Blood Platelet Disorders - congenital | Hemorrhage - blood | Blood Platelets - physiology | Blood Platelet Disorders - blood | Blood Platelet Disorders - diagnosis | Platelet Count | Uremia - blood | Platelet Aggregation Inhibitors - pharmacology | Platelet Function Tests - instrumentation | Blood Platelets - drug effects
PFA-100(TM) SYSTEM | PERCUTANEOUS CORONARY INTERVENTION | IN-VITRO | PRIMARY HEMOSTASIS | TEMPLATE BLEEDING-TIME | VON-WILLEBRAND-DISEASE | HIGH-SHEAR STRESS | PERIPHERAL VASCULAR DISEASE | HEALTHY-VOLUNTEERS | DYSFUNCTION | HEMATOLOGY | ASPIRIN RESISTANCE | Liver Diseases - blood | Coronary Disease - blood | Hemorrhage - therapy | Cardiopulmonary Bypass - adverse effects | Humans | Blood Platelet Disorders - congenital | Hemorrhage - blood | Blood Platelets - physiology | Blood Platelet Disorders - blood | Blood Platelet Disorders - diagnosis | Platelet Count | Uremia - blood | Platelet Aggregation Inhibitors - pharmacology | Platelet Function Tests - instrumentation | Blood Platelets - drug effects
Journal Article
JAMA, ISSN 0098-7484, 11/2012, Volume 308, Issue 17, pp. 1785 - 1794
CONTEXT The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically...
TRIAL | REACTIVITY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Body Weight | Age Factors | Ticlopidine - therapeutic use | Humans | Acute Coronary Syndrome - physiopathology | Male | Aspirin - administration & dosage | Angina, Unstable - drug therapy | Platelet Function Tests | Myocardial Ischemia - physiopathology | Female | Myocardial Infarction - physiopathology | Platelet Aggregation Inhibitors - therapeutic use | Stroke | Treatment Outcome | Piperazines - therapeutic use | Myocardial Ischemia - drug therapy | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Myocardial Infarction - drug therapy | Angina, Unstable - physiopathology | Aged | Platelet Activation - drug effects | Clinical trials | Blood platelets | Acute coronary syndromes | Drug therapy | Patients | Clinical outcomes | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
TRIAL | REACTIVITY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Body Weight | Age Factors | Ticlopidine - therapeutic use | Humans | Acute Coronary Syndrome - physiopathology | Male | Aspirin - administration & dosage | Angina, Unstable - drug therapy | Platelet Function Tests | Myocardial Ischemia - physiopathology | Female | Myocardial Infarction - physiopathology | Platelet Aggregation Inhibitors - therapeutic use | Stroke | Treatment Outcome | Piperazines - therapeutic use | Myocardial Ischemia - drug therapy | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Myocardial Infarction - drug therapy | Angina, Unstable - physiopathology | Aged | Platelet Activation - drug effects | Clinical trials | Blood platelets | Acute coronary syndromes | Drug therapy | Patients | Clinical outcomes | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Circulation, ISSN 0009-7322, 09/2010, Volume 122, Issue 11, pp. 1056 - 1067
Background-Reduced renal function is associated with a poorer prognosis and increased bleeding risk in patients with acute coronary syndromes and may therefore...
clopidogrel | mortality | renal function | acute coronary syndrome | bleeding | myocardial infarction | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | MYOCARDIAL-INFARCTION | INSUFFICIENCY | RISK | CLASSIFICATION | IMPACT | EPTIFIBATIDE | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | CHRONIC KIDNEY-DISEASE | Kidney Diseases - physiopathology | Outcome Assessment (Health Care) | Ticlopidine - therapeutic use | Humans | Middle Aged | Acute Coronary Syndrome - physiopathology | Male | Adenosine - adverse effects | Adenosine - therapeutic use | Receptors, Purinergic P2Y12 | Ticlopidine - adverse effects | Cardiovascular Diseases - epidemiology | Female | Kidney Diseases - complications | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - physiopathology | Hemorrhage - epidemiology | Hemorrhage - physiopathology | Risk Factors | Kaplan-Meier Estimate | Purinergic P2 Receptor Antagonists | Treatment Outcome | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Adenosine - analogs & derivatives | Aged | Chronic Disease | Aggregation | Usage | Blood platelets | Patient outcomes | Clopidogrel | Drug therapy | Comparative analysis | Health aspects | Heart attack | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
clopidogrel | mortality | renal function | acute coronary syndrome | bleeding | myocardial infarction | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | MYOCARDIAL-INFARCTION | INSUFFICIENCY | RISK | CLASSIFICATION | IMPACT | EPTIFIBATIDE | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | CHRONIC KIDNEY-DISEASE | Kidney Diseases - physiopathology | Outcome Assessment (Health Care) | Ticlopidine - therapeutic use | Humans | Middle Aged | Acute Coronary Syndrome - physiopathology | Male | Adenosine - adverse effects | Adenosine - therapeutic use | Receptors, Purinergic P2Y12 | Ticlopidine - adverse effects | Cardiovascular Diseases - epidemiology | Female | Kidney Diseases - complications | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Cardiovascular Diseases - physiopathology | Hemorrhage - epidemiology | Hemorrhage - physiopathology | Risk Factors | Kaplan-Meier Estimate | Purinergic P2 Receptor Antagonists | Treatment Outcome | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Adenosine - analogs & derivatives | Aged | Chronic Disease | Aggregation | Usage | Blood platelets | Patient outcomes | Clopidogrel | Drug therapy | Comparative analysis | Health aspects | Heart attack | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
Journal Article
Haematologica, ISSN 0390-6078, 06/2018, Volume 103, Issue 6, pp. e259 - e263
PLATELET DYSFUNCTION | ACTIVATION | DOMAIN | INTEGRIN | MACROTHROMBOCYTOPENIA | PHENOTYPE | HEMATOLOGY | Loss of Function Mutation | Genetic Association Studies | Humans | Erythrocyte Indices | Phenotype | Thrombasthenia - diagnosis | Genes, Dominant | Blood Platelets - metabolism | DNA Mutational Analysis | Pedigree | Thrombasthenia - genetics | Blood Platelets - ultrastructure | Alleles | Platelet Function Tests | Biomarkers | Adult | Female | Integrin beta3 - genetics | Gain of Function Mutation | Amino Acid Substitution | Online Only | Clinical Medicine | Hematologi | Medical and Health Sciences | Hematology | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
2005, Contemporary cardiology, ISBN 1588292444, xi, 397
A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors...
physiopathology | Blood platelets | therapy | physiology | Diagnosis | Blood platelet disorders | Examination | Clinical & internal medicine | Medicine & Public Health | Cardiology
physiopathology | Blood platelets | therapy | physiology | Diagnosis | Blood platelet disorders | Examination | Clinical & internal medicine | Medicine & Public Health | Cardiology
Book
Thrombosis and Haemostasis, ISSN 0340-6245, 2011, Volume 106, Issue 2, pp. 322 - 330
Platelets play a central role in coagulation. Currently, information on platelet function following trauma is limited. We performed a retrospective analysis of...
Acquired coagulation disorders | Haemostasis | Acquired | Platelet pathology/inherited | MANAGEMENT | CONTROL RESUSCITATION | COAGULOPATHY | REPLACEMENT | WHOLE-BLOOD AGGREGOMETRY | CONCENTRATES TRANSFUSION | FIBRINOGEN CONCENTRATE | haemostasis | platelet pathology / inherited | CARDIAC-SURGERY | MAJOR TRAUMA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | acquired | AGGREGATION | Thrombelastography | Platelet Function Tests - methods | Wounds and Injuries - blood | Humans | Middle Aged | Austria - epidemiology | Trauma Centers | Male | Peptide Fragments - pharmacology | Adenosine Diphosphate - pharmacology | Injury Severity Score | Electrodes | Wounds and Injuries - mortality | Platelet Count | Adult | Female | Platelet Function Tests - instrumentation | Collagen - pharmacology | Platelet Aggregation - drug effects | Retrospective Studies
Acquired coagulation disorders | Haemostasis | Acquired | Platelet pathology/inherited | MANAGEMENT | CONTROL RESUSCITATION | COAGULOPATHY | REPLACEMENT | WHOLE-BLOOD AGGREGOMETRY | CONCENTRATES TRANSFUSION | FIBRINOGEN CONCENTRATE | haemostasis | platelet pathology / inherited | CARDIAC-SURGERY | MAJOR TRAUMA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | acquired | AGGREGATION | Thrombelastography | Platelet Function Tests - methods | Wounds and Injuries - blood | Humans | Middle Aged | Austria - epidemiology | Trauma Centers | Male | Peptide Fragments - pharmacology | Adenosine Diphosphate - pharmacology | Injury Severity Score | Electrodes | Wounds and Injuries - mortality | Platelet Count | Adult | Female | Platelet Function Tests - instrumentation | Collagen - pharmacology | Platelet Aggregation - drug effects | Retrospective Studies
Journal Article
Circulation: Cardiovascular Interventions, ISSN 1941-7640, 04/2012, Volume 5, Issue 2, pp. 261 - 269
Background-Aspirin and clopidogrel therapy is associated with a variable bleeding risk in patients undergoing coronary artery bypass graft surgery (CABG). We...
Antiplatelet therapy | Cardiopulmonary bypass | Bleeding | ISCHEMIC EVENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | bleeding | PRACTICE GUIDELINES | MYOCARDIAL-INFARCTION | antiplatelet therapy | RANDOMIZED CONTROLLED-TRIAL | ORAL ANTIPLATELET THERAPY | CARDIAC-SURGERY | cardiopulmonary bypass | BLOOD-TRANSFUSION | OUTCOMES | ST-SEGMENT ELEVATION | INTERVENTION | Thrombelastography | Ticlopidine - therapeutic use | Humans | Middle Aged | Postoperative Hemorrhage - diagnosis | Postoperative Hemorrhage - epidemiology | Male | Blood Transfusion - statistics & numerical data | Chest Tubes | Preoperative Care | Ticlopidine - analogs & derivatives | Drainage - statistics & numerical data | Postoperative Hemorrhage - drug therapy | Watchful Waiting - methods | Platelet Function Tests | Coronary Artery Bypass | Female | Aged | Practice Guidelines as Topic
Antiplatelet therapy | Cardiopulmonary bypass | Bleeding | ISCHEMIC EVENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | bleeding | PRACTICE GUIDELINES | MYOCARDIAL-INFARCTION | antiplatelet therapy | RANDOMIZED CONTROLLED-TRIAL | ORAL ANTIPLATELET THERAPY | CARDIAC-SURGERY | cardiopulmonary bypass | BLOOD-TRANSFUSION | OUTCOMES | ST-SEGMENT ELEVATION | INTERVENTION | Thrombelastography | Ticlopidine - therapeutic use | Humans | Middle Aged | Postoperative Hemorrhage - diagnosis | Postoperative Hemorrhage - epidemiology | Male | Blood Transfusion - statistics & numerical data | Chest Tubes | Preoperative Care | Ticlopidine - analogs & derivatives | Drainage - statistics & numerical data | Postoperative Hemorrhage - drug therapy | Watchful Waiting - methods | Platelet Function Tests | Coronary Artery Bypass | Female | Aged | Practice Guidelines as Topic
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2010, Volume 56, Issue 2, pp. 134 - 143
Objectives: The aim of this study was to assess the association between the loss-of-function cytochrome P450 2C19 (CYP2C19)*2 variant (10 studies, 11,959...
antiplatelet drugs | proton pump inhibitors | genetics | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | CORONARY | AMERICAN-COLLEGE | OMEPRAZOLE | DUAL ANTIPLATELET THERAPY | FUNCTION POLYMORPHISM | ASSOCIATION | PLATELET REACTIVITY | Myocardial Ischemia - chemically induced | Humans | Risk Factors | Ticlopidine - analogs & derivatives | Proton Pump Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - administration & dosage | Sensitivity and Specificity | Alleles | Ticlopidine - adverse effects | Cytochrome P-450 Enzyme System - genetics | Ticlopidine - administration & dosage | Coronary Thrombosis - etiology | Myocardial Ischemia - mortality | Stents | Platelet Aggregation Inhibitors - adverse effects | Studies | Confidence intervals | Stroke | Heart attacks | Publications | Metabolites | Mortality | Coronary vessels | Cardiovascular disease | Drug therapy | Meta-analysis
antiplatelet drugs | proton pump inhibitors | genetics | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | CORONARY | AMERICAN-COLLEGE | OMEPRAZOLE | DUAL ANTIPLATELET THERAPY | FUNCTION POLYMORPHISM | ASSOCIATION | PLATELET REACTIVITY | Myocardial Ischemia - chemically induced | Humans | Risk Factors | Ticlopidine - analogs & derivatives | Proton Pump Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - administration & dosage | Sensitivity and Specificity | Alleles | Ticlopidine - adverse effects | Cytochrome P-450 Enzyme System - genetics | Ticlopidine - administration & dosage | Coronary Thrombosis - etiology | Myocardial Ischemia - mortality | Stents | Platelet Aggregation Inhibitors - adverse effects | Studies | Confidence intervals | Stroke | Heart attacks | Publications | Metabolites | Mortality | Coronary vessels | Cardiovascular disease | Drug therapy | Meta-analysis
Journal Article
JAMA, ISSN 0098-7484, 03/2011, Volume 305, Issue 11, pp. 1097 - 1105
CONTEXT High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a...
MEDICINE, GENERAL & INTERNAL | OF-CARE ASSAY | RESPONSIVENESS | IMPACT | INHIBITION | GENOTYPE | REACTIVITY | POLYMORPHISM | ASPIRIN | ANTIPLATELET THERAPY | ARTERY-DISEASE | Drug-Eluting Stents | Prospective Studies | Double-Blind Method | Hemorrhage - epidemiology | Humans | Middle Aged | Male | Risk | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Dose-Response Relationship, Drug | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Cardiovascular Diseases - mortality | Ticlopidine - administration & dosage | Female | Aged | Myocardial Infarction - prevention & control | Platelet Activation - drug effects | Platelet Aggregation - drug effects | Hemorrhage - chemically induced | Thrombosis - prevention & control | Heart attacks | Angioplasty | Mortality | Clinical trials | Drug therapy | Drug dosages | Thrombosis
MEDICINE, GENERAL & INTERNAL | OF-CARE ASSAY | RESPONSIVENESS | IMPACT | INHIBITION | GENOTYPE | REACTIVITY | POLYMORPHISM | ASPIRIN | ANTIPLATELET THERAPY | ARTERY-DISEASE | Drug-Eluting Stents | Prospective Studies | Double-Blind Method | Hemorrhage - epidemiology | Humans | Middle Aged | Male | Risk | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Dose-Response Relationship, Drug | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Cardiovascular Diseases - mortality | Ticlopidine - administration & dosage | Female | Aged | Myocardial Infarction - prevention & control | Platelet Activation - drug effects | Platelet Aggregation - drug effects | Hemorrhage - chemically induced | Thrombosis - prevention & control | Heart attacks | Angioplasty | Mortality | Clinical trials | Drug therapy | Drug dosages | Thrombosis
Journal Article
JAMA, ISSN 0098-7484, 10/2010, Volume 304, Issue 16, pp. 1821 - 1830
CONTENT Clopidogrel, one of the most commonly prescribed medications, is a prodrug requiring CYP450 biotransformation. Data suggest its pharmacologic effect...
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | RESPONSIVENESS | MYOCARDIAL-INFARCTION | TASK-FORCE | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | PHARMACODYNAMICS | PRASUGREL | ASSOCIATION | PLATELET REACTIVITY | Pharmacogenetics | Thrombosis - chemically induced | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Genotype | Male | Risk | Treatment Outcome | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Cytochrome P-450 CYP2C19 | Ticlopidine - adverse effects | Ticlopidine - metabolism | Acute Coronary Syndrome - therapy | Female | Cardiovascular Diseases - chemically induced | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Drugs | Angioplasty | Medical treatment | Cardiovascular disease | Patients | Clinical outcomes | Meta-analysis
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | RESPONSIVENESS | MYOCARDIAL-INFARCTION | TASK-FORCE | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | PHARMACODYNAMICS | PRASUGREL | ASSOCIATION | PLATELET REACTIVITY | Pharmacogenetics | Thrombosis - chemically induced | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Genotype | Male | Risk | Treatment Outcome | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Cytochrome P-450 CYP2C19 | Ticlopidine - adverse effects | Ticlopidine - metabolism | Acute Coronary Syndrome - therapy | Female | Cardiovascular Diseases - chemically induced | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Drugs | Angioplasty | Medical treatment | Cardiovascular disease | Patients | Clinical outcomes | Meta-analysis
Journal Article
Circulation, ISSN 0009-7322, 06/2007, Volume 115, Issue 25, pp. 3156 - 3164
Background - The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition. Controversy exists on the prevalence of platelet...
Aggregation | Resistance | Aspirin | Platelets | Coronary disease | STROKE | coronary disease | CARDIAC & CARDIOVASCULAR SYSTEMS | CLOPIDOGREL | PROFILE | EFFICACY | BIOSYNTHESIS | aspirin | PERIPHERAL VASCULAR DISEASE | aggregation | platelets | resistance | Prospective Studies | Humans | Middle Aged | Male | Dose-Response Relationship, Drug | Flow Cytometry | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Aspirin - therapeutic use | Collagen - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Drug Resistance | Cyclooxygenase 1 - blood | Coronary Disease - blood | Nephelometry and Turbidimetry | Thrombelastography | Double-Blind Method | Platelet Function Tests - methods | Platelet Glycoprotein GPIIb-IIIa Complex - analysis | Thromboxane B2 - analogs & derivatives | Adenosine Diphosphate - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Cross-Over Studies | Thromboxane B2 - urine | Arachidonic Acid - pharmacology | Physiological aspects | Usage | Drug therapy | Coronary heart disease | Patient outcomes
Aggregation | Resistance | Aspirin | Platelets | Coronary disease | STROKE | coronary disease | CARDIAC & CARDIOVASCULAR SYSTEMS | CLOPIDOGREL | PROFILE | EFFICACY | BIOSYNTHESIS | aspirin | PERIPHERAL VASCULAR DISEASE | aggregation | platelets | resistance | Prospective Studies | Humans | Middle Aged | Male | Dose-Response Relationship, Drug | Flow Cytometry | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Aspirin - therapeutic use | Collagen - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Drug Resistance | Cyclooxygenase 1 - blood | Coronary Disease - blood | Nephelometry and Turbidimetry | Thrombelastography | Double-Blind Method | Platelet Function Tests - methods | Platelet Glycoprotein GPIIb-IIIa Complex - analysis | Thromboxane B2 - analogs & derivatives | Adenosine Diphosphate - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Cross-Over Studies | Thromboxane B2 - urine | Arachidonic Acid - pharmacology | Physiological aspects | Usage | Drug therapy | Coronary heart disease | Patient outcomes
Journal Article
JAMA, ISSN 0098-7484, 12/2011, Volume 306, Issue 24, pp. 2704 - 2714
CONTEXT The US Food and Drug Administration recently recommended that CYP2C19 genotyping be considered prior to prescribing clopidogrel, but the American Heart...
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | GENE VARIANTS | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | CLINICAL-EFFICACY | REACTIVITY | ANTIPLATELET TREATMENT | TREATED PATIENTS | PROTON-PUMP INHIBITORS | GENOME-WIDE ASSOCIATION | Hemorrhage - epidemiology | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Genotype | Risk | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Platelet Function Tests | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Thrombosis - prevention & control | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Genotype & phenotype | Systematic review | Cardiovascular disease | Genetic testing | Meta-analysis
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | GENE VARIANTS | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | CLINICAL-EFFICACY | REACTIVITY | ANTIPLATELET TREATMENT | TREATED PATIENTS | PROTON-PUMP INHIBITORS | GENOME-WIDE ASSOCIATION | Hemorrhage - epidemiology | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Genotype | Risk | Ticlopidine - analogs & derivatives | Angioplasty, Balloon, Coronary | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Platelet Function Tests | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Thrombosis - prevention & control | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Genotype & phenotype | Systematic review | Cardiovascular disease | Genetic testing | Meta-analysis
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 10/2015, Volume 13, Issue 10, pp. 1878 - 1887
Summary Background Systemic hyperfibrinolysis is a lethal phenotype of trauma‐induced coagulopathy. Its pathogenesis is poorly understood. Recent studies have...
fibrinolysis | trauma | fibrinogen | blood platelet disorder | platelet function tests | Platelet function tests | Blood platelet disorder | Fibrinolysis | Trauma | Fibrinogen | SEVERE INJURY | BILE-SALTS | FIBRINOLYSIS SHUTDOWN | HEMORRHAGIC-SHOCK | HYPERFIBRINOLYSIS | ACUTE COAGULOPATHY | FACTOR-XIII | COAGULATION | PERIPHERAL VASCULAR DISEASE | ANTIFIBRINOLYTIC THERAPY | HEMATOLOGY | CLOT STRENGTH | Fibrinolysis - drug effects | Multivariate Analysis | Predictive Value of Tests | Prospective Studies | Blood Viscosity | Humans | Middle Aged | Elasticity | Male | Tissue Plasminogen Activator - therapeutic use | Injury Severity Score | Patient Selection | Adenosine Diphosphate - blood | Calcium - blood | Fibrinolytic Agents - therapeutic use | Platelet Function Tests | Thrombolytic Therapy - methods | Adult | Female | Blood Platelets - drug effects | Wounds and Injuries - blood | Linear Models | Treatment Outcome | Biomarkers - blood | Blood Platelets - metabolism | Fibrinogen - metabolism | Wounds and Injuries - diagnosis | Wounds and Injuries - drug therapy | Measurement | Medicine, Experimental | Medical research | Fibrin | Analysis | Viscoelasticity | Pathogenesis
fibrinolysis | trauma | fibrinogen | blood platelet disorder | platelet function tests | Platelet function tests | Blood platelet disorder | Fibrinolysis | Trauma | Fibrinogen | SEVERE INJURY | BILE-SALTS | FIBRINOLYSIS SHUTDOWN | HEMORRHAGIC-SHOCK | HYPERFIBRINOLYSIS | ACUTE COAGULOPATHY | FACTOR-XIII | COAGULATION | PERIPHERAL VASCULAR DISEASE | ANTIFIBRINOLYTIC THERAPY | HEMATOLOGY | CLOT STRENGTH | Fibrinolysis - drug effects | Multivariate Analysis | Predictive Value of Tests | Prospective Studies | Blood Viscosity | Humans | Middle Aged | Elasticity | Male | Tissue Plasminogen Activator - therapeutic use | Injury Severity Score | Patient Selection | Adenosine Diphosphate - blood | Calcium - blood | Fibrinolytic Agents - therapeutic use | Platelet Function Tests | Thrombolytic Therapy - methods | Adult | Female | Blood Platelets - drug effects | Wounds and Injuries - blood | Linear Models | Treatment Outcome | Biomarkers - blood | Blood Platelets - metabolism | Fibrinogen - metabolism | Wounds and Injuries - diagnosis | Wounds and Injuries - drug therapy | Measurement | Medicine, Experimental | Medical research | Fibrin | Analysis | Viscoelasticity | Pathogenesis
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2009, Volume 53, Issue 8, pp. 667 - 677
Objective: This study was conducted to assess the thromboxane (TX) dependence of biochemical and functional indexes used to monitor the effect of low-dose...
aspirin | prostaglandins | antiplatelet drugs | platelets | pharmacology | STROKE | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | THERAPY | ATHEROTHROMBOSIS | HEALTHY-SUBJECTS | THROMBOXANE | BIOSYNTHESIS | CARDIOVASCULAR-DISEASE | PREVENTION | RISK | Thromboxane B2 - metabolism | Humans | Cyclooxygenase Inhibitors - administration & dosage | Male | Thrombopoietin - blood | Adenosine Diphosphate - pharmacology | Aspirin - administration & dosage | Young Adult | Blood Platelets - cytology | Blood Platelets - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Cyclooxygenase 2 - metabolism | Platelet Function Tests | Adult | Female | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Drug Resistance | Aspirin | Blood platelets | Womens health | Collagen | Software | Nonsteroidal anti-inflammatory drugs | Drug therapy | Variance analysis | Drug dosages
aspirin | prostaglandins | antiplatelet drugs | platelets | pharmacology | STROKE | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | THERAPY | ATHEROTHROMBOSIS | HEALTHY-SUBJECTS | THROMBOXANE | BIOSYNTHESIS | CARDIOVASCULAR-DISEASE | PREVENTION | RISK | Thromboxane B2 - metabolism | Humans | Cyclooxygenase Inhibitors - administration & dosage | Male | Thrombopoietin - blood | Adenosine Diphosphate - pharmacology | Aspirin - administration & dosage | Young Adult | Blood Platelets - cytology | Blood Platelets - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Cyclooxygenase 2 - metabolism | Platelet Function Tests | Adult | Female | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Drug Resistance | Aspirin | Blood platelets | Womens health | Collagen | Software | Nonsteroidal anti-inflammatory drugs | Drug therapy | Variance analysis | Drug dosages
Journal Article