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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 5, pp. 382 - 393
A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here, we demonstrate that a small regulatory microRNA, miR-296,... 
CELLCYCLE | THERAPY | ONCOLOGY | VASCULAR INTEGRITY | IN-VIVO | GENE-EXPRESSION | DEGRADATION | TARGETS | OCULAR NEOVASCULARIZATION | TUMOR ANGIOGENESIS | MICRORNAS | CANCER | CELL BIOLOGY | Endothelium, Vascular - cytology | Luciferases - metabolism | MicroRNAs - antagonists & inhibitors | Humans | Neovascularization, Pathologic | Molecular Sequence Data | MicroRNAs - metabolism | Brain Neoplasms - blood supply | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Kidney - metabolism | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Oligonucleotides - pharmacology | Base Sequence | RNA, Messenger - antagonists & inhibitors | Glioma - therapy | Umbilical Veins - cytology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Signal Transduction | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Kidney - cytology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Blotting, Western | Hepatocyte Growth Factor - metabolism | Glioma - blood supply | Xenograft Model Antitumor Assays | Magnetic Resonance Imaging | Animals | Endothelium, Vascular - metabolism | Brain Neoplasms - therapy | Fluorescent Antibody Technique | Mice | MicroRNAs - genetics | Cell Movement | Umbilical Veins - metabolism | Tyrosine | Medical colleges | Neurosciences | Messenger RNA | Gliomas | Oncology, Experimental | Brain tumors | Research | Growth factors | Cancer | Endothelium | Index Medicus | PDGFR | VEGFR | miRNA | cancer | HGS | angiogenesis
Journal Article
Cancer Research, ISSN 0008-5472, 06/2008, Volume 68, Issue 12, pp. 4774 - 4782
Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a novel treatment modality in oncology.... 
CELLS | POTENT | ONCOLOGY | CRYSTAL-STRUCTURE | VEGF | KINASE INHIBITORS | TYROSINE KINASES | TUMOR ANGIOGENESIS | SORAFENIB | CANCER | ENDOTHELIAL GROWTH-FACTOR | Endothelium, Vascular - cytology | Pericytes - drug effects | Apoptosis - drug effects | Humans | Pericytes - cytology | Rats, Inbred F344 | Indoles - chemical synthesis | Endothelium, Vascular - drug effects | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - immunology | Enzyme Inhibitors - chemical synthesis | Neoplasms, Experimental - pathology | Tissue Distribution | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Female | Molecular Structure | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Signal Transduction | Pericytes - metabolism | Cells, Cultured | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Rats | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Enzyme Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Animals | Endothelium, Vascular - metabolism | Mice, Nude | Blood Coagulation Factors - antagonists & inhibitors | Receptors, Fibroblast Growth Factor - metabolism | Indoles - pharmacokinetics | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - metabolism | Neoplasms, Experimental - drug therapy | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2007, Volume 117, Issue 10, pp. 2766 - 2777
Tumors produce multiple growth factors, but little is known about the interplay between various angiogenic factors in promoting tumor angiogenesis, growth, and... 
MEDICINE, RESEARCH & EXPERIMENTAL | INHIBITION | THERAPY | ALPHA-RECEPTOR | LYMPHANGIOGENESIS | FIBROBLAST-GROWTH-FACTOR | EMERGING MECHANISMS | CELL-GROWTH | CANCER | LYMPHATIC METASTASIS | BETA-RECEPTOR | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Humans | Fibroblast Growth Factor 2 - pharmacology | Endothelium, Vascular - drug effects | Fibrosarcoma - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Platelet-Derived Growth Factor - genetics | Fibrosarcoma - pathology | Lung Neoplasms - secondary | Pericytes - pathology | Fibroblast Growth Factor 2 - metabolism | Capillaries | Fibrosarcoma - blood | Muscle, Smooth, Vascular - drug effects | Promoter Regions, Genetic | Signal Transduction | Proto-Oncogene Proteins c-sis | Pericytes - metabolism | Rats | Platelet-Derived Growth Factor - pharmacology | Mice, SCID | Muscle, Smooth, Vascular - pathology | Platelet-Derived Growth Factor - metabolism | Animals | Fibroblast Growth Factor 2 - genetics | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Cell Movement | Complications and side effects | Causes of | Development and progression | Metastasis | Research | Neovascularization | Growth factors | Index Medicus | Abridged Index Medicus | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2008, Volume 178, Issue 1, pp. 81 - 88
Journal Article
Journal Article
Cell, ISSN 0092-8674, 01/2018, Volume 172, Issue 3, pp. 534 - 548.e19
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 347 - 364
Journal Article
Gut, ISSN 0017-5749, 12/2014, Volume 63, Issue 12, pp. 1951 - 1959
Journal Article