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Genes & development, ISSN 0890-9369, 2008, Volume 22, Issue 10, pp. 1276 - 1312
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years... 
Development | PDGF receptor | Platelet-derived growth factor | Fibrosis | Cancer | development | platelet-derived growth factor | DEVELOPMENTAL BIOLOGY | FACTOR-B-CHAIN | FACTOR-RECEPTOR-BETA | CELL BIOLOGY | SIMIAN SARCOMA-VIRUS | GENETICS & HEREDITY | PDGF-ALPHA-RECEPTOR | FACTOR-A-CHAIN | TYROSINE KINASE INHIBITOR | cancer | fibrosis | SMOOTH-MUSCLE-CELLS | IDIOPATHIC HYPEREOSINOPHILIC SYNDROME | HEPARAN-SULFATE PROTEOGLYCANS | GASTROINTESTINAL STROMAL TUMORS | Receptors, Vascular Endothelial Growth Factor - physiology | Genetic Predisposition to Disease | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Embryo, Mammalian | Humans | Embryonic Development - genetics | Receptors, Platelet-Derived Growth Factor - genetics | Receptors, Platelet-Derived Growth Factor - physiology | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Organogenesis | Disease - etiology | Tissue Distribution | Platelet-Derived Growth Factor - metabolism | Animals | Models, Biological | Signal Transduction - physiology | Polymorphism, Single Nucleotide | Receptors, Vascular Endothelial Growth Factor - genetics | Bone and Bones - embryology | Nervous System - embryology | Platelet-Derived Growth Factor - physiology | Vascular Endothelial Growth Factor A - physiology | Cardiovascular System - embryology | Tyrosine | Hematopoiesis | Pharmacology | Research | Chemical properties | Phosphotransferases | Health aspects | Review
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61426
.... Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric... 
THERAPY | PLATELETS | MULTIDISCIPLINARY SCIENCES | INJURY | PREVALENCE | RELEASE | LIVER-DISEASE | PEPTIC-ULCER | PORTAL-HYPERTENSION | Demography | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Middle Aged | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - blood | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Stomach Ulcer - complications | Angiogenesis Inducing Agents - metabolism | Fibroblast Growth Factor 2 - metabolism | Female | Stomach Ulcer - genetics | Liver Cirrhosis - genetics | Receptor, Platelet-Derived Growth Factor beta - metabolism | Vascular Endothelial Growth Factor Receptor-1 - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Liver Cirrhosis - complications | RNA, Messenger - genetics | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Cell Surface - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Platelet-Derived Growth Factor - metabolism | Platelet Count | Stomach Ulcer - blood | Fibroblast Growth Factor 2 - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Receptors, Cell Surface - genetics | RNA | Peptic ulcer | Comparative analysis | Vascular endothelial growth factor | Health aspects | Liver cirrhosis | Growth factors | Fibroblast growth factor | Platelet-derived growth factor | Pathogenesis | Mucosa | mRNA | Angiogenesis | Receptors | Blood platelets | Rodents | Gastroenterology | Nonsteroidal anti-inflammatory drugs | Endoscopy | Fibroblast growth factor receptor 1 | Fibroblast growth factor receptor 2 | Deoxyribonucleic acid--DNA | Fibroblast growth factor 2 | Thrombocytopenia | Liver diseases | Patients | Medicine | Hospitals | Biopsy | Ulcers | Platelets | Deoxyribonucleic acid | DNA
Journal Article
The oncologist (Dayton, Ohio), ISSN 1549-490X, 2015, Volume 20, Issue 6, pp. 660 - 673
Journal Article
Sports Medicine, ISSN 0112-1642, 2003, Volume 33, Issue 5, pp. 381 - 394
.... Growth factors represent one of the most important of the molecular families involved in healing, and a considerable number of studies have been undertaken in an effort to elucidate their many functions... 
Tendon injuries | Connective tissue disorders | Growth factors, pharmacodynamics | Medicine & Public Health | Sports Medicine | SPORT SCIENCES | FACTOR-BETA | MEDIAL COLLATERAL LIGAMENT | MESSENGER-RNA | FACTOR-BB | RAT | TISSUE-REPAIR | FACTOR EXPRESSION | FACTOR-I | MODEL | BINDING-PROTEINS | Vascular Endothelial Growth Factor A | Insulin-Like Growth Factor I - pharmacology | Tendons - drug effects | Vascular Endothelial Growth Factors | Humans | Fibroblast Growth Factor 2 - pharmacology | Tendon Injuries - physiopathology | Endothelial Growth Factors - pharmacology | Intercellular Signaling Peptides and Proteins - physiology | Ligaments - physiopathology | Fibroblast Growth Factor 2 - physiology | Lymphokines - pharmacology | Wound Healing - drug effects | Endothelial Growth Factors - physiology | Ligaments - drug effects | Lymphokines - physiology | Transforming Growth Factor beta - physiology | Platelet-Derived Growth Factor - pharmacology | Transforming Growth Factor beta - pharmacology | Tendons - physiopathology | Animals | Insulin-Like Growth Factor I - physiology | Growth Substances - physiology | Intercellular Signaling Peptides and Proteins - pharmacology | Growth Substances - pharmacology | Wound Healing - physiology | Platelet-Derived Growth Factor - physiology
Journal Article
PLoS medicine, ISSN 1549-1676, 2008, Volume 5, Issue 1, pp. e19 - 0138
Background Important support functions, including promotion of tumor growth, angiogenesis, and invasion, have been attributed to the different cell types populating the tumor stroma, i.e... 
HUMAN BREAST-CARCINOMA | MEDICINE, GENERAL & INTERNAL | TGF-BETA | GROWTH-FACTOR-RECEPTOR | SQUAMOUS CARCINOGENESIS | TYPE-16 TRANSGENIC MICE | FACTOR-BETA-RECEPTOR | CELL INVASION | MOUSE MODEL | TISSUE STROMA | CERVICAL-CANCER | Fibroblast Growth Factor 7 - physiology | Fibroblasts - enzymology | Uterine Cervical Neoplasms - blood supply | Humans | Carcinoma - virology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Receptors, Platelet-Derived Growth Factor - physiology | Proto-Oncogene Proteins c-kit - biosynthesis | Neovascularization, Pathologic - physiopathology | Neoplasm Proteins - genetics | Carcinoma - drug therapy | Estradiol - administration & dosage | Receptors, Platelet-Derived Growth Factor - genetics | Mice, Transgenic | Piperazines - therapeutic use | Uterine Cervical Neoplasms - physiopathology | Pyrimidines - pharmacology | Fibroblast Growth Factor 7 - biosynthesis | Piperazines - pharmacology | Carcinoma - physiopathology | Stromal Cells - secretion | Fibroblast Growth Factor 2 - genetics | Neovascularization, Pathologic - drug therapy | Fibroblasts - drug effects | Carcinoma - blood supply | Mice | Fibroblasts - secretion | Epithelial Cells - metabolism | Neoplasm Proteins - physiology | Platelet-Derived Growth Factor - genetics | Human papillomavirus 16 | Paracrine Communication - physiology | Stromal Cells - enzymology | Stromal Cells - drug effects | Female | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Fibroblast Growth Factor 2 - physiology | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Neoplasm Proteins - biosynthesis | Pericytes - metabolism | Fibroblast Growth Factor 2 - biosynthesis | Uterine Cervical Neoplasms - drug therapy | Mice, Inbred Strains | Imatinib Mesylate | Fibroblast Growth Factor 7 - genetics | Animals | Estradiol - toxicity | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Paracrine Communication - drug effects | Uterine Cervical Neoplasms - virology | Protein Kinase Inhibitors - pharmacology | Benzamides | Platelet-Derived Growth Factor - physiology | Platelet-Derived Growth Factor - antagonists & inhibitors | Proteins | Medical research | Human papillomavirus | Cervical cancer | Tumors | Index Medicus | Oncology | Gynecological | Chemotherapy | Cancer
Journal Article
by Wang, LP and Wan, MJ and Li, ZM and Zhong, NY and Liang, DL and Ge, LH
MOLECULAR MEDICINE REPORTS, ISSN 1791-2997, 08/2019, Volume 20, Issue 2, pp. 1039 - 1048
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2018, Volume 22, Issue 9, pp. 4545 - 4549
Recently, platelet‐derived growth factors present in lysates became an extreme interest in the field of regenerative medicine such as in wound healing and as substitutes to foetal bovine serum in xeno... 
megakaryocytes | growth factors | platelet lysate | regenerative medicine | MEDICINE, RESEARCH & EXPERIMENTAL | BONE-MARROW | GROWTH-FACTORS | STROMAL CELLS | CULTURE | REFRACTORINESS | CELL BIOLOGY | Vascular Endothelial Growth Factor A - biosynthesis | Cell Proliferation | Humans | Insulin-Like Growth Factor I - genetics | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Regenerative Medicine - methods | RNA, Messenger - biosynthesis | Platelet-Derived Growth Factor - biosynthesis | Blood Platelets - cytology | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Megakaryocytes - cytology | Megakaryocytes - metabolism | Thromboplastin - biosynthesis | Transforming Growth Factor beta1 - biosynthesis | Induced Pluripotent Stem Cells - metabolism | Gene Expression | Insulin-Like Growth Factor I - biosynthesis | Epidermal Growth Factor - biosynthesis | Epidermal Growth Factor - genetics | RNA, Messenger - genetics | Cell Extracts - chemistry | Transforming Growth Factor beta1 - genetics | Blood Platelets - metabolism | Thromboplastin - genetics | Primary Cell Culture | Transforming growth factors | Vascular endothelial growth factor | Stem cells | Cell culture | Wound healing | Transcription | Tissue engineering | Transforming growth factor | Tissue factor | Insulin-like growth factors | Insulin | Endothelial cells | Regeneration (physiology) | Proteins | Regeneration | Lysates | Epidermal growth factor | Megakaryocytes | Platelets | Growth factors | Pluripotency | Inhibitory postsynaptic potentials | Short Communications | Short Communication
Journal Article
Clinical & Experimental Ophthalmology, ISSN 1442-6404, 11/2008, Volume 36, Issue 8, pp. 717 - 720
Background:  To perform a comprehensive serum growth factor analysis in dry eye syndrome patients and to compare this with matched controls. Methods... 
growth factor | anterior segment | autologous serum | dry eye syndrome | Dry eye syndrome | Autologous serum | Anterior segment | Growth factor | DROPS | MAINTENANCE | DISEASE | OPHTHALMOLOGY | EYEDROPS | Fibroblast Growth Factor 7 - blood | Proto-Oncogene Proteins c-sis | Humans | Middle Aged | Vascular Endothelial Growth Factor A - blood | Brain-Derived Neurotrophic Factor - blood | Insulin-Like Growth Factor I - analysis | Fibroblast Growth Factor 2 - blood | Case-Control Studies | Epidermal Growth Factor - blood | Intercellular Signaling Peptides and Proteins - blood | Nerve Growth Factor - blood | Hepatocyte Growth Factor - blood | Dry Eye Syndromes - blood | Platelet-Derived Growth Factor - analysis | Aged, 80 and over | Ophthalmic Solutions | Female | Transforming Growth Factor beta2 - blood | Aged | Transforming Growth Factor beta1 - blood | Dry Eye Syndromes - etiology | Nerve Growth Factor, blood | Platelet-Derived Growth Factor, analysis | Intercellular Signaling Peptides and Proteins, blood | Transforming Growth Factor beta1, blood | Transforming Growth Factor beta2, blood | Dry Eye Syndromes, etiology | Fibroblast Growth Factor 7, blood | Brain-Derived Neurotrophic Factor, blood | Insulin-Like Growth Factor I, analysis | Fibroblast Growth Factor 2, blood | Hepatocyte Growth Factor, blood | Vascular Endothelial Growth Factor A, blood | Epidermal Growth Factor, blood | Dry Eye Syndromes, blood | Peptides | Analysis | Eye diseases | Nerve growth factor | Ophthalmology | Growth factors | Vascular endothelial growth factor
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2018, Volume 233, Issue 3, pp. 2067 - 2074
.... Fibroblasts were stimulated with transforming growth factor β1 (TGF‐β1), and then treated either with a specific fibrosis pathway inhibitor targeting TGF‐β receptor type 1 (TβRI), platelet... 
carpal tunnel syndrome | fibrosis | subsynovial connective tissue | transforming growth factor β | CANCER-CELLS | SUBSYNOVIAL CONNECTIVE-TISSUE | ATTENUATES LIVER FIBROSIS | PHYSIOLOGY | TGF-BETA | transforming growth factor beta | SYSTEMIC-SCLEROSIS | PDGF RECEPTOR | CELL BIOLOGY | RENAL FIBROSIS | GROWTH-FACTOR-BETA | RECEPTOR TYROSINE KINASES | LUNG-DISEASE | Fibrosis - drug therapy | ErbB Receptors - antagonists & inhibitors | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Collagen Type III - biosynthesis | Connective Tissue - pathology | Humans | Cells, Cultured | Synovial Membrane - pathology | Collagen Type III - genetics | Connective Tissue Growth Factor - biosynthesis | Plasminogen Activator Inhibitor 1 - biosynthesis | Carpal Tunnel Syndrome - pathology | Collagen Type I - biosynthesis | Collagen Type I - genetics | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Connective Tissue Growth Factor - genetics | Fibrosis - pathology | Plasminogen Activator Inhibitor 1 - genetics | Carpal Tunnel Syndrome - drug therapy | Transforming Growth Factor beta - metabolism | Synovial Membrane - cytology | Connective Tissue Cells - cytology | Fibroblasts - metabolism | Carpal tunnel syndrome | Collagen | Analysis | Genes | Gene expression | Vascular endothelial growth factor | Growth factors | Smad protein | Collagen (type I) | Platelet-derived growth factor | Epidermal growth factor receptors | Gene regulation | Overuse injuries | Collagen (type III) | Connective tissue growth factor | Patients | Vascular endothelial growth factor receptors | Polymerase chain reaction | Connective tissues | Signal transduction | Signaling | Epidermal growth factor | Down-regulation | Fibrosis | Fibroblasts | Inhibition | Subsynovial connective tissue
Journal Article
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 2017, Volume 171, pp. 30 - 42
Pericytes are a heterogeneous population of cells located in the blood vessel wall. They were first identified in the 19th century by Rouget, however their... 
Pericytes | Perivascular stem cells | Diabetic retinopathy | Diabetic nephropathy | Pericyte fibrosis | Cancer stem cells | DIABETIC-RETINOPATHY | Cancer stern cells | VEGF-A | BLOOD-BRAIN-BARRIER | MESENCHYMAL STEM-CELLS | EPITHELIUM-DERIVED FACTOR | HIGH GLUCOSE | PHARMACOLOGY & PHARMACY | STROMAL CELLS | TUMOR-GROWTH | GLYCATION END-PRODUCTS | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - therapy | Animals | Diabetes Mellitus - physiopathology | Vascular Diseases - therapy | Diabetes Mellitus - therapy | Humans | Pericytes - cytology | Ischemia - therapy | Vascular Diseases - physiopathology | Ischemia - physiopathology | Molecular Targeted Therapy | Neoplasms - pathology | Blood circulation disorders | Therapeutics | Homeopathy | Materia medica and therapeutics | Impotence | Diabetic nephropathies | T cells | Muscle proteins | Cardiovascular agents | Blood coagulation factor VIII | Interleukins | Chronic kidney failure | Type 1 diabetes | Stem cells | Vascular endothelial growth factor | Mitogens | Protein kinases | Growth factors | UUO, unilateral ureteric obstruction | EGFR, EGF receptor | EMT, epithelial-mesenchymal transition | SFT, solitary fibrous tumour | DAN, diabetic autonomous neuropathy | ECM, extracellular matrix | NRF2, nuclear factor (erythroid-derived 2)-like 2 | IL-6, interleukin 6 | PSC, perivascular stem cell | BBB, blood-brain barrier | SOD, super oxide dismutase | HIF, hypoxia inducible factor | ED, erectile dysfunction | SDF-1, stromal derived factor 1 | RAGE, receptors of AGEs | CKD, chronic kidney disease | MMP, matrix metalloproteinases | MDSC, myeloid-derived suppressor cells | DN, diabetic nephropathy | TGF β, transforming growth factor β | PDL-1, programmed death-ligand 1 | ANG2, angiopoietin-2 | Olmfl3, Olfactomedin-like 3 | VEGF, vascular endothelial growth factor | AGE, Advanced Glycation End-Products | EC, endothelial cells | NG2, neural | R, ischemia-reperfusion | MSC, mesenchymal stromal cell | MF-EGF8, milk fat globule epidermal growth factor VIII | IL-8, interleukin 8 | glial antigen 2 | T1D, type 1 diabetic | PDGFb, platelet-derived growth factor B | MAPK, mitogen-activated protein kinase | PDGFRβ, platelet derived growth factor receptor β | DR, diabetic retinopathy | CNS, blood-retinal barrier | HB-EGF, heparin-binding EGF-like growth factor | HPC, hemangiopericytoma | PDR, proliferative diabetic retinopathy | DME, diabetic macular oedema | GFR, glomerular filtration rate | MI, myocardial infarction | SMA, smooth muscle actin | CSC, cancer stem cell | NPDR, non-proliferative diabetic retinopathy | T2D, type 2 diabetic | ROS, reactive oxygen species | Treg, regulatory T cells | BRB, blood-retina barrier | PKC, protein kinase C | DPN, diabetic peripheral neuropathy | TME, tumour microenvironment | ANG1, angiopoietin-1 | GSC, glioblastoma CSC | iPS, induced pluripotent stem cells | GSI, g-secretase inhibitor | FGF-9, fibroblastic growth factor 9 | PEDF, Pigment Epithelium-Derived Factor
Journal Article