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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 263 - 267
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 5, pp. 382 - 393
A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here, we demonstrate that a small regulatory microRNA, miR-296,... 
CELLCYCLE | THERAPY | ONCOLOGY | VASCULAR INTEGRITY | IN-VIVO | GENE-EXPRESSION | DEGRADATION | TARGETS | OCULAR NEOVASCULARIZATION | TUMOR ANGIOGENESIS | MICRORNAS | CANCER | CELL BIOLOGY | Endothelium, Vascular - cytology | Luciferases - metabolism | MicroRNAs - antagonists & inhibitors | Humans | Neovascularization, Pathologic | Molecular Sequence Data | MicroRNAs - metabolism | Brain Neoplasms - blood supply | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Kidney - metabolism | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Oligonucleotides - pharmacology | Base Sequence | RNA, Messenger - antagonists & inhibitors | Glioma - therapy | Umbilical Veins - cytology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Signal Transduction | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Kidney - cytology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Blotting, Western | Hepatocyte Growth Factor - metabolism | Glioma - blood supply | Xenograft Model Antitumor Assays | Magnetic Resonance Imaging | Animals | Endothelium, Vascular - metabolism | Brain Neoplasms - therapy | Fluorescent Antibody Technique | Mice | MicroRNAs - genetics | Cell Movement | Umbilical Veins - metabolism | Tyrosine | Medical colleges | Neurosciences | Messenger RNA | Gliomas | Oncology, Experimental | Brain tumors | Research | Growth factors | Cancer | Endothelium | Index Medicus | PDGFR | VEGFR | miRNA | cancer | HGS | angiogenesis
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2007, Volume 177, Issue 3, pp. 489 - 500
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 06/2012, Volume 26, Issue 11, pp. 1247 - 1262
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0178619 - e0178619
Cardiac fibrosis is a significant global health problem with limited treatment choices. Although previous studies have shown that imatinib (IMA) inhibited... 
TYROSINE KINASE INHIBITORS | MYOCARDIAL FIBROSIS | REMODELING FOLLOWING INFARCTION | MULTIDISCIPLINARY SCIENCES | SYSTEMIC FIBROSIS | FIBROBLAST PROLIFERATION | ANGIOTENSIN-II | CONGESTIVE-HEART-FAILURE | PDGF RECEPTOR | CHRONIC MYELOID-LEUKEMIA | TRANSGENIC MICE | Cell Survival - drug effects | Phosphorylation | Echocardiography | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Gene Expression - drug effects | Imatinib Mesylate - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Heart Diseases - prevention & control | Male | Ventricular Remodeling | Animals | Receptors, Platelet-Derived Growth Factor - metabolism | Isoproterenol - pharmacology | Mice | Heart Diseases - diagnostic imaging | Fibrosis - prevention & control | Heart Diseases - chemically induced | Heart Diseases - genetics | Psychological aspects | Care and treatment | Platelet-derived growth factor | Heart enlargement | Fibrosis | Dosage and administration | Isoproterenol | Heart | Heart attacks | Syngeneic grafts | Heart surgery | Collagens | Smooth muscle | Receptors | Fibroblasts | Inhibition | Growth factors | Public health | Heart failure | Imatinib | Growth factor receptors | Gene expression | Wall thickness | Hospitals | Hypertrophy | Transcription | Leukemia | Genes | Activation | Matrix metalloproteinase | Kinases | Accumulation | Blood platelets | Actin | Rodents | Xenografts | Attenuation | Tumor necrosis factor-TNF | Metalloproteinase | Heart diseases | Platelet-derived growth factor receptors | Hypertension | Health | Markers | Data processing | Gelatinase B | Medical prognosis | Collagen | Ventricle | Laboratory animals | Platelets | Apoptosis | Index Medicus
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2001, Volume 61, Issue 7, pp. 2929 - 2934
Journal Article
Journal Article