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1. Full Text Stimuli-Responsive Metal-Ligand Assemblies
by McConnell, Anna J and Wood, Christopher S and Neelakandan, Prakash P and Nitschke, Jonathan R
Chemical Reviews, ISSN 0009-2665, 2015, Volume 115, Issue 15, pp. 7729 - 7793
DOUBLE-DECKER PORPHYRIN | DYNAMIC CHEMICAL-DEVICES | PHOTOLUMINESCENCE PROPERTIES | MECHANOCHROMIC LUMINESCENCE | SUPRAMOLECULAR POLYMERS | TRANSITION-METAL | MOLECULAR REDOX-SWITCHES | PLATINUM(II) COMPLEX | CHEMISTRY-BASED APPROACH | COORDINATION POLYMERS | CHEMISTRY, MULTIDISCIPLINARY | Ligands | Organometallic Compounds - chemistry | Polymers - chemistry | Macrocyclic Compounds - chemistry | Metals - chemistry | Humans | Molecular mechanics | Chemical properties | Transition metal compounds | Polymers | Cyclic compounds | Analysis
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2. Full Text Organometallic Compounds: An Opportunity for Chemical Biology?
by Patra, Malay and Gasser, Gilles
ChemBioChem, ISSN 1439-4227, 06/2012, Volume 13, Issue 9, pp. 1232 - 1252
Organometallic compounds are renowned for their remarkable applications in the field of catalysis, but much less is known about their potential in chemical... 
organometallic compounds | organometallic chemical biology | bioorganometallic chemistry | imaging agents | bioinorganic chemistry | Bioorganometallic chemistry | Imaging agents | Bioinorganic chemistry | Organometallic chemical biology | Organometallic compounds | CHEMISTRY, MEDICINAL | LUMINESCENT BIOTINYLATION REAGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE INHIBITORS | CELL IMAGING APPLICATIONS | IN-VITRO | IRIDIUM(III) POLYPYRIDINE COMPLEXES | ANTICANCER COMPLEXES | CYCLOMETALATED PLATINUM(II) COMPLEXES | DITHIOL-CONTAINING PROTEINS | METAL-COMPLEXES | LIVING CELLS | Cell Line | Animals | Immobilized Proteins - chemistry | Organometallic Compounds - metabolism | Humans | Staining and Labeling | Immobilized Proteins - metabolism | Biology - methods | Organometallic Compounds - chemistry | Biological Transport - drug effects | Chemistry - methods | Organometallic Compounds - pharmacology
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3. Full Text Nanocarriers for delivery of platinum anticancer drugs
by Oberoi, Hardeep S and Nukolova, Natalia V and Kabanov, Alexander V and Bronich, Tatiana K
Advanced Drug Delivery Reviews, ISSN 0169-409X, 11/2013, Volume 65, Issue 13-14, pp. 1667 - 1685
Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of... 
Drug delivery systems | Nanoparticle | Dendrime | Nanotube | Liposome | Micelle | Block ionomer complex | Platinum drugs | Polymer conjugate | TARGETED THERAPY | OVARIAN-CANCER | ANTITUMOR-ACTIVITY | WALLED CARBON NANOTUBES | PHASE-III TRIAL | LIPOSOMAL CISPLATIN LIPOPLATIN | IN-VITRO | INCORPORATED POLYMERIC MICELLES | METAL COMPLEX MICELLE | PHARMACOLOGY & PHARMACY | HYPERSENSITIVITY REACTIONS | Nanoparticles - chemistry | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Antineoplastic Agents - administration & dosage | Platinum Compounds - chemistry | Antineoplastic Agents - chemistry | Platinum Compounds - pharmacokinetics | Drug Discovery | Drug Carriers - chemistry | Dose-Response Relationship, Drug | Platinum Compounds - therapeutic use | Organoplatinum Compounds - administration & dosage | Animals | Organoplatinum Compounds - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Molecular Structure | Platinum Compounds - administration & dosage | Organoplatinum Compounds - therapeutic use | Organoplatinum Compounds - chemistry | Antimitotic agents | Drugs | Dendrimers | Chemotherapy | Analysis | Drug resistance | Antineoplastic agents | Tumors | Vehicles | Cancer | Index Medicus
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4. Full Text Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents
by Peacock, Anna F. A and Sadler, Peter J
Chemistry – An Asian Journal, ISSN 1861-4728, 11/2008, Volume 3, Issue 11, pp. 1890 - 1899
The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic... 
ruthenium | osmium | organometallics | arene ligands | anticancer agents | Organometallics | Ruthenium | Anticancer agents | Arene ligands | Osmium | ESTROGEN-RECEPTOR MODULATORS | CANCER-CELL CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | INORGANIC-CHEMISTRY | IN-VITRO | BIOORGANOMETALLIC CHEMISTRY | AQUEOUS CHEMISTRY | OSMIUM(II) COMPLEXES | RUTHENIUM(II) | MOLECULAR RECOGNITION | BINDING | Osmium Compounds - chemistry | Antineoplastic Agents - chemical synthesis | Structure-Activity Relationship | Platinum Compounds - chemistry | Antineoplastic Agents - chemistry | Ruthenium Compounds - chemistry | Platinum Compounds - therapeutic use | Drug Design | Osmium Compounds - therapeutic use | Inhibitory Concentration 50 | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Ruthenium Compounds - therapeutic use | Organometallic Compounds - pharmacology | Index Medicus
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5. Full Text Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile
by Ga Young Park and Justin J. Wilson and Ying Song and Stephen J. Lippard
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 30, pp. 11987 - 11992
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH₃)₂(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double... 
Cell culture techniques | HT29 cells | Reactivity | Platinum | DNA | Cell lines | Antineoplastics | Ligands | Kinetics | Adducts | X-ray crystallography | Metals in medicine | Cancer therapy | DNA damage | Transcription inhibition | cancer therapy | RESPONSES | COMPLEX | CISPLATIN | MULTIDISCIPLINARY SCIENCES | KINETIC CONTROL | metals in medicine | ADDUCTS | CIS-DIAMMINEDICHLOROPLATINUM(II) | transcription inhibition | Phenanthridines - chemistry | Crystallography, X-Ray | Drug Discovery - methods | Platinum Compounds - chemistry | Platinum Compounds - pharmacokinetics | Phenanthridines - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Luciferases | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Deoxyguanine Nucleotides - metabolism | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | Organoplatinum Compounds - chemistry | Phenanthridines - pharmacokinetics | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Genetic Vectors | Phenanthridines - metabolism | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Antimitotic agents | Composition | Platinum compounds | Physiological aspects | Genetic aspects | DNA binding proteins | Research | Antineoplastic agents | Health aspects | Pharmaceutical chemistry | Biological Sciences | Physical Sciences
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6. Full Text Platinum(iv) anticancer prodrugs - hypotheses and facts
by Gibson, Dan
Dalton Transactions, ISSN 1477-9226, 8/2016, Volume 45, Issue 33, pp. 12983 - 12991
In this manuscript we focus on Pt( iv ) anticancer prodrugs. We explore the main working hypotheses for the design of effective Pt( iv ) prodrugs and note the... 
CANCER-CELLS | ANTITUMOR AGENTS | PT(IV) PRODRUGS | L-ASCORBATE | ANTIPROLIFERATIVE ACTIVITY | DRUG-DELIVERY | CARBOXYLATE LIGANDS | MITOCHONDRIAL DYSFUNCTION | TUMOR-CELLS | NF-KAPPA-B | CHEMISTRY, INORGANIC & NUCLEAR | Prodrugs - administration & dosage | Humans | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Platinum Compounds - chemistry | Antineoplastic Agents - chemistry | Organoplatinum Compounds - pharmacology | Drug Delivery Systems | Platinum Compounds - therapeutic use | Organoplatinum Compounds - administration & dosage | Animals | Antineoplastic Agents - pharmacology | Prodrugs - therapeutic use | Organoplatinum Compounds - therapeutic use | Platinum Compounds - pharmacology | Prodrugs - pharmacology | Organoplatinum Compounds - chemistry
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7. Full Text Recent advances in the total synthesis of cyclopropane-containing natural products
by Chen, David Y.-K and Pouwer, Rebecca H and Richard, Jean-Alexandre
Chemical Society Reviews, ISSN 0306-0012, 6/2012, Volume 41, Issue 13, pp. 4631 - 4642
In this tutorial review, recent advances in the synthesis of cyclopropane-containing natural products are discussed, highlighting the application of novel... 
INTRAMOLECULAR CYCLOPROPANATION | ALPHA-DIAZOCARBONYL COMPOUNDS | ORGANIC-SYNTHESIS | DIAZO CARBONYL-COMPOUNDS | STABILIZED PHOSPHORUS YLIDES | DIELS-ALDER REACTIONS | FACE-SELECTIVE PLATINUM | DNA ALKYLATION REACTION | CHEMISTRY, MULTIDISCIPLINARY | CATALYZED CYCLOISOMERIZATION REACTIONS | UNSATURATED TERMINAL EPOXIDES | Cyclopropanes - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Cyclopropanes - chemical synthesis | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Catalysis | Ruthenium - chemistry | Chemistry Techniques, Synthetic - methods
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8. Full Text New trends for metal complexes with anticancer activity
by Bruijnincx, Pieter CA and Sadler, Peter J
Current Opinion in Chemical Biology, ISSN 1367-5931, 2008, Volume 12, Issue 2, pp. 197 - 206
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical... 
metals - chemistry; metabolism; pharmacology | DNA - metabolism | enzymes - metabolism | Antineoplastic agents - chemistry; metabolism; pharmacology | drug design | organometallic compounds - chemistry; metabolism; pharmacology | PLATINUM COMPLEX | APOPTOSIS-INDUCING ACTIVITY | BIOPHYSICS | NUCLEOSIDE ANALOGS | ARENE COMPLEXES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORGANOMETALLIC CHEMISTRY | RUTHENIUM COMPLEXES | SUPEROXIDE-DISMUTASE | PROTEIN-KINASE INHIBITORS | ANTITUMOR DRUGS | CELLULAR UPTAKE | Antineoplastic Agents - metabolism | Metals - metabolism | Metals - chemistry | Organometallic Compounds - metabolism | Drug Design | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Antineoplastic Agents - chemistry | Enzymes - metabolism | Organometallic Compounds - pharmacology | Metals - pharmacology | Chemotherapy | Cancer
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