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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 30, pp. 11987 - 11992
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH₃)₂(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double... 
Cell culture techniques | HT29 cells | Reactivity | Platinum | DNA | Cell lines | Antineoplastics | Ligands | Kinetics | Adducts | X-ray crystallography | Metals in medicine | Cancer therapy | DNA damage | Transcription inhibition | cancer therapy | RESPONSES | COMPLEX | CISPLATIN | MULTIDISCIPLINARY SCIENCES | KINETIC CONTROL | metals in medicine | ADDUCTS | CIS-DIAMMINEDICHLOROPLATINUM(II) | transcription inhibition | Phenanthridines - chemistry | Crystallography, X-Ray | Drug Discovery - methods | Platinum Compounds - chemistry | Platinum Compounds - pharmacokinetics | Phenanthridines - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Luciferases | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Deoxyguanine Nucleotides - metabolism | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | Organoplatinum Compounds - chemistry | Phenanthridines - pharmacokinetics | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Genetic Vectors | Phenanthridines - metabolism | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Antimitotic agents | Composition | Platinum compounds | Physiological aspects | Genetic aspects | DNA binding proteins | Research | Antineoplastic agents | Health aspects | Pharmaceutical chemistry | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 29, pp. E3800 - E3805
The organometallic “half-sandwich” compound [Os(η⁶- -cymene) (4-(2-pyridylazo)- -dimethylaniline)I]PF₆ is 49× more potent than the clinical drug cisplatin in... 
Protein microarrays | Organometallic anticancer compound | Mitochondria | Transcriptome sequencing | Cancer metabolism | MITOCHONDRIAL-DNA MUTATIONS | APOPTOSIS | OXIDATIVE STRESS | PROTEIN | mitochondria | MULTIDISCIPLINARY SCIENCES | organometallic anticancer compound | DAMAGE | cancer metabolism | transcriptome sequencing | DISEASE | TARGETS | ANTICANCER COMPLEXES | AGENTS | METALLODRUGS | protein microarrays | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Gene Expression Profiling | Osmium Compounds - pharmacology | Transcription Factor AP-1 - metabolism | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | DNA Damage - genetics | Organometallic Compounds - therapeutic use | Female | Ovarian Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Ovarian Neoplasms - drug therapy | Neoplasms, Glandular and Epithelial - pathology | Osmium Compounds - chemistry | Chromosomes, Human - genetics | Oxidative Stress - genetics | Mutation - genetics | Sequence Analysis, RNA | NF-E2-Related Factor 2 - metabolism | Neoplasms, Glandular and Epithelial - drug therapy | Osmium Compounds - therapeutic use | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Organometallic Compounds - chemistry | Oxidative Stress - drug effects | Organometallic Compounds - pharmacology | Usage | Platinum compounds | Genetic aspects | Research | Drug therapy | Health aspects | Ovarian cancer | Biological Sciences | PNAS Plus
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 898 - 908
Background:  Solute carriers (SLCs), in particular organic cation transporters (OCTs), have been implicated in the cellular uptake of platinum-containing... 
platinum uptake | SLC22A2 | oxaliplatin | solute carrier (SLC) | organic cation transporter (OCT) | drug resistance | cisplatin | Solute carrier (SLC) | Organic cation transporter (OCT) | Oxaliplatin | Drug resistance | Cisplatin | Platinum uptake | MEMBRANE TRANSPORTERS | COPPER TRANSPORTERS | OVARIAN-CANCER | CELL-LINES | CISPLATIN-INDUCED APOPTOSIS | PHARMACOLOGY | RESISTANCE | PHARMACOLOGY & PHARMACY | CLINICAL ACTIVITY | EXPRESSION | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | RNA, Messenger - metabolism | Organic Cation Transporter 2 | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Platinum Compounds - therapeutic use | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Biological Transport | Organoplatinum Compounds - metabolism | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Cell Line | Cell Survival - drug effects | Organic Cation Transport Proteins - metabolism | Treatment Outcome | Cisplatin - metabolism | Spectrophotometry, Atomic | Carboplatin - metabolism | Cell Line, Tumor | Kinetics | Organic Cation Transport Proteins - genetics | Organoplatinum Compounds - therapeutic use | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Index Medicus | Research Papers
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2015, Volume 472, Issue 2, pp. 217 - 223
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 380 - 392
Journal Article
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2006, Volume 9, Issue 3, pp. 111 - 122
Transition-metal-based compounds constitute a discrete class of chemotherapeutics, widely used in the clinic as antitumor and antiviral agents. Examples of... 
Transition metals | Ruthenium anticancer drugs | Polynuclear metal-based compounds | Intercalation | DNA | Topoisomerase II | polynuclear metal-based compounds | COVALENT BINDING | transition metals | FREE MEDIA | COLORECTAL-CARCINOMA | PLATINUM ANTITUMOR DRUGS | NAMI-A | topoisomerase II | DOUBLE-HELICAL DNA | intercalation | ARENE COMPLEXES | ruthenium anticancer drugs |