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Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP) family, are endoplasmic reticulum membrane proteins implicated in lipid... 
PLECKSTRIN HOMOLOGY DOMAINS | CONTACT SITES | METABOLISM | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | PROTEINS | EXCHANGE | STEROL TRANSPORT | PHOSPHATIDYLSERINE | PHOSPHOINOSITIDES | NIR2 | Binding | Phosphates | Plasma | Phosphoinositides | Membrane junctions | Trafficking | Homeostasis | Lipids | Homology | Recruitment | Membrane proteins | Proteins | Pleckstrin | Transport | Phosphatidylserine | Endoplasmic reticulum | Plasmas (physics)
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 6, pp. 716 - 727
Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration-resistant prostate cancer (CRPC) growth. Vav3,... 
Vav3 | androgen receptor | castration-resistant prostate cancer | guanine nucleotide exchange factor | pleckstrin homology | coactivator | ACTIVATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR DETERMINANTS | PH DOMAINS | PHOSPHOINOSITIDES | CELL BIOLOGY | ONCOLOGY | STRUCTURAL BASIS | GENETICS & HEREDITY | PLECKSTRIN-HOMOLOGY DOMAINS | TUMOR-GROWTH | BINDING | PROGRESSION | Prostatic Neoplasms - metabolism | Proto-Oncogene Proteins c-vav - genetics | Humans | Receptors, Androgen - metabolism | Cytoplasm - metabolism | Male | Transplantation, Heterologous | Green Fluorescent Proteins - genetics | Cell Nucleus - metabolism | Prostatic Neoplasms - genetics | Chromatin Immunoprecipitation | Protein Binding - drug effects | Trans-Activators - genetics | Metribolone - pharmacology | Green Fluorescent Proteins - metabolism | Prostatic Neoplasms - pathology | Binding Sites - genetics | Tumor Burden | Mice, SCID | Blotting, Western | Orchiectomy | Animals | Receptors, Androgen - genetics | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Mutation | Microscopy, Fluorescence | Proto-Oncogene Proteins c-vav - metabolism | Purines | Physiological aspects | Genetic aspects | Research | Genetic transcription | Gene expression | Prostate cancer | Proteins | Androgens | Cellular biology | Potentiation | Chromatin | Immunoprecipitation | Vav protein | Transcription | pleckstrin | Androgen receptors | Data processing | Homology | Nuclei | Enhancers | Xenografts | Cytoplasm | Guanosinetriphosphatase | Tumors | castration resistant prostate cancer | tumor xenografts | pleckstrin homology domain
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 11/2015, Volume 5, Issue 11, pp. 1194 - 1209
mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation... 
TARGET | PROTEIN | RAG GTPASES | ONCOLOGY | PHOSPHORYLATION | INTEGRITY | PLECKSTRIN HOMOLOGY DOMAIN | SIGNALS | AKT | BINDING | SIN1
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 11/2010, Volume 6, Issue 1, pp. 430 - n/a
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 399 - 408
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their... 
Allosteric inhibitor | Protein kinase B (PKB) | Inhibitor | Pleckstrin homology domain | Akt | Kinase | PROTEIN-KINASE-B | INDUCED APOPTOSIS | TYROSINE KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | pleckstrin homology domain | allosteric inhibitor | COWDEN-DISEASE | kinase | inhibitor | STRUCTURAL BASIS | protein kinase B (PKB) | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | CELL-LINE LNCAP | HUMAN CANCER | Phosphoproteins - immunology | Prostatic Neoplasms - chemistry | Humans | Peptides - genetics | Blood Proteins - immunology | Male | Isoenzymes - chemistry | Phosphoproteins - chemistry | Carcinoma - chemistry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Blood Proteins - genetics | Adenosine Triphosphate - metabolism | Phosphorylation - drug effects | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Peptides - immunology | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - metabolism | Uterine Cervical Neoplasms - pathology | Quinoxalines - pharmacology | Caspases - metabolism | Uterine Cervical Neoplasms - metabolism | Cloning, Molecular | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Molecular Structure | Carcinoma - pathology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Membrane Glycoproteins - pharmacology | Blood Proteins - chemistry | Phosphoproteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-akt | Sequence Homology, Amino Acid | Apoptosis Regulatory Proteins | Signal Transduction - physiology | Uterine Cervical Neoplasms - chemistry | Carcinoma - metabolism | Benzylamines - pharmacology | Isoenzymes - antagonists & inhibitors | cdk2, cyclin-dependent kinase 2 | FGFR, fibroblast growth factor receptor | MEK, MAPK | SH, Src homology | PI3K, phosphoinositide 3-kinase | DOPS, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine | ERK kinase | DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine | DTT, dithiothreitol | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PEG, poly(ethylene glycol) | PKC, protein kinase C | FLT, Fms-related tyrosine kinase | lymphoma 1 | GSK3, glycogen synthase kinase 3 | TRAIL, tumour-necrosis-factor-related apoptosis-inducing ligand | HTRF, homogeneous time-resolved fluorescence | PH, pleckstrin homology | MAPKK1, MAPK kinase 1 | FBS, foetal bovine serum | PDK, phosphoinositide-dependent kinase | TCL1, T-cell leukaemia | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | SGK, serum- and glucocorticoid-inducible kinase
Journal Article
by Lin, AF and Hu, QS and Li, CL and Xing, Z and Ma, GL and Wang, C and Li, J and Ye, Y and Yao, J and Liang, K and Wang, SY and Park, PK and Marks, JR and Zhou, Y and Zhou, JW and Hung, MC and Liang, H and Hu, ZB and Shen, HB and Hawke, DH and Han, L and Zhou, YB and Lin, CR and Yang, LQ
NATURE CELL BIOLOGY, ISSN 1465-7392, 03/2017, Volume 19, Issue 3, pp. 238 - 251
Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns(3,4,5)P-3 or PIP3) mediates signalling pathways as a second messenger in response to extracellular signals.... 
BREAST-CANCER | INOSITOL PHOSPHATES | IN-VITRO | PROTEIN-KINASE-B | LONG NONCODING RNA | SOLID TUMORS | SIGNALING PATHWAY | PLECKSTRIN HOMOLOGY DOMAIN | GLOBAL ANALYSIS | HIGH-AFFINITY BINDING | CELL BIOLOGY
Journal Article
11.