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Leukemia, ISSN 0887-6924, 08/2009, Volume 23, Issue 8, pp. 1398 - 1405
Dasatinib, a broad-spectrum tyrosine kinase inhibitor (TKI), predominantly targets BCR-ABL and SRC oncoproteins and also inhibits off-target kinases, which may... 
CHRONIC MYELOGENOUS LEUKEMIA | CYTOGENETIC RESPONSES | immunomodulation | NATURAL-KILLER | BMS-354825 | FAILURE | CHRONIC MYELOID-LEUKEMIA | RESISTANT | IN-VITRO | dasatinib | ONCOLOGY | PATIENTS RECEIVING IMATINIB | Ph plus leukemia | TKI therapy | HEMATOLOGY | LYMPHOCYTES | Lymphocytosis - chemically induced | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Thiazoles - therapeutic use | Thiazoles - adverse effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | T-Lymphocytes, Cytotoxic - drug effects | Multicenter Studies as Topic | Antineoplastic Agents - adverse effects | T-Lymphocyte Subsets - drug effects | Colitis - chemically induced | Clinical Trials, Phase II as Topic - statistics & numerical data | Adult | Female | Antineoplastic Agents - pharmacology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Dasatinib | Immunophenotyping | Pleurisy - chemically induced | Pyrimidines - pharmacology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Aged | Killer Cells, Natural - drug effects | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Cohort Studies | Physiological aspects | Dosage and administration | Chronic myeloid leukemia | Research | Drug therapy | T cells | Tyrosine metabolism | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2006, Volume 12, Issue 9, pp. 1056 - 1064
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 3/2012, Volume 385, Issue 3, pp. 253 - 263
Carvacrol is a phenolic monoterpene present in the essential oil of the family Lamiaceae, as in the genera Origanum and Thymus. We previously reported that... 
Neurosciences | Biomedicine | TNF-α | Mechanical hypernociception | Monoterpene | Carvacrol | Inflammation | Pharmacology/Toxicology | SYSTEM | CARRAGEENAN | ANTIINFLAMMATORY ACTIVITY | ESSENTIAL OILS | TNF-alpha | BIOASSAY-GUIDED EVALUATION | MICE INVOLVEMENT | PAIN | MOUSE PAW EDEMA | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | HYPERALGESIA | Tumor Necrosis Factor-alpha - metabolism | Analgesics - pharmacology | Motor Activity - drug effects | Male | Pleurisy - metabolism | Pain - chemically induced | Monoterpenes - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Pleurisy - drug therapy | Anti-Inflammatory Agents - therapeutic use | Behavior, Animal - drug effects | Carrageenan - adverse effects | Macrophages, Peritoneal - drug effects | Monoterpenes - therapeutic use | Analgesics - therapeutic use | Cell Survival - drug effects | Anti-Inflammatory Agents - pharmacology | Dopamine - adverse effects | Pleurisy - chemically induced | Dinoprostone - adverse effects | Animals | Tumor Necrosis Factor-alpha - adverse effects | Pain - physiopathology | Lipopolysaccharides - pharmacology | Mice | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | Inflammation - physiopathology | Antioxidants | Prostaglandins | Carrageenin | Analgesics | Analysis | Prostaglandins E | Respiratory tract diseases | Mitogens | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2005, Volume 13, Issue 13, pp. 4243 - 4252
Journal Article
Journal Article
Annals of the rheumatic diseases, ISSN 0003-4967, 2015, Volume 74, Issue 6, pp. 1058 - 1064
Journal Article
Oncogene, ISSN 0950-9232, 06/2012, Volume 31, Issue 26, pp. 3148 - 3163
Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic... 
chemoresistance | mesothelioma | EMT | SASP | TUBERCULOUS PLEURISY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MALIGNANT PLEURAL MESOTHELIOMA | MESENCHYMAL TRANSITION | CELLULAR SENESCENCE | CANCER STEM-CELLS | CELL BIOLOGY | BREAST-CANCER | IN-VITRO | ONCOLOGY | AUTOCRINE GROWTH-FACTOR | GENETICS & HEREDITY | EXPRESSION | SIGNAL TRANSDUCER | RNA, Small Interfering - genetics | Mesothelioma - pathology | Guanine - analogs & derivatives | Cell Count | Humans | Mesoderm - drug effects | Cellular Senescence - drug effects | Epithelial-Mesenchymal Transition - drug effects | Male | Gene Knockdown Techniques | Guanine - pharmacology | STAT3 Transcription Factor - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Aldehyde Dehydrogenase - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Genes, ras - genetics | Cell Survival - drug effects | Mitogens - secretion | Cytokines - secretion | Mesothelioma - genetics | Pemetrexed | Phenotype | Animals | Mesothelioma - metabolism | Signal Transduction - drug effects | Glutamates - pharmacology | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | Mesoderm - pathology | Culture Media, Conditioned - metabolism | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Cancer cells | Aging | Mesothelioma | Development and progression | Research | Drug resistance | Drug therapy | Health aspects | Cells | Cancer | Oncology | Cytokines | Cellular biology | Tumors | Index Medicus | Flow cytometry | Senescence | Media (enrichment) | Chemoresistance | Stat3 protein | Inflammation | Aldehyde dehydrogenase | p53 protein
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2013, Volume 145, Issue 1, pp. 127 - 138
Journal Article