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Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18784
.... Melanoma comprises multi-subpopulations of cancer cells some of which may possess stem cell-like properties... 
INITIATING CELLS | IN-VITRO | ACTIVATION | METASTASIS | MULTIDISCIPLINARY SCIENCES | B-16 MELANOMA | PHENOTYPE | LIGAND | EXPRESSION | CANCER STEM-CELLS | MHC CLASS-II | Embryonic Stem Cells - metabolism | Immunomodulation - drug effects | Transcription, Genetic - drug effects | Neoplastic Stem Cells - drug effects | Genes, Neoplasm | Humans | Neural Crest - pathology | Spheroids, Cellular - pathology | Gene Expression Profiling | Cell Lineage - drug effects | Neural Crest - metabolism | Neoplastic Stem Cells - metabolism | Melanoma - genetics | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Neoplasm Invasiveness | Spheroids, Cellular - metabolism | Melanoma - pathology | Neural Crest - drug effects | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Movement - drug effects | Phenotype | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Melanoma - immunology | Pluripotent Stem Cells - drug effects | Culture Media - pharmacology | Cell Proliferation - drug effects | Metastasis | T cells | Gene expression | Analysis | Stem cells | Cancer | Cell proliferation | Transcription factors | Mesenchyme | Oct-4 protein | Lymphocytes T | Activation | Assaying | Immunity | Metastases | Skin cancer | Heterogeneity | Genotype & phenotype | Cell activation | KLF4 protein | Lymphocytes | Mathematical models | Immune system | Subpopulations | Antigens | Aggressive behavior | Cytokines | Immunomodulation | Tumor cells | Invasiveness | Melanoma | Tumorigenicity | Neural crest | Embryos | Spheroids | Studies | Ligands | Prostate cancer | Cell migration | Chemokines | Tumors | Apoptosis | Cell Proliferation | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells | Cellular Biology | Neural Crest | Life Sciences | Cell Lineage | Pluripotent Stem Cells | Culture Media | Transcription, Genetic | Cell Differentiation | Transcription Factors | Embryonic Stem Cells | Spheroids, Cellular | Cell Movement
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and offer a cost-effective approach... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56289
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22261
Elucidating the in vitro differentiation of human embryonic stem (ES) and induced pluripotent stem (iPS... 
PRIMITIVE STREAK | CD34(+) CELLS | DEFINITIVE HEMATOPOIESIS | IN-VITRO | EXTENSIVE CAPABILITY | EMBRYONIC STEM-CELLS | ENDOTHELIAL-CELLS | CORD BLOOD | BIOLOGY | HEMOANGIOGENIC PROGENITORS | COMMON PRECURSOR | Embryonic Stem Cells - metabolism | Antigens, CD34 - metabolism | Embryonic Stem Cells - cytology | Leukocyte Common Antigens - metabolism | Humans | Mesoderm - drug effects | Mesoderm - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Hematopoiesis - drug effects | Blood Cells - cytology | Clone Cells | Culture Media, Serum-Free - pharmacology | Induced Pluripotent Stem Cells - cytology | Blood Cells - drug effects | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Hematopoietic Stem Cells - drug effects | Cell Line | Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - drug effects | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Hematopoietic Stem Cells - metabolism | Pluripotent Stem Cells - metabolism | Animals | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Pluripotent Stem Cells - drug effects | Stromal Cells - cytology | Cytokines | Monomolecular films | Cell culture | Pediatrics | Medical research | Leukemia | Blood cells | Embryos | Blood | Hemopoiesis | Medicine | Studies | Primitive streak | Angiogenesis | Hematopoiesis | Monolayers | Stem cells | In vivo methods and tests | Differentiation | Pluripotency
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 5, pp. 547 - 556
...). Here we demonstrate that patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXRAZOXANE | INDUCED CARDIOMYOPATHY | MATURATION | MUSCLE GENE-EXPRESSION | CELL BIOLOGY | HEART | INHIBITION | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SURVIVORS | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Calcium - metabolism | Humans | Middle Aged | Transcriptome | Antibiotics, Antineoplastic - adverse effects | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Flow Cytometry | Adult | Female | Real-Time Polymerase Chain Reaction | Cardiotoxicity - genetics | DNA Damage - drug effects | Cell Survival - drug effects | Disease Susceptibility | Heart Failure - genetics | Breast Neoplasms - drug therapy | Myocytes, Cardiac - drug effects | Fluorescent Antibody Technique | Myocytes, Cardiac - metabolism | Aged | Polymorphism, Single Nucleotide | Oxidative Stress - drug effects | Induced Pluripotent Stem Cells | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Heart Failure - chemically induced | Complications and side effects | Patient outcomes | Stem cells | Development and progression | Breast cancer | Transplantation | Cardiovascular diseases | Drug therapy | Doxorubicin | Methods | Heart failure | Chemotherapy | Toxicity | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20526
Background: Mesenchymal stem cells (MSCs) hold great promise for the treatment of difficult diseases... 
IN-VITRO | MYOCARDIAL-INFARCTION | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | MICE | STROMAL CELLS | HISTONE ACETYLATION | EXPRESSION | CARDIAC REPAIR | TRANSPLANTATION | Estrogens - pharmacology | Epigenesis, Genetic | Humans | Multipotent Stem Cells - metabolism | Fibroblast Growth Factor 2 - pharmacology | Cellular Senescence - drug effects | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Multipotent Stem Cells - drug effects | Osteogenesis - genetics | Cellular Senescence - genetics | Pluripotent Stem Cells - cytology | Osteogenesis - drug effects | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Cell Shape - drug effects | Pluripotent Stem Cells - metabolism | Acetylation - drug effects | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Pluripotent Stem Cells - drug effects | Cell Proliferation - drug effects | Histones - metabolism | DNA Methylation - drug effects | Stem cell research | Epigenetic inheritance | Tissue engineering | Genes | Stem cells | Fibroblast growth factors | Methylation | Cell differentiation | Cell culture | Disease | Mesenchyme | Laboratories | Oct-4 protein | Differentiation (biology) | Adipocytes | Osteoblasts | Biomedical materials | DNA methylation | Aging | Bone marrow | Biocompatibility | Life sciences | Acetylation | Expansion | Deoxyribonucleic acid--DNA | CpG islands | Fibroblast growth factor 2 | Cbfa-1 protein | Medical treatment | Gene expression | Medicine | Molecular modelling | Placenta | Osteoblastogenesis | Respiratory diseases | Morphology | Epigenetics | Histone H3 | Osteogenesis | Deoxyribonucleic acid | DNA
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2013, Volume 127, Issue 16, pp. 1677 - 1691
.... Here we generated a library of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs... 
arrhythmias, cardiac | stem cells | induced pluripotent stem cells | LONG-QT | INDUCED ARRHYTHMIAS | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | QT INTERVAL PROLONGATION | DISCOVERY | CHANNEL | MODELS | TORSADE-DE-POINTES | PERIPHERAL VASCULAR DISEASE | MOLECULAR-BASIS | Cardiomyopathy, Dilated - pathology | Embryonic Stem Cells - cytology | Kidney - embryology | Cardiomyopathy, Hypertrophic, Familial - genetics | Humans | Ion Channels - genetics | Verapamil - toxicity | Gene Expression Profiling | HEK293 Cells - drug effects | Cell Line - drug effects | Nicorandil - toxicity | Cell Line - physiology | Myofibrils - ultrastructure | Drug-Related Side Effects and Adverse Reactions - genetics | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Action Potentials - drug effects | Cardiomyopathy, Dilated - genetics | Drug Evaluation, Preclinical - methods | Genetic Predisposition to Disease | Ion Channels - biosynthesis | Cardiomyopathy, Hypertrophic, Familial - pathology | Cell Size | Kidney - cytology | Long QT Syndrome - pathology | Embryonic Stem Cells - physiology | Embryoid Bodies - drug effects | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | HEK293 Cells - physiology | Myocytes, Cardiac - physiology | Long QT Syndrome - genetics | Cisapride - toxicity | In Vitro Techniques | Drugs | Usage | Analysis | Heart cells | Stem cells | Product/Service Evaluations | Research | Health aspects | Methods | cardiotoxicity | Induced pluripotent stem cells | arrhythmia
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 8, pp. 994 - 1003
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types... 
DIRECTED DIFFERENTIATION | IN-VIVO | MOUSE | DEFINITIVE ENDODERM | GROWTH-FACTOR | HUMAN BLASTOCYSTS | STROMAL CELLS | WNT | CULTURE | LINES | CELL BIOLOGY | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium
Journal Article
Journal Article