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Journal Article
Nature, ISSN 0028-0836, 2012, Volume 486, Issue 7405, pp. 57 - 63
Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the... 
PREIMPLANTATION MOUSE EMBRYOS | EVOLUTION | TROPHECTODERM | REGULATORY NETWORKS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | TRANSPOSABLE ELEMENTS | SELF-RENEWAL | DIFFERENTIATION | MUERV-L | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Histones - chemistry | Epigenesis, Genetic | Totipotent Stem Cells - virology | Endogenous Retroviruses - genetics | Pluripotent Stem Cells - virology | Embryo, Mammalian - metabolism | Chimera - embryology | Gene Expression Regulation, Developmental | Embryo, Mammalian - virology | Female | Embryonic Stem Cells - virology | Lysine - metabolism | Induced Pluripotent Stem Cells - cytology | Totipotent Stem Cells - cytology | Totipotent Stem Cells - metabolism | Cell Lineage - genetics | Induced Pluripotent Stem Cells - metabolism | Cell Dedifferentiation - physiology | Pluripotent Stem Cells - cytology | Genes, Reporter - genetics | Transcriptome - genetics | Terminal Repeat Sequences - genetics | Pluripotent Stem Cells - metabolism | Phenotype | Animals | Embryo, Mammalian - cytology | Mice | Histones - metabolism | Lysine - chemistry | Methylation | Cell Dedifferentiation - genetics | Chromatin - genetics | Physiological aspects | Retroviruses | Disease transmission | Research | Embryonic stem cells | Health aspects | Proteins | Fetuses | Stem cells | Evolution | Gene expression | Embryos | Binding sites | Virology | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 222 - 226
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 62, Issue 3, pp. 581 - 589
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 37, pp. 15720 - 15725
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7313, pp. 285 - 290
Journal Article