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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 691 - 696
...). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 51, pp. E7128 - E7137
.... In particular, it stresses and explains the importance of the recently described monogenic inborn errors of immunity underlying resistance or susceptibility to specific infections... 
Pediatrics | Immunology | Infectious diseases | Human genetics | Primary immunodeficiency | human genetics | LINKED LYMPHOPROLIFERATIVE SYNDROME | CALMETTE-GUERIN INFECTION | RECEPTOR BETA-1 DEFICIENCY | MULTIDISCIPLINARY SCIENCES | infectious diseases | ANHIDROTIC ECTODERMAL DYSPLASIA | T-CELL IMMUNODEFICIENCY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | PRIMARY IMMUNODEFICIENCY DISEASES | PYOGENIC BACTERIAL-INFECTIONS | pediatrics | primary immunodeficiency | immunology | HERPES-SIMPLEX ENCEPHALITIS | INHERITED CARD9 DEFICIENCY | Encephalitis, Herpes Simplex - immunology | Humans | Genetic Diseases, Inborn - genetics | Lymphoproliferative Disorders - immunology | Mycobacterium Infections - immunology | Young Adult | Pneumococcal Infections - immunology | Mycobacterium Infections - genetics | Pneumococcal Infections - genetics | Complement System Proteins - genetics | Encephalitis, Herpes Simplex - genetics | Epidermodysplasia Verruciformis - immunology | Interferon-gamma - genetics | Immunologic Deficiency Syndromes - immunology | Child | Genetic Predisposition to Disease | Neisseria - immunology | Tinea - immunology | Infection - immunology | Candidiasis, Chronic Mucocutaneous - genetics | Malaria - immunology | Candidiasis, Chronic Mucocutaneous - immunology | Genetic Diseases, Inborn - immunology | Tinea - genetics | Epidermodysplasia Verruciformis - genetics | Lymphoproliferative Disorders - genetics | Infection - genetics | Models, Immunological | Neisseria - pathogenicity | Influenza, Human - genetics | Interferon-gamma - immunology | Adolescent | Immunologic Deficiency Syndromes - genetics | Models, Genetic | Malaria - genetics | Influenza, Human - immunology | Development and progression | Genetic aspects | Disease susceptibility | Immune response | Communicable diseases | Biological Sciences | PNAS Plus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e41879
Secondary bacterial pneumonias are a frequent complication of influenza and other respiratory viral infections, but the mechanisms underlying viral-induced susceptibility to bacterial infections are poorly understood... 
TOLL-LIKE RECEPTOR-3 | COMMUNITY-ACQUIRED PNEUMONIA | DOUBLE-STRANDED-RNA | PANDEMIC INFLUENZA | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | RIG-I | MICROBIAL ETIOLOGY | NF-KAPPA-B | RESPIRATORY-TRACT INFECTION | INFLUENZA INFECTION | Poly I-C - administration & dosage | Antigens, Viral - administration & dosage | Interferon Type I - immunology | Streptococcus pneumoniae - immunology | Pneumococcal Infections - immunology | Pneumococcal Infections - genetics | Pneumonia, Bacterial - mortality | Pneumococcal Infections - microbiology | Pneumonia, Bacterial - genetics | Poly I-C - immunology | Receptor, Interferon alpha-beta - genetics | Staphylococcal Infections - microbiology | Toll-Like Receptor 3 - genetics | Aminoquinolines - pharmacology | Pneumonia, Bacterial - microbiology | Staphylococcal Infections - genetics | Disease Susceptibility | Nerve Tissue Proteins - immunology | Staphylococcal Infections - immunology | Membrane Proteins - genetics | Pneumococcal Infections - mortality | Membrane Proteins - immunology | Survival Rate | Toll-Like Receptor 3 - immunology | Imidazoles - pharmacology | Methicillin-Resistant Staphylococcus aureus - immunology | Nerve Tissue Proteins - genetics | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Antigens, Viral - immunology | Staphylococcal Infections - mortality | Animals | Receptor, Interferon alpha-beta - immunology | Signal Transduction - drug effects | Interferon Type I - genetics | Pneumonia, Bacterial - immunology | Mice | Interferon Inducers - pharmacology | Pneumonia | Bacterial pneumonia | Influenza | Staphylococcus aureus infections | Bacteria | Disease susceptibility | Interferon | Nucleic acids | Health aspects | Antibacterial agents | Pandemics | Imiquimod | Immune clearance | Impairment | Gram-positive bacteria | Viruses | Infections | Drug resistance | Methicillin | Proteins | Toll-like receptors | Trachea | Immune system | Pathogens | Bacterial infections | Double-stranded RNA | Poly (I:C) | Signaling | Lungs | Ligands | Retinoic acid | Viral infections | Indexing in process
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 12, p. e0144739
... asymptomatic but can result in non-invasive mucosal infections or invasive pneumococcal disease (IPD). More than 90 SP serotypes of have been identified, of which about 20... 
ANTIBODIES | IMMUNIZATION | MULTIPLEX IMMUNOASSAY | SAFETY | MULTIDISCIPLINARY SCIENCES | DISEASE | BORDETELLA-PERTUSSIS | NETHERLANDS | PHID-CV | SEROTYPE 19A | CHILDREN | Streptococcus pneumoniae - classification | Immunoglobulin G - blood | Haemophilus influenzae type b - drug effects | Poliovirus Vaccine, Inactivated - administration & dosage | Humans | Child, Preschool | Haemophilus Infections - prevention & control | Infant | Haemophilus Vaccines - administration & dosage | Haemophilus influenzae type b - immunology | Pneumococcal Vaccines - administration & dosage | Tetanus - microbiology | Vaccines, Combined - administration & dosage | Vaccines, Combined - immunology | Whooping Cough - microbiology | Poliovirus Vaccine, Inactivated - immunology | Streptococcus pneumoniae - immunology | Vaccines, Conjugate - immunology | Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage | Netherlands | Pneumococcal Infections - immunology | Immunization, Secondary | Vaccination - methods | Time Factors | Immunoglobulin G - immunology | Tetanus - immunology | Whooping Cough - prevention & control | Diphtheria-Tetanus-Pertussis Vaccine - immunology | Diphtheria - prevention & control | Immunization Schedule | Pneumococcal Infections - microbiology | Diphtheria - microbiology | Antibodies, Bacterial - blood | Serotyping | Antibody Formation - immunology | Streptococcus pneumoniae - drug effects | Diphtheria - immunology | Hepatitis B Vaccines - administration & dosage | Tetanus - prevention & control | Haemophilus Vaccines - immunology | Vaccines, Conjugate - administration & dosage | Haemophilus Infections - microbiology | Pneumococcal Infections - prevention & control | Pneumococcal Vaccines - immunology | Antibodies, Bacterial - immunology | Hepatitis B Vaccines - immunology | Haemophilus Infections - immunology | Whooping Cough - immunology | Physiological aspects | Genetic aspects | Immune response | Research | Pneumococcal vaccine | Pediatrics | Immunoglobulin G | Childrens health | Infants | Vaccines | Streptococcus infections | Proteins | Pertussis | Children | Age | Public health | Antigens | Immunization | Immunoglobulins | Mortality | Diphtheria | Disease control | Opsonophagocytosis | Whooping cough | Infectious diseases | Immunogenicity | Correlation analysis | Serotypes | Avidity | Tetanus | Carrier density
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 135, Issue 3, pp. 598 - 608
Virtually all cells and extracellular material are heavily decorated by various glycans, yet our understanding of the structure and function of these moieties... 
Allergy and Immunology | glycan | treatment | glycan-binding proteins | Siglec | selectin | dectin | sialic acid | glycobiology | ANTIINFLAMMATORY ACTIVITY | HUMAN-EOSINOPHIL APOPTOSIS | IMMUNOLOGY | FUNGAL-INFECTIONS | ALLERGY | IN-VIVO | INHIBITORY RECEPTOR | HUMAN MAST-CELLS | INTRAVENOUS IMMUNOGLOBULIN PREPARATIONS | CD33-RELATED SIGLECS | B-CELL TOLERANCE | TARGETED DELIVERY | Inflammation - pathology | Humans | Selectins - genetics | Selectins - immunology | Hypersensitivity - immunology | Selectins - chemistry | Sialic Acid Binding Immunoglobulin-like Lectins - immunology | HIV Infections - immunology | Pneumococcal Infections - immunology | HIV Infections - pathology | Neoplasms - genetics | Sialic Acid Binding Immunoglobulin-like Lectins - chemistry | Reactive Oxygen Species - immunology | Pneumococcal Infections - genetics | Polysaccharides - chemistry | Hypersensitivity - genetics | Schistosomiasis - immunology | Signal Transduction | Gene Expression Regulation - immunology | HIV Infections - genetics | Pneumococcal Infections - pathology | Inflammation - immunology | Polysaccharides - immunology | Immunity, Innate | Sialic Acid Binding Immunoglobulin-like Lectins - genetics | Animals | Hypersensitivity - pathology | Neoplasms - immunology | Inflammation - genetics | Protein Binding | Schistosomiasis - genetics | Neoplasms - pathology | Schistosomiasis - pathology | Proteins | Polysaccharides | Immune response | Lipids | Chemical properties | Organic acids | Protein binding | Enzymes | Immunology | Disease | Rodents | Ligands | Kinases | Immune system | Apoptosis | Endothelium
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 9, pp. 3657 - 3665
Journal Article
PLoS pathogens, ISSN 1553-7374, 2010, Volume 6, Issue 11, p. e1001191
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7410, pp. 222 - 225
.... During intestinal Citrobacter rodentium infection(4-6), a mouse model for enteropathogenic Escherichia coli infection, Hvem... 
INTESTINAL INFLAMMATION | PROTECTS MICE | HERPESVIRUS ENTRY MEDIATOR | NK CELLS | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | RECEPTOR | CITROBACTER-RODENTIUM | CELL-DIFFERENTIATION | NF-KAPPA-B | INNATE IMMUNITY | Antigens, CD - immunology | Immunity, Mucosal - immunology | Lung - microbiology | Epithelial Cells - metabolism | Enteropathogenic Escherichia coli | Citrobacter rodentium - pathogenicity | Intestines - immunology | Antigens, CD - metabolism | Streptococcus pneumoniae - immunology | Enterobacteriaceae Infections - immunology | Pneumococcal Infections - immunology | Lymphocytes - immunology | Escherichia coli Infections | Pneumococcal Infections - microbiology | Receptors, Immunologic - immunology | Protein-Serine-Threonine Kinases - metabolism | Receptors, Tumor Necrosis Factor, Member 14 - immunology | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Lymphocytes - metabolism | Receptors, Tumor Necrosis Factor, Member 14 - genetics | Cell Line | Citrobacter rodentium - immunology | GPI-Linked Proteins - immunology | Signal Transduction | Enterobacteriaceae Infections - microbiology | Mice, Inbred C57BL | Survival Rate | Bacterial Load | GPI-Linked Proteins - metabolism | Mucous Membrane - metabolism | Receptors, Tumor Necrosis Factor, Member 14 - metabolism | Animals | Intestines - microbiology | Mucous Membrane - immunology | Epithelial Cells - immunology | Receptors, Tumor Necrosis Factor, Member 14 - deficiency | Ligands | Mice | Lung - immunology | Mucous Membrane - microbiology | Receptors, Immunologic - metabolism | Physiological aspects | Bacteria | Cellular signal transduction | Research | Health aspects | Mucous membrane | Immune system | Phosphorylation | Bacterial infections | Cytokines | Rodents | Kinases | Gene expression | Chemokines | Streptococcus infections
Journal Article