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1. Full Text Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia
by Cillóniz, Catia and Ceccato, Adrian and Calle, Cristina de la and Gabarrús, Albert and Garcia Vidal, Carolina and Almela, M. (Manel) and Soriano Viladomiu, Alex and Martinez, José Antonio and Marco, Francesc and Vila Estapé, Jordi and Torres Martí, Antoni
ISSN 1932-6203, 08/2017
Objectives: We aimed to investigate the association between the time to positivity of blood culture (TTP) with clinical outcome and severity of pneumococcal... 
Pneumonia | Pneumònia | Pneumococs | Streptococcus pneumonia
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2. Full Text Nasopharyngeal bacterial load as a marker for rapid and easy diagnosis of invasive pneumococcal disease in children from Mozambique
by Brotons, Pedro and Bassat Orellana, Quique and Lanaspa, Miguel and Henares, Desiree and Perez-Arguello, Amaresh and Madrid, Lola and Balcells, Reyes and Acácio, Sozinho and Andres-Franch, Maria and Marcos Maeso, Ma. Angeles and Valero-Rello, Ana and Muñoz-Almagro, Carmen
ISSN 1932-6203, 09/2017
Background Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of... 
Pneumococcal Infections | Mozambique | Infeccions per pneumococs | Infants | Children | Moçambic
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3. Full Text Twenty-year trend in mortality among hospitalized patients with pneumococcal community-acquired pneumonia
by Cillóniz, Catia and Liapikou, Adamantia and Martin Loeches, Ignacio and Garcia Vidal, Carolina and Gabarrús, Albert and Ceccato, Adrian and Magdaleno, Daniel and Mensa Pueyo, Josep and Marco, Francesc and Torres Martí, Antoni
ISSN 1932-6203, 07/2018
Background: There is only limited information on mortality over extended periods in hospitalized patients with pneumococcal community-acquired pneumonia (CAP).... 
Mortality | Mortalitat | Pneumococs | Community-acquired pneumonia | Pneumònia adquirida a la comunitat | Streptococcus pneumoniae
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4. Full Text Spread of streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant clone, Spain
by Ardanuy Tisaire, María Carmen and Campa, Adela G. de la and García, Ernesto and Fenoll, Asunción and Calatayud, Laura and Cercenado, Emilia and Pérez Trallero, Emilio and Bouza, Emilio and Liñares Louzao, Josefina
ISSN 1080-6040, 11/2014
Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed... 
Pneumococcal Infections | Respiratory organs diseases | Estreptococs | Malalties infeccioses | Communicable diseases | Drug resistance | Spain | Streptococcus | Espanya | Resistència als medicaments | Infeccions per pneumococs | Pneumococs | Malalties de l'aparell respiratori | Streptococcus pneumonia
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5. Full Text Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
by Càmara, Jordi and Marimón, José María and Cercenado, Emilia and Larrosa, Nieves and Quesada, María Dolores and Fontanals, Dionísia and Cubero, Meritxell and Pérez-Trallero, Emilio and Fenoll, Asunción and Liñares, Josefina and Ardanuy, Carmen
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175224
A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before... 
UNITED-STATES | GENETIC-STRUCTURE | IMPACT | STREPTOCOCCUS-PNEUMONIAE | ERA | MULTIDISCIPLINARY SCIENCES | SURVEILLANCE | MASSACHUSETTS | PNEUMONIAE SEROTYPE 19A | EPIDEMIOLOGY | CHILDREN | Young Adult | Prospective Studies | Humans | Middle Aged | Adolescent | Pneumococcal Infections - prevention & control | Adult | Female | Male | Pneumococcal Vaccines - administration & dosage | Spain | Care and treatment | Dosage and administration | Pneumococcal vaccine | Drug therapy | Pneumococcal infections | Penicillin | Cefotaxime | DNA topoisomerase IV | Vaccines | Antiinfectives and antibacterials | Epidemiology | Risk factors | Incidence | Governments | Mathematical analysis | Breakpoints | Immunization | Data acquisition | Chloramphenicol | Thorax | Erythromycin | Hospitals | Amoxicillin | Minimum inhibitory concentration | Adults | Pneumonia | Populations | Structural stability | Clindamycin | Amides | Infections | Criteria | Streptococcus infections | Confidence intervals | Antibiotic resistance | Bacteria | Meningitis | Children | Stains | Genotypes | Age | Serotyping | Immune system | Immune response | Statistical analysis | Multidrug resistance | Co-trimoxazole | Health risks | Antimicrobial agents | Population structure | Statistics | Standards | Computer programs | Antibiotics | Data collection | Elderly | Inhabitants | Pneumococcal Infections | Pneumònia | Espanya | Vacunes | Infeccions per pneumococs
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6. Full Text Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
by Càmara, Jordi and Marimón, José María and Cercenado, Emilia and Larrosa, Nieves and Quesada, María Dolores and Fontanals, Dionísia and Cubero, Meritxell and Perez Trallero, Emilio and Fenoll, Asunción and Liñares Louzao, Josefina and Ardanuy, Carmen
ISSN 1932-6203, 04/2017
A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before... 
Pneumococcal Infections | Pneumonia | Pneumònia | Espanya | Vacunes | Infeccions per pneumococs | Vaccines | Spain
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7. Full Text Estimating the Burden of Pneumococcal Pneumonia among Adults: A Systematic Review and Meta-Analysis of Diagnostic Techniques
by Said, Maria A and Johnson, Hope L and Nonyane, Bareng A. S and Deloria-Knoll, Maria and OBrien, Katherine L and AGEDD Adult Pneumococcal Burden and AGEDD Adult Pneumococcal Burden Study Team and for the AGEDD Adult Pneumococcal Burden Study Team
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60273
Background: Pneumococcal pneumonia causes significant morbidity and mortality among adults. Given limitations of diagnostic tests for non-bacteremic... 
ETIOLOGIC DIAGNOSIS | COMMUNITY-ACQUIRED PNEUMONIA | HOSPITALIZED-PATIENTS | STREPTOCOCCUS-PNEUMONIAE | MANAGEMENT | ASSAY | MULTIDISCIPLINARY SCIENCES | RISK PATIENTS | BINAX | PREDICTION RULE | URINARY ANTIGEN TEST | Streptococcus pneumoniae - isolation & purification | Pneumonia, Pneumococcal - epidemiology | Humans | Sensitivity and Specificity | Pneumonia, Pneumococcal - diagnosis | Adult | Bacteremia - diagnosis | Community-Acquired Infections | Streptococcus pneumoniae - immunology | Diagnosis | Research | Pneumonia, Pneumococcal | Analysis | Risk factors | Prevalence studies (Epidemiology) | Developed countries | Urine | Antigens | Pneumonia | Immunization | Estimation | Systematic review | Vaccines | Medical diagnosis | Morbidity | Streptococcus infections | Literature reviews | Studies | Infectious diseases | Human immunodeficiency virus--HIV | Sputum | Adults | Diagnostic systems | Public health | Pneumococs | Estreptococs | Pneumònia | Streptococcus | Streptococcus pneumonia | HIV | Human immunodeficiency virus
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8. Full Text Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites
by Feikin, Daniel R and Kagucia, Eunice W and Loo, Jennifer D and Link-Gelles, Ruth and Puhan, Milo A and Cherian, Thomas and Levine, Orin S and Whitney, Cynthia G and O'Brien, Katherine L and Moore, Matthew R and Adegbola, Claire A and Agocs, Mary and Ampofo, Krow and Anews, Nick and Barton, Theresa and Benito, Javier and Broome, Claire V and Bruce, Michael G and Bulkow, Lisa R and Byington, Carrie L and Camou, Teresa and Cook, Heather and Cotter, Suzanne and Dagan, Ron and de Wals, Philippe and Deceuninck, Geneviève and Denham, Barbara and Edwards, Giles and Eskola, Juhani and Fitzgerald, Margaret and Galanakis, Emmanouil and Garcia-Gabarrot, Gabriela and Garcia-Garcia, Juan J and Gene, Amadeu and Gomez, Borja and Heffernan, Helen and Hennessy, Thomas W and Heuberger, Sigrid and Hilty, Markus and Ingels, Helene and Jayasinghe, Sanjay and Kellner, James D and Klein, Nicola P and Kormann-Klement, Anea and Kozakova, Jana and Krause, Vicki and Kriz, Paula and Lambertsen, Lotte and Lepoutre, Agnès and Lipsitch, Marc and Lopez-Vega, Mariana and Lovgren, Marguerite and Maraki, Sofia and Mason, Edward O and McIntyre, Peter B and Menzies, Robert and Messina, Allison and Miller, Elizabeth and Mintegi, Santiago and Motlova, Jitka and Moulton, Lawrence H and Mühlemann, Kathrin and Muñoz-Almagro, Carmen and Murdoch, David R and Park, Daniel E and Reingold, Arthur L and Sa-Leao, Raquel and Sanyal, Abanti and Smith, Peter G and Spanjaard, Lodewijk and Techasaensiri, Chonnamet and Thompson, Richard E and Thoon, Koh C and Tyrrell, Gregory J and Valentiner-Branth, Palle and van der Ende, Arie and Vanderkooi, Otto G and van der Linden, Mark P. G and Varon, Emmanuelle and Verhaegen, Jan and Vestrheim, Diik F and Vickers, Imelda and von Gottberg, Anne and von Kries, Rüdiger and Waight, Pauline and Weatherholtz, Robert and Weiss, Susanne and Yee, Arnold and Zaidi, Anita K. M and Serotype Replacement Study Grp and Serotype Replacement Study Group and the Serotype Replacement Study Group
PLoS medicine, ISSN 1549-1277, 2013, Volume 10, Issue 9, p. e1001517
Background: Vaccine-serotype (VT) invasive pneumococcal disease (IPD) rates declined substantially following introduction of 7-valent pneumococcal conjugate... 
POPULATION | IMMUNIZATION | MEDICINE, GENERAL & INTERNAL | INFECTIONS | STREPTOCOCCUS-PNEUMONIAE | ERA | ACUTE OTITIS-MEDIA | TEMPORAL TRENDS | ANTIMICROBIAL RESISTANCE | EPIDEMIOLOGY | CHILDREN | Meta-Analysis as Topic | Humans | Health Planning Guidelines | Child, Preschool | Meningitis, Pneumococcal - prevention & control | Heptavalent Pneumococcal Conjugate Vaccine | Meningitis, Pneumococcal - immunology | Databases as Topic | Young Adult | Pneumococcal Infections - epidemiology | Pneumococcal Infections - immunology | Adolescent | Pneumococcal Infections - prevention & control | Pneumococcal Vaccines - immunology | Adult | Aged | Population Surveillance | Serotyping | Prevention | Physiological aspects | Host-parasite relationships | Dosage and administration | Vaccines | Pneumococcal infections | Immunology | Vacunes | Pneumococs | Immunologia | Infants | Children | Streptococcus pneumonia | Studies | Low income groups | Pneumonia | Disease | Streptococcus infections
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9. Full Text Epidemiology of invasive pneumococcal disease in older people in Spain (2007-2009): Implications for future vaccination strategies
by Ardanuy, Carmen and Marimón, José María and Calatayud, Laura and Giménez, Montserrat and Alonso, Marta and Grau, Immaculada and Pallarés, Román and Pérez-Trallero, Emilio and Liñares, Josefina
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e43619
Background: Recently, the 13-valent pneumococcal conjugate vaccine (PCV13) has been recommended for adults. We analyzed the epidemiology of invasive... 
UNITED-STATES | DRUG-RESISTANT | REPLACEMENT | CONJUGATE VACCINE | MULTIDISCIPLINARY SCIENCES | STREPTOCOCCUS-PNEUMONIAE SEROTYPES | ADULTS | 19A | TEMPORAL TRENDS | ANTIMICROBIAL RESISTANCE | EMERGENCE | Streptococcus pneumoniae - classification | Humans | Middle Aged | Genotype | Male | Pneumococcal Infections - epidemiology | Streptococcus pneumoniae - pathogenicity | Vaccination - methods | Spain - epidemiology | Pneumococcal Infections - prevention & control | Adult | Female | Aged | Serotyping | Analysis | Patient outcomes | Dosage and administration | Children | Drug therapy | Pneumococcal vaccine | Epidemiology | Health aspects | Pneumococcal infections | Elderly people | Pneumonia | Laboratories | Vaccination | Vaccines | Drug resistance | Streptococcus infections | Demographics | Older people | Penicillin | Meningitis | Chronic obstructive pulmonary disease | Genotypes | Invasiveness | Diabetes mellitus | Lung diseases | Infectious diseases | Hospitals | Antibiotics | Surveillance | Obstructive lung disease | Serotypes | Adults | Elderly | Cancer | Pneumococcal Infections | Estreptococs | Streptococcus | Espanya | Infeccions per pneumococs | Pneumococs | Persones grans | Vacuna antipneumocòccica | Streptococcus pneumonia | Spain
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10. Full Text Invasive Pneumococcal disease in healthy adults: Increase of Empyema associated with the clonal-type Sweden1-ST306
by Grau, Imma and Ardanuy, Carmen and Calatayud, Laura and Rolo, Dora and Domenech, Arnau and Liñares, Josefina and Pallares, Roman
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42595
Background Adult invasive pneumococcal disease (IPD) occurs mainly in the elderly and patients with co-morbidities. Little is known about the clinical... 
Elderly people | Drug abuse | Pneumonia | Immunization | Abuse | Mortality | Vaccination | Vaccines | Patients | Immunosuppression | Tobacco | Microbiological studies | Genotyping | Penicillin | Serotypes | Alcoholic beverages | Empyema | Adults | Health risk assessment | Elderly | Genotypes | Serotyping | Smoking | Geriatrics | Pneumococcal Infections | Empiema | Estreptococs | Streptococcus | Infeccions per pneumococs | Pneumococs | Streptococcus pneumonia
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11. Full Text Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae
by Selva Jové, Laura and Ciruela, Pilar and Blanchette, Krystle and Amo Moran, Eva del and Pallarés Giner, Roman and Orihuela, Carlos J and Muñoz-Almagro, Carmen
ISSN 1932-6203, 07/2012
Streptococcus pneumoniae is the leading cause of vaccine-preventable deaths globally. The objective of this study was to determine the distribution and clonal... 
Pneumococcal Infections | Pediatrics | Vacunació dels infants | Vaccination of children | Vaccines | Pneumococcal vaccine | Drug resistance | Resistència als medicaments | Infeccions per pneumococs | Vacunes | Pneumococs | Vacuna antipneumocòccica | Streptococcus pneumonia | Pediatria
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12. Full Text Disease Isolates of Streptococcus pseudopneumoniae and Non-Typeable S. pneumoniae Presumptively Identified as Atypical S. pneumoniae in Spain
by Rolo, Dora and S. Simões, Alexandra and Domenech, Arnau and Fenoll, Asunción and Liñares, Josefina and de Lencastre, Hermínia and Ardanuy, Carmen and Sá-Leão, Raquel
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e57047
We aimed to obtain insights on the nature of a collection of isolates presumptively identified as atypical Streptococcus pneumoniae recovered from invasive and... 
SEROTYPES | GENE | MITIS GROUP | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ORALIS | LYTA | SAMPLES | PNEUMOCOCCAL STRAINS | VIRIDANS GROUP STREPTOCOCCI | CHILDREN | Streptococcus pneumoniae - classification | Streptococcus pneumoniae - drug effects | Humans | Genotype | Male | Phylogeny | Multilocus Sequence Typing | Streptococcus - drug effects | Spain | Microbial Sensitivity Tests | Streptococcus - classification | Phenotype | Streptococcal Infections - diagnosis | Streptococcus - genetics | Streptococcus pneumoniae - genetics | Female | Pneumonia | RNA | Bacterial pneumonia | Analysis | Health aspects | Antibacterial agents | Genetic polymorphisms | Pathogens | rRNA 16S | Disease | Laboratories | Genes | Carbon dioxide | Clinical isolates | Identification | Genetic diversity | Erythromycin | PspA protein | Gene polymorphism | Streptococcus infections | Respiratory tract | Streptococcus | Restriction fragment length polymorphism | Penicillin | Genetics | Chronic obstructive pulmonary disease | Polymorphism | Bile | Pneumococcal Infections | Infeccions per pneumococs | Pneumococs | Bilis | Streptococcus pneumonia
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13. Full Text Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
by Zunt, Joseph Raymond and Kassebaum, Nicholas J and Blake, Natacha and Glennie, Linda and Wright, Claire and Nichols, Emma and Abd-Allah, Foad and Abdela, Jemal and Abdelalim, Ahmed and Adamu, Abdu A and Adib, Mina G and Ahmadi, Alireza and Ahmed, Muktar Beshir and Aichour, Miloud Taki Eddine and Aichour, Amani Nidhal and Aichour, Ibtihel and Akseer, Nadia and Al-Raddadi, Rajaa M and Alahdab, Fares and Alene, Kefyalew Addis and Aljunid, Syed Mohamed and AlMazroa, Mohammad A and Altirkawi, Khalid and Alvis-Guzman, Nelson and Animut, Megbaru Debalkie and Anjomshoa, Mina and Ansha, Mustafa Geleto and Asghar, Rana Jawad and Avokpaho, Euripide F G A and Awasthi, Ashish and Badali, Hamid and Barac, Aleksandra and Bärnighausen, Till Winfried and Bassat, Quique and Bedi, Neeraj and Belachew, Abate Bekele and Bhattacharyya, Krittika and Bhutta, Zulfiqar A and Bijani, Ali and Butt, Zahid A and Carvalho, Félix and Castañeda-Orjuela, Carlos A and Chitheer, Abdulaal and Choi, Jee-Young J and Christopher, Devasahayam J and Dang, Anh Kim and Daryani, Ahmad and Demoz, Gebre Teklemariam and Djalalinia, Shirin and Do, Huyen Phuc and Dubey, Manisha and Dubljanin, Eleonora and Duken, Eyasu Ejeta and El Sayed Zaki, Maysaa and Elyazar, Iqbal RF and Fakhim, Hamed and Fernandes, Eduarda and Fischer, Florian and Fukumoto, Takeshi and Ganji, Morsaleh and Gebre, Abadi Kahsu and Gebremeskel, Afewerki and Gessner, Bradford D and Gopalani, Sameer Vali and Guo, Yuming and Gupta, Rahul and Hailu, Gessessew Bugssa and Haj-Mirzaian, Arvin and Hamidi, Samer and Hay, Simon I and Henok, Andualem and Irvani, Seyed Sina Naghibi and Jha, Ravi Prakash and JÜRISSON, Mikk and Kahsay, Amaha and Karami, Manoochehr and Karch, André and Kasaeian, Amir and Kassa, Tesfaye Dessale Dessale and Kassa, Getachew Mullu and Kefale, Adane Teshome and Khader, Yousef Saleh and Khalil, Ibrahim A and Khan, Ejaz Ahmad and Khang, Young-Ho and Khubchandani, Jagdish and Kimokoti, Ruth W and Kisa, Adnan and Lami, Faris Hasan and Levi, Miriam and Li, Shanshan and Loy, Clement T and Majdan, Marek and Majeed, Azeem and Mantovani, Lorenzo Giovanni and Martins-Melo, Francisco Rogerlândio and Mcalinden, Colm and Mehta, Varshil and Melese, Addisu and Memish, Ziad A and ... and GBD 2016 Meningitis Collaborators
The Lancet Neurology, ISSN 1474-4422, 12/2018, Volume 17, Issue 12, pp. 1061 - 1082
Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels... 
UNITED-STATES | PNEUMOCOCCAL CONJUGATE VACCINE | AFRICA | IMPACT | BACTERIAL-MENINGITIS | RISK | HEALTH-CARE | MENINGOCOCCAL DISEASE | EPIDEMIOLOGY | CLINICAL NEUROLOGY | CHILDREN | Medicine, Experimental | Medical research | Meningitis | Mortality | Analysis | Immunization | Life span | Autopsy | Data processing | Fatalities | Vaccines | Bayesian analysis | Risk factors | Long-term effects | Pneumococs | Streptococcus pneumoniae
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14. Full Text Spread of streptococcus pneumoniae serotype 8-st63 multidrug-resistant recombinant clone, Spain
by Ardanuy, Carmen and De La Campa, Adela G and García, Ernesto and Fenoll, AsuncióN and Calatayud, Laura and Cercenado, Emilia and Pérez-Trallero, Emilio and Bouza, Emilio and Liñares, Josefina
Emerging Infectious Diseases, ISSN 1080-6040, 11/2014, Volume 20, Issue 11, pp. 1848 - 1856
Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed... 
UNITED-STATES | INFECTIOUS DISEASES | SEQUENCE | DISEASE | SUSCEPTIBILITY | BINDING PROTEIN GENES | INVASIVE PNEUMOCOCCI | IMMUNOLOGY | ANTIMICROBIAL RESISTANCE | FLUOROQUINOLONE | CLINICAL ISOLATE | EPIDEMIOLOGY | Streptococcus pneumoniae - classification | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Molecular Typing | Microbial Sensitivity Tests | Young Adult | Codon | Recombination, Genetic | Base Sequence | Streptococcus pneumoniae - genetics | Adult | Pneumococcal Infections - microbiology | Child | Gene Order | Amino Acid Sequence | Genome, Bacterial | Bacterial Proteins - genetics | Serogroup | Genotype | Polymorphism, Genetic | Pneumococcal Infections - epidemiology | Phenotype | Spain - epidemiology | Adolescent | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Genetic aspects | Research | Distribution | Streptococcus pneumoniae | Pneumococcal Infections | Respiratory organs diseases | Estreptococs | Malalties infeccioses | Communicable diseases | Drug resistance | Spain | Streptococcus | Espanya | Resistència als medicaments | Infeccions per pneumococs | Pneumococs | Malalties de l'aparell respiratori | Streptococcus pneumonia | Serotype 8-ST63 Multidrug-Resistant Recombinant Clone, Spain | bacteria | multidrug-resistant recombinant clone | fluoroquinolone resistance | serotype 8-ST63 | spread | Sweden 15A-ST63 clone | antimicrobial resistance | dissemination | Spread of | clone Sweden15A-ST63 | fluoroquine resistant | serotype 8
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